{"id":"https://openalex.org/W2012247257","doi":"https://doi.org/10.1158/1538-7445.am10-2107","title":"Abstract 2107: Deregulation of tumor suppressor miRNAs results in Six1 oncogene overexpression in pediatric and adult human cancers","display_name":"Abstract 2107: Deregulation of tumor suppressor miRNAs results in Six1 oncogene overexpression in pediatric and adult human cancers","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W2012247257","doi":"https://doi.org/10.1158/1538-7445.am10-2107","mag":"2012247257"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-2107","doi":"https://doi.org/10.1158/1538-7445.am10-2107","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2107","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060974352","display_name":"J. Saadi Imam","orcid":"https://orcid.org/0000-0003-3463-838X","observed_orcids":["https://orcid.org/0000-0003-3463-838X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Saadi Imam","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001777570","display_name":"Kalyan Buddavarapu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyan Buddavarapu","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007990664","display_name":"Jennifer S. Lee-Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer S. Lee-Chang","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108095389","display_name":"Peter J. Hornsby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Hornsby","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689059","display_name":"Yidong Chen","orcid":"https://orcid.org/0000-0002-3154-6511","observed_orcids":["https://orcid.org/0000-0002-3154-6511"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yidong Chen","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074570405","display_name":"Kihoon Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kihoon Yoon","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060628869","display_name":"Manjeet K. Rao","orcid":"https://orcid.org/0000-0001-7573-2677","observed_orcids":["https://orcid.org/0000-0001-7573-2677"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Manjeet Rao","raw_affiliation_strings":["1UT Health Science Ctr. San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT Health Science Ctr. San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"2107","last_page":"2107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7860000133514404},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.8960000276565552},{"id":"https://openalex.org/keywords/wilms-tumor","display_name":"Wilms tumor","score":0.9810000061988831},{"id":"https://openalex.org/keywords/pediatric-renal-cancer","display_name":"pediatric renal cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.7940000295639038},{"id":"https://openalex.org/keywords/mirna-microarray","display_name":"miRNA microarray","score":0.4819999933242798},{"id":"https://openalex.org/keywords/3-utr-targeting","display_name":"3' UTR targeting","score":0.7580000162124634},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":1.0},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.5630000233650208},{"id":"https://openalex.org/keywords/comparative-genomic-hybridization","display_name":"comparative genomic hybridization","score":0.7599999904632568},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C2775999222","wikidata":"https://www.wikidata.org/wiki/Q756289","display_name":"Wilms' tumor","level":2,"score":0.8742102384567261},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.803954005241394},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7748479843139648},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.6902404427528381},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6702329516410828},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6603069305419922},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5685926675796509},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5602968335151672},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5223413705825806},{"id":"https://openalex.org/C39845236","wikidata":"https://www.wikidata.org/wiki/Q7092103","display_name":"Oncomir","level":4,"score":0.4705774188041687},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.4248896539211273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25969985127449036},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.20622745156288147},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19831788539886475},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-2107","doi":"https://doi.org/10.1158/1538-7445.am10-2107","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-2107","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2103679640","https://openalex.org/W1968011172","https://openalex.org/W2103924156","https://openalex.org/W2152151858","https://openalex.org/W2796932159","https://openalex.org/W2095102324","https://openalex.org/W4361821826","https://openalex.org/W2170933474","https://openalex.org/W2125545284","https://openalex.org/W1980826276"],"abstract_inverted_index":{"Abstract":[0],"MicroRNAs":[1],"(miRNAs)":[2],"are":[3,139,288],"naturally":[4],"occurring,":[5],"short":[6],"non-coding":[7],"RNAs":[8],"believed":[9],"to":[10,150,154,173,240,263,290,323],"be":[11,29,174],"involved":[12],"in":[13,32,57,65,92,115,130,158,176,215,246,256,261,299,332],"many":[14],"biological":[15],"processes":[16],"including":[17,164],"normal":[18,42,98,306],"development":[19,132,160],"and":[20,44,118,133,161,185,201,243],"adult":[21,336],"cancer.":[22],"It":[23],"seems":[24],"logical":[25],"that":[26,63,88,105,122,142,268,286,294],"miRNAs":[27,56,87,109,149,207,255,287,317],"would":[28],"particularly":[30],"important":[31,127,297],"pediatric":[33,58,72,333],"cancers":[34],"as":[35,189,191,230,272,334],"these":[36,108,254,270],"malignancies":[37],"generally":[38],"involve":[39],"perturbations":[40],"of":[41,55,86,107,146,181,206,236,253,266,313,346,351],"developmental":[43],"differentiation":[45],"processes,":[46],"yet":[47],"relatively":[48],"little":[49],"is":[50,76],"known":[51,153],"about":[52],"the":[53,69,165,209,234,250,291,319,347,352],"role":[54,129,157,225,298],"cancers.":[59],"Here,":[60],"we":[61],"show":[62,89,110,143],"oncogenesis":[64],"Wilms\u2019":[66,93,116,134,162,183,257,300],"tumor":[67,193,223,244,315],"-":[68,75],"most":[70],"common":[71],"renal":[73],"cancer":[74,187,200,237],"mediated":[77],"by":[78,274,302],"miRNAs.":[79],"MiRNA":[80],"microarray":[81],"analysis":[82],"identified":[83],"a":[84,144,156,169,221,325],"cohort":[85],"altered":[90],"expression":[91,112,205,232,252],"tumors":[94,117,184,258],"when":[95],"compared":[96],"with":[97],"matched":[99],"control":[100],"kidney.":[101],"Our":[102],"results":[103],"reveal":[104],"several":[106,177],"similar":[111],"patterns":[113],"both":[114],"fetal":[119],"kidney,":[120],"suggesting":[121],"they":[123],"may":[124],"play":[125,155],"an":[126,213,296],"regulatory":[128,327],"kidney":[131,159,307],"tumorigenesis.":[135],"Supporting":[136],"this":[137],"notion":[138],"our":[140,283,311],"findings":[141,284],"number":[145],"differentially":[147],"expressed":[148],"target":[151],"genes":[152],"tumorigenesis,":[163],"Six1":[166,210,216,227,320,330],"homeobox":[167],"gene,":[168],"potent":[170,222],"oncogene":[171,321],"reported":[172],"overexpressed":[175],"solid":[178],"tumors.":[179,337],"Analyses":[180],"primary":[182],"ovarian":[186,199],"tissues":[188],"well":[190,335],"multiple":[192],"cell":[194,238],"lines":[195,239],"from":[196],"breast":[197],"cancer,":[198],"rhabdomyosarcoma":[202],"showed":[203],"decreased":[204],"targeting":[208,228,318],"3\u2032UTR,":[211],"paralleling":[212],"increase":[214],"levels.":[217],"Further":[218],"investigation":[219],"revealed":[220,273],"suppressor":[224,316],"for":[226,329,355],"miRNAs,":[229,271],"ectopic":[231],"suppressed":[233],"ability":[235],"form":[241],"colonies":[242],"growth":[245],"nude":[247],"mice.":[248],"Interestingly,":[249],"reduced":[251],"was":[259],"due":[260],"part":[262],"genomic":[264,278],"loss":[265],"loci":[267],"contain":[269],"high":[275],"resolution":[276],"comparative":[277],"hybridization":[279],"analysis.":[280],"In":[281,309],"summary,":[282],"suggest":[285],"integral":[289],"molecular":[292],"circuitry":[293],"plays":[295],"tumorigenesis":[301],"regulating":[303],"events":[304],"during":[305],"development.":[308],"addition,":[310],"discovery":[312],"novel":[314],"promises":[322],"unravel":[324],"unique":[326],"mechanism":[328],"deregulation":[331],"Citation":[338],"Format:":[339],"{Authors}.":[340],"{Abstract":[341],"title}":[342],"[abstract].":[343],"In:":[344],"Proceedings":[345],"101st":[348],"Annual":[349],"Meeting":[350],"American":[353],"Association":[354],"Cancer":[356,366],"Research;":[357],"2010":[358],"Apr":[359],"17-21;":[360],"Washington,":[361],"DC.":[362],"Philadelphia":[363],"(PA):":[364],"AACR;":[365],"Res":[367],"2010;70(8":[368],"Suppl):Abstract":[369],"nr":[370],"2107.":[371]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
