{"id":"https://openalex.org/W2012248287","doi":"https://doi.org/10.1007/bf00755602","title":"Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123","display_name":"Assessment of P-glycoprotein-dependent drug transport in isolated rat hepatocytes using rhodamine 123","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2012248287","doi":"https://doi.org/10.1007/bf00755602","mag":"2012248287","pmid":"https://pubmed.ncbi.nlm.nih.gov/7905358"},"language":"en","primary_location":{"id":"doi:10.1007/bf00755602","doi":"https://doi.org/10.1007/bf00755602","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00755602","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043982635","display_name":"Elisabetta Chieli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Chieli","raw_affiliation_strings":["Dipartimento de Biomedicina Sperimentale, Universit\u00e0 di Pisa, Italy","Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Universit\u00e0 di Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033396141","display_name":"Eric Santoni\u2010Rugiu","orcid":"https://orcid.org/0000-0002-2283-3535","observed_orcids":["https://orcid.org/0000-0002-2283-3535"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"E. Santoni Rugiu","raw_affiliation_strings":["Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036851381","display_name":"Fabrizio Cervelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Cervelli","raw_affiliation_strings":["Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050239368","display_name":"Aldo Paolicchi","orcid":"https://orcid.org/0000-0002-9940-8481","observed_orcids":["https://orcid.org/0000-0002-9940-8481"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Paolicchi","raw_affiliation_strings":["Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081337474","display_name":"Roberto Tongiani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"R. Tongiani","raw_affiliation_strings":["Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Scuola Medica, via Roma 55, I-56126, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dipartimento de Biomedicina Sperimentale, Sezione di Patologia Generale, Universit\u00e0 di, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":0.3115,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.61754927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"9","issue":"3","first_page":"235","last_page":"241"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9940000176429749},{"id":"https://openalex.org/keywords/multidrug-resistance-protein","display_name":"multidrug resistance protein","score":0.7080000042915344},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.6880000233650208},{"id":"https://openalex.org/keywords/rhodamine-123","display_name":"rhodamine 123","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.5730000138282776},{"id":"https://openalex.org/keywords/sodium-azide","display_name":"sodium azide","score":0.9589999914169312},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.4410000145435333},{"id":"https://openalex.org/keywords/age-related-changes","display_name":"age-related changes","score":0.5669999718666077}],"concepts":[{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.9229735136032104},{"id":"https://openalex.org/C2781417787","wikidata":"https://www.wikidata.org/wiki/Q407577","display_name":"Sodium azide","level":2,"score":0.8925716876983643},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.8261663913726807},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.7385232448577881},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.7332735657691956},{"id":"https://openalex.org/C2779916640","wikidata":"https://www.wikidata.org/wiki/Q420410","display_name":"Rhodamine","level":3,"score":0.5253923535346985},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5242928862571716},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5179478526115417},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4812590777873993},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4792197346687317},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4324411451816559},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42058265209198},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.4183228015899658},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4123801589012146},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3830493092536926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34538382291793823},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.32411882281303406},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.1698421835899353},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.06959551572799683},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001693","descriptor_name":"Biological Transport, Active","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012235","descriptor_name":"Rhodamines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019810","descriptor_name":"Sodium Azide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020112","descriptor_name":"Rhodamine 123","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00755602","doi":"https://doi.org/10.1007/bf00755602","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00755602","pdf_url":null,"source":{"id":"https://openalex.org/S31257671","display_name":"Cell Biology and Toxicology","issn_l":"0742-2091","issn":["0742-2091","1573-6822"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biology and Toxicology","raw_type":"journal-article"},{"id":"pmid:7905358","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7905358","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biology and toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/22881","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/22881","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W324750310","https://openalex.org/W1651390879","https://openalex.org/W1977782761","https://openalex.org/W1991925356","https://openalex.org/W2003837018","https://openalex.org/W2016103267","https://openalex.org/W2020931673","https://openalex.org/W2024437663","https://openalex.org/W2138791276","https://openalex.org/W4245797813"],"related_works":["https://openalex.org/W3139500423","https://openalex.org/W2519749407","https://openalex.org/W2030322255","https://openalex.org/W2036403778","https://openalex.org/W2163023957","https://openalex.org/W2201626923","https://openalex.org/W2040905261","https://openalex.org/W2009098269","https://openalex.org/W2472356848","https://openalex.org/W2399620515"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
