{"id":"https://openalex.org/W2012230126","doi":"https://doi.org/10.1016/s1076-6332(98)80108-6","title":"Development of a novel nonaromatic small-molecule MR contrast agent for the blood pool","display_name":"Development of a novel nonaromatic small-molecule MR contrast agent for the blood pool","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W2012230126","doi":"https://doi.org/10.1016/s1076-6332(98)80108-6","mag":"2012230126","pmid":"https://pubmed.ncbi.nlm.nih.gov/9561083"},"language":"en","primary_location":{"id":"doi:10.1016/s1076-6332(98)80108-6","doi":"https://doi.org/10.1016/s1076-6332(98)80108-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1076-6332(98)80108-6","pdf_url":null,"source":{"id":"https://openalex.org/S182038535","display_name":"Academic Radiology","issn_l":"1076-6332","issn":["1076-6332","1878-4046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014045705","display_name":"Kofi Adzamli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kofi Adzamli","raw_affiliation_strings":["Imaging Division, Mallinckrodt, St. Louis, MO 63134, USA","Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, St. Louis, MO 63134, USA","institution_ids":[]},{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055021802","display_name":"Joseph P. Haar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph P. Haar","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049082745","display_name":"Michael R. Hynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Hynes","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111887229","display_name":"Donald B. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald B. Miller","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042401569","display_name":"John A. Polta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Polta","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102929055","display_name":"Rebecca A. Wallace","orcid":"https://orcid.org/0000-0001-8351-4231","observed_orcids":["https://orcid.org/0000-0001-8351-4231"]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Wallace","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017260150","display_name":"Steven R. Woulfe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Woulfe","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112832824","display_name":"Max D. Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102181","display_name":"Mallinckrodt (United States)","ror":"https://ror.org/01akman82","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102181"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Max D. Adams","raw_affiliation_strings":["Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging Division, Mallinckrodt, 675 McDonnell Blvd, PO Box 5840, St. Louis, MO 63134 USA","institution_ids":["https://openalex.org/I4210102181"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014045705"],"corresponding_institution_ids":["https://openalex.org/I4210102181"],"apc_list":{"value":3510,"currency":"USD","value_usd":3510},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.16694808,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":null,"first_page":"S210","last_page":"S213"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadolinium-based-contrast-agents","display_name":"gadolinium-based contrast agents","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mri-contrast-agents","display_name":"MRI contrast agents","score":0.8109999895095825},{"id":"https://openalex.org/keywords/blood-pool-agents","display_name":"blood pool agents","score":0.8059999942779541},{"id":"https://openalex.org/keywords/magnetic-resonance-angiography","display_name":"magnetic resonance angiography","score":0.8600000143051147},{"id":"https://openalex.org/keywords/serum-albumin-binding","display_name":"serum albumin binding","score":0.8999999761581421},{"id":"https://openalex.org/keywords/lipophilic-ligands","display_name":"lipophilic ligands","score":0.7749999761581421},{"id":"https://openalex.org/keywords/ms-325","display_name":"MS-325","score":0.8920000195503235},{"id":"https://openalex.org/keywords/blood-retention","display_name":"blood retention","score":0.46299999952316284},{"id":"https://openalex.org/keywords/contrast-agent-clearance","display_name":"contrast agent clearance","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.8081415891647339},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.759939432144165},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6459835767745972},{"id":"https://openalex.org/C2778978742","wikidata":"https://www.wikidata.org/wiki/Q6717498","display_name":"MRI contrast agent","level":3,"score":0.49816131591796875},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.45827412605285645},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.42960745096206665},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35558849573135376},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19781753420829773},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.1917305290699005},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1741909682750702}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018810","descriptor_name":"Magnetic Resonance Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1076-6332(98)80108-6","doi":"https://doi.org/10.1016/s1076-6332(98)80108-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1076-6332(98)80108-6","pdf_url":null,"source":{"id":"https://openalex.org/S182038535","display_name":"Academic Radiology","issn_l":"1076-6332","issn":["1076-6332","1878-4046"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic Radiology","raw_type":"journal-article"},{"id":"pmid:9561083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9561083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Academic radiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1978673416","https://openalex.org/W1992635038","https://openalex.org/W1995976462","https://openalex.org/W2002272577","https://openalex.org/W2018760263","https://openalex.org/W2022309796","https://openalex.org/W2117759541","https://openalex.org/W2159207181","https://openalex.org/W2951950555","https://openalex.org/W6639686838"],"related_works":["https://openalex.org/W2109719749","https://openalex.org/W1981760264","https://openalex.org/W2076219894","https://openalex.org/W2043638187","https://openalex.org/W2000996750","https://openalex.org/W1993002396","https://openalex.org/W2032839161","https://openalex.org/W1970735855","https://openalex.org/W1999889302","https://openalex.org/W2949642823"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
