{"id":"https://openalex.org/W2012192009","doi":"https://doi.org/10.1056/nejme1301249","title":"Circulating Tumor DNA \u2014 Ready for Prime Time?","display_name":"Circulating Tumor DNA \u2014 Ready for Prime Time?","publication_year":2013,"publication_date":"2013-03-13","ids":{"openalex":"https://openalex.org/W2012192009","doi":"https://doi.org/10.1056/nejme1301249","mag":"2012192009","pmid":"https://pubmed.ncbi.nlm.nih.gov/23484798"},"language":"en","primary_location":{"id":"doi:10.1056/nejme1301249","doi":"https://doi.org/10.1056/nejme1301249","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme1301249","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028539104","display_name":"Marc E. Lippman","orcid":"https://orcid.org/0000-0001-5280-4084","observed_orcids":["https://orcid.org/0000-0001-5280-4084"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Lippman","raw_affiliation_strings":["Leonard M. Miller School of Medicine, University of Miami, Miami"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard M. Miller School of Medicine, University of Miami, Miami","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037774999","display_name":"Charles Kent Osborne","orcid":"https://orcid.org/0000-0002-0044-618X","observed_orcids":["https://orcid.org/0000-0002-0044-618X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Kent Osborne","raw_affiliation_strings":["Breast Center at Baylor College of Medicine, Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Center at Baylor College of Medicine, Houston","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"368","issue":"13","first_page":"1249","last_page":"1250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9380000233650208},{"id":"https://openalex.org/keywords/recurrence-detection","display_name":"recurrence detection","score":0.6830000281333923},{"id":"https://openalex.org/keywords/early-detection-of-recurrence","display_name":"early detection of recurrence","score":0.7289999723434448},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6629999876022339},{"id":"https://openalex.org/keywords/disease-progression-monitoring","display_name":"disease progression monitoring","score":0.9150000214576721},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.5839999914169312},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.931571364402771},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7355537414550781},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5190714001655579},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.479857861995697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4366832673549652},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.42115166783332825},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35690993070602417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34382525086402893},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2564746141433716}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018396","descriptor_name":"Mucin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejme1301249","doi":"https://doi.org/10.1056/nejme1301249","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejme1301249","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:23484798","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23484798","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Editorial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2140575188"],"related_works":["https://openalex.org/W4415711298","https://openalex.org/W7162673337","https://openalex.org/W1523640001","https://openalex.org/W4411489218","https://openalex.org/W1991937007","https://openalex.org/W2569946794","https://openalex.org/W3188237025","https://openalex.org/W2939548416","https://openalex.org/W2024175597","https://openalex.org/W4379648461"],"abstract_inverted_index":{"Multiple":[0],"aspects":[1],"of":[2,5,17,25,32,44,54,69,80,90,97],"the":[3,23,29,72,95],"management":[4],"metastatic":[6],"breast":[7],"cancer":[8],"need":[9],"improvement.":[10],"Patients":[11],"are":[12,20,37],"anxious":[13],"about":[14],"their":[15],"risk":[16],"recurrence":[18],"and":[19,67,85],"disappointed":[21],"at":[22,71],"lack":[24],"reliable":[26],"tests":[27],"for":[28],"early":[30],"detection":[31,43],"recurrence,":[33],"even":[34],"though":[35],"there":[36],"no":[38],"data":[39],"to":[40,63,83],"suggest":[41],"that":[42,60],"asymptomatic":[45],"recurrences":[46],"a":[47,64],"few":[48],"weeks":[49],"or":[50],"months":[51],"earlier":[52,88],"is":[53],"any":[55],"benefit.":[56],"It":[57],"seems":[58],"reasonable":[59],"identifying":[61],"resistance":[62],"new":[65],"therapy":[66],"progression":[68],"disease":[70],"earliest":[73],"moment":[74],"would":[75,86],"avoid":[76],"needless":[77],"toxic":[78],"effects":[79],"therapies":[81],"doomed":[82],"fail":[84],"permit":[87],"initiation":[89],"other":[91],"potential":[92],"therapies.":[93],"Finally,":[94],"means":[96],"estimating":[98],"overall":[99],".":[100,101,102]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
