{"id":"https://openalex.org/W2012199729","doi":"https://doi.org/10.1007/s00408-004-2512-5","title":"Drotrecogin Alfa (activated) Prevents Smoke-Induced Increases in Pulmonary Microvascular Permeability and Proinflammatory Cytokine IL-1\u03b2 in Rats","display_name":"Drotrecogin Alfa (activated) Prevents Smoke-Induced Increases in Pulmonary Microvascular Permeability and Proinflammatory Cytokine IL-1\u03b2 in Rats","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W2012199729","doi":"https://doi.org/10.1007/s00408-004-2512-5","mag":"2012199729","pmid":"https://pubmed.ncbi.nlm.nih.gov/15765924"},"language":"en","primary_location":{"id":"doi:10.1007/s00408-004-2512-5","doi":"https://doi.org/10.1007/s00408-004-2512-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00408-004-2512-5","pdf_url":null,"source":{"id":"https://openalex.org/S104471971","display_name":"Lung","issn_l":"0341-2040","issn":["0341-2040","1432-1750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102098657","display_name":"Simon S. Wong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. S. Wong","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049275812","display_name":"Nina Sun","orcid":"https://orcid.org/0000-0002-6164-3646","observed_orcids":["https://orcid.org/0000-0002-6164-3646"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. N. Sun","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110017664","display_name":"Juanita Hyde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. D. Hyde","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. Ruiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Ruiz","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064998566","display_name":"E. Meigs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Meigs","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086356232","display_name":"Bradley R. Herrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. R. Herrin","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088486895","display_name":"Cynthia D. Fastje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. D. Fastje","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S. J. Macdonald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. J. Macdonald","raw_affiliation_strings":["Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069707174","display_name":"Mark L. Witten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. L. Witten","raw_affiliation_strings":["Department of Pediatrics, AHSCB Room #3352, University of Arizona, 1501 N. Campbell Avenue, P.O. Box 245073, Tucson, AZ, 85724-5073, USA","Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, AHSCB Room #3352, University of Arizona, 1501 N. Campbell Avenue, P.O. Box 245073, Tucson, AZ, 85724-5073, USA","institution_ids":["https://openalex.org/I138006243"]},{"raw_affiliation_string":"Lung Injury Laboratory, Department of Pediatrics, The University of Arizona Health Sciences Center, Tucson, Arizona , 85724, USA","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069707174"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":1.1976,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.79618838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"182","issue":"6","first_page":"319","last_page":"330"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11422","display_name":"Burn Injury Management and Outcomes","score":0.7026000022888184,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.14339999854564667,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drotrecogin-alfa-activated","display_name":"drotrecogin alfa (activated)","score":0.9559999704360962},{"id":"https://openalex.org/keywords/activated-protein-c","display_name":"activated protein C","score":0.8859999775886536},{"id":"https://openalex.org/keywords/smoke-inhalation-injury","display_name":"smoke inhalation injury","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pulmonary-microvascular-permeability","display_name":"pulmonary capillary permeability","score":0.984000027179718},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9010000228881836},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.9259999990463257},{"id":"https://openalex.org/keywords/anti-inflammatory-therapy","display_name":"anti-inflammatory therapy","score":0.8460000157356262},{"id":"https://openalex.org/keywords/lung-compliance","display_name":"lung compliance","score":0.7559999823570251},{"id":"https://openalex.org/keywords/pulmonary-resistance","display_name":"pulmonary resistance","score":0.7820000052452087},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage-fluid","display_name":"bronchoalveolar lavage fluid","score":0.9179999828338623},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.7526094913482666},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7500312328338623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6745874881744385},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4669654667377472},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40899211168289185},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2990080416202545},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.26708751916885376},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25692373514175415}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011486","descriptor_name":"Protein C","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012906","descriptor_name":"Smoke","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013373","descriptor_name":"Substance P","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015208","descriptor_name":"Smoke Inhalation Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00408-004-2512-5","doi":"https://doi.org/10.1007/s00408-004-2512-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00408-004-2512-5","pdf_url":null,"source":{"id":"https://openalex.org/S104471971","display_name":"Lung","issn_l":"0341-2040","issn":["0341-2040","1432-1750"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung","raw_type":"journal-article"},{"id":"pmid:15765924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15765924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lung","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W304077197","https://openalex.org/W314977035","https://openalex.org/W1590629056","https://openalex.org/W1964415576","https://openalex.org/W1971696195","https://openalex.org/W1979676940","https://openalex.org/W1979899953","https://openalex.org/W1998400980","https://openalex.org/W2004031334","https://openalex.org/W2018919353","https://openalex.org/W2033461490","https://openalex.org/W2034865588","https://openalex.org/W2037011084","https://openalex.org/W2052812481","https://openalex.org/W2054683023","https://openalex.org/W2055476019","https://openalex.org/W2064998096","https://openalex.org/W2067356952","https://openalex.org/W2072070555","https://openalex.org/W2073605647","https://openalex.org/W2078837391","https://openalex.org/W2079377586","https://openalex.org/W2080386965","https://openalex.org/W2111818334","https://openalex.org/W2114288049","https://openalex.org/W2133651852","https://openalex.org/W2139155519","https://openalex.org/W2145463845","https://openalex.org/W2155912601","https://openalex.org/W2159487576","https://openalex.org/W2167351713","https://openalex.org/W2189482669","https://openalex.org/W2255568310","https://openalex.org/W2322121630","https://openalex.org/W2333140339","https://openalex.org/W2336871225","https://openalex.org/W2406089599","https://openalex.org/W2413875952","https://openalex.org/W2414623081","https://openalex.org/W2417681579"],"related_works":["https://openalex.org/W2064956840","https://openalex.org/W2008830288","https://openalex.org/W2080378329","https://openalex.org/W2328407631","https://openalex.org/W2925372427","https://openalex.org/W2383131481","https://openalex.org/W2027471559","https://openalex.org/W7129017761","https://openalex.org/W2023180777","https://openalex.org/W3032248600"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
