{"id":"https://openalex.org/W2012221118","doi":"https://doi.org/10.1096/fj.99-0843com","title":"Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts","display_name":"Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2012221118","doi":"https://doi.org/10.1096/fj.99-0843com","mag":"2012221118","pmid":"https://pubmed.ncbi.nlm.nih.gov/10928983"},"language":"en","primary_location":{"id":"doi:10.1096/fj.99-0843com","doi":"https://doi.org/10.1096/fj.99-0843com","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.99-0843com","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2012221118"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.25405/ncl.34583250","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015130196","display_name":"Nicolle Sitte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nicolle Sitte","raw_affiliation_strings":["Clinics of Physical Medicine and Rehabilitation, Charit\u00e9, Humboldt University, Berlin, Germany","Institute of Pathology, Charit\u00e9, Humboldt University, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinics of Physical Medicine and Rehabilitation, Charit\u00e9, Humboldt University, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]},{"raw_affiliation_string":"Institute of Pathology, Charit\u00e9, Humboldt University, Berlin, Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Huber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Huber","raw_affiliation_strings":["Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tilman Grune","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tilman Grune","raw_affiliation_strings":["Clinics of Physical Medicine and Rehabilitation Charit\u00e9, Humboldt University Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinics of Physical Medicine and Rehabilitation Charit\u00e9, Humboldt University Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Axel Ladhoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Axel Ladhoff","raw_affiliation_strings":["Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wolf\u2010Dietrich Doecke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolf\u2010Dietrich Doecke","raw_affiliation_strings":["Institute of Medical Immunology Charit\u00e9, Humboldt University Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Immunology Charit\u00e9, Humboldt University Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Von Zglinicki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39343248","display_name":"Humboldt-Universit\u00e4t zu Berlin","ror":"https://ror.org/01hcx6992","country_code":"DE","type":"education","lineage":["https://openalex.org/I39343248"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Von Zglinicki","raw_affiliation_strings":["Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology Charit\u00e9, Humboldt University Berlin Germany","institution_ids":["https://openalex.org/I39343248","https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":null,"display_name":"Kelvin J. A. Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kelvin J. A. Davies","raw_affiliation_strings":["Ethel Percy Andrus Gerontology Center and Division of Molecular Biology The University of Southern California Los Angeles California 90089\u20100191 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ethel Percy Andrus Gerontology Center and Division of Molecular Biology The University of Southern California Los Angeles California 90089\u20100191 USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":5.3454,"has_fulltext":false,"cited_by_count":321,"citation_normalized_percentile":{"value":0.96829268,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"11","first_page":"1490","last_page":"1498"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.19709999859333038,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.07339999824762344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.8889999985694885},{"id":"https://openalex.org/keywords/lipofuscin","display_name":"lipofuscin","score":0.996999979019165},{"id":"https://openalex.org/keywords/ceroid","display_name":"ceroid","score":0.6470000147819519},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.7179999947547913},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.7870000004768372},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/lysosomal-cathepsins","display_name":"lysosomal cathepsins","score":0.7300000190734863},{"id":"https://openalex.org/keywords/oxidized-proteins","display_name":"oxidized proteins","score":0.8050000071525574},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.5210000276565552},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C186198217","wikidata":"https://www.wikidata.org/wiki/Q217740","display_name":"Lipofuscin","level":2,"score":0.9598779678344727},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.6781737804412842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5161669850349426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46232369542121887},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32602977752685547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2999291718006134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2546043395996094}],"mesh":[{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002566","descriptor_name":"Ceroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002566","descriptor_name":"Ceroid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D002918","descriptor_name":"Chymotrypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008062","descriptor_name":"Lipofuscin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008062","descriptor_name":"Lipofuscin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1096/fj.99-0843com","doi":"https://doi.org/10.1096/fj.99-0843com","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.99-0843com","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"doi:10.1096/fj.14.11.1490","doi":"https://doi.org/10.1096/fj.14.11.1490","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.14.11.1490","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:10928983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10928983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"doi:10.25405/ncl.34583250","doi":"https://doi.org/10.25405/ncl.34583250","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34583250","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34583250.v1","doi":"https://doi.org/10.25405/ncl.34583250.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34583250.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.25405/ncl.34583250","doi":"https://doi.org/10.25405/ncl.34583250","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34583250","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G517582310","display_name":null,"funder_award_id":"ES03598","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1511670599","https://openalex.org/W1522000230","https://openalex.org/W1531318383","https://openalex.org/W1566636169","https://openalex.org/W1966387364","https://openalex.org/W1966529358","https://openalex.org/W1983673827","https://openalex.org/W1986119684","https://openalex.org/W1987558049","https://openalex.org/W1991494214","https://openalex.org/W2002053089","https://openalex.org/W2018603115","https://openalex.org/W2022282591","https://openalex.org/W2023677185","https://openalex.org/W2028587126","https://openalex.org/W2035868526","https://openalex.org/W2044320834","https://openalex.org/W2046761749","https://openalex.org/W2048966030","https://openalex.org/W2054360287","https://openalex.org/W2056763451","https://openalex.org/W2060677651","https://openalex.org/W2068337326","https://openalex.org/W2069029183","https://openalex.org/W2071673220","https://openalex.org/W2074643484","https://openalex.org/W2075470612","https://openalex.org/W2077782146","https://openalex.org/W2080426159","https://openalex.org/W2082188935","https://openalex.org/W2084556573","https://openalex.org/W2086551090","https://openalex.org/W2087688547","https://openalex.org/W2089000157","https://openalex.org/W2094613097","https://openalex.org/W2123190575","https://openalex.org/W2131243502","https://openalex.org/W2178503716","https://openalex.org/W2272181562","https://openalex.org/W2402105339","https://openalex.org/W2443663492","https://openalex.org/W4213223628"],"related_works":["https://openalex.org/W1972647829","https://openalex.org/W2017658570","https://openalex.org/W2061368959","https://openalex.org/W2063062219","https://openalex.org/W2049566430","https://openalex.org/W2080453174","https://openalex.org/W2035004399","https://openalex.org/W2022754327","https://openalex.org/W400376671","https://openalex.org/W2414114263"],"abstract_inverted_index":{"We":[0,259],"have":[1],"studied":[2],"the":[3,18,54,100,146,227,294],"effects":[4],"of":[5,8,21,58,65,94,181,229,274],"hyperoxia":[6,28],"and":[7,41,77,104,129,140,151],"cell":[9,25,69,208],"loading":[10,163],"with":[11,109,254],"artificial":[12],"lipofuscin":[13],"or":[14,115],"ceroid":[15],"pigment":[16],"on":[17],"postmitotic":[19,43],"aging":[20,291],"human":[22],"lung":[23],"fibroblast":[24],"cultures.":[26],"Normobaric":[27],"(40%":[29],"oxygen)":[30],"caused":[31,122,221],"an":[32,212,272],"irreversible":[33],"senescence-like":[34],"growth":[35],"arrest":[36],"after":[37],"about":[38],"4":[39,179],"wk":[40,57,76,93,180],"shortened":[42],"life":[44],"span":[45],"from":[46],"1-1/2":[47],"years":[48],"down":[49],"to":[50,161,248],"3":[51],"months.":[52],"During":[53],"first":[55],"8":[56],"hyperoxia-induced":[59],"'aging',":[60],"overall":[61,79,175],"protein":[62,86,176,184],"degradation":[63,177],"(breakdown":[64],"[(35)S]methionine":[66],"metabolically":[67],"radiolabeled":[68],"proteins)":[70],"increased":[71],"somewhat,":[72],"but":[73],"by":[74,91,113,136,192,222,266,292],"12":[75,92,118,132],"thereafter":[78],"proteolysis":[80,153],"was":[81,186,219],"significantly":[82],"depressed.":[83],"In":[84,210],"contrast,":[85,211],"synthesis":[87,185],"rates":[88],"were":[89],"unaffected":[90],"hyperoxia.":[95],"Lysosomal":[96],"cathepsin-specific":[97],"activity":[98,107,190,218],"(using":[99],"fluorogenic":[101],"substrate":[102],"z-FR-MCA)":[103],"cytoplasmic":[105],"proteasome-specific":[106],"(measured":[108],"suc-LLVY-MCA)":[110],"both":[111,137],"declined":[112],"80%":[114],"more":[116],"over":[117,131,178,194],"wk.":[119],"Hyperoxia":[120],"also":[121],"a":[123,171,223],"remarkable":[124],"increase":[125,214,225],"in":[126,174,215,226,238,257,287],"lipofuscin/ceroid":[127,149,162,236,255,281],"formation":[128],"accumulation":[130,150,273,289],"wk,":[133],"as":[134,280],"judged":[135],"fluorescence":[138],"measurements":[139],"FACscan":[141],"methods.":[142],"To":[143,233],"test":[144,234],"whether":[145,235],"association":[147],"between":[148],"decreased":[152,191],"might":[154],"be":[155],"causal,":[156],"we":[157,250],"next":[158],"exposed":[159],"cells":[160,168],"under":[164],"normoxic":[165],"conditions.":[166],"Lipofuscin/ceroid-loaded":[167],"indeed":[169],"exhibited":[170],"gradual":[172],"decrease":[173],"treatment,":[182],"whereas":[183],"unaffected.":[187],"Proteasome":[188],"specific":[189],"25%":[193],"this":[195],"period,":[196],"which":[197],"is":[198,202,263],"important":[199],"since":[200],"proteasome":[201,242,253,262],"normally":[203],"responsible":[204],"for":[205],"degrading":[206],"oxidized":[207,246,275],"proteins.":[209],"apparent":[213],"lysosomal":[216],"cathepsin":[217],"actually":[220,283],"large":[224],"number":[228],"lysosomes":[230],"per":[231],"cell.":[232],"could":[237],"fact":[239],"directly":[240,264],"inhibit":[241],"activity,":[243],"thus":[244],"causing":[245],"proteins":[247,276],"accumulate,":[249],"incubated":[251],"purified":[252],"preparations":[256],"vitro.":[258],"found":[260],"that":[261,271],"inhibited":[265],"lipofuscin/ceroid.":[267],"Our":[268],"results":[269],"indicate":[270],"(and":[277],"lipids)":[278],"such":[279],"may":[282],"cause":[284],"further":[285],"increases":[286],"damage":[288],"during":[290],"inhibiting":[293],"proteasome.":[295]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}