{"id":"https://openalex.org/W2012201322","doi":"https://doi.org/10.1158/1538-7445.am2013-2829","title":"Abstract 2829: Patient-derived primary melanoma cells that differentially express melano-specific antigens as a model for vaccines.","display_name":"Abstract 2829: Patient-derived primary melanoma cells that differentially express melano-specific antigens as a model for vaccines.","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2012201322","doi":"https://doi.org/10.1158/1538-7445.am2013-2829","mag":"2012201322"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2013-2829","doi":"https://doi.org/10.1158/1538-7445.am2013-2829","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2829","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066369249","display_name":"Robert Suriano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Suriano","raw_affiliation_strings":["1New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042657669","display_name":"Andrea L. George","orcid":"https://orcid.org/0000-0002-4112-8639","observed_orcids":["https://orcid.org/0000-0002-4112-8639"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L. George","raw_affiliation_strings":["1New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027333146","display_name":"Shilpi Rajoria","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shilpi Rajoria","raw_affiliation_strings":["1New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037029599","display_name":"Jan Geliebter","orcid":"https://orcid.org/0000-0002-2944-7960","observed_orcids":["https://orcid.org/0000-0002-2944-7960"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Geliebter","raw_affiliation_strings":["1New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101444099","display_name":"Raj K. Tiwari","orcid":"https://orcid.org/0000-0002-9048-0700","observed_orcids":["https://orcid.org/0000-0002-9048-0700"]},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raj K. Tiwari","raw_affiliation_strings":["1New York Medical College, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1New York Medical College, Valhalla, NY","institution_ids":["https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109172388","display_name":"Marc K. Wallack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799765569","display_name":"Metropolitan Hospital Center","ror":"https://ror.org/005h65c20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1283621791","https://openalex.org/I2799765569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Wallack","raw_affiliation_strings":["2Metropolitan Hospital Center, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Metropolitan Hospital Center, New York, NY","institution_ids":["https://openalex.org/I2799765569"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"8_Supplement","first_page":"2829","last_page":"2829"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.7705000042915344,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.09070000052452087,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.06729999929666519,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9610000252723694},{"id":"https://openalex.org/keywords/melanoma-associated-antigens","display_name":"melanoma-associated antigens","score":0.9089999794960022},{"id":"https://openalex.org/keywords/melanin-synthesis","display_name":"melanogenesis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/melanosome-biogenesis","display_name":"melanosome biogenesis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gp100","display_name":"gp100","score":0.8949999809265137},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.8420000076293945},{"id":"https://openalex.org/keywords/trp-2","display_name":"TRP-2","score":1.0},{"id":"https://openalex.org/keywords/melan-a","display_name":"Melan-A","score":0.6809999942779541},{"id":"https://openalex.org/keywords/mage-a1","display_name":"MAGE-1","score":0.9900000095367432},{"id":"https://openalex.org/keywords/ny-eso-1","display_name":"NY-ESO-1","score":1.0},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"transferrin receptor","score":0.7229999899864197},{"id":"https://openalex.org/keywords/cd146","display_name":"CD146","score":0.9940000176429749},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7229999899864197},{"id":"https://openalex.org/keywords/melanoma-vaccine","display_name":"melanoma vaccine","score":0.7210000157356262},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6119999885559082},{"id":"https://openalex.org/keywords/melanocyte-transformation","display_name":"melanocyte transformation","score":0.3869999945163727}],"concepts":[{"id":"https://openalex.org/C107538193","wikidata":"https://www.wikidata.org/wiki/Q187526","display_name":"Melanin","level":2,"score":0.7342535257339478},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.7064568996429443},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6198738217353821},{"id":"https://openalex.org/C2779093498","wikidata":"https://www.wikidata.org/wiki/Q14911804","display_name":"CD146","level":4,"score":0.5809088945388794},{"id":"https://openalex.org/C87554066","wikidata":"https://www.wikidata.org/wiki/Q85942926","display_name":"Tyrosinase","level":3,"score":0.5799441337585449},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5305538177490234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5092483758926392},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4897165596485138},{"id":"https://openalex.org/C94435474","wikidata":"https://www.wikidata.org/wiki/Q1065756","display_name":"Melanosome","level":3,"score":0.4894965887069702},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.4266197085380554},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42505815625190735},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41365548968315125},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40319734811782837},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3438013792037964},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.17679527401924133},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10627052187919617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06618893146514893},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2013-2829","doi":"https://doi.org/10.1158/1538-7445.am2013-2829","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2013-2829","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2152394274","https://openalex.org/W7096359418","https://openalex.org/W2565246504","https://openalex.org/W2045166186","https://openalex.org/W1508383316","https://openalex.org/W1970253222","https://openalex.org/W122300776","https://openalex.org/W2088278402","https://openalex.org/W1965504034","https://openalex.org/W2030623883"],"abstract_inverted_index":{"Abstract":[0],"Transformation":[1],"of":[2,19,24,42,84,105,122,132,153,168,175,203,242,260,298,304,373,378],"pigment":[3],"producing":[4,123],"melanocytes":[5],"into":[6],"melanoma":[7,26,237,277,338,358],"is":[8,54],"a":[9,287,296,302,321,336,366],"complex":[10],"multi-step":[11],"process":[12],"involving":[13],"the":[14,49,82,133,176,243,258,374,379],"generation":[15],"and/or":[16],"over":[17],"expression":[18,167,202],"various":[20,204],"immunotherapeutic":[21,108,290],"antigens.":[22],"Several":[23],"these":[25,87,117,269],"associated":[27,51,94],"antigens":[28,218,244,270,300,364],"(MAAs)":[29],"are":[30,107,271,319],"directly":[31],"involved":[32,44],"in":[33,45,110,114,127,140,146,183,189,246,283],"melanin":[34,46,74,85,96,139,145,188],"biosynthesis":[35],"and":[36,69,76,102,172,196,213,233,301],"melanosome":[37],"biogenesis.":[38],"The":[39],"precise":[40],"contribution":[41],"proteins":[43,93],"synthesis":[47,75],"to":[48,72,143,181,285,333],"MAA":[50],"immune":[52,310],"response":[53],"poorly":[55],"understood.":[56],"To":[57,315],"this":[58,316],"end,":[59,317],"we":[60,280,318],"have":[61,256],"developed":[62],"primary":[63,88,194,276,330,357],"cell":[64,89,118,135,178,238,248,293,331],"lines":[65,90,119,136,179,294,332],"from":[66,81],"human":[67],"patients":[68],"xenograft":[70],"models":[71],"analyze":[73],"antigen":[77,324],"expression.":[78],"In":[79],"vitro,":[80,147],"perspective":[83],"production,":[86],"express":[91,362],"essential":[92,224],"with":[95,151],"synthesis,":[97],"namely":[98],"tyrosinase,":[99,169],"Trp-1,":[100,170],"Trp-2,":[101,171],"gp100,":[103,173,252],"all":[104],"which":[106,208,327],"targets":[109,259],"melanoma.":[111],"When":[112],"grafted":[113],"nude":[115,184],"mice,":[116],"were":[120,198],"capable":[121],"solid":[124],"pigmented":[125],"tumors":[126],"vivo.":[128],"However,":[129],"three":[130],"out":[131],"five":[134,177],"that":[137,268,282,306,360],"produced":[138],"vivo":[141],"failed":[142,180],"produce":[144,187],"even":[148],"when":[149],"cultured":[150],"supplementation":[152],"either":[154],"\u03b1-melanocyte":[155],"stimulating":[156],"hormone":[157],"(MSH),":[158],"basic":[159],"fibroblast":[160],"growth":[161],"factor":[162],"(bFGF),":[163],"or":[164,186,236],"matrigel.":[165],"Despite":[166],"two":[174],"grow":[182],"mice":[185],"vitro.":[190],"These":[191],"patient":[192],"derived":[193],"cells":[195,359],"xenografts":[197],"also":[199],"analyzed":[200,245],"for":[201,225,308,368,382],"other":[205],"significant":[206],"MAAs,":[207],"included":[209],"MART-1":[210],"(Melan-A),":[211],"MAGE-A1,":[212,255],"NY-ESO-1":[214],"as":[215,217,221,229,251,365],"well":[216],"not":[219],"classified":[220],"MAAs":[222,305],"but":[223,263],"tumor":[226],"progression":[227],"such":[228,250,335],"CD71":[230],"(transferring":[231],"receptor)":[232],"CD146":[234],"(MCAM":[235],"adhesion":[239],"molecule).":[240],"All":[241],"our":[247,264,275],"lines,":[249],"NY-ESO-1,":[253],"MART-1,":[254],"been":[257],"clinical":[261],"trials":[262],"results":[265],"clearly":[266],"indicate":[267],"differentially":[272,361],"expressed":[273],"by":[274],"cells.":[278],"Therefore,":[279],"believe":[281],"order":[284],"develop":[286,334],"clinically":[288],"effective":[289],"vaccine,":[291],"multiple":[292,329],"expressing":[295],"combination":[297],"melano-specific":[299,363],"repertoire":[303],"allows":[307],"minimal":[309],"evasion":[311],"may":[312],"be":[313],"necessary.":[314],"exploring":[320],"vaccinia":[322],"virus":[323],"retrieval":[325],"technology,":[326],"incorporates":[328],"pan-antigen":[337],"vaccine.":[339],"Citation":[340],"Format:":[341],"Robert":[342],"Suriano,":[343],"Andrea":[344],"L.":[345],"George,":[346],"Shilpi":[347],"Rajoria,":[348],"Jan":[349],"Geliebter,":[350],"Raj":[351],"K.":[352],"Tiwari,":[353],"Marc":[354],"Wallack.":[355],"Patient-derived":[356],"model":[367],"vaccines.":[369],"[abstract].":[370],"In:":[371],"Proceedings":[372],"104th":[375],"Annual":[376],"Meeting":[377],"American":[380],"Association":[381],"Cancer":[383,393],"Research;":[384],"2013":[385],"Apr":[386],"6-10;":[387],"Washington,":[388],"DC.":[389],"Philadelphia":[390],"(PA):":[391],"AACR;":[392],"Res":[394],"2013;73(8":[395],"Suppl):Abstract":[396],"nr":[397],"2829.":[398],"doi:10.1158/1538-7445.AM2013-2829":[399]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}