{"id":"https://openalex.org/W2012194014","doi":"https://doi.org/10.1159/000335606","title":"Polymorphism of the TLR4 Gene Reduces the Risk of Hepatitis C Virus-Induced Hepatocellular Carcinoma","display_name":"Polymorphism of the TLR4 Gene Reduces the Risk of Hepatitis C Virus-Induced Hepatocellular Carcinoma","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2012194014","doi":"https://doi.org/10.1159/000335606","mag":"2012194014","pmid":"https://pubmed.ncbi.nlm.nih.gov/22286521"},"language":"en","primary_location":{"id":"doi:10.1159/000335606","doi":"https://doi.org/10.1159/000335606","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000335606","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081399911","display_name":"Jos\u00e9 A. G. Ag\u00fandez","orcid":"https://orcid.org/0000-0001-6895-9160","observed_orcids":["https://orcid.org/0000-0001-6895-9160"]},"institutions":[{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 A. Ag\u00fandez","raw_affiliation_strings":["Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain","Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain","institution_ids":["https://openalex.org/I80606768"]},{"raw_affiliation_string":"Pharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077352921","display_name":"Elena Garc\u00eda\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0002-8094-046X","observed_orcids":["https://orcid.org/0000-0002-8094-046X"]},"institutions":[{"id":"https://openalex.org/I80606768","display_name":"Universidad de Extremadura","ror":"https://ror.org/0174shg90","country_code":"ES","type":"education","lineage":["https://openalex.org/I80606768"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Garc\u00eda-Mart\u00edn","raw_affiliation_strings":["Biochemistry and Molecular Biology, Medical School, University of Extremadura, Badajoz,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology, Medical School, University of Extremadura, Badajoz,","institution_ids":["https://openalex.org/I80606768"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087886903","display_name":"Mar\u00eda Jos\u00e9 Devesa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mar\u00eda J. Devesa","raw_affiliation_strings":["Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035827719","display_name":"Miguel Carballo","orcid":"https://orcid.org/0000-0002-0222-3588","observed_orcids":["https://orcid.org/0000-0002-0222-3588"]},"institutions":[{"id":"https://openalex.org/I4210093812","display_name":"Hospital Terrassa","ror":"https://ror.org/00j9f7w81","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210093812","https://openalex.org/I4210098336"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Miguel Carballo","raw_affiliation_strings":["Laboratory of Molecular Genetics, Hospital de Terrassa, Terrassa, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, Hospital de Terrassa, Terrassa, Spain","institution_ids":["https://openalex.org/I4210093812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008597414","display_name":"Carmen Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0002-8401-7306","observed_orcids":["https://orcid.org/0000-0002-8401-7306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Mart\u00ednez","raw_affiliation_strings":["Pharmacology and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacology and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031826258","display_name":"Anna Lee-Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Anna Lee-Brunner","raw_affiliation_strings":["Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102763452","display_name":"Cristina Fern\u00e1ndez","orcid":"https://orcid.org/0000-0001-5205-7680","observed_orcids":["https://orcid.org/0000-0001-5205-7680"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristina Fern\u00e1ndez","raw_affiliation_strings":["Service of Clinical Epidemiology, Hospital Cl\u00ednico San Carlos and School of Medicine, Complutense University, Madrid, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Clinical Epidemiology, Hospital Cl\u00ednico San Carlos and School of Medicine, Complutense University, Madrid, and","institution_ids":["https://openalex.org/I121748325","https://openalex.org/I2961216182"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104141335","display_name":"Manuel D\u00edaz\u2010Rubio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Manuel D\u00edaz-Rubio","raw_affiliation_strings":["Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and","institution_ids":["https://openalex.org/I2961216182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112075093","display_name":"Jos\u00e9 M. Ladero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2961216182","display_name":"Hospital Cl\u00ednico San Carlos","ror":"https://ror.org/04d0ybj29","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2961216182","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 M. Ladero","raw_affiliation_strings":["Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Gastroenterology (Liver Unit), Hospital Cl\u00ednico San Carlos, Department of Medicine, and","institution_ids":["https://openalex.org/I2961216182"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.2566,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.95628624,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"82","issue":"1","first_page":"35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.03819999843835831,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.9020000100135803},{"id":"https://openalex.org/keywords/tlr4-polymorphisms","display_name":"TLR4 polymorphisms","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9309999942779541},{"id":"https://openalex.org/keywords/rs4986791","display_name":"rs4986791","score":0.9890000224113464},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7480000257492065},{"id":"https://openalex.org/keywords/innate-immune-response","display_name":"innate immune response","score":0.7379999756813049},{"id":"https://openalex.org/keywords/chronic-liver-disease","display_name":"chronic liver disease","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8566780090332031},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.6280008554458618},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6080571413040161},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5533129572868347},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.5518931150436401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5091149210929871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4702388644218445},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.46264350414276123},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.46261507272720337},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.45002418756484985},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4498915374279022},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43789297342300415},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.4141232669353485},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4134278893470764},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4047967195510864},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2920697331428528},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.22793391346931458},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22165769338607788},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21294018626213074},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07396474480628967}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D006579","descriptor_name":"Heterozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013030","descriptor_name":"Spain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000335606","doi":"https://doi.org/10.1159/000335606","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000335606","pdf_url":null,"source":{"id":"https://openalex.org/S198727964","display_name":"Oncology","issn_l":"0030-2414","issn":["0030-2414","1423-0232"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"journal-article"},{"id":"pmid:22286521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22286521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1924062600","https://openalex.org/W1986013893","https://openalex.org/W1996529632","https://openalex.org/W1998113154","https://openalex.org/W1998799665","https://openalex.org/W1999928502","https://openalex.org/W2012989864","https://openalex.org/W2042554205","https://openalex.org/W2061486008","https://openalex.org/W2074213282","https://openalex.org/W2076794498","https://openalex.org/W2077226805","https://openalex.org/W2079955793","https://openalex.org/W2082880246","https://openalex.org/W2085618266","https://openalex.org/W2092884146","https://openalex.org/W2094986548","https://openalex.org/W2101363646","https://openalex.org/W2114376411","https://openalex.org/W2120970673","https://openalex.org/W2131529605","https://openalex.org/W2132290252","https://openalex.org/W2145146728","https://openalex.org/W2160978572","https://openalex.org/W2164906049"],"related_works":["https://openalex.org/W3181090449","https://openalex.org/W2912714252","https://openalex.org/W1998637232","https://openalex.org/W2980462258","https://openalex.org/W1998799665","https://openalex.org/W4381060601","https://openalex.org/W4389066734","https://openalex.org/W2067980128","https://openalex.org/W2901865504","https://openalex.org/W4293677535"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Toll-like":[1],"receptor":[2],"4":[3],"(TLR4)":[4],"signalling":[5],"participates":[6],"in":[7,47,51,77,121,126,135,194],"the":[8,23,38,74,111,147,169],"innate":[9],"immune":[10],"response":[11],"against":[12],"hepatitis":[13,87,139],"C":[14,88,140],"virus":[15],"(HCV)":[16],"infection.":[17],"TLR4":[18,42,75,175],"gene":[19,43,76],"polymorphisms":[20,46,68],"may":[21],"influence":[22],"risk":[24,184],"of":[25,40,149,160,185],"HCV-induced":[26,195],"hepatocellular":[27],"carcinoma":[28],"(HCC).":[29],"This":[30],"is":[31,179],"a":[32,182],"single-centre-based":[33],"study":[34],"designed":[35],"to":[36],"analyse":[37],"distribution":[39],"several":[41],"single":[44,66],"nucleotide":[45,67],"healthy":[48,91,127],"controls":[49,128],"and":[50,58,71,89,96,105,134,187],"patients":[52,79,84,122,136],"chronically":[53],"infected":[54],"with":[55,57,80,85,123,137,156,181],"HCV,":[56],"without":[59],"HCC.":[60],"METHODS:":[61],"We":[62],"have":[63],"determined":[64],"three":[65],"(rs2149356,":[69],"rs4986791":[70,170],"rs5030719)":[72],"at":[73],"155":[78],"HCV-related":[81],"HCC,":[82],"153":[83],"chronic":[86,138,196],"390":[90],"controls.":[92],"All":[93],"were":[94,98,166],"white":[95],"most":[97],"Spaniards.":[99],"RESULTS:":[100],"(1)":[101],"rs5030719":[102],"was":[103,106,117],"monomorphic":[104],"not":[107],"further":[108],"analysed;":[109],"(2)":[110],"rs2149356":[112,150],"T":[113,151,171,177],"allele":[114,152,178],"carrier":[115],"state":[116],"significantly":[118],"less":[119],"frequent":[120],"HCC":[124,186],"than":[125],"(OR":[129,141],"0.421,":[130],"95%":[131,143],"CI":[132,144],"0.285-0.625)":[133],"0.426,":[142],"0.236-0.767);":[145],"(3)":[146],"proportion":[148],"carriers":[153],"progressively":[154],"diminished":[155],"increasing":[157],"clinical":[158,192],"stage":[159],"HCC;":[161],"(4)":[162],"no":[163],"significant":[164],"differences":[165],"observed":[167],"for":[168],"allele.":[172],"CONCLUSION:":[173],"The":[174],"rs2148356":[176],"associated":[180],"reduced":[183],"could":[188],"slow":[189],"down":[190],"its":[191],"progression":[193],"liver":[197],"disease.":[198]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}