{"id":"https://openalex.org/W2012222271","doi":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","title":"Analysis of the binding surfaces of proteins","display_name":"Analysis of the binding surfaces of proteins","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2012222271","doi":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","mag":"2012222271","pmid":"https://pubmed.ncbi.nlm.nih.gov/10398928"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S22382660","display_name":"Medicinal Research Reviews","issn_l":"0198-6325","issn":["0198-6325","1098-1128"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Research Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014900252","display_name":"Dagmar Ringe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dagmar Ringe","raw_affiliation_strings":["Departments of Biochemistry and Chemistry, Brandeis University, MS 029, Waltham, MA 02454-9110, USA","Departments of Biochemistry and Chemistry, Brandeis University, MS 029, Waltham, MA 02454-9110","Rosenstiel Basic Medical Sciences Research Center, Brandeis University, MS 029, Waltham, MA 02454-9110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, Brandeis University, MS 029, Waltham, MA 02454-9110, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Departments of Biochemistry and Chemistry, Brandeis University, MS 029, Waltham, MA 02454-9110","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center, Brandeis University, MS 029, Waltham, MA 02454-9110","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033766917","display_name":"Carla Mattos","orcid":"https://orcid.org/0000-0002-4112-0696","observed_orcids":["https://orcid.org/0000-0002-4112-0696"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Mattos","raw_affiliation_strings":["Rosenstiel Basic Medical Sciences Research Center, Brandeis University, MS 029, Waltham, MA 02454-9110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rosenstiel Basic Medical Sciences Research Center, Brandeis University, MS 029, Waltham, MA 02454-9110","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5014900252"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":0.517,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.42105263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"19","issue":"4","first_page":"321","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzene","display_name":"benzene","score":0.453000009059906},{"id":"https://openalex.org/keywords/dimethylformamide","display_name":"dimethylformamide","score":0.9269999861717224},{"id":"https://openalex.org/keywords/peptide-binding-site","display_name":"peptide binding site","score":0.7429999709129333},{"id":"https://openalex.org/keywords/elastase","display_name":"elastase","score":0.7149999737739563},{"id":"https://openalex.org/keywords/active-site-cleft","display_name":"active site cleft","score":0.9110000133514404},{"id":"https://openalex.org/keywords/amphipathicity","display_name":"amphipathicity","score":0.921999990940094},{"id":"https://openalex.org/keywords/water-displacement","display_name":"water displacement","score":0.7889999747276306},{"id":"https://openalex.org/keywords/protein-ligand-interactions","display_name":"protein-ligand interactions","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.7059075832366943},{"id":"https://openalex.org/C204389451","wikidata":"https://www.wikidata.org/wiki/Q178593","display_name":"Macromolecule","level":2,"score":0.6717782616615295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6446103453636169},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.5445639491081238},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4341820180416107},{"id":"https://openalex.org/C2778270854","wikidata":"https://www.wikidata.org/wiki/Q283917","display_name":"Formamide","level":2,"score":0.4234757423400879},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4157383441925049},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.41312727332115173},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.37630635499954224},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.36185044050216675},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22060537338256836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1780289113521576},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14017179608345032},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09160485863685608}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","doi":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1128(199907)19:4<321::aid-med5>3.0.co;2-f","pdf_url":null,"source":{"id":"https://openalex.org/S22382660","display_name":"Medicinal Research Reviews","issn_l":"0198-6325","issn":["0198-6325","1098-1128"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal Research Reviews","raw_type":"journal-article"},{"id":"pmid:10398928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10398928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicinal research reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1243769774","https://openalex.org/W1533226288","https://openalex.org/W1972091733","https://openalex.org/W1978883716","https://openalex.org/W1990752587","https://openalex.org/W1994902154","https://openalex.org/W1994923840","https://openalex.org/W1999900298","https://openalex.org/W1999947781","https://openalex.org/W2004709088","https://openalex.org/W2010974527","https://openalex.org/W2015647379","https://openalex.org/W2022224158","https://openalex.org/W2023450156","https://openalex.org/W2030795605","https://openalex.org/W2039127550","https://openalex.org/W2040861628","https://openalex.org/W2044099939","https://openalex.org/W2055747785","https://openalex.org/W2058527555","https://openalex.org/W2063330894","https://openalex.org/W2064514012","https://openalex.org/W2065057333","https://openalex.org/W2069298274","https://openalex.org/W2069328396","https://openalex.org/W2071349077","https://openalex.org/W2078359063","https://openalex.org/W2080653934","https://openalex.org/W2087431455","https://openalex.org/W2087659265","https://openalex.org/W2089878534","https://openalex.org/W2112194058","https://openalex.org/W2115080364","https://openalex.org/W2115133620","https://openalex.org/W2166924299","https://openalex.org/W2408809102"],"related_works":["https://openalex.org/W2168865322","https://openalex.org/W1994923840","https://openalex.org/W2103935162","https://openalex.org/W2008421309","https://openalex.org/W2025157967","https://openalex.org/W2151884301","https://openalex.org/W2249803543","https://openalex.org/W2101362041","https://openalex.org/W2139432351","https://openalex.org/W2134952459"],"abstract_inverted_index":{"We":[0,134],"have":[1,135],"developed":[2],"an":[3],"experimental":[4],"approach":[5],"to":[6,49,76,98,139],"map":[7,140],"the":[8,23,32,45,50,100,105,131,141,153,189],"complete":[9,142],"binding":[10,85,102,143,172,184],"surface":[11,107,144],"of":[12,22,92,145,170],"any":[13,166],"crystalline":[14],"macromolecule":[15],"that":[16,119,124,149,180],"is":[17,68,80,186],"fast":[18],"and":[19,31,87,147,160,176,188],"flexible.":[20],"Crystals":[21],"target":[24],"protein":[25,51,106],"are":[26,35,52,157],"transferred":[27],"into":[28],"organic":[29,63],"solvents":[30,57],"crystal":[33],"structures":[34],"determined":[36],"at":[37],"high":[38],"(about":[39],"2A)":[40],"resolution.":[41],"The":[42],"sites":[43,111,173],"where":[44,72],"solvent":[46],"molecules":[47],"bind":[48],"thus":[53],"identified":[54],"directly.":[55],"Different":[56],"serve":[58],"as":[59],"probes":[60],"for":[61,71,83,130],"different":[62,110],"functional":[64,167],"groups;":[65],"thus,":[66],"benzene":[67],"a":[69,81,183],"probe":[70,82],"aromatic":[73],"groups":[74],"like":[75],"bind,":[77],"dimethyl":[78],"formamide":[79],"peptide":[84],"sites,":[86],"so":[88],"forth.":[89],"A":[90],"series":[91],"about":[93],"six":[94],"such":[95],"experiments":[96],"suffices":[97],"locate":[99],"major":[101],"regions":[103],"on":[104,174],"unambiguously.":[108],"These":[109],"can":[112,161,194],"then":[113],"be":[114,195],"targeted":[115],"with":[116,122,164,191],"\"Hydra-headed\"":[117],"inhibitors":[118],"interact":[120],"simultaneously":[121],"more":[123],"one":[125],"site,":[126],"thereby":[127],"providing":[128],"specificity":[129],"desired":[132],"target.":[133],"used":[136],"this":[137],"method":[138],"elastase,":[146],"find":[148],"three":[150],"regions,":[151],"including":[152],"active":[154],"site":[155,185],"cleft,":[156],"generally":[158],"\"sticky\"":[159],"make":[162],"interactions":[163],"almost":[165],"group.":[168],"Analyses":[169],"these":[171],"elastase":[175],"other":[177],"proteins":[178],"suggests":[179],"what":[181],"makes":[182],"amphipathicity":[187],"ease":[190],"which":[192],"water":[193],"displaced.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
