{"id":"https://openalex.org/W2012226885","doi":"https://doi.org/10.1358/dot.2007.43.9.1088823","title":"Langerhans cell histiocytosis: A review of past, current and future therapies","display_name":"Langerhans cell histiocytosis: A review of past, current and future therapies","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2012226885","doi":"https://doi.org/10.1358/dot.2007.43.9.1088823","mag":"2012226885","pmid":"https://pubmed.ncbi.nlm.nih.gov/17940639"},"language":"en","primary_location":{"id":"doi:10.1358/dot.2007.43.9.1088823","doi":"https://doi.org/10.1358/dot.2007.43.9.1088823","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2007.43.9.1088823","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006499960","display_name":"Carl E. Allen","orcid":"https://orcid.org/0000-0002-6625-739X","observed_orcids":["https://orcid.org/0000-0002-6625-739X","https://orcid.org/0000-0002-2241-5712"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen, C.E.","raw_affiliation_strings":["Texas Children's Cancer Center/Hematology Service, Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Children's Cancer Center/Hematology Service, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006923130","display_name":"Kenneth L. McClain","orcid":"https://orcid.org/0000-0003-0725-6263","observed_orcids":["https://orcid.org/0000-0003-0725-6263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"McCain, K.L.","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9564,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.8977712,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"43","issue":"9","first_page":"627","last_page":"627"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10980","display_name":"Vascular Malformations and Hemangiomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/langerhans-cell-histiocytosis","display_name":"Langerhans cell histiocytosis","score":1.0},{"id":"https://openalex.org/keywords/organs-at-risk","display_name":"organs at risk","score":0.5820000171661377},{"id":"https://openalex.org/keywords/multisystem-disease","display_name":"multisystem disease","score":0.7329999804496765},{"id":"https://openalex.org/keywords/central-nervous-system-involvement","display_name":"central nervous system involvement","score":0.847000002861023},{"id":"https://openalex.org/keywords/bone-lesions","display_name":"bone lesions","score":0.5339999794960022},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"diabetes insipidus","score":0.7289999723434448},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5740000009536743},{"id":"https://openalex.org/keywords/surgical-excision","display_name":"surgical excision","score":0.8299999833106995},{"id":"https://openalex.org/keywords/corticosteroid-injection","display_name":"corticosteroid injection","score":0.6790000200271606},{"id":"https://openalex.org/keywords/clinical-trial-enrollment","display_name":"clinical trial recruitment","score":0.5249999761581421},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.46000000834465027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9635328650474548},{"id":"https://openalex.org/C2777484599","wikidata":"https://www.wikidata.org/wiki/Q374036","display_name":"Langerhans cell histiocytosis","level":3,"score":0.696637749671936},{"id":"https://openalex.org/C2780174970","wikidata":"https://www.wikidata.org/wiki/Q1411740","display_name":"Histiocytosis","level":3,"score":0.6582518815994263},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48444440960884094},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4526505172252655},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.416583389043808},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40935084223747253},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4074602723121643}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006646","descriptor_name":"Histiocytosis, Langerhans-Cell","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006646","descriptor_name":"Histiocytosis, Langerhans-Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006646","descriptor_name":"Histiocytosis, Langerhans-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1358/dot.2007.43.9.1088823","doi":"https://doi.org/10.1358/dot.2007.43.9.1088823","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2007.43.9.1088823","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},{"id":"pmid:17940639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17940639","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of today (Barcelona, Spain : 1998)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2567542925","https://openalex.org/W2142651172","https://openalex.org/W4313456893","https://openalex.org/W69780090","https://openalex.org/W2109270945","https://openalex.org/W3200178994","https://openalex.org/W183882435","https://openalex.org/W2037213098","https://openalex.org/W2054690739","https://openalex.org/W2289037320"],"abstract_inverted_index":{"The":[0,166,188],"goal":[1],"of":[2,16,86,117,121,134,180,193,212,217,225,252,276,286,313],"therapy":[3,218],"in":[4,54,75,103,138,142,184,191,206,295],"Langerhans":[5],"cell":[6],"histiocytosis":[7],"(LCH)":[8],"is":[9,29,168,195,291],"to":[10,31,153,241,282,309],"decrease":[11],"the":[12,23,76,87,104,149,185,210,213,250,261,314],"activity":[13],"and":[14,19,34,46,69,99,125,148,236,254,297,318],"proliferation":[15],"histiocytes,":[17],"lymphocytes":[18],"macrophages":[20],"that":[21,28,278],"cause":[22],"disease.":[24,101,199],"Patients":[25,200],"with":[26,52,73,136,197,201,232,238,273],"disease":[27,150,205,294],"localized":[30],"skin,":[32],"bone":[33,60,141],"lymph":[35],"node":[36],"(defined":[37],"as":[38,113,258,260],"\"nonrisk\"":[39,143],"organs)":[40],"generally":[41,146,169],"have":[42,62,219,279],"a":[43,63,172,178,274,292],"good":[44],"prognosis":[45,66],"require":[47],"minimal":[48],"treatment.":[49,226],"However,":[50],"patients":[51,72,135,196,231,300],"lesions":[53],"\"risk\"":[55],"organs":[56,208],"(liver,":[57],"spleen,":[58],"lung,":[59],"marrow)":[61],"worse":[64],"overall":[65,222],"regarding":[67],"mortality":[68],"morbidity.":[70],"Likewise,":[71],"LCH":[74,102,137,194,239,284,290],"central":[77],"nervous":[78],"system":[79],"(CNS),":[80],"vertebrae,":[81],"facial":[82],"bones":[83,85],"or":[84,89,107,129,163,176,203],"anterior":[88],"middle":[90],"cranial":[91],"fossa":[92],"are":[93,111,145],"at":[94],"higher":[95],"risk":[96,179,207],"for":[97,171,230],"morbidity":[98],"recurrent":[100],"orbit,":[105],"mastoid":[106],"temporal":[108],"skull":[109],"regions":[110],"classified":[112],"\"CNS":[114],"risk\"":[115],"because":[116],"an":[118],"increased":[119],"frequency":[120],"developing":[122],"diabetes":[123],"insipidus":[124],"other":[126],"endocrine":[127],"abnormalities":[128],"parenchymal":[130],"brain":[131],"lesions.":[132],"Outcomes":[133],"only":[139],"one":[140],"locations":[144],"benign,":[147],"responds":[151],"well":[152,259],"several":[154],"treatment":[155,192,229,256,266],"modalities":[156],"including":[157],"observation,":[158],"surgical":[159],"excision,":[160],"steroid":[161],"injection":[162],"radiation":[164],"therapy.":[165],"last":[167],"reserved":[170],"single":[173],"vertebral":[174],"lesion":[175],"when":[177],"pathologic":[181],"fracture":[182],"exists":[183],"greater":[186],"trochanter.":[187],"greatest":[189],"challenge":[190],"multisystem":[198],"persistent":[202],"worsening":[204],"by":[209],"end":[211],"first":[214],"6-12":[215],"weeks":[216],"significantly":[220],"decreased":[221],"survival":[223],"regardless":[224],"Additionally,":[227],"optimal":[228,315],"late-onset":[233],"CNS":[234],"symptoms":[235],"adults":[237],"remain":[240],"be":[242,302],"defined.":[243],"In":[244],"this":[245],"article":[246],"we":[247],"will":[248],"review":[249,271],"evolution":[251],"multicenter":[253],"international":[255],"studies":[257],"current":[262],"Histiocyte":[263],"Society":[264],"research":[265],"protocol,":[267],"LCH-III.":[268],"We":[269],"also":[270],"experiences":[272],"variety":[275],"agents":[277],"been":[280],"used":[281],"treat":[283],"outside":[285],"clinical":[287,305],"trials.":[288],"Since":[289],"rare":[293],"children":[296],"adults,":[298],"these":[299],"should":[301],"enrolled":[303],"on":[304],"trials":[306],"whenever":[307],"possible":[308],"advance":[310],"our":[311],"knowledge":[312],"therapeutic":[316],"interventions":[317],"long-term":[319],"outcomes.":[320]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
