{"id":"https://openalex.org/W2012185701","doi":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","title":"Acetylcholine releases endothelium\u2010derived hyperpolarizing factor and EDRF from rat blood vessels","display_name":"Acetylcholine releases endothelium\u2010derived hyperpolarizing factor and EDRF from rat blood vessels","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2012185701","doi":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","mag":"2012185701","pmid":"https://pubmed.ncbi.nlm.nih.gov/2851359","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1854275"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1988.tb11752.x","doi":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2012185701"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1854275/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061277029","display_name":"Guifa Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Guifa Chen","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan","Department of Pharmacology, Faculty of Medicine, Kyushu University 60 Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka, Japan","institution_ids":["https://openalex.org/I135598925"]},{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyushu University 60 Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100516637","display_name":"Hikaru Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru Suzuki","raw_affiliation_strings":["Department of Pharmacology, Faculty of Medicine, Kyushu University 60, Fukuoka 812, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Medicine, Kyushu University 60, Fukuoka 812, Japan","institution_ids":["https://openalex.org/I135598925"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111991883","display_name":"A.H. Weston","orcid":"https://orcid.org/0009-0000-8153-0983","observed_orcids":["https://orcid.org/0009-0000-8153-0983"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Arthur H. Weston","raw_affiliation_strings":["Department of Physiological Sciences, University of Manchester, Manchester, M13 9PT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Sciences, University of Manchester, Manchester, M13 9PT","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":9.3322,"has_fulltext":false,"cited_by_count":692,"citation_normalized_percentile":{"value":0.98622328,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"95","issue":"4","first_page":"1165","last_page":"1174"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.984000027179718},{"id":"https://openalex.org/keywords/endothelium-derived-hyperpolarizing-factor","display_name":"endothelium-derived hyperpolarizing factor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelium-derived-relaxing-factor","display_name":"endothelium-derived relaxing factor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/endothelial-hyperpolarization","display_name":"endothelial hyperpolarization","score":0.7360000014305115},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7580000162124634},{"id":"https://openalex.org/keywords/methylene-blue","display_name":"methylene blue","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.8569999933242798},{"id":"https://openalex.org/keywords/86rb-efflux","display_name":"86Rb efflux","score":0.9150000214576721},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.6919999718666077},{"id":"https://openalex.org/keywords/pulmonary-artery","display_name":"pulmonary artery","score":0.9900000095367432},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9340000152587891}],"concepts":[{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.8301037549972534},{"id":"https://openalex.org/C131453863","wikidata":"https://www.wikidata.org/wiki/Q1641079","display_name":"Hyperpolarization (physics)","level":3,"score":0.8093287944793701},{"id":"https://openalex.org/C2780310817","wikidata":"https://www.wikidata.org/wiki/Q5376433","display_name":"Endothelium-derived relaxing factor","level":3,"score":0.7826694250106812},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.6708277463912964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5916527509689331},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5885307788848877},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5445970296859741},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.5216801166534424},{"id":"https://openalex.org/C2779191827","wikidata":"https://www.wikidata.org/wiki/Q422134","display_name":"Methylene blue","level":4,"score":0.4447691738605499},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.43740174174308777},{"id":"https://openalex.org/C4141045","wikidata":"https://www.wikidata.org/wiki/Q83183","display_name":"Depolarization","level":2,"score":0.4208317995071411},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4167472720146179},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3596838712692261},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2572319507598877},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22214069962501526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1980588436126709},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.09158167243003845},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.07524183392524719},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.0},{"id":"https://openalex.org/C65165184","wikidata":"https://www.wikidata.org/wiki/Q218831","display_name":"Photocatalysis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001685","descriptor_name":"Biological Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008751","descriptor_name":"Methylene Blue","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011651","descriptor_name":"Pulmonary Artery","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1476-5381.1988.tb11752.x","doi":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1988.tb11752.x","pdf_url":null,"source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:2851359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2851359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1854275","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1854275/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1854275","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1854275/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1976360613","https://openalex.org/W1980829338","https://openalex.org/W1995115564","https://openalex.org/W2007737411","https://openalex.org/W2010482778","https://openalex.org/W2021783313","https://openalex.org/W2024324287","https://openalex.org/W2030709032","https://openalex.org/W2039693019","https://openalex.org/W2043474405","https://openalex.org/W2051356239","https://openalex.org/W2051929797","https://openalex.org/W2072451378","https://openalex.org/W2082891565","https://openalex.org/W2086076780","https://openalex.org/W2091701022","https://openalex.org/W2098108865","https://openalex.org/W2129367506","https://openalex.org/W2141911503","https://openalex.org/W2142975032","https://openalex.org/W2146341064","https://openalex.org/W2151601590","https://openalex.org/W2160532766","https://openalex.org/W2162804111","https://openalex.org/W2169182236","https://openalex.org/W2378789304","https://openalex.org/W2396652815"],"related_works":["https://openalex.org/W2021205474","https://openalex.org/W7006203481","https://openalex.org/W2004283605","https://openalex.org/W2119878742","https://openalex.org/W1991536795","https://openalex.org/W2083818545","https://openalex.org/W2043912153","https://openalex.org/W1983441765","https://openalex.org/W1995115564","https://openalex.org/W1982573306"],"abstract_inverted_index":{"1.":[0],"The":[1,96],"effects":[2],"of":[3,16,44,88,205],"haemoglobin":[4,105],"and":[5,13,25,41,51,61,91,135,145,159,174],"methylene":[6,62,107],"blue":[7,63,108],"on":[8,131,139,193],"the":[9,32,65,70,86,114,132,140,156,180,203],"acetylcholine":[10],"(ACh)-induced":[11],"electrical":[12,134],"mechanical":[14,136],"responses":[15,137],"smooth":[17],"muscle":[18],"cells":[19],"were":[20,53,101],"investigated":[21],"in":[22,55,84,98,109,116,142,155,202],"rat":[23,26,157,160],"aorta":[24,75,158],"main":[27,161],"pulmonary":[28,162],"artery.":[29],"2.":[30],"When":[31],"endothelium":[33],"was":[34],"intact,":[35],"ACh":[36,80,164],"induced":[37],"a":[38,175,190,199],"transient":[39,71],"hyperpolarization":[40,50],"sustained":[42],"relaxation":[43,52,204],"tissues":[45],"precontracted":[46],"with":[47,76,123],"noradrenaline.":[48],"Both":[49],"absent":[54],"preparations":[56],"without":[57],"endothelium.":[58],"3.":[59],"Haemoglobin":[60],"inhibited":[64],"ACh-induced":[66,133],"relaxation,":[67],"but":[68],"not":[69],"hyperpolarization.":[72],"4.":[73],"In":[74,121],"an":[77,82,124,169],"intact":[78,125],"endothelium,":[79,126],"produced":[81],"increase":[83,115,141],"both":[85],"rate":[87],"86Rb":[89,143],"efflux":[90,144],"tissue":[92,146],"cyclic":[93,117,147],"GMP":[94,118,148],"levels.":[95,149],"changes":[97],"ion":[99],"flux":[100],"unaffected":[102],"by":[103],"either":[104],"or":[106,138],"concentrations":[110],"which":[111],"almost":[112],"abolished":[113],"concentrations.":[119],"5.":[120],"arteries":[122],"indomethacin":[127],"had":[128],"no":[129],"effect":[130],"6.":[150],"It":[151],"is":[152],"concluded":[153],"that":[154],"artery,":[163],"releases":[165],"two":[166],"different":[167],"substances,":[168],"endothelium-derived":[170],"relaxing":[171],"factor":[172,177],"(EDRF)":[173],"hyperpolarizing":[176],"(EDHF),":[178],"from":[179,189],"endothelial":[181],"cells.":[182],"Neither":[183],"substance":[184],"appears":[185],"to":[186,197],"be":[187],"derived":[188],"pathway":[191],"dependent":[192],"cyclo-oxygenase.":[194],"EDHF":[195],"seems":[196],"play":[198],"minor":[200],"role":[201],"noradrenaline-induced":[206],"contractions.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":16}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}