{"id":"https://openalex.org/W2012212797","doi":"https://doi.org/10.1167/iovs.14-13889","title":"Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis","display_name":"Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis","publication_year":2014,"publication_date":"2014-05-23","ids":{"openalex":"https://openalex.org/W2012212797","doi":"https://doi.org/10.1167/iovs.14-13889","mag":"2012212797","pmid":"https://pubmed.ncbi.nlm.nih.gov/24854858","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4062400"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.14-13889","doi":"https://doi.org/10.1167/iovs.14-13889","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.14-13889","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/932990/i1552-5783-55-6-3775.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/932990/i1552-5783-55-6-3775.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067556827","display_name":"Satyabrata Sinha","orcid":"https://orcid.org/0000-0003-0514-8613","observed_orcids":["https://orcid.org/0000-0003-0514-8613"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satyabrata Sinha","raw_affiliation_strings":["Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111400927","display_name":"Marycharmain Belcastro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marycharmain Belcastro","raw_affiliation_strings":["Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019405283","display_name":"Poppy Datta","orcid":"https://orcid.org/0000-0003-4989-0975","observed_orcids":["https://orcid.org/0000-0003-4989-0975"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Poppy Datta","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081449876","display_name":"Seongjin Seo","orcid":"https://orcid.org/0000-0002-7908-3210","observed_orcids":["https://orcid.org/0000-0002-7908-3210"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seongjin Seo","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103120784","display_name":"Maxim Sokolov","orcid":"https://orcid.org/0000-0001-5048-8874","observed_orcids":["https://orcid.org/0000-0001-5048-8874"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Maxim Sokolov","raw_affiliation_strings":["Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States 3Department of Biochemistry, West Virginia University, Morgantown, West Virginia, United States","Department of Biochemistry, West Virginia University, Morgantown, West Virginia, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States 3Department of Biochemistry, West Virginia University, Morgantown, West Virginia, United States","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Biochemistry, West Virginia University, Morgantown, West Virginia, United States","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103120784"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":1.5284,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.81711159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"55","issue":"6","first_page":"3775","last_page":"3775"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chaperonin-cct","display_name":"chaperonin CCT","score":0.9319999814033508},{"id":"https://openalex.org/keywords/rod-photoreceptors","display_name":"rod photoreceptors","score":0.8579999804496765},{"id":"https://openalex.org/keywords/sensory-cilia","display_name":"sensory cilia","score":0.7129999995231628},{"id":"https://openalex.org/keywords/ciliary-trafficking","display_name":"ciliary trafficking","score":0.7559999823570251},{"id":"https://openalex.org/keywords/post-translational-processing","display_name":"post-translational processing","score":0.718999981880188},{"id":"https://openalex.org/keywords/ciliogenesis","display_name":"ciliogenesis","score":0.7409999966621399},{"id":"https://openalex.org/keywords/photoreceptor-morphology","display_name":"photoreceptor morphology","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C85755625","wikidata":"https://www.wikidata.org/wiki/Q24771589","display_name":"Chaperonin","level":3,"score":0.7954070568084717},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.6128773093223572},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37465283274650574},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3723776936531067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3677805960178375},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35317152738571167},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1745246946811676},{"id":"https://openalex.org/C204328495","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein folding","level":2,"score":0.10304829478263855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.04729121923446655}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004596","descriptor_name":"Electroretinography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012374","descriptor_name":"Rod Cell Outer Segment","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020788","descriptor_name":"Bardet-Biedl Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020788","descriptor_name":"Bardet-Biedl Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020788","descriptor_name":"Bardet-Biedl Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056404","descriptor_name":"Chaperonin Containing TCP-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D056404","descriptor_name":"Chaperonin Containing TCP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1167/iovs.14-13889","doi":"https://doi.org/10.1167/iovs.14-13889","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.14-13889","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/932990/i1552-5783-55-6-3775.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4062400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4062400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Invest Ophthalmol Vis Sci","raw_type":"Text"},{"id":"pmid:24854858","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24854858","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1167/iovs.14-13889","doi":"https://doi.org/10.1167/iovs.14-13889","is_oa":true,"landing_page_url":"https://doi.org/10.1167/iovs.14-13889","pdf_url":"https://iovs.arvojournals.org/arvo/content_public/journal/iovs/932990/i1552-5783-55-6-3775.pdf","source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1274820946","display_name":null,"funder_award_id":"P30-RR-032138","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1656996701","display_name":"West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)","funder_award_id":"2p20rr016477-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2461264676","display_name":null,"funder_award_id":"P20-RR016477","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2978690669","display_name":"CoBRE for Signal Transduction and Cancer Phase III","funder_award_id":"1p30rr032138-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3481722785","display_name":null,"funder_award_id":"EY019665","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G3618465841","display_name":null,"funder_award_id":"RR016440","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3842410188","display_name":"Molecular Pathophysiology of Retinal Degeneration in Bardet-Biedl Syndrome","funder_award_id":"R01EY022616","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G419361209","display_name":"Assembly and Trafficking of Heterotrimeric G Proteins in Vertebrate Photoreceptor","funder_award_id":"R01EY019665","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G474381023","display_name":null,"funder_award_id":"GM103488","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G486607418","display_name":null,"funder_award_id":"P20 RR016440","funder_id":"https://openalex.org/F4320311274","funder_display_name":"West Virginia University"},{"id":"https://openalex.org/G5417591456","display_name":"Cobre for Signal Transduction and Cancer","funder_award_id":"P20RR016440","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6213436903","display_name":"COBRE Transitional Center in Neuroscience","funder_award_id":"P30RR031155","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G715705074","display_name":"CoBRE for Signal Transduction and Cancer Phase III","funder_award_id":"P30GM103488","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8157331893","display_name":null,"funder_award_id":"RR031155","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8722319956","display_name":null,"funder_award_id":"EY022616","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000011515","display_name":null,"funder_award_id":"P20 RR 016477","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000161317","display_name":null,"funder_award_id":"GM103488","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306811","display_name":"Research to Prevent Blindness","ror":"https://ror.org/04drjs621"},{"id":"https://openalex.org/F4320311274","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012212797.pdf","grobid_xml":"https://content.openalex.org/works/W2012212797.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1516827124","https://openalex.org/W1518382324","https://openalex.org/W1532878531","https://openalex.org/W1586056883","https://openalex.org/W1965187701","https://openalex.org/W1965621240","https://openalex.org/W1976421227","https://openalex.org/W1978376889","https://openalex.org/W1979921735","https://openalex.org/W1981400373","https://openalex.org/W1981876866","https://openalex.org/W1996659835","https://openalex.org/W1999032458","https://openalex.org/W2004577799","https://openalex.org/W2009432227","https://openalex.org/W2018203229","https://openalex.org/W2024644086","https://openalex.org/W2031508896","https://openalex.org/W2031964961","https://openalex.org/W2037830911","https://openalex.org/W2038521670","https://openalex.org/W2050040558","https://openalex.org/W2058150442","https://openalex.org/W2067324083","https://openalex.org/W2068918824","https://openalex.org/W2071206111","https://openalex.org/W2071390670","https://openalex.org/W2078094267","https://openalex.org/W2095486148","https://openalex.org/W2100378298","https://openalex.org/W2100648176","https://openalex.org/W2110459060","https://openalex.org/W2113887763","https://openalex.org/W2128525434","https://openalex.org/W2132676325","https://openalex.org/W2134996138","https://openalex.org/W2137418427","https://openalex.org/W2153574614","https://openalex.org/W2161570516","https://openalex.org/W2169538657","https://openalex.org/W2323469571","https://openalex.org/W4300672362","https://openalex.org/W6662836956"],"related_works":["https://openalex.org/W2128525434","https://openalex.org/W878799824","https://openalex.org/W7097696032","https://openalex.org/W4246116569","https://openalex.org/W2767601133","https://openalex.org/W2903534447","https://openalex.org/W2137418427","https://openalex.org/W1964744845","https://openalex.org/W2906361666","https://openalex.org/W1966980921"],"abstract_inverted_index":{"PURPOSE:":[0],"While":[1],"some":[2],"evidence":[3,209],"suggests":[4],"an":[5],"essential":[6,212],"role":[7,213],"for":[8,185],"the":[9,50,54,79,86,112,115,124,131,143,153,179,194,211,215,219,234,238,241,251],"chaperonin":[10,80,113,195,216,239],"containing":[11],"t-complex":[12],"protein":[13,83],"1":[14],"(CCT)":[15],"in":[16,30,41,70,191,200,218,240],"ciliogenesis,":[17],"this":[18,62,140],"function":[19],"remains":[20],"poorly":[21],"understood":[22],"mechanistically.":[23],"We":[24],"used":[25],"transgenic":[26],"mice,":[27],"previously":[28],"generated":[29],"our":[31],"lab,":[32],"and":[33,85,96,107,136,168,226,248],"characterized":[34],"by":[35,77,94,104],"a":[36,47,148,181],"genetically-induced":[37],"suppression":[38,196],"of":[39,49,73,89,139,161,214,221,237,244,250],"CCT":[40,68,217],"rod":[42,51,71],"photoreceptors":[43,72,116],"as":[44,46],"well":[45],"malformation":[48],"sensory":[52,224],"cilia,":[53,225],"outer":[55,121,132],"segments,":[56],"to":[57,118,129,172,177,193,233],"gain":[58],"new":[59,208],"insights":[60],"into":[61],"underlying":[63,146],"molecular":[64,144],"mechanism.":[65],"METHODS:":[66],"The":[67],"activity":[69],"mice":[74],"was":[75,197],"suppressed":[76],"overexpressing":[78],"inhibitor,":[81],"phosducin-like":[82],"short,":[84],"ensuing":[87],"changes":[88],"cellular":[90],"morphology":[91],"were":[92,102,175],"analyzed":[93],"light":[95],"electron":[97],"microscopy.":[98],"Protein":[99],"expression":[100],"levels":[101,160],"studied":[103],"fluorescent":[105],"microscopy":[106],"Western":[108],"blotting.":[109],"RESULTS:":[110],"Suppressing":[111],"made":[114],"incompetent":[117],"build":[119],"their":[120],"segments.":[122],"Specifically,":[123],"CCT-deficient":[125],"rods":[126,155],"appeared":[127],"unable":[128,176],"expand":[130],"segment":[133],"plasma":[134],"membrane,":[135],"accommodate":[137],"growth":[138],"compartment.":[141],"Seeking":[142],"mechanisms":[145],"such":[147],"shortcoming,":[149],"we":[150],"found":[151],"that":[152,173,228],"affected":[154],"could":[156],"not":[157],"express":[158],"normal":[159],"Bardet-Biedl":[162],"Syndrome":[163],"(BBS)":[164],"proteins":[165,247],"2,":[166],"5,":[167],"7":[169],"and,":[170],"owing":[171],"deficiency,":[174],"assemble":[178],"BBSome,":[180],"multisubunit":[182],"complex":[183],"responsible":[184],"ciliary":[186],"trafficking.":[187],"A":[188],"similar":[189],"effect":[190],"response":[192],"also":[198],"observed":[199],"cultured":[201],"ciliated":[202],"cells.":[203],"CONCLUSIONS:":[204],"Our":[205],"data":[206],"provide":[207],"indicating":[210],"biogenesis":[220],"vertebrate":[222],"photoreceptor":[223],"suggest":[227],"it":[229],"may":[230],"be":[231],"due":[232],"direct":[235],"participation":[236],"posttranslational":[242],"processing":[243],"selected":[245],"BBS":[246],"assembly":[249],"BBSome.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
