{"id":"https://openalex.org/W2012187186","doi":"https://doi.org/10.1016/j.molcatb.2009.11.016","title":"Increased activity of enzymatic transacylation of acrylates through rational design of lipases","display_name":"Increased activity of enzymatic transacylation of acrylates through rational design of lipases","publication_year":2009,"publication_date":"2009-12-04","ids":{"openalex":"https://openalex.org/W2012187186","doi":"https://doi.org/10.1016/j.molcatb.2009.11.016","mag":"2012187186"},"language":"en","primary_location":{"id":"doi:10.1016/j.molcatb.2009.11.016","doi":"https://doi.org/10.1016/j.molcatb.2009.11.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molcatb.2009.11.016","pdf_url":null,"source":{"id":"https://openalex.org/S21009921","display_name":"Journal of Molecular Catalysis B Enzymatic","issn_l":"1381-1177","issn":["1381-1177","1873-3158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Catalysis B: Enzymatic","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042728325","display_name":"Per\u2010Olof Syr\u00e9n","orcid":"https://orcid.org/0000-0002-4066-2776","observed_orcids":["https://orcid.org/0000-0002-4066-2776"]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per-Olof Syr\u00e9n","raw_affiliation_strings":["Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000762808","display_name":"Ebba Lindgren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ebba Lindgren","raw_affiliation_strings":["Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049446561","display_name":"H.W. Hoeffken","orcid":"https://orcid.org/0000-0002-5157-1511","observed_orcids":["https://orcid.org/0000-0002-5157-1511"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans Wolfgang Hoeffken","raw_affiliation_strings":["BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003296751","display_name":"Cecilia Branneby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cecilia Branneby","raw_affiliation_strings":["BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064001331","display_name":"Steffen Maurer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Steffen Maurer","raw_affiliation_strings":["BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012903224","display_name":"Bernhard Hauer","orcid":"https://orcid.org/0000-0001-6259-3348","observed_orcids":["https://orcid.org/0000-0001-6259-3348"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernhard Hauer","raw_affiliation_strings":["BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF SE, GVF/E - A030, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075204548","display_name":"Karl Hult","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135511","display_name":"AlbaNova","ror":"https://ror.org/044kkfr75","country_code":"SE","type":"facility","lineage":["https://openalex.org/I4210135511"]},{"id":"https://openalex.org/I86987016","display_name":"KTH Royal Institute of Technology","ror":"https://ror.org/026vcq606","country_code":"SE","type":"education","lineage":["https://openalex.org/I86987016"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Karl Hult","raw_affiliation_strings":["Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal Institute of Technology (KTH), School of Biotechnology, Department of Biochemistry, AlbaNova University Centre, SE-106 91 Stockholm, Sweden","institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075204548"],"corresponding_institution_ids":["https://openalex.org/I4210135511","https://openalex.org/I86987016"],"apc_list":null,"apc_paid":null,"fwci":1.3185,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.77589236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"65","issue":"1-4","first_page":"3","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11831","display_name":"Chemical Synthesis and Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-antarctica-lipase-b","display_name":"Candida antarctica lipase B","score":0.9449999928474426},{"id":"https://openalex.org/keywords/transacylation","display_name":"transacylation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/acrylates","display_name":"acrylates","score":0.9900000095367432},{"id":"https://openalex.org/keywords/methyl-methacrylate","display_name":"methyl methacrylate","score":0.9509999752044678},{"id":"https://openalex.org/keywords/rational-enzyme-design","display_name":"rational enzyme design","score":0.5249999761581421},{"id":"https://openalex.org/keywords/saturated-esters","display_name":"saturated esters","score":0.6019999980926514},{"id":"https://openalex.org/keywords/cutinase","display_name":"cutinase","score":0.6850000023841858},{"id":"https://openalex.org/keywords/lipase","display_name":"lipase","score":0.6230000257492065},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2777613533","wikidata":"https://www.wikidata.org/wiki/Q4273972","display_name":"Cutinase","level":3,"score":0.878549337387085},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.861225962638855},{"id":"https://openalex.org/C2779542420","wikidata":"https://www.wikidata.org/wiki/Q15632647","display_name":"Candida antarctica","level":4,"score":0.8415610790252686},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.6315242052078247},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5237070322036743},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.46975329518318176},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4643704295158386},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.4497813284397125},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.4292204976081848},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.3663938045501709},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.31651201844215393},{"id":"https://openalex.org/C65024703","wikidata":"https://www.wikidata.org/wiki/Q373406","display_name":"Reaction mechanism","level":3,"score":0.09912192821502686}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.molcatb.2009.11.016","doi":"https://doi.org/10.1016/j.molcatb.2009.11.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.molcatb.2009.11.016","pdf_url":null,"source":{"id":"https://openalex.org/S21009921","display_name":"Journal of Molecular Catalysis B Enzymatic","issn_l":"1381-1177","issn":["1381-1177","1873-3158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-70"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Catalysis B: Enzymatic","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1875906722","https://openalex.org/W1969592458","https://openalex.org/W1971882434","https://openalex.org/W1982147796","https://openalex.org/W1986478563","https://openalex.org/W1997480730","https://openalex.org/W1997690922","https://openalex.org/W1998969159","https://openalex.org/W2016054402","https://openalex.org/W2018584315","https://openalex.org/W2034923095","https://openalex.org/W2035687084","https://openalex.org/W2037535298","https://openalex.org/W2065784370","https://openalex.org/W2083061348","https://openalex.org/W2083799886","https://openalex.org/W2086728923","https://openalex.org/W2089847643","https://openalex.org/W2107025108","https://openalex.org/W2114057682","https://openalex.org/W2131288855","https://openalex.org/W2144175569","https://openalex.org/W2154998149","https://openalex.org/W2163167546","https://openalex.org/W3086983054"],"related_works":["https://openalex.org/W2072341309","https://openalex.org/W1983825395","https://openalex.org/W1606552272","https://openalex.org/W2128536420","https://openalex.org/W2009905703","https://openalex.org/W2181160810","https://openalex.org/W2094810622","https://openalex.org/W1972960052","https://openalex.org/W2148415831","https://openalex.org/W1997690922"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}