{"id":"https://openalex.org/W2012194535","doi":"https://doi.org/10.1016/0006-2952(90)90265-m","title":"1-Substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases","display_name":"1-Substituted phthalazines as probes of the substrate-binding site of mammalian molybdenum hydroxylases","publication_year":1990,"publication_date":"1990-04-01","ids":{"openalex":"https://openalex.org/W2012194535","doi":"https://doi.org/10.1016/0006-2952(90)90265-m","mag":"2012194535","pmid":"https://pubmed.ncbi.nlm.nih.gov/2322306"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(90)90265-m","doi":"https://doi.org/10.1016/0006-2952(90)90265-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(90)90265-m","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062542126","display_name":"Christine Beedham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christine Beedham","raw_affiliation_strings":["School of Pharmacy, University of Bradford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, University of Bradford, U.K","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037884904","display_name":"Sally E. Bruce","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally E. Bruce","raw_affiliation_strings":["Pharmaceutical Chemistry, School of Pharmacy, University of Bradford BD1 1DP, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry, School of Pharmacy, University of Bradford BD1 1DP, U.K","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055294109","display_name":"David J.P. Critchley","orcid":"https://orcid.org/0000-0003-1043-7794","observed_orcids":["https://orcid.org/0000-0003-1043-7794"]},"institutions":[{"id":"https://openalex.org/I139894009","display_name":"University of Bradford","ror":"https://ror.org/00vs8d940","country_code":"GB","type":"education","lineage":["https://openalex.org/I139894009"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Critchley","raw_affiliation_strings":["Pharmaceutical Chemistry, School of Pharmacy, University of Bradford BD1 1DP, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Chemistry, School of Pharmacy, University of Bradford BD1 1DP, U.K","institution_ids":["https://openalex.org/I139894009"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076510664","display_name":"David J. Rance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189718659","display_name":"Pfizer (United Kingdom)","ror":"https://ror.org/04x4v8p40","country_code":"GB","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I189718659"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Rance","raw_affiliation_strings":["Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Drug Metabolism, Pfizer Central Research, Sandwich, Kent CT13 9NJ, U.K","institution_ids":["https://openalex.org/I189718659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5062542126"],"corresponding_institution_ids":["https://openalex.org/I139894009"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":1.5657,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.79844017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"39","issue":"7","first_page":"1213","last_page":"1221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8476999998092651,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molybdenum-hydroxylases","display_name":"molybdenum hydroxylases","score":0.8669999837875366},{"id":"https://openalex.org/keywords/aldehyde-oxidase","display_name":"aldehyde oxidase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/substrate-binding-site","display_name":"substrate binding site","score":0.9639999866485596},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.7419999837875366},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6589999794960022},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.34299999475479126},{"id":"https://openalex.org/keywords/milk-enzymes","display_name":"milk enzymes","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C549387045","wikidata":"https://www.wikidata.org/wiki/Q1053","display_name":"Molybdenum","level":2,"score":0.7556355595588684},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.7169046401977539},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.617027997970581},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6142796874046326},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5090729594230652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.46194133162498474},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34488609433174133},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2835957407951355},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.190518319606781},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1896463930606842},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.04661789536476135}],"mesh":[{"descriptor_ui":"D000445","descriptor_name":"Aldehyde Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008982","descriptor_name":"Molybdenum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010215","descriptor_name":"Papio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010793","descriptor_name":"Phthalazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011724","descriptor_name":"Pyridazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013055","descriptor_name":"Spectrophotometry, Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015335","descriptor_name":"Molecular Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042931","descriptor_name":"Aldehyde Oxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(90)90265-m","doi":"https://doi.org/10.1016/0006-2952(90)90265-m","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(90)90265-m","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:2322306","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2322306","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W168883833","https://openalex.org/W1416253925","https://openalex.org/W1751259345","https://openalex.org/W1965809313","https://openalex.org/W1972488286","https://openalex.org/W1974398989","https://openalex.org/W1976928257","https://openalex.org/W1987268792","https://openalex.org/W1994350255","https://openalex.org/W1995867377","https://openalex.org/W2001204930","https://openalex.org/W2024191422","https://openalex.org/W2037454336","https://openalex.org/W2042452751","https://openalex.org/W2057539368","https://openalex.org/W2058340685","https://openalex.org/W2058525495","https://openalex.org/W2061344288","https://openalex.org/W2069881072","https://openalex.org/W2070270392","https://openalex.org/W2078145821","https://openalex.org/W2084757160","https://openalex.org/W2100438158","https://openalex.org/W2107723834"],"related_works":["https://openalex.org/W2165452325","https://openalex.org/W1481032886","https://openalex.org/W2034086280","https://openalex.org/W2046360546","https://openalex.org/W1995867377","https://openalex.org/W1994350255","https://openalex.org/W2058340685","https://openalex.org/W1965189920","https://openalex.org/W4242792246","https://openalex.org/W1965977591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
