{"id":"https://openalex.org/W2012237359","doi":"https://doi.org/10.1074/jbc.m510223200","title":"Physical and Functional Interactions of the Cytomegalovirus US6 Glycoprotein with the Transporter Associated with Antigen Processing","display_name":"Physical and Functional Interactions of the Cytomegalovirus US6 Glycoprotein with the Transporter Associated with Antigen Processing","publication_year":2005,"publication_date":"2005-12-16","ids":{"openalex":"https://openalex.org/W2012237359","doi":"https://doi.org/10.1074/jbc.m510223200","mag":"2012237359","pmid":"https://pubmed.ncbi.nlm.nih.gov/16356928"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m510223200","doi":"https://doi.org/10.1074/jbc.m510223200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510223200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m510223200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036032049","display_name":"Anne Halenius","orcid":"https://orcid.org/0000-0001-6335-1017","observed_orcids":["https://orcid.org/0000-0001-6335-1017"]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anne Halenius","raw_affiliation_strings":["Division of Viral Infections, Robert Koch-Institute, Nordurfer 20, 13353 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch-Institute, Nordurfer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086069152","display_name":"Frank Momburg","orcid":"https://orcid.org/0000-0002-9475-0122","observed_orcids":["https://orcid.org/0000-0002-9475-0122"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Frank Momburg","raw_affiliation_strings":["Division of Molecular Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Immunology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073003523","display_name":"Henrike Reinhard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Henrike Reinhard","raw_affiliation_strings":["Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113572672","display_name":"Dagmar Bauer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Bauer","raw_affiliation_strings":["Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072894345","display_name":"Mario Lobigs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mario Lobigs","raw_affiliation_strings":["Division of Immunology and Genetics, the John Curtin School of Medical Research, the Australian National University, Acton ACT 0200, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Immunology and Genetics, the John Curtin School of Medical Research, the Australian National University, Acton ACT 0200, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044552413","display_name":"Hartmut Hengel","orcid":"https://orcid.org/0000-0002-3482-816X","observed_orcids":["https://orcid.org/0000-0002-3482-816X"]},"institutions":[{"id":"https://openalex.org/I24359323","display_name":"Robert Koch Institute","ror":"https://ror.org/01k5qnb77","country_code":"DE","type":"government","lineage":["https://openalex.org/I24359323"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hartmut Hengel","raw_affiliation_strings":["Division of Viral Infections, Robert Koch-Institute, Nordurfer 20, 13353 Berlin, Germany","Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Viral Infections, Robert Koch-Institute, Nordurfer 20, 13353 Berlin, Germany","institution_ids":["https://openalex.org/I24359323"]},{"raw_affiliation_string":"Institute for Virology, Heinrich-Heine-University D\u00fcsseldorf, Moorenstrasse 5, D-40225 D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5044552413"],"corresponding_institution_ids":["https://openalex.org/I24359323","https://openalex.org/I44260953"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.4848,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.81479565,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"281","issue":"9","first_page":"5383","last_page":"5390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.9028000235557556,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":0.8949999809265137},{"id":"https://openalex.org/keywords/transporter-associated-with-antigen-processing","display_name":"transporter associated with antigen processing","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tap1","display_name":"TAP1","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tap2","display_name":"TAP2","score":1.0},{"id":"https://openalex.org/keywords/mhc-class-i-loading","display_name":"MHC class I loading","score":0.7950000166893005},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8309999704360962},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"transmembrane domain","score":0.7509999871253967},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7860000133514404},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.8220000267028809},{"id":"https://openalex.org/keywords/viral-immune-evasion","display_name":"viral immune evasion","score":0.6930000185966492}],"concepts":[{"id":"https://openalex.org/C22845430","wikidata":"https://www.wikidata.org/wiki/Q224879","display_name":"Transporter associated with antigen processing","level":5,"score":0.8605765104293823},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.621636688709259},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5409823656082153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5090979933738708},{"id":"https://openalex.org/C170627219","wikidata":"https://www.wikidata.org/wiki/Q13218497","display_name":"MHC class I","level":4,"score":0.46437138319015503},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4388258159160614},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.43838199973106384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39253056049346924},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35824912786483765},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3353685140609741},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.3045274615287781},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.16800233721733093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1557299792766571}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015395","descriptor_name":"Histocompatibility Antigens Class I","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m510223200","doi":"https://doi.org/10.1074/jbc.m510223200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510223200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16356928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16356928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/89732","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/89732","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Biological Chemistry","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m510223200","doi":"https://doi.org/10.1074/jbc.m510223200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m510223200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W37697317","https://openalex.org/W93066099","https://openalex.org/W1502966885","https://openalex.org/W1511721705","https://openalex.org/W1517021800","https://openalex.org/W1779335972","https://openalex.org/W1937597224","https://openalex.org/W1964506466","https://openalex.org/W1977630302","https://openalex.org/W1979011182","https://openalex.org/W1982180580","https://openalex.org/W1991768318","https://openalex.org/W1994880461","https://openalex.org/W1995198210","https://openalex.org/W1997566415","https://openalex.org/W1998548282","https://openalex.org/W2007048801","https://openalex.org/W2008527255","https://openalex.org/W2014047349","https://openalex.org/W2028977956","https://openalex.org/W2032592226","https://openalex.org/W2033054937","https://openalex.org/W2041188360","https://openalex.org/W2043151506","https://openalex.org/W2044070030","https://openalex.org/W2049773295","https://openalex.org/W2053093244","https://openalex.org/W2055034075","https://openalex.org/W2055771920","https://openalex.org/W2059259572","https://openalex.org/W2068514170","https://openalex.org/W2071652768","https://openalex.org/W2071692669","https://openalex.org/W2078382230","https://openalex.org/W2085275703","https://openalex.org/W2093148044","https://openalex.org/W2093539004","https://openalex.org/W2098702227","https://openalex.org/W2109634012","https://openalex.org/W2120628290","https://openalex.org/W2124734530","https://openalex.org/W2127682895","https://openalex.org/W2140814973","https://openalex.org/W2142614224","https://openalex.org/W2150565917","https://openalex.org/W2154826631","https://openalex.org/W2156280292","https://openalex.org/W2171968561","https://openalex.org/W2322945902","https://openalex.org/W4234329713"],"related_works":["https://openalex.org/W1502966885","https://openalex.org/W2152578993","https://openalex.org/W1979011182","https://openalex.org/W2033054937","https://openalex.org/W2098702227","https://openalex.org/W2071652768","https://openalex.org/W2080604980","https://openalex.org/W7000744529","https://openalex.org/W1796276079","https://openalex.org/W7028642035"],"abstract_inverted_index":{"The":[0,151,190,231],"endoplasmic":[1,213],"reticulum-resident":[2],"human":[3,73,81,93],"cytomegalovirus":[4],"glycoprotein":[5],"US6":[6],"(gpUS6)":[7],"inhibits":[8,72],"peptide":[9,165,229],"translocation":[10],"by":[11,39,66,169,184,198,242],"the":[12,62,174,187,203,223,239],"transporter":[13],"associated":[14],"with":[15,108,114,149],"antigen":[16,30],"processing":[17],"(TAP)":[18],"to":[19,32,92,102,158,227],"prevent":[20],"loading":[21],"of":[22,64,80,85,90,121,132,164,173,186,202,209,238],"major":[23],"histocompatibility":[24],"complex":[25],"class":[26],"I":[27],"molecules":[28],"and":[29,43,52,82,95,127],"presentation":[31],"CD8+":[33],"T":[34],"cells.":[35],"TAP":[36,65,74,86,104,116,122,136,139,194,240],"is":[37,68,167,196],"formed":[38,183],"two":[40,142,178],"subunits,":[41],"TAP1":[42,94,210],"TAP2,":[44,96],"each":[45],"containing":[46],"one":[47],"multispanning":[48],"transmembrane":[49,215],"domain":[50,191],"(TMD)":[51],"a":[53,170,199,207,234],"cytosolic":[54],"nucleotide":[55],"binding":[56,89,126,180],"domain.":[57],"Here":[58],"we":[59,129],"reported":[60],"that":[61],"blockade":[63],"gpUS6":[67,71,91,98,106,125,179,221],"species-restricted,":[69],"i.e.":[70],"but":[75,112],"not":[76,100,113],"rat":[77,83,103],"TAP.":[78],"Co-expression":[79],"subunits":[84],"demonstrates":[87],"independent":[88],"whereas":[97,162],"does":[99],"bind":[101],"subunits.":[105,117],"associates":[107],"preformed":[109],"TAP1/2":[110],"heterodimers":[111],"unassembled":[115],"To":[118],"locate":[119],"domains":[120,181,226],"required":[123,192],"for":[124,193],"function,":[128],"took":[130],"advantage":[131],"reciprocal":[133],"human/rat":[134],"intrachain":[135],"chimeras.":[137],"Each":[138],"subunit":[140],"forms":[141],"contact":[143],"sites":[144],"within":[145],"its":[146],"TMD":[147],"interacting":[148],"gpUS6.":[150,243],"dominant":[152],"gpUS6-binding":[153],"site":[154],"on":[155],"TAP2":[156],"maps":[157],"an":[159],"N-terminal":[160],"loop,":[161],"inhibition":[163],"transport":[166],"mediated":[168],"C-terminal":[171,188,204],"loop":[172,201],"TMD.":[175,189],"For":[176],"TAP1,":[177],"are":[182],"loops":[185],"inactivation":[195],"built":[197],"distal":[200],"TMD,":[205],"indicating":[206],"topology":[208],"comprising":[211],"10":[212],"reticulum":[214],"segments.":[216],"By":[217],"forming":[218],"multimeric":[219],"complexes,":[220],"reaches":[222],"distant":[224],"target":[225],"arrest":[228],"transport.":[230],"data":[232],"revealed":[233],"nonanalogous":[235],"multipolar":[236],"bridging":[237],"TMDs":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
