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148,151,166,267,314,382,385,400,1754,1843,1988,2905,4815,5201,5601,5838,7360,7396,7749,7846],"N-terminal":[34,268,1076,1208,3637,4577,4818,5185,6147,6156,6470,7163,7511],"ectodomain":[35,88,116,134,153,197,215,269,322,350,368,387,431,449,1273,1751,1779,1793,1804,1820,1839,3642,3860,4186,4428,4775,4787,5017,5044,5175,5564,5869,6104,6131,6148,6328,6706,6871,7114,7140,7229,7270,7487,7592,7612,7653,7822,7888,8069,8160],"containing":[36,270,2533,2805],"moderately":[38,272,568,1810,6226],"apolar":[39,103,273,337,1811,4677,6978,7380,8167],"N-proximal":[40,53,121,274,287,355,4208,4586,8147],"region,":[41,275],"termed":[42,276,3648],"hydrophobic":[44,58,199,278,292,433,569,676,1065,1188,1201,1414,1437,1960,3628,3650,3760,4139,4151,4170,4681,4718,4883,5878,5890,6032,6227,6284,8196],"patch.":[45,279],"Mutagenic":[46,280,6081],"analysis":[47,281,3786,3856,4615,4870,5012,5171,7818,7863],"indicated":[48,282,5048,6083,6112],"sequence-specific":[49,283,1783,4190,4753,5159,5354,6408],"elements":[50,284],"in":[51,95,101,173,285,329,335,407,577,934,1060,1267,1364,1429,1457,1468,1686,1704,1855,1907,2214,2510,2514,2526,2735,2741,2782,2788,2802,2874,2908,3594,3611,3873,3894,3958,3971,3991,4041,4064,4095,4192,4321,4425,4600,4672,4806,4835,4866,4996,4999,5053,5055,5063,5101,5104,5107,5110,5114,5118,5123,5307,5424,5436,5547,5561,5570,5582,5620,5644,5695,5744,5746,5790,5809,5819,5930,6010,6488,6599,6619,6709,6849,6856,6878,6897,6966,6976,6991,7069,7095,7151,7201,7214,7244,7267,7498,7503,7593,7657,7735,7835,7868,7909,7974,7984,8041,8046,8075,8094,8186,8215,8237,8246,8279],"portion":[54,288,4209,4587,5152,5376,6956,6995],"patch":[59,200,293,434,1961,3651,4140,4884,5891],"affected":[60,294],"cell-cell":[61,295,1695,1787,4339,6308,6332,7110,7175,8056,8097],"activity,":[63,183,297,417,4285,5164,5709],"independent":[64,298,6501],"overall":[66,300,3510,4135,6301,6371],"effects":[67,301,1008],"on":[68,143,179,228,302,377,413,462,509,791,1009,1190,2163,2414,2879,3017,3080,3213,3372,3885,4569,4621,4713,4722,5161,5635,5862,5900,5919,6279,6406,6717,6945,7165,7670,7872,7943],"relative":[70,304,2188,7767],"hydrophobicity":[71,305,3790,4136,6249,6302,6372],"motif.":[74,308],"Circular":[75,309,2484],"dichroism":[76,310,2496,5037],"(CD)":[77,311],"peptide":[81,117,135,163,221,315,351,369,397,455,512,701,895,1004,1010,1037,1046,1056,1101,1426,1845,1962,1982,2503,2781,2786,2847,2900,2907,3367,3820,4645,4776,4780,4807,4812,4833,4859,4925,4937,4945,4972,5186,5206,5379,5634,5734,5751,5804,5823,5844,5870,5910,5980,6025,6033,6158,6329,6496,6923,7230,7766,7894,7982],"representing":[82,316],"majority":[84,211,318,445,3092,4783,7884],"suggested":[89,323,4182,5013,5507,6129],"this":[90,324,3725,3967,4119,4291,4502,4743,4932,5205,5437,5475,5687],"region":[91,325,1812,3618,3646,3654,3726,3817,3968,4873,5476,5679,5688,6168,6484,6885,6916,7136],"is":[92,137,216,326,371,450,507,1072,1427,1744,1753,1852,2863,3635,3727,3757,3763,3889,4362,4366,4430,4473,4822,5176,5365,5487,5624,6087,6132,6224,6229,6291,6392,6404,6469,6472,6486,6516,6707,6779,6842,6950,7220,7248,7282,7372,7501,7573,7691,7740,7889,7908,7931,7941,7971,8032,8038],"mostly":[93,327,5177],"disordered":[94,328,6487,6708,6884,6965,7001,7135],"solution":[96,330,2546,2778,2911,6710],"but":[97,155,331,389,1689,6711,8044],"assumes":[98,332,6971,7147],"increased":[99,333,4933,5006,6714,6972,7744],"structure":[100,136,334,370,1071,1107,1197,1420,1450,1470,1825,2615,3325,4607,4688,4697,4770,4855,4934,5007,5030,5073,5435,5458,5584,6848,6900,6973,7002,7097,7150,7271,7276,7387,7413,7488,7837,7844,8220],"environment.":[104,338,6979,7154],"From":[105,339],"NMR":[106,340,1058,1796,2887,2930,3027,3058,3069,3085,3294,4371,5127,5137,5190,5197,5595,6110,6127,6969,7078,7126,7862],"spectroscopic":[107,341],"data":[108,342,2606,2931,3028,3059,3072],"and":[109,190,198,343,424,432,579,693,745,747,880,917,1006,1080,1089,1184,1368,1465,1619,1697,1782,1786,1797,1808,1862,1891,1902,2002,2014,2023,2028,2096,2125,2161,2210,2233,2276,2287,2343,2352,2382,2389,2422,2434,2440,2469,2480,2549,2557,2559,2676,2721,2723,2752,2765,2771,2818,2881,2916,2974,2996,3038,3048,3115,3126,3163,3193,3203,3328,3433,3662,3698,3731,3794,3854,3867,3998,4099,4164,4174,4224,4297,4307,4365,4480,4543,4580,4593,4716,4734,4737,4809,4845,4916,4929,5002,5089,5285,5296,5323,5330,5359,5406,5409,5412,5415,5417,5419,5522,5528,5530,5535,5539,5554,5565,5580,5615,5671,5762,5796,5871,5965,6027,6120,6124,6126,6139,6173,6203,6215,6228,6253,6307,6377,6410,6418,6439,6471,6574,6651,6654,6662,6671,6696,7112,7156,7379,7585,7602,7751,7847,7983,7989,8081,8136,8273],"simulated":[110,344,3358],"annealing,":[111,345],"soluble":[113,347,7820],"nonmyristoylated":[114,158,348,392,5180,5905,6321,7227,7848],"consists":[118,352],"extended":[122,356,1823,3324,4773,5509,6601],"loop":[123,357,1449,1824,1850,5505,5510,5669,5963,6117,6365,6522,6584,6670,6685,6855,8148],"flanked":[124,358,1439,1826],"two":[126,360,2889,3044,5452],"proline":[127,361,1828],"hinges.":[128,362,1829],"remaining":[130,364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