{"id":"https://openalex.org/W2012209371","doi":"https://doi.org/10.1126/stke.2002.141.pe32","title":"Multivesicular Bodies and Multivesicular Endosomes: The \"Ins and Outs\" of Endosomal Traffic","display_name":"Multivesicular Bodies and Multivesicular Endosomes: The \"Ins and Outs\" of Endosomal Traffic","publication_year":2002,"publication_date":"2002-07-16","ids":{"openalex":"https://openalex.org/W2012209371","doi":"https://doi.org/10.1126/stke.2002.141.pe32","mag":"2012209371","pmid":"https://pubmed.ncbi.nlm.nih.gov/12122203"},"language":"en","primary_location":{"id":"doi:10.1126/stke.2002.141.pe32","doi":"https://doi.org/10.1126/stke.2002.141.pe32","is_oa":false,"landing_page_url":"https://doi.org/10.1126/stke.2002.141.pe32","pdf_url":null,"source":{"id":"https://openalex.org/S4210180107","display_name":"Science s STKE","issn_l":"1525-8882","issn":["1525-8882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science's STKE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064162089","display_name":"Philip D. Stahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip D. Stahl","raw_affiliation_strings":["Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110613097","display_name":"Manuel Alejandro Barbieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Alejandro Barbieri","raw_affiliation_strings":["Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":3.1525,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.90709729,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2002","issue":"141","first_page":"pe32","last_page":"pe32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivesicular-endosomes","display_name":"multivesicular endosomes","score":0.9670000076293945},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-sorting","display_name":"protein sorting","score":0.6259999871253967},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.6909999847412109},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.7919999957084656},{"id":"https://openalex.org/keywords/lysosomal-degradation","display_name":"lysosomal degradation","score":0.75},{"id":"https://openalex.org/keywords/yeast-vacuole","display_name":"yeast vacuole","score":0.8830000162124634},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/reticulocytes","display_name":"reticulocytes","score":0.9089999794960022}],"concepts":[{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.9593214392662048},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.841830849647522},{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.8244929313659668},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.818869948387146},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.6637923717498779},{"id":"https://openalex.org/C102568950","wikidata":"https://www.wikidata.org/wiki/Q127702","display_name":"Vacuole","level":3,"score":0.5505082607269287},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5188466310501099},{"id":"https://openalex.org/C2778283623","wikidata":"https://www.wikidata.org/wiki/Q18032200","display_name":"TSG101","level":5,"score":0.505000650882721},{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.47817379236221313},{"id":"https://openalex.org/C143876685","wikidata":"https://www.wikidata.org/wiki/Q22327705","display_name":"ESCRT","level":4,"score":0.464540034532547},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4219525456428528},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.3782798647880554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36625897884368896},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3155701756477356},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1889013648033142},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.16044968366622925},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15183478593826294},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.14987587928771973},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011992","descriptor_name":"Endosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022161","descriptor_name":"Transport Vesicles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/stke.2002.141.pe32","doi":"https://doi.org/10.1126/stke.2002.141.pe32","is_oa":false,"landing_page_url":"https://doi.org/10.1126/stke.2002.141.pe32","pdf_url":null,"source":{"id":"https://openalex.org/S4210180107","display_name":"Science s STKE","issn_l":"1525-8882","issn":["1525-8882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science's STKE","raw_type":"journal-article"},{"id":"pmid:12122203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12122203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science's STKE : signal transduction knowledge environment","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W162350361","https://openalex.org/W1494035906","https://openalex.org/W1581255805","https://openalex.org/W1979171720","https://openalex.org/W1979274256","https://openalex.org/W2005993715","https://openalex.org/W2007215986","https://openalex.org/W2007230636","https://openalex.org/W2038153529","https://openalex.org/W2055253116","https://openalex.org/W2065538108","https://openalex.org/W2089340389","https://openalex.org/W2090130819","https://openalex.org/W2094630875","https://openalex.org/W2101218054","https://openalex.org/W2105341630","https://openalex.org/W2137744872","https://openalex.org/W2145625720","https://openalex.org/W2169290377","https://openalex.org/W2170832451","https://openalex.org/W2327324759","https://openalex.org/W4233302168"],"related_works":["https://openalex.org/W2109691647","https://openalex.org/W2031136388","https://openalex.org/W3048247311","https://openalex.org/W1990307334","https://openalex.org/W2095798079","https://openalex.org/W1987462880","https://openalex.org/W2328773576","https://openalex.org/W2744528944","https://openalex.org/W2108187046","https://openalex.org/W2169653722"],"abstract_inverted_index":{"Multivesicular":[0],"endosomes":[1],"(MVEs)":[2],"are":[3,37,102,137],"complex":[4],"intracellular":[5],"organelles":[6],"that":[7,97],"function":[8,13],"in":[9,53,73],"endocytosis.":[10],"A":[11],"major":[12],"of":[14,57,88,92,115],"the":[15,44,54,58,70,74,81,89,105,111,119,140,145,154],"endocytic":[16],"pathway":[17,71],"is":[18,78],"to":[19,43,80,118,139],"sort":[20],"internalized":[21],"macromolecules":[22],"and":[23,113,132],"membrane":[24,91,116,142],"proteins.":[25],"Appropriately":[26],"sorted":[27],"proteins,":[28],"such":[29,96],"as":[30],"epidermal":[31],"growth":[32],"factor":[33],"(EGF)":[34],"receptor":[35],"(EGFR),":[36],"incorporated":[38],"into":[39,153],"MVEs":[40,51,84,136],"before":[41],"transport":[42],"lysosomal":[45],"compartment,":[46],"where":[47,63],"degradation":[48],"occurs.":[49],"Thus,":[50],"operate":[52],"endosome-to-lysosome":[55],"portion":[56],"pathway.":[59],"In":[60,109,130],"yeast":[61,75],"cells,":[62,135],"MVE":[64,120],"formation":[65],"has":[66],"been":[67],"extensively":[68],"studied,":[69],"terminates":[72],"vacuole,":[76],"which":[77],"equivalent":[79],"vertebrate":[82],"lysosome.":[83],"arise":[85],"by":[86],"invagination":[87],"limiting":[90],"an":[93],"endosomal":[94],"vesicle":[95],"many":[98],"small":[99,124,148],"internal":[100],"vesicles":[101,149],"formed,":[103],"hence":[104],"term":[106],"\"multivesicular":[107],"endosome.\"":[108],"part,":[110],"internalization":[112],"targeting":[114],"proteins":[117],"involves":[121],"ubiquitin,":[122],"a":[123],"protein":[125,128],"associated":[126],"with":[127],"degradation.":[129],"reticulocytes":[131],"certain":[133],"antigen-presenting":[134],"routed":[138],"plasma":[141],"rather":[143],"than":[144],"lysosome,":[146],"releasing":[147],"called":[150],"\"exosomes\"":[151],"back":[152],"extracellular":[155],"space.":[156]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
