{"id":"https://openalex.org/W2012219744","doi":"https://doi.org/10.1074/jbc.m805287200","title":"Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation","display_name":"Cysteine S-Nitrosylation Protects Protein-tyrosine Phosphatase 1B against Oxidation-induced Permanent Inactivation","publication_year":2008,"publication_date":"2008-10-08","ids":{"openalex":"https://openalex.org/W2012219744","doi":"https://doi.org/10.1074/jbc.m805287200","mag":"2012219744","pmid":"https://pubmed.ncbi.nlm.nih.gov/18840608","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3259880"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m805287200","doi":"https://doi.org/10.1074/jbc.m805287200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m805287200","pdf_url":"http://www.jbc.org/article/S002192582063349X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S002192582063349X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yi-Yun Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Yun Chen","raw_affiliation_strings":["Institute of Biological Chemistry, National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"raw_affiliation_string":"Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]},{"raw_affiliation_string":"National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003499321","display_name":"Hsing\u2010Mao Chu","orcid":"https://orcid.org/0000-0001-8692-6039","observed_orcids":["https://orcid.org/0000-0001-8692-6039"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hsing-Mao Chu","raw_affiliation_strings":["Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021481490","display_name":"Kuan\u2010Ting Pan","orcid":"https://orcid.org/0000-0001-6974-5324","observed_orcids":["https://orcid.org/0000-0001-6974-5324"]},"institutions":[{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kuan-Ting Pan","raw_affiliation_strings":["National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079588457","display_name":"Chun-Hung Teng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chun-Hung Teng","raw_affiliation_strings":["Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074281806","display_name":"Danny-Ling Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096666","display_name":"Institute of Biomedical Sciences, Academia Sinica","ror":"https://ror.org/00tk6s776","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Danny-Ling Wang","raw_affiliation_strings":["Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210096666","https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016567722","display_name":"Andrew H.\u2010J. Wang","orcid":"https://orcid.org/0000-0002-0016-5337","observed_orcids":["https://orcid.org/0000-0002-0016-5337"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Andrew H.-J. Wang","raw_affiliation_strings":["Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]},{"raw_affiliation_string":"National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063635262","display_name":"Kay\u2010Hooi Khoo","orcid":"https://orcid.org/0000-0003-2906-406X","observed_orcids":["https://orcid.org/0000-0003-2906-406X"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]},{"id":"https://openalex.org/I84653119","display_name":"Academia Sinica","ror":"https://ror.org/05bxb3784","country_code":"TW","type":"facility","lineage":["https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Kay-Hooi Khoo","raw_affiliation_strings":["Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]},{"raw_affiliation_string":"National Core Facility for Proteomics Research, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I84653119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018097202","display_name":"Tzu\u2010Ching Meng","orcid":"https://orcid.org/0000-0001-7693-2021","observed_orcids":["https://orcid.org/0000-0001-7693-2021"]},"institutions":[{"id":"https://openalex.org/I16733864","display_name":"National Taiwan University","ror":"https://ror.org/05bqach95","country_code":"TW","type":"education","lineage":["https://openalex.org/I16733864"]},{"id":"https://openalex.org/I4210092384","display_name":"Institute of Biological Chemistry, Academia Sinica","ror":"https://ror.org/00jt3dw39","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210092384","https://openalex.org/I84653119"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Tzu-Ching Meng","raw_affiliation_strings":["Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemical Sciences, College of Life Sciences, National Taiwan University, Taipei 10617, Taiwan","institution_ids":["https://openalex.org/I16733864"]},{"raw_affiliation_string":"Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan","institution_ids":["https://openalex.org/I4210092384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018097202","https://openalex.org/A5063635262"],"corresponding_institution_ids":["https://openalex.org/I16733864","https://openalex.org/I4210092384","https://openalex.org/I84653119"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.584,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.94231792,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"283","issue":"50","first_page":"35265","last_page":"35272"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.5497999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.44510000944137573,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/ptp1b","display_name":"PTP1B","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cysteine-oxidation","display_name":"cysteine oxidation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.652999997138977},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":0.6769999861717224},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.5989999771118164},{"id":"https://openalex.org/keywords/protein-inactivation","display_name":"protein inactivation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6759999990463257},{"id":"https://openalex.org/keywords/nitric-oxide-synthase","display_name":"nitric oxide synthase","score":0.6840000152587891},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C2777553025","wikidata":"https://www.wikidata.org/wiki/Q25323683","display_name":"S-Nitrosylation","level":4,"score":0.9530354142189026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7551363706588745},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.7088965177536011},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6353976726531982},{"id":"https://openalex.org/C45068187","wikidata":"https://www.wikidata.org/wiki/Q9050270","display_name":"Nitrosylation","level":3,"score":0.6218605041503906},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.6193856000900269},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5391792058944702},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5355285406112671},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5025029182434082},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.46894073486328125},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.45484623312950134},{"id":"https://openalex.org/C2781139505","wikidata":"https://www.wikidata.org/wiki/Q5201195","display_name":"Cysteine metabolism","level":4,"score":0.4257078170776367},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.23372769355773926},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.20324355363845825},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009584","descriptor_name":"Nitrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054562","descriptor_name":"Protein Tyrosine Phosphatase, Non-Receptor Type 1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m805287200","doi":"https://doi.org/10.1074/jbc.m805287200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m805287200","pdf_url":"http://www.jbc.org/article/S002192582063349X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:18840608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18840608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3259880","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3259880/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"mag:2184840315","doi":null,"is_oa":false,"landing_page_url":"https://www.jbc.org/content/283/50/35265.full.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1074/jbc.m805287200","doi":"https://doi.org/10.1074/jbc.m805287200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m805287200","pdf_url":"http://www.jbc.org/article/S002192582063349X/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012219744.pdf","grobid_xml":"https://content.openalex.org/works/W2012219744.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W107445082","https://openalex.org/W109036740","https://openalex.org/W1492951734","https://openalex.org/W1512538844","https://openalex.org/W1539796472","https://openalex.org/W1569199195","https://openalex.org/W1585390661","https://openalex.org/W1963784434","https://openalex.org/W1966726553","https://openalex.org/W1977628398","https://openalex.org/W1979119013","https://openalex.org/W1983510345","https://openalex.org/W1988461310","https://openalex.org/W1989268736","https://openalex.org/W1997280515","https://openalex.org/W2009601307","https://openalex.org/W2011233979","https://openalex.org/W2013021682","https://openalex.org/W2017642315","https://openalex.org/W2018565008","https://openalex.org/W2019899535","https://openalex.org/W2022595505","https://openalex.org/W2023397454","https://openalex.org/W2026207397","https://openalex.org/W2028902675","https://openalex.org/W2031729422","https://openalex.org/W2033357754","https://openalex.org/W2033691305","https://openalex.org/W2033879223","https://openalex.org/W2043549608","https://openalex.org/W2043833227","https://openalex.org/W2047095668","https://openalex.org/W2049860136","https://openalex.org/W2052030086","https://openalex.org/W2052464531","https://openalex.org/W2054027791","https://openalex.org/W2054730594","https://openalex.org/W2061693087","https://openalex.org/W2065773243","https://openalex.org/W2066451762","https://openalex.org/W2072174276","https://openalex.org/W2076649422","https://openalex.org/W2080031356","https://openalex.org/W2080322781","https://openalex.org/W2083038958","https://openalex.org/W2085664820","https://openalex.org/W2091949587","https://openalex.org/W2093935547","https://openalex.org/W2094949453","https://openalex.org/W2097325779","https://openalex.org/W2098453482","https://openalex.org/W2100998391","https://openalex.org/W2102619095","https://openalex.org/W2106475826","https://openalex.org/W2109734459","https://openalex.org/W2123311108","https://openalex.org/W2136573391","https://openalex.org/W2140077773","https://openalex.org/W2141522397","https://openalex.org/W2157645688","https://openalex.org/W2182340497"],"related_works":["https://openalex.org/W7098448057","https://openalex.org/W2184840315","https://openalex.org/W2043833227","https://openalex.org/W1988461310","https://openalex.org/W2026207397","https://openalex.org/W2111681808","https://openalex.org/W2065465922","https://openalex.org/W4310423045","https://openalex.org/W2476247901","https://openalex.org/W2131675399"],"abstract_inverted_index":{"Protein":[0],"S-nitrosylation":[1,21,46,70,131,176],"mediated":[2],"by":[3,28,149,157,184],"cellular":[4,147],"nitric":[5],"oxide":[6],"(NO)":[7],"plays":[8],"a":[9],"primary":[10,88],"role":[11],"in":[12,16,122],"executing":[13],"biological":[14,36],"functions":[15],"cGMP-independent":[17],"NO":[18,57,64,97,148,154,161],"signaling.":[19],"Although":[20],"appears":[22],"similar":[23],"to":[24,66,91],"Cys":[25,69,119],"oxidation":[26,168],"induced":[27],"reactive":[29,164],"oxygen":[30,165],"species,":[31],"the":[32,42,82,87,106,133,144],"molecular":[33],"mechanism":[34],"and":[35,62],"consequence":[37],"remain":[38],"unclear.":[39],"We":[40,52,127],"investigated":[41],"structural":[43],"process":[44],"of":[45,47,96,132,146,169],"protein-tyrosine":[48],"phosphatase":[49],"1B":[50],"(PTP1B).":[51],"treated":[53],"PTP1B":[54,99,137],"with":[55,152],"various":[56],"donors,":[58],"including":[59],"S-nitrosothiol":[60],"reagents":[61],"compound-releasing":[63],"radicals,":[65],"produce":[67],"site-specific":[68],"identified":[71],"using":[72],"advanced":[73],"mass":[74],"spectrometry":[75],"(MS)":[76],"techniques.":[77],"Quantitative":[78],"MS":[79],"showed":[80],"that":[81,105,130,175],"active":[83],"site":[84],"Cys-215":[85,110,134],"was":[86],"residue":[89,135],"susceptible":[90],"S-nitrosylation.":[92],"The":[93],"crystal":[94],"structure":[95],"donor-reacted":[98],"at":[100,109],"2.6":[101],"A":[102],"resolution":[103],"revealed":[104],"S-NO":[107],"state":[108],"had":[111],"no":[112],"discernible":[113],"irreversibly":[114],"oxidized":[115],"forms,":[116],"whereas":[117],"other":[118],"residues":[120],"remained":[121],"their":[123],"free":[124],"thiol":[125],"states.":[126],"further":[128],"demonstrated":[129],"protected":[136],"from":[138,180],"subsequent":[139],"H(2)O(2)-induced":[140],"irreversible":[141,167],"oxidation.":[142],"Increasing":[143],"level":[145],"pretreating":[150],"cells":[151],"an":[153],"donor":[155],"or":[156],"activating":[158],"ectopically":[159],"expressed":[160],"synthase":[162],"inhibited":[163],"species-induced":[166],"endogenous":[170],"PTP1B.":[171],"These":[172],"findings":[173],"suggest":[174],"might":[177],"prevent":[178],"PTPs":[179],"permanent":[181],"inactivation":[182],"caused":[183],"oxidative":[185],"stress.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}