{"id":"https://openalex.org/W2012177407","doi":"https://doi.org/10.1159/000175646","title":"Long-Term Effects of Starvation-Refeeding in the Rat","display_name":"Long-Term Effects of Starvation-Refeeding in the Rat","publication_year":1975,"publication_date":"1975-01-01","ids":{"openalex":"https://openalex.org/W2012177407","doi":"https://doi.org/10.1159/000175646","mag":"2012177407","pmid":"https://pubmed.ncbi.nlm.nih.gov/1226270"},"language":"en","primary_location":{"id":"doi:10.1159/000175646","doi":"https://doi.org/10.1159/000175646","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000175646","pdf_url":null,"source":{"id":"https://openalex.org/S153227239","display_name":"Annals of Nutrition and Metabolism","issn_l":"0250-6807","issn":["0250-6807","1421-9697"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Nutrition and Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049430098","display_name":"Bela Szepesi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Szepesi","raw_affiliation_strings":["Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065944093","display_name":"R. Vegors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. Vegors","raw_affiliation_strings":["Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028835059","display_name":"O. E. Michaelis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1312222531","display_name":"Agricultural Research Service","ror":"https://ror.org/02d2m2044","country_code":"US","type":"government","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I1336096307","display_name":"United States Department of Agriculture","ror":"https://ror.org/01na82s61","country_code":"US","type":"government","lineage":["https://openalex.org/I1336096307"]},{"id":"https://openalex.org/I4210125976","display_name":"Beltsville Agricultural Research Center","ror":"https://ror.org/03b08sh51","country_code":"US","type":"facility","lineage":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976","https://openalex.org/I4210138094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O.E. Michaelis IV","raw_affiliation_strings":["Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nutrition Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Md","institution_ids":["https://openalex.org/I1312222531","https://openalex.org/I1336096307","https://openalex.org/I4210125976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023089311","display_name":"J. M. Demouy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.M. DeMouy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2303,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.87038328,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"19","issue":"1-2","first_page":"45","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.8080999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.09839999675750732,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.03799999877810478,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/starvation-refeeding","display_name":"starvation-refeeding","score":0.9459999799728394},{"id":"https://openalex.org/keywords/fasting","display_name":"fasting","score":0.36500000953674316},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.7089999914169312},{"id":"https://openalex.org/keywords/body-fat","display_name":"fat mass","score":0.9200000166893005},{"id":"https://openalex.org/keywords/isocitrate-dehydrogenase","display_name":"isocitrate dehydrogenase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase","display_name":"glucose-6-phosphate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/6-phosphogluconate-dehydrogenase","display_name":"6-phosphogluconate dehydrogenase","score":1.0},{"id":"https://openalex.org/keywords/malic-enzyme","display_name":"malic enzyme","score":0.9890000224113464},{"id":"https://openalex.org/keywords/liver-enzyme-activity","display_name":"hepatic enzyme activity","score":0.5239999890327454},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.7390000224113464},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.9199754595756531},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.8163424730300903},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7122964859008789},{"id":"https://openalex.org/C2778957662","wikidata":"https://www.wikidata.org/wiki/Q6743424","display_name":"Malic enzyme","level":4,"score":0.6721184253692627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6596278548240662},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.6349731087684631},{"id":"https://openalex.org/C2780606744","wikidata":"https://www.wikidata.org/wiki/Q853930","display_name":"Starvation","level":2,"score":0.5835698246955872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5630635619163513},{"id":"https://openalex.org/C2780196906","wikidata":"https://www.wikidata.org/wiki/Q421793","display_name":"Glucose-6-phosphate dehydrogenase","level":4,"score":0.49072039127349854},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.44922322034835815},{"id":"https://openalex.org/C2781101655","wikidata":"https://www.wikidata.org/wiki/Q1812693","display_name":"Refeeding syndrome","level":3,"score":0.4283071756362915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34646767377853394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17454585433006287},{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.06418213248252869}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007521","descriptor_name":"Isocitrate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008291","descriptor_name":"Malate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010734","descriptor_name":"Phosphogluconate Dehydrogenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013217","descriptor_name":"Starvation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013217","descriptor_name":"Starvation","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000175646","doi":"https://doi.org/10.1159/000175646","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000175646","pdf_url":null,"source":{"id":"https://openalex.org/S153227239","display_name":"Annals of Nutrition and Metabolism","issn_l":"0250-6807","issn":["0250-6807","1421-9697"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Nutrition and Metabolism","raw_type":"journal-article"},{"id":"pmid:1226270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1226270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrition and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1494481260","https://openalex.org/W1927935849","https://openalex.org/W2052348574","https://openalex.org/W2056841194","https://openalex.org/W2069284483","https://openalex.org/W2077440677","https://openalex.org/W2146126743","https://openalex.org/W2169617630","https://openalex.org/W2279136020","https://openalex.org/W2324955444","https://openalex.org/W2326720869","https://openalex.org/W2336888804","https://openalex.org/W3008945731"],"related_works":["https://openalex.org/W1870754491","https://openalex.org/W1581265880","https://openalex.org/W2086236216","https://openalex.org/W1547543216","https://openalex.org/W1592925288","https://openalex.org/W2076475573","https://openalex.org/W2314403996","https://openalex.org/W2021880131","https://openalex.org/W2414440799","https://openalex.org/W2324955444"],"abstract_inverted_index":{"The":[0,39,58],"effects":[1],"of":[2,7,18,25,51,60,98,105,110],"one":[3],"vs.":[4],"two":[5,23],"episodes":[6,24],"starvation-refeeding":[8],"were":[9,92,140],"studied":[10],"in":[11,41,54,137],"young":[12],"male":[13],"rats":[14,28],"as":[15],"a":[16],"function":[17],"elapsed":[19],"time":[20],"between":[21],"the":[22,48,55],"starvation-refeeding.":[26],"Starved-refed":[27],"ate":[29],"more":[30],"and":[31,84,101,126,132],"gained":[32],"weight":[33,42],"faster":[34],"than":[35],"ad":[36],"libitum-fed":[37],"rats.":[38,57],"difference":[40,119],"gains":[43],"could":[44],"be":[45],"attributed":[46],"to":[47],"greater":[49,115],"amount":[50],"body":[52],"fat":[53],"starved-refed":[56],"responses":[59],"four":[61],"NADP-linked":[62],"liver":[63],"dehydrogenases:isocitrate":[64],"dehydrogenase":[65,72,78],"(ICD)/LS-isocitrate:NADP":[66],"oxidoreductase":[67,74,80,88],"(decarboxylating)":[68,81,89],"(EC":[69,75,82,90],"1.1.1.42),":[70],"glucose-6-phosphate":[71],"(G6PD)/D-glucose-6-phosphate:NADP":[73],"1.1.1.49);":[76],"6-phosphogluconate":[77],"(6PGD/6-phospho-D-gluconate:NADP":[79],"1.1.1.44);":[83],"malic":[85],"enzyme":[86,116],"(ME)/L-malate:NADP":[87],"1.1.1.40)":[91],"studied.":[93],"Starvation-refeeding":[94],"caused":[95,112],"an":[96,113],"overshoot":[97],"G6PD,":[99],"6PGD,":[100],"ME,":[102],"but":[103],"not":[104],"ICD.":[106],"A":[107],"second":[108],"episode":[109],"starvation":[111],"even":[114],"overshoot;":[117],"this":[118],"persisted":[120],"for":[121,127],"3":[122],"weeks":[123,129],"with":[124,130],"G6PD":[125],"2":[128],"6PGD":[131],"ME.":[133],"No":[134],"significant":[135],"differences":[136],"blood":[138],"cholesterol":[139],"detected.":[141]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}