{"id":"https://openalex.org/W2012198935","doi":"https://doi.org/10.1359/jbmr.070611","title":"Maspin Is Involved in Bone Matrix Maturation by Enhancing the Accumulation of Latent TGF-\u03b2","display_name":"Maspin Is Involved in Bone Matrix Maturation by Enhancing the Accumulation of Latent TGF-\u03b2","publication_year":2007,"publication_date":"2007-06-11","ids":{"openalex":"https://openalex.org/W2012198935","doi":"https://doi.org/10.1359/jbmr.070611","mag":"2012198935","pmid":"https://pubmed.ncbi.nlm.nih.gov/17563239"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.070611","doi":"https://doi.org/10.1359/jbmr.070611","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.070611","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058976287","display_name":"Reiko Tokuyama-Toda","orcid":"https://orcid.org/0000-0003-3932-5913","observed_orcids":["https://orcid.org/0000-0003-3932-5913"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Reiko Tokuyama","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007374424","display_name":"Kazuhito Satomura","orcid":"https://orcid.org/0000-0003-2159-1279","observed_orcids":["https://orcid.org/0000-0003-2159-1279"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhito Satomura","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024838294","display_name":"Eriko Maeda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eriko Maeda","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083624895","display_name":"Keiko Kudoh","orcid":"https://orcid.org/0000-0002-6210-0512","observed_orcids":["https://orcid.org/0000-0002-6210-0512"]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiko Kudoh","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049873606","display_name":"Yasuhumi Yamasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhumi Yamasaki","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108489266","display_name":"Masaru Nagayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I922474255","display_name":"Tokushima University","ror":"https://ror.org/044vy1d05","country_code":"JP","type":"education","lineage":["https://openalex.org/I922474255"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Nagayama","raw_affiliation_strings":["Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral and Maxillofacial Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan","institution_ids":["https://openalex.org/I922474255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5007374424"],"corresponding_institution_ids":["https://openalex.org/I922474255"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.1324,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.49253586,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"22","issue":"10","first_page":"1581","last_page":"1591"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7573000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.1581999957561493,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maspin","display_name":"maspin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/latent-tgf-beta","display_name":"latent TGF-beta","score":0.8610000014305115},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9850000143051147},{"id":"https://openalex.org/keywords/serine-protease-inhibitors","display_name":"serine protease inhibitors","score":0.8479999899864197},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9039999842643738},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.9409999847412109},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tgf-beta-activation","display_name":"TGF-beta activation","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C2778900538","wikidata":"https://www.wikidata.org/wiki/Q15320674","display_name":"Maspin","level":4,"score":0.9862887263298035},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6533714532852173},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5347371101379395},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43433454632759094},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.4215904474258423},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3764503002166748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3594662547111511},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34876447916030884},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3296475112438202},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25978899002075195},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.2527032494544983},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001857","descriptor_name":"Bone Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010447","descriptor_name":"Peptide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015843","descriptor_name":"Serpins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016372","descriptor_name":"RNA, Antisense","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.070611","doi":"https://doi.org/10.1359/jbmr.070611","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.070611","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:17563239","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17563239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1502713173","https://openalex.org/W1522781444","https://openalex.org/W1529693712","https://openalex.org/W1531475302","https://openalex.org/W1568669558","https://openalex.org/W1964524187","https://openalex.org/W1966170741","https://openalex.org/W1969528708","https://openalex.org/W1969858456","https://openalex.org/W1981213353","https://openalex.org/W1981570640","https://openalex.org/W1989042099","https://openalex.org/W1990368876","https://openalex.org/W1997526503","https://openalex.org/W2001116495","https://openalex.org/W2003263309","https://openalex.org/W2005201208","https://openalex.org/W2013662783","https://openalex.org/W2014001027","https://openalex.org/W2019528718","https://openalex.org/W2036960054","https://openalex.org/W2048263097","https://openalex.org/W2062392379","https://openalex.org/W2071660979","https://openalex.org/W2072273255","https://openalex.org/W2085864430","https://openalex.org/W2086364694","https://openalex.org/W2107410754","https://openalex.org/W2113652248","https://openalex.org/W2118639213","https://openalex.org/W2141793288","https://openalex.org/W2144206769","https://openalex.org/W2150472477","https://openalex.org/W2155383324","https://openalex.org/W2166584371","https://openalex.org/W2292256778","https://openalex.org/W2406489612","https://openalex.org/W2415869996","https://openalex.org/W2614999422","https://openalex.org/W3022509986","https://openalex.org/W4253517795","https://openalex.org/W4285719527","https://openalex.org/W6634037619","https://openalex.org/W6642429986"],"related_works":["https://openalex.org/W2945912234","https://openalex.org/W2043781041","https://openalex.org/W2045742059","https://openalex.org/W1966170741","https://openalex.org/W2158798310","https://openalex.org/W1522781444","https://openalex.org/W2098183783","https://openalex.org/W2119491066","https://openalex.org/W4288734194","https://openalex.org/W2041882100"],"abstract_inverted_index":{"UNLABELLED:":[0],"Maspin,":[1],"a":[2,60,77,198,218],"serine":[3,61],"protease":[4,62],"inhibitor,":[5],"is":[6,59],"expressed":[7,166,228],"by":[8,118,157],"formative":[9],"osteoblasts.":[10],"The":[11],"repression":[12],"of":[13,22,32,54,92,95,104,130,136,155,176,205,215,239,249,251],"maspin":[14,33,41,81,96,105,147,149,156,167,199,227],"expression":[15,94,103,154],"in":[16,25,46,51,82,109,132,160,171,179,185,208,229,244,254],"osteoblastic":[17,116,163],"cells":[18,112,117,140,164,194,216],"decreased":[19,184],"the":[20,26,30,52,93,102,128,133,174,180,209,240,247,255],"level":[21],"latent":[23,35,55,177,206,252],"TGF-beta":[24,131,178,207,253],"extracellular":[27,134,181,210,256],"matrix,":[28,242],"whereas":[29],"overexpression":[31],"increased":[34,212],"TGF-beta.":[36,56],"These":[37,223],"findings":[38,224],"suggest":[39,225],"that":[40,64,226],"plays":[42,232],"an":[43,189,233],"important":[44,234],"role":[45,79,236],"bone":[47,83,241],"matrix":[48,135,182,211],"formation,":[49],"particularly":[50],"accumulation":[53,129,175,204,250],"INTRODUCTION:":[57],"Maspin":[58],"inhibitor":[63],"exhibits":[65],"tumor":[66],"suppressive":[67],"and":[68,107,113,121,169,192,243],"anti-angiogenic":[69],"activities.":[70],"This":[71],"study":[72],"was":[73],"performed":[74,89],"to":[75,188],"elucidate":[76],"possible":[78],"for":[80],"formation.":[84],"MATERIALS":[85],"AND":[86],"METHODS:":[87],"We":[88,100,125,152],"immunohistochemical":[90],"analysis":[91],"during":[97,237,246],"endochondral":[98],"ossification.":[99],"evaluated":[101],"mRNA":[106,168],"protein":[108,170],"ROS":[110,138],"17/2.8":[111,139],"primary":[114],"rat":[115],"RT-PCR,":[119],"immunocytochemistry,":[120],"Western":[122],"blot":[123],"analysis.":[124],"also":[126,165],"examined":[127],"cultured":[137],"after":[141,213],"transfection":[142,214],"with":[143,197,217],"vectors":[144],"expressing":[145,220],"either":[146],"or":[148],"antisense.":[150],"RESULTS:":[151],"observed":[153],"active":[158,230],"osteoblasts":[159,231],"vivo.":[161],"Rat":[162],"vitro.":[172],"Moreover,":[173],"significantly":[183],"cultures":[186],"exposed":[187],"anti-maspin":[190],"antibody":[191],"when":[193],"were":[195],"transfected":[196],"antisense-expressing":[200],"vector.":[201],"In":[202],"contrast,":[203],"vector":[219],"maspin.":[221],"CONCLUSIONS:":[222],"physiological":[235],"maturation":[238],"particular,":[245],"process":[248],"matrix.":[257]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
