{"id":"https://openalex.org/W2012215243","doi":"https://doi.org/10.1254/jphs.fp0050691","title":"The Effects of Ethosuximide on Amino Acids in Genetic Absence Epilepsy Rat Model","display_name":"The Effects of Ethosuximide on Amino Acids in Genetic Absence Epilepsy Rat Model","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2012215243","doi":"https://doi.org/10.1254/jphs.fp0050691","mag":"2012215243","pmid":"https://pubmed.ncbi.nlm.nih.gov/16538026"},"language":"en","primary_location":{"id":"doi:10.1254/jphs.fp0050691","doi":"https://doi.org/10.1254/jphs.fp0050691","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fp0050691","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/100/3/100_3_227/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/jphs/100/3/100_3_227/_pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035450083","display_name":"Berna Terzi\u0307o\u011flu Bebi\u0307to\u011flu","orcid":"https://orcid.org/0000-0003-4601-7871","observed_orcids":["https://orcid.org/0000-0003-4601-7871"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Berna Terzioglu","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University School of Medicine, 81326 Haydarpa\u015fa, Istanbul, Turkey","Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University School of Medicine, 81326 Haydarpa\u015fa, Istanbul, Turkey","institution_ids":["https://openalex.org/I74897591"]},{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041268732","display_name":"Cenk Aypak","orcid":"https://orcid.org/0000-0002-8381-790X","observed_orcids":["https://orcid.org/0000-0002-8381-790X"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cenk Aypak","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051998462","display_name":"Filiz Onat","orcid":"https://orcid.org/0000-0003-0680-4782","observed_orcids":["https://orcid.org/0000-0003-0680-4782"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Filiz Y. Onat","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028490030","display_name":"Esra K\u00fc\u00e7\u00fckibrahimo\u011flu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Esra K\u00fc\u00e7\u00fckibrahimoglu","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111529933","display_name":"Aydan Erg\u00fcn \u00d6zkaynak\u00e7i","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aydan E. \u00d6zkaynak\u00e7i","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043447094","display_name":"Mehmet Zafer G\u00f6ren","orcid":"https://orcid.org/0000-0002-8800-4043","observed_orcids":["https://orcid.org/0000-0002-8800-4043"]},"institutions":[{"id":"https://openalex.org/I74897591","display_name":"Marmara University","ror":"https://ror.org/02kswqa67","country_code":"TR","type":"education","lineage":["https://openalex.org/I74897591"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M. Zafer G\u00f6ren","raw_affiliation_strings":["Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Pharmacology, Marmara University, School of Medicine, Turkey","institution_ids":["https://openalex.org/I74897591"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I74897591"],"apc_list":{"value":2070,"currency":"USD","value_usd":2070},"apc_paid":null,"fwci":0.6361,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.71430534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"100","issue":"3","first_page":"227","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethosuximide","display_name":"ethosuximide","score":1.0},{"id":"https://openalex.org/keywords/genetic-absence-epilepsy-rats-from-strasbourg","display_name":"GAERS","score":0.9089999794960022},{"id":"https://openalex.org/keywords/absence-epilepsy","display_name":"absence epilepsy","score":0.890999972820282},{"id":"https://openalex.org/keywords/gaba","display_name":"GABA","score":0.7250000238418579},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.875},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.6769999861717224},{"id":"https://openalex.org/keywords/spike-and-wave-discharges","display_name":"spike-wave discharges","score":0.9309999942779541},{"id":"https://openalex.org/keywords/ventrolateral-thalamic-nucleus","display_name":"ventrolateral thalamic nucleus","score":0.9430000185966492},{"id":"https://openalex.org/keywords/primary-motor-cortex","display_name":"primary motor cortex","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gabaergic-tone","display_name":"GABAergic tone","score":0.5590000152587891},{"id":"https://openalex.org/keywords/microdialysis","display_name":"microdialysis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/antiepileptic-drug-effects","display_name":"antiepileptic drug effects","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2779619453","wikidata":"https://www.wikidata.org/wiki/Q421567","display_name":"Ethosuximide","level":4,"score":0.9150515198707581},{"id":"https://openalex.org/C50156730","wikidata":"https://www.wikidata.org/wiki/Q3856966","display_name":"Microdialysis","level":3,"score":0.7447946667671204},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.7143868207931519},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6311444044113159},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5893277525901794},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.569524884223938},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5198031663894653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5105096101760864},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4825989007949829},{"id":"https://openalex.org/C2778187257","wikidata":"https://www.wikidata.org/wiki/Q464210","display_name":"Basal ganglia","level":3,"score":0.4824110269546509},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.46699726581573486},{"id":"https://openalex.org/C2983163835","wikidata":"https://www.wikidata.org/wiki/Q749520","display_name":"Frontal cortex","level":2,"score":0.4338535666465759},{"id":"https://openalex.org/C2778740566","wikidata":"https://www.wikidata.org/wiki/Q181136","display_name":"Glutamic acid","level":3,"score":0.4293704926967621},{"id":"https://openalex.org/C2778373776","wikidata":"https://www.wikidata.org/wiki/Q18696","display_name":"Motor cortex","level":3,"score":0.4143407940864563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3692029118537903},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2703266739845276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25155919790267944},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22049909830093384},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.2162160873413086},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.14165446162223816},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0907890796661377},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07606104016304016},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.06695786118507385}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000927","descriptor_name":"Anticonvulsants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004832","descriptor_name":"Epilepsy, Absence","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004832","descriptor_name":"Epilepsy, Absence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004832","descriptor_name":"Epilepsy, Absence","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005013","descriptor_name":"Ethosuximide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009044","descriptor_name":"Motor Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017551","descriptor_name":"Microdialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020651","descriptor_name":"Ventral Thalamic Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020651","descriptor_name":"Ventral Thalamic Nuclei","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1254/jphs.fp0050691","doi":"https://doi.org/10.1254/jphs.fp0050691","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fp0050691","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/100/3/100_3_227/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},{"id":"pmid:16538026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16538026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmacological sciences","raw_type":"Comparative Study"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/241547","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11424/241547","pdf_url":"http://openaccess.marmara.edu.tr/bitstreams/6872e17e-3433-44fd-8ac0-d96043856fad/download","source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:57f91418213e460ea4a7d1f6baa85641","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/57f91418213e460ea4a7d1f6baa85641","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Pharmacological Sciences, Vol 100, Iss 3, Pp 227-233 (2006)","raw_type":"article"},{"id":"pmh:oai:openaccess.marmara.edu.tr:11424/90854","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11424/90854","pdf_url":null,"source":{"id":"https://openalex.org/S4306401380","display_name":"Dspace Repository (Marmara \u00dcniversitesi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I74897591","host_organization_name":"Marmara University","host_organization_lineage":["https://openalex.org/I74897591"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1254/jphs.fp0050691","doi":"https://doi.org/10.1254/jphs.fp0050691","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jphs.fp0050691","pdf_url":"https://www.jstage.jst.go.jp/article/jphs/100/3/100_3_227/_pdf","source":{"id":"https://openalex.org/S163931769","display_name":"Journal of Pharmacological Sciences","issn_l":"1347-8613","issn":["1347-8613","1347-8648"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7200000286102295,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012215243.pdf","grobid_xml":"https://content.openalex.org/works/W2012215243.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W151034637","https://openalex.org/W1571175443","https://openalex.org/W1886118302","https://openalex.org/W1965417826","https://openalex.org/W1973551643","https://openalex.org/W1975103185","https://openalex.org/W1985557212","https://openalex.org/W2009202604","https://openalex.org/W2015743538","https://openalex.org/W2022890204","https://openalex.org/W2024636534","https://openalex.org/W2029837689","https://openalex.org/W2036859913","https://openalex.org/W2040930527","https://openalex.org/W2052312994","https://openalex.org/W2083553396","https://openalex.org/W2084741382","https://openalex.org/W2087188787","https://openalex.org/W2088393247","https://openalex.org/W2088616807","https://openalex.org/W2091306505","https://openalex.org/W2092165668","https://openalex.org/W2109746889","https://openalex.org/W2117083037","https://openalex.org/W2121584771","https://openalex.org/W2163815564","https://openalex.org/W4239594659","https://openalex.org/W4321509056"],"related_works":["https://openalex.org/W1983627046","https://openalex.org/W2083553396","https://openalex.org/W2048330792","https://openalex.org/W1985557212","https://openalex.org/W2074588573","https://openalex.org/W2080331466","https://openalex.org/W2032541433","https://openalex.org/W2032714219","https://openalex.org/W4213464464","https://openalex.org/W7043919768"],"abstract_inverted_index":{"Genetic":[0],"absence":[1,23],"epilepsy":[2],"rats":[3,82],"from":[4,68],"Strasbourg":[5],"(GAERS),":[6],"a":[7],"selectively":[8],"inbred":[9],"strain":[10],"of":[11,30,80,120,147,155,161,171],"Wistar":[12,81],"rats,":[13],"has":[14],"been":[15],"validated":[16],"as":[17],"an":[18],"experimental":[19],"model":[20],"for":[21],"human":[22],"epilepsy.":[24],"In":[25,43],"this":[26,44],"model,":[27],"systemic":[28],"administration":[29],"ethosuximide":[31],"(ETX)":[32],"was":[33,98,102],"shown":[34,103],"to":[35,55,104,179],"reduce":[36],"the":[37,64,69,74,92,106,116,135,139,145,153,159,183],"spike":[38],"and":[39,49,73,83,118,122,158,169,186],"wave":[40],"discharges":[41],"(SWD).":[42],"study,":[45],"gamma-aminobutyric":[46],"acid":[47,51],"(GABA)":[48],"L-glutamic":[50],"levels":[52,114,133,142],"in":[53,63,115,134,144,165,182],"response":[54],"ETX":[56,101,123,187],"injections":[57],"(i.p.,":[58],"100":[59],"mg/kg)":[60],"were":[61],"measured":[62],"microdialysis":[65,93],"samples":[66],"collected":[67],"ventrolateral":[70],"thalamus":[71,170],"(VLT)":[72],"primary":[75,166,174],"motor":[76,167,175],"cortex":[77,168,176],"(M1)":[78],"area":[79],"GAERS":[84],"by":[85],"using":[86],"HPLC":[87],"with":[88],"fluorescent":[89],"detection.":[90],"Throughout":[91],"procedure,":[94],"continuous":[95],"EEG":[96],"recording":[97],"performed":[99],"where":[100],"suppress":[105],"SWD":[107,184],"activity.":[108],"We":[109],"demonstrated":[110],"increased":[111,140,162],"basal":[112],"GABA":[113,132,141,163],"M1":[117,146],"VLT":[119],"GAERS,":[121],"treatment":[124],"did":[125],"not":[126],"produce":[127],"any":[128],"effect":[129],"on":[130],"higher":[131],"VLT,":[136],"but":[137],"suppressed":[138],"significantly":[143],"GAERS.":[148,172],"All":[149],"these":[150],"findings":[151],"denote":[152],"importance":[154],"corticothalamic":[156],"circuitry":[157],"role":[160],"tonus":[164],"The":[173],"also":[177],"seems":[178],"be":[180],"involved":[181],"activity":[185],"exerts,":[188],"at":[189],"least":[190],"partially,":[191],"its":[192],"neurotransmitter":[193],"effects":[194],"through":[195],"it.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}