{"id":"https://openalex.org/W2012190398","doi":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","title":"Neuroprotection by Manganese Superoxide Dismutase ( M n SOD ) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke","display_name":"Neuroprotection by Manganese Superoxide Dismutase ( M n SOD ) Mimics: Antioxidant Effect and Oxidative Stress Regulation in Acute Experimental Stroke","publication_year":2012,"publication_date":"2012-08-31","ids":{"openalex":"https://openalex.org/W2012190398","doi":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","mag":"2012190398","pmid":"https://pubmed.ncbi.nlm.nih.gov/22934841","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493411"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-5949.2012.00380.x","doi":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-5949.2012.00380.x","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-5949.2012.00380.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hai\u2010Feng Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai\u2010Feng Huang","raw_affiliation_strings":["State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing (China)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing (China)","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103777462","display_name":"Fei Guo","orcid":"https://orcid.org/0000-0002-7072-2522","observed_orcids":["https://orcid.org/0000-0002-7072-2522"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Guo","raw_affiliation_strings":["State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079737755","display_name":"Yuanzhao Cao","orcid":"https://orcid.org/0000-0001-6406-4239","observed_orcids":["https://orcid.org/0000-0001-6406-4239"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan\u2010Zhao Cao","raw_affiliation_strings":["State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101734182","display_name":"Wen Shi","orcid":"https://orcid.org/0000-0002-9206-1411","observed_orcids":["https://orcid.org/0000-0002-9206-1411"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Shi","raw_affiliation_strings":["State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100673498","display_name":"Qing Xia","orcid":"https://orcid.org/0000-0002-5509-6981","observed_orcids":["https://orcid.org/0000-0002-5509-6981"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4391768132","display_name":"State Key Laboratory of Natural and Biomimetic Drugs","ror":"https://ror.org/049mqh532","country_code":"CN","type":"facility","lineage":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qing Xia","raw_affiliation_strings":["State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology School of Pharmaceutical Sciences Peking University Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences Peking University State Key Laboratory of Natural and Biomimetic Drugs Department of Chemical Biology Beijing China","institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100673498"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4391768132"],"apc_list":{"value":4140,"currency":"USD","value_usd":4140},"apc_paid":null,"fwci":3.0567,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.90465901,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"10","first_page":"811","last_page":"818"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.8230000138282776},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9459999799728394},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.5550000071525574},{"id":"https://openalex.org/keywords/superoxide-radical-scavenging","display_name":"superoxide radical scavenging","score":0.8090000152587891},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.492000013589859},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8320000171661377},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8960000276565552},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.746999979019165},{"id":"https://openalex.org/keywords/hydrogen-peroxide-injury","display_name":"hydrogen peroxide injury","score":0.7609999775886536},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8818598985671997},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.8290762901306152},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.8217413425445557},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7438502311706543},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5743197202682495},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.545266330242157},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4778275489807129},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.4759537875652313},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4752243161201477},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4123711585998535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2783638834953308},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26730412244796753},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000091342","descriptor_name":"Endoplasmic Reticulum Chaperone BiP","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002734","descriptor_name":"Chlorophyll","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002734","descriptor_name":"Chlorophyll","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017601","descriptor_name":"Oxygen Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D020520","descriptor_name":"Brain Infarction","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020520","descriptor_name":"Brain Infarction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051742","descriptor_name":"Transcription Factor CHOP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1755-5949.2012.00380.x","doi":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-5949.2012.00380.x","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5559475","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6493411","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6493411","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neurosci Ther","raw_type":"Text"},{"id":"pmid:22934841","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22934841","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS neuroscience & therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1755-5949.2012.00380.x","doi":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1755-5949.2012.00380.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1755-5949.2012.00380.x","source":{"id":"https://openalex.org/S84392608","display_name":"CNS Neuroscience & Therapeutics","issn_l":"1755-5930","issn":["1755-5930","1755-5949"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Neuroscience &amp; Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.979200005531311,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3148009641","display_name":null,"funder_award_id":"2010CB12300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G4628902135","display_name":null,"funder_award_id":"2010010","funder_id":"https://openalex.org/F4320334978","funder_display_name":"Beijing Nova Program"},{"id":"https://openalex.org/G8134150208","display_name":"SOD\u6a21\u62df\u7269\u7684\u795e\u7ecf\u6297\u6c27\u5316\u4f5c\u7528\u53ca\u5176\u673a\u5236\u7814\u7a76","funder_award_id":"20901005","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334978","display_name":"Beijing Nova Program","ror":"https://ror.org/034k14f91"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012190398.pdf","grobid_xml":"https://content.openalex.org/works/W2012190398.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1510815870","https://openalex.org/W1533259206","https://openalex.org/W1556814137","https://openalex.org/W1604389902","https://openalex.org/W1879740621","https://openalex.org/W1942718624","https://openalex.org/W1956953708","https://openalex.org/W1979622182","https://openalex.org/W1981558989","https://openalex.org/W1987096917","https://openalex.org/W1989347991","https://openalex.org/W1989649022","https://openalex.org/W1990188785","https://openalex.org/W1990808935","https://openalex.org/W1997018082","https://openalex.org/W1997474765","https://openalex.org/W1998695769","https://openalex.org/W2008757142","https://openalex.org/W2010714560","https://openalex.org/W2024858204","https://openalex.org/W2026539080","https://openalex.org/W2035411579","https://openalex.org/W2043058882","https://openalex.org/W2043530905","https://openalex.org/W2049378335","https://openalex.org/W2050824673","https://openalex.org/W2053383941","https://openalex.org/W2058821788","https://openalex.org/W2059879622","https://openalex.org/W2064468843","https://openalex.org/W2071271032","https://openalex.org/W2077404304","https://openalex.org/W2081643662","https://openalex.org/W2091200367","https://openalex.org/W2094655287","https://openalex.org/W2097978963","https://openalex.org/W2103278596","https://openalex.org/W2112505121","https://openalex.org/W2119121198","https://openalex.org/W2122054000","https://openalex.org/W2134845552","https://openalex.org/W2151025194","https://openalex.org/W2152093646","https://openalex.org/W2159103481","https://openalex.org/W2163043182","https://openalex.org/W2167832002","https://openalex.org/W2169079203","https://openalex.org/W3142858943"],"related_works":["https://openalex.org/W1989649022","https://openalex.org/W4398166469","https://openalex.org/W2156851838","https://openalex.org/W7126052118","https://openalex.org/W4200224204","https://openalex.org/W2095329663","https://openalex.org/W1993059590","https://openalex.org/W7098374020","https://openalex.org/W1917740761","https://openalex.org/W4391448378"],"abstract_inverted_index":{"AIMS:":[0],"Manganese":[1],"superoxide":[2,52,158],"dismutase":[3,53],"(MnSOD),":[4],"one":[5,21],"of":[6,22,32,60,82,130,149,196],"the":[7,13,23,30,57,63,79,83,131],"most":[8],"crucial":[9],"antioxidant":[10,198],"enzymes":[11],"in":[12,67,191],"central":[14],"nervous":[15],"system,":[16],"is":[17,186],"thought":[18],"to":[19,55,77],"be":[20],"major":[24],"mechanisms":[25,66],"by":[26,153],"which":[27],"cells":[28],"counteract":[29],"injuries":[31],"reactive":[33],"oxygen":[34],"species":[35],"after":[36,111,151],"cerebral":[37,68,88],"ischemia.":[38,69],"In":[39,137,163],"this":[40],"study,":[41],"we":[42],"used":[43,76,92],"a":[44],"novel":[45],"synthesized":[46],"compound":[47],"(MnTm4PyP)":[48],"with":[49,86,101],"highly":[50],"effective":[51,188],"activity":[54],"study":[56],"therapeutic":[58,189],"potential":[59],"MnSOD":[61,142,177,185],"and":[62,115,123,172,182,200],"possible":[64],"underlying":[65],"METHODS:":[70],"Primary":[71],"cultured":[72,124],"cortical":[73],"neurons":[74,125,150],"were":[75,91,99,118,126,161],"examine":[78],"protective":[80],"effect":[81],"compounds.":[84],"Mice":[85],"middle":[87],"artery":[89],"occlusion":[90],"as":[93],"ischemic":[94,192],"stroke":[95,193],"animal":[96],"model.":[97],"Animals":[98],"pretreated":[100],"MnTm4PyP":[102,144,167],"intravenously":[103],"30":[104],"min":[105],"before":[106],"surgery.":[107],"At":[108],"24":[109],"h":[110],"surgery,":[112],"neurological":[113,174],"behavior":[114],"histological":[116],"function":[117],"observed.":[119],"Infarcted":[120],"cortex":[121],"tissues":[122],"collected":[127],"for":[128],"investigation":[129],"oxidative":[132,180,201],"stress":[133,181,202],"signaling":[134],"pathways.":[135],"RESULTS:":[136],"vitro":[138],"studies":[139],"revealed":[140],"that":[141],"mimic":[143,178],"pretreatment":[145,168],"significantly":[146],"increased":[147],"viability":[148],"injury":[152],"H(2)":[154],"O(2)":[155],".":[156],"Intracellular":[157],"radical":[159],"levels":[160],"eliminated.":[162],"vivo":[164],"experiments":[165],"demonstrated":[166],"reduced":[169],"infarct":[170],"volume":[171],"improved":[173],"function.":[175],"The":[176],"alleviated":[179],"apoptosis.":[183],"CONCLUSION:":[184],"an":[187],"target":[190],"prevention":[194],"because":[195],"its":[197],"effects":[199],"regulation.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
