{"id":"https://openalex.org/W2012209586","doi":"https://doi.org/10.1152/ajpregu.00286.2014","title":"Chronic hyperleptinemia results in the development of hypertension in pregnant rats","display_name":"Chronic hyperleptinemia results in the development of hypertension in pregnant rats","publication_year":2015,"publication_date":"2015-03-11","ids":{"openalex":"https://openalex.org/W2012209586","doi":"https://doi.org/10.1152/ajpregu.00286.2014","mag":"2012209586","pmid":"https://pubmed.ncbi.nlm.nih.gov/25761697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436978"},"language":"en","primary_location":{"id":"doi:10.1152/ajpregu.00286.2014","doi":"https://doi.org/10.1152/ajpregu.00286.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00286.2014","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065894848","display_name":"Ana Carolina Palei","orcid":"https://orcid.org/0000-0002-2669-5301","observed_orcids":["https://orcid.org/0000-0002-2669-5301"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ana C. Palei","raw_affiliation_strings":["Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","Department of Physiology and Biophysics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Physiology and Biophysics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082451578","display_name":"Frank Travis Spradley","orcid":"https://orcid.org/0000-0003-3293-2753","observed_orcids":["https://orcid.org/0000-0003-3293-2753"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank T. Spradley","raw_affiliation_strings":["Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","Department of Physiology and Biophysics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Physiology and Biophysics and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033919728","display_name":"Joey P. Granger","orcid":"https://orcid.org/0000-0002-4078-5629","observed_orcids":["https://orcid.org/0000-0002-4078-5629"]},"institutions":[{"id":"https://openalex.org/I29606459","display_name":"University of Mississippi Medical Center","ror":"https://ror.org/044pcn091","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I29606459","https://openalex.org/I4210141039"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joey P. Granger","raw_affiliation_strings":["Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","Department of Physiology and Biophysics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi","institution_ids":["https://openalex.org/I29606459"]},{"raw_affiliation_string":"Department of Physiology and Biophysics and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033919728"],"corresponding_institution_ids":["https://openalex.org/I29606459"],"apc_list":null,"apc_paid":null,"fwci":4.1722,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.93388347,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"308","issue":"10","first_page":"R855","last_page":"R861"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12464","display_name":"Neurological Complications and Syndromes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperleptinemia","display_name":"hyperleptinemia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9259999990463257},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypertension-in-pregnancy","display_name":"hypertension in pregnancy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.800000011920929},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8389999866485596},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.9430000185966492},{"id":"https://openalex.org/keywords/dietary-restriction","display_name":"dietary restriction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mean-arterial-pressure","display_name":"mean arterial pressure","score":0.6610000133514404},{"id":"https://openalex.org/keywords/gestational-hypertension","display_name":"gestational hypertension","score":0.48500001430511475},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8578839302062988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7436749935150146},{"id":"https://openalex.org/C2777218350","wikidata":"https://www.wikidata.org/wiki/Q61335","display_name":"Preeclampsia","level":3,"score":0.7361794710159302},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7139711380004883},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.6629328727722168},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.6528278589248657},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5856444239616394},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5779439210891724},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5458430051803589},{"id":"https://openalex.org/C2777583542","wikidata":"https://www.wikidata.org/wiki/Q1519482","display_name":"Gestational hypertension","level":4,"score":0.5397918820381165},{"id":"https://openalex.org/C2778376644","wikidata":"https://www.wikidata.org/wiki/Q2253111","display_name":"Gestational age","level":3,"score":0.4601801633834839},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.4416770040988922},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12338653206825256},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010920","descriptor_name":"Placenta","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpregu.00286.2014","doi":"https://doi.org/10.1152/ajpregu.00286.2014","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpregu.00286.2014","pdf_url":null,"source":{"id":"https://openalex.org/S59702976","display_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","issn_l":"0363-6119","issn":["0363-6119","1522-1490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4436978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},{"id":"pmid:25761697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25761697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Regulatory, integrative and comparative physiology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4436978","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4436978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Regul Integr Comp Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3771073078","display_name":null,"funder_award_id":"14POST18970005","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G6129585621","display_name":"Cardiovascular Dynamics & Their Control","funder_award_id":"P01HL051971","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000896017","display_name":"Hypertension and Cardiorenal Research Training Program","funder_award_id":"T32HL105324","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1480299516","https://openalex.org/W1499852624","https://openalex.org/W1502596718","https://openalex.org/W1959886060","https://openalex.org/W1964249453","https://openalex.org/W1992968247","https://openalex.org/W1995118720","https://openalex.org/W2004583907","https://openalex.org/W2005848269","https://openalex.org/W2006553724","https://openalex.org/W2014737092","https://openalex.org/W2019623114","https://openalex.org/W2021432134","https://openalex.org/W2024716428","https://openalex.org/W2028039109","https://openalex.org/W2028999598","https://openalex.org/W2029135104","https://openalex.org/W2041817035","https://openalex.org/W2043207514","https://openalex.org/W2043532592","https://openalex.org/W2043591623","https://openalex.org/W2053815511","https://openalex.org/W2054740597","https://openalex.org/W2055157873","https://openalex.org/W2055465794","https://openalex.org/W2059639090","https://openalex.org/W2066392602","https://openalex.org/W2072206476","https://openalex.org/W2072436009","https://openalex.org/W2083860819","https://openalex.org/W2089647515","https://openalex.org/W2090078097","https://openalex.org/W2093830639","https://openalex.org/W2096229046","https://openalex.org/W2101921785","https://openalex.org/W2104378956","https://openalex.org/W2104549321","https://openalex.org/W2113089068","https://openalex.org/W2117740888","https://openalex.org/W2118358710","https://openalex.org/W2119365719","https://openalex.org/W2122607033","https://openalex.org/W2122722123","https://openalex.org/W2124035721","https://openalex.org/W2124318924","https://openalex.org/W2126412697","https://openalex.org/W2129010834","https://openalex.org/W2134634254","https://openalex.org/W2136003807","https://openalex.org/W2137020418","https://openalex.org/W2138546430","https://openalex.org/W2139084894","https://openalex.org/W2152401910","https://openalex.org/W2159747044","https://openalex.org/W2160153755","https://openalex.org/W2160230584","https://openalex.org/W2168245358","https://openalex.org/W2354731773"],"related_works":["https://openalex.org/W2731572164","https://openalex.org/W3016985078","https://openalex.org/W4400868430","https://openalex.org/W2266993919","https://openalex.org/W2100365283","https://openalex.org/W2337551907","https://openalex.org/W2972096984","https://openalex.org/W2410897956","https://openalex.org/W3173872421","https://openalex.org/W2147747764"],"abstract_inverted_index":{"Despite":[0],"the":[1,13,40,55,86,117,196,270],"fact":[2],"that":[3,34],"obesity":[4,17,267],"is":[5,36,50],"a":[6,74,264],"major":[7],"risk":[8,26],"factor":[9],"for":[10],"preeclampsia":[11],"(PE),":[12],"pathophysiological":[14],"mechanisms":[15],"whereby":[16,266],"and":[18,68,108,132,146,186,193,202,245,259,262],"metabolic":[19],"factors":[20,70],"such":[21],"as":[22],"leptin":[23,60,137,241],"increase":[24,65],"this":[25],"are":[27],"unclear.":[28],"While":[29],"human":[30],"data":[31],"have":[32],"shown":[33],"hyperleptinemia":[35,44],"associated":[37,165],"with":[38,90,102,112,144,166,226],"PE,":[39],"long-term":[41],"effect":[42,254],"of":[43,120,198,204,211,216,255,272],"on":[45],"blood":[46,66,243],"pressure":[47,67,128,244],"during":[48,250],"pregnancy":[49,251],"unknown.":[51],"Thus":[52],"we":[53],"tested":[54],"hypothesis":[56],"whether":[57],"chronic":[58],"circulating":[59],"elevations":[61],"in":[62,76,141,191,223,274],"pregnant":[63,88,100,110],"rats":[64,82,122],"placental":[69,214,246],"known":[71],"to":[72,85,116],"play":[73],"role":[75],"PE.":[77,275],"On":[78,124],"gestational":[79],"day":[80],"(GD)14,":[81],"were":[83,134,189,207],"assigned":[84],"normal":[87,109],"group":[89,101,111],"food":[91,103,113,118,257],"intake":[92,104,114,119,185,258],"ad":[93,105],"libitum":[94,106],"(control),":[95],"leptin-treated":[96],"(0.5":[97],"\u03bcg\u00b7kg(-1)\u00b7min(-1)":[98],"ip)":[99],"(pregnant+LEP),":[107],"adjusted":[115],"pregnant+LEP":[121,142,192,224],"(pregnant-FR).":[123],"GD19,":[125],"mean":[126],"arterial":[127],"(MAP)":[129],"was":[130,139,164,220],"assessed":[131],"tissues":[133],"collected.":[135],"Serum":[136],"concentration":[138],"elevated":[140],"compared":[143,225],"control":[145],"pregnant-FR":[147,194],"(18.0":[148],"\u00b1":[149,153,157,170,174,178,229,233],"2.8":[150],"vs.":[151,155,172,176,231],"0.8":[152],"0.1":[154,158,230,234],"0.3":[156],"ng/ml;":[159],"P":[160,181,236],"<":[161,182,237],"0.05),":[162],"which":[163],"increased":[167],"MAP":[168],"(121.3":[169],"8.1":[171],"102.4":[173],"2.4":[175],"101.3":[177],"1.8":[179],"mmHg;":[180],"0.05).":[183,238],"Food":[184],"body":[187,260],"weight":[188],"reduced":[190],"by":[195],"end":[197],"gestation.":[199],"Additionally,":[200],"placentas":[201],"fetuses":[203],"these":[205],"groups":[206],"lighter":[208],"than":[209],"those":[210],"control.":[212],"However,":[213],"expression":[215],"tumor":[217,247],"necrosis":[218,248],"factor-\u03b1":[219,249],"significantly":[221],"greater":[222],"controls":[227],"(1.6":[228],"1.1":[232],"pg/mg;":[235],"In":[239],"conclusion,":[240],"increases":[242],"despite":[252],"its":[253],"reducing":[256],"weight,":[261],"represents":[263],"mechanism":[265],"can":[268],"promote":[269],"development":[271],"hypertension":[273]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
