{"id":"https://openalex.org/W2012174476","doi":"https://doi.org/10.1371/journal.pone.0112900","title":"Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture","display_name":"Reprogramming Suppresses Premature Senescence Phenotypes of Werner Syndrome Cells and Maintains Chromosomal Stability over Long-Term Culture","publication_year":2014,"publication_date":"2014-11-12","ids":{"openalex":"https://openalex.org/W2012174476","doi":"https://doi.org/10.1371/journal.pone.0112900","mag":"2012174476","pmid":"https://pubmed.ncbi.nlm.nih.gov/25390333","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4229309"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0112900","doi":"https://doi.org/10.1371/journal.pone.0112900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112900&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048873795","display_name":"Akira Shimamoto","orcid":"https://orcid.org/0000-0002-4697-4770","observed_orcids":["https://orcid.org/0000-0002-4697-4770"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Akira Shimamoto","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082533654","display_name":"Harunobu Kagawa","orcid":"https://orcid.org/0000-0003-0436-3805","observed_orcids":["https://orcid.org/0000-0003-0436-3805"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Harunobu Kagawa","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077919250","display_name":"Zensho Kazumasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Zensho","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055556928","display_name":"Yukihiro Sera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yukihiro Sera","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004986891","display_name":"Yasuhiro Kazuki","orcid":"https://orcid.org/0000-0003-4818-4710","observed_orcids":["https://orcid.org/0000-0003-4818-4710"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhiro Kazuki","raw_affiliation_strings":["Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033310099","display_name":"Mitsuhiko Osaki","orcid":"https://orcid.org/0009-0002-5202-1543","observed_orcids":["https://orcid.org/0009-0002-5202-1543"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuhiko Osaki","raw_affiliation_strings":["Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan; Division of Pathological Biochemistry, Faculty of Medicine, Tottori University, Yonago, Japan","Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan","Division of Pathological Biochemistry, Faculty of Medicine, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan; Division of Pathological Biochemistry, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Pathological Biochemistry, Faculty of Medicine, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108409966","display_name":"Mitsuo Oshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Oshimura","raw_affiliation_strings":["Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Yonago, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056449434","display_name":"Yasuhito Ishigaki","orcid":"https://orcid.org/0000-0003-1012-8430","observed_orcids":["https://orcid.org/0000-0003-1012-8430"]},"institutions":[{"id":"https://openalex.org/I16568816","display_name":"Kanazawa Medical University","ror":"https://ror.org/0535cbe18","country_code":"JP","type":"education","lineage":["https://openalex.org/I16568816"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuhito Ishigaki","raw_affiliation_strings":["Medical Research Institute, Kanazawa Medical University, Kahoku, Ishikawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Institute, Kanazawa Medical University, Kahoku, Ishikawa, Japan","institution_ids":["https://openalex.org/I16568816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103092222","display_name":"K. Hamasaki","orcid":"https://orcid.org/0000-0002-1876-0425","observed_orcids":["https://orcid.org/0000-0002-1876-0425"]},"institutions":[{"id":"https://openalex.org/I21578748","display_name":"Radiation Effects Research Foundation","ror":"https://ror.org/01fmtas32","country_code":"JP","type":"facility","lineage":["https://openalex.org/I21578748"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanya Hamasaki","raw_affiliation_strings":["Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan","institution_ids":["https://openalex.org/I21578748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110205671","display_name":"Yoshiaki Kodama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21578748","display_name":"Radiation Effects Research Foundation","ror":"https://ror.org/01fmtas32","country_code":"JP","type":"facility","lineage":["https://openalex.org/I21578748"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki Kodama","raw_affiliation_strings":["Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan","institution_ids":["https://openalex.org/I21578748"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020837304","display_name":"Shinsuke Yuasa","orcid":"https://orcid.org/0000-0001-5593-7552","observed_orcids":["https://orcid.org/0000-0001-5593-7552"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinsuke Yuasa","raw_affiliation_strings":["Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069453818","display_name":"Keiichi Fukuda","orcid":"https://orcid.org/0000-0003-1413-0482","observed_orcids":["https://orcid.org/0000-0003-1413-0482"]},"institutions":[{"id":"https://openalex.org/I203951103","display_name":"Keio University","ror":"https://ror.org/02kn6nx58","country_code":"JP","type":"education","lineage":["https://openalex.org/I203951103"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keiichi Fukuda","raw_affiliation_strings":["Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Keio University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I203951103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060015514","display_name":"Kyotaro Hirashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyotaro Hirashima","raw_affiliation_strings":["Division of Molecular Biotherapy, The Cancer Chemotherapy Center, Japanese Foundation For Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biotherapy, The Cancer Chemotherapy Center, Japanese Foundation For Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053099287","display_name":"Hiroyuki Seimiya","orcid":"https://orcid.org/0000-0003-3314-9736","observed_orcids":["https://orcid.org/0000-0003-3314-9736"]},"institutions":[{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Seimiya","raw_affiliation_strings":["Division of Molecular Biotherapy, The Cancer Chemotherapy Center, Japanese Foundation For Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular Biotherapy, The Cancer Chemotherapy Center, Japanese Foundation For Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086004105","display_name":"Hirofumi Koyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirofumi Koyama","raw_affiliation_strings":["Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052789879","display_name":"Takahiko Shimizu","orcid":"https://orcid.org/0000-0002-3351-3342","observed_orcids":["https://orcid.org/0000-0002-3351-3342"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Shimizu","raw_affiliation_strings":["Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Advanced Aging Medicine, Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047898749","display_name":"Minoru Takemoto","orcid":"https://orcid.org/0000-0002-9599-2465","observed_orcids":["https://orcid.org/0000-0002-9599-2465"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Minoru Takemoto","raw_affiliation_strings":["Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079640536","display_name":"Koutaro Yokote","orcid":"https://orcid.org/0000-0003-3033-4813","observed_orcids":["https://orcid.org/0000-0003-3033-4813"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koutaro Yokote","raw_affiliation_strings":["Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091648023","display_name":"Makoto Goto","orcid":"https://orcid.org/0000-0002-9473-7673","observed_orcids":["https://orcid.org/0000-0002-9473-7673"]},"institutions":[{"id":"https://openalex.org/I4210136522","display_name":"Tokyo Women's Medical University","ror":"https://ror.org/03kjjhe36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4210136522"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Goto","raw_affiliation_strings":["Division of Orthopedic Surgery & Rheumatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Orthopedic Surgery & Rheumatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan","institution_ids":["https://openalex.org/I4210136522"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076672133","display_name":"Hidetoshi Tahara","orcid":"https://orcid.org/0000-0003-3054-4175","observed_orcids":["https://orcid.org/0000-0003-3054-4175"]},"institutions":[{"id":"https://openalex.org/I113306721","display_name":"Hiroshima University","ror":"https://ror.org/03t78wx29","country_code":"JP","type":"education","lineage":["https://openalex.org/I113306721"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hidetoshi Tahara","raw_affiliation_strings":["Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Biology, Graduate School of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan","institution_ids":["https://openalex.org/I113306721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5048873795","https://openalex.org/A5076672133"],"corresponding_institution_ids":["https://openalex.org/I113306721"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":3.1312,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.92089651,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"11","first_page":"e112900","last_page":"e112900"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.6685000061988831,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.3296000063419342,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/werner-syndrome","display_name":"Werner syndrome","score":1.0},{"id":"https://openalex.org/keywords/wrn-gene","display_name":"WRN gene","score":0.652999997138977},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cells","display_name":"induced pluripotent stem cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.8399999737739563},{"id":"https://openalex.org/keywords/premature-senescence","display_name":"premature senescence","score":0.9620000123977661},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9300000071525574},{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/telomerase-reactivation","display_name":"telomerase reactivation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chromosomal-stability","display_name":"chromosome stability","score":0.7979999780654907},{"id":"https://openalex.org/keywords/karyotype-stability","display_name":"karyotype stability","score":0.8489999771118164},{"id":"https://openalex.org/keywords/long-term-culture","display_name":"long-term culture","score":0.7820000052452087},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.5709999799728394},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.8497974276542664},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.8276735544204712},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7420580387115479},{"id":"https://openalex.org/C140752955","wikidata":"https://www.wikidata.org/wiki/Q1087752","display_name":"Chromosome instability","level":4,"score":0.729320228099823},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.697799563407898},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6725316643714905},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6428492665290833},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.596840500831604},{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.5860018730163574},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.536361038684845},{"id":"https://openalex.org/C2778090637","wikidata":"https://www.wikidata.org/wiki/Q1154619","display_name":"Werner syndrome","level":5,"score":0.5256915092468262},{"id":"https://openalex.org/C2778465436","wikidata":"https://www.wikidata.org/wiki/Q213098","display_name":"Progeria","level":3,"score":0.4530456066131592},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.445202112197876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44270968437194824},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43302029371261597},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3813932538032532},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.26188063621520996},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23749664425849915},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.23634320497512817},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.20286357402801514},{"id":"https://openalex.org/C161223559","wikidata":"https://www.wikidata.org/wiki/Q138864","display_name":"Helicase","level":4,"score":0.06974658370018005},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014898","descriptor_name":"Werner Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014898","descriptor_name":"Werner Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019588","descriptor_name":"Aging, Premature","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D065150","descriptor_name":"Cellular Reprogramming","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0112900","doi":"https://doi.org/10.1371/journal.pone.0112900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3203414","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4229309","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25390333","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25390333","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4229309","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4229309/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:022f8c96cdef46b1aa9ece260e7121c0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/022f8c96cdef46b1aa9ece260e7121c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 11, p e112900 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1238635","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Reprogramming_Suppresses_Premature_Senescence_Phenotypes_of_Werner_Syndrome_Cells_and_Maintains_Chromosomal_Stability_over_Long_Term_Culture_/1238635","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0112900","doi":"https://doi.org/10.1371/journal.pone.0112900","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0112900","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0112900&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1716382762","display_name":"Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas","funder_award_id":"221S0001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2376917815","display_name":"Establishment of system for direct detection of exosome","funder_award_id":"26640091","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3146874128","display_name":"Characterization of inflammageing in progeroid \"Werner syndrome\"","funder_award_id":"24590902","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5003213055","display_name":"Gene correction in iPS cells of premature aging syndrome toward clinical application by genome editing","funder_award_id":"25670030","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5443430199","display_name":"Application of cancer therapy of senescence-associated microRNA","funder_award_id":"26290047","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5591416402","display_name":"Aging research using telomere age","funder_award_id":"26310106","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G728005759","display_name":"Risk assessment of cancer using telomere G-tail length measurement","funder_award_id":"20014015","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320310076","display_name":"National Center for Child Health and Development","ror":"https://ror.org/03fvwxc59"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320324144","display_name":"National Institute of Biomedical Innovation","ror":"https://ror.org/001rkbe13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012174476.pdf","grobid_xml":"https://content.openalex.org/works/W2012174476.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1487697828","https://openalex.org/W1966265116","https://openalex.org/W1966584160","https://openalex.org/W1973300568","https://openalex.org/W1981169569","https://openalex.org/W1984653142","https://openalex.org/W1993922963","https://openalex.org/W1994736930","https://openalex.org/W2001884031","https://openalex.org/W2002180347","https://openalex.org/W2006322108","https://openalex.org/W2010345740","https://openalex.org/W2012918968","https://openalex.org/W2013798852","https://openalex.org/W2022534144","https://openalex.org/W2030056309","https://openalex.org/W2045081995","https://openalex.org/W2049358079","https://openalex.org/W2050160133","https://openalex.org/W2059383180","https://openalex.org/W2064310741","https://openalex.org/W2068592712","https://openalex.org/W2081455569","https://openalex.org/W2083140157","https://openalex.org/W2087594051","https://openalex.org/W2090525461","https://openalex.org/W2094556673","https://openalex.org/W2095000492","https://openalex.org/W2095417588","https://openalex.org/W2095919671","https://openalex.org/W2124472585","https://openalex.org/W2125987139","https://openalex.org/W2135086442","https://openalex.org/W2136731336","https://openalex.org/W2138809668","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2143229579","https://openalex.org/W2146889272","https://openalex.org/W2155437022","https://openalex.org/W2155835896","https://openalex.org/W2161080185","https://openalex.org/W2168934407","https://openalex.org/W2405236315"],"related_works":["https://openalex.org/W2105389571","https://openalex.org/W2886597185","https://openalex.org/W2965371888","https://openalex.org/W2763115744","https://openalex.org/W2138809668","https://openalex.org/W3087314895","https://openalex.org/W2885116520","https://openalex.org/W1993922963","https://openalex.org/W2890749589","https://openalex.org/W4303685877"],"abstract_inverted_index":{"Werner":[0],"syndrome":[1],"(WS)":[2],"is":[3],"a":[4,212],"premature":[5,89,180],"aging":[6],"disorder":[7],"characterized":[8],"by":[9,148],"chromosomal":[10,132,192],"instability":[11],"and":[12,23,66,85,88,125,168,186,209],"cancer":[13],"predisposition.":[14],"Mutations":[15],"in":[16,28,94,100,171,183,207],"WRN":[17,104],"are":[18],"responsible":[19],"for":[20,71,215],"the":[21,51,56,112,128,195,216],"disease":[22],"cause":[24],"telomere":[25,169],"dysfunction,":[26],"resulting":[27],"accelerated":[29],"aging.":[30],"Recent":[31],"studies":[32],"have":[33],"revealed":[34],"that":[35,120,134,177],"cells":[36,48,96,185],"from":[37],"WS":[38,62,79,95,101,106,121,172,184,187,198,208],"patients":[39],"can":[40],"be":[41,146],"successfully":[42],"reprogrammed":[43],"into":[44],"induced":[45,149],"pluripotent":[46],"stem":[47],"(iPSCs).":[49],"In":[50],"present":[52],"study,":[53],"we":[54],"describe":[55],"effects":[57],"of":[58,91,111,127,139,151,164,218],"long-term":[59,77],"culture":[60],"on":[61],"iPSCs,":[63],"which":[64,157],"acquired":[65],"maintained":[67],"infinite":[68],"proliferative":[69],"potential":[70],"self-renewal":[72],"over":[73,194],"2":[74],"years.":[75],"After":[76],"cultures,":[78],"iPSCs":[80,102,107,122,188,199],"exhibited":[81],"stable":[82],"undifferentiated":[83],"states":[84],"differentiation":[86],"capacity,":[87],"upregulation":[90],"senescence-associated":[92],"genes":[93],"was":[97],"completely":[98],"suppressed":[99,179],"despite":[103],"deficiency.":[105],"also":[108],"showed":[109],"recapitulation":[110],"phenotypes":[113,182],"during":[114,155],"differentiation.":[115],"Furthermore,":[116],"karyotype":[117],"analysis":[118],"indicated":[119],"were":[123,135],"stable,":[124],"half":[126],"descendant":[129],"clones":[130],"had":[131],"profiles":[133],"similar":[136],"to":[137,162,191,203,210],"those":[138],"parental":[140],"cells.":[141,173],"These":[142,174],"unexpected":[143],"properties":[144],"might":[145],"achieved":[147],"expression":[150],"endogenous":[152],"telomerase":[153,159],"gene":[154],"reprogramming,":[156],"trigger":[158],"reactivation":[160],"leading":[161],"suppression":[163],"both":[165],"replicative":[166],"senescence":[167,181],"dysfunction":[170],"findings":[175],"demonstrated":[176],"reprogramming":[178],"could":[189],"lead":[190],"stability":[193],"long":[196],"term.":[197],"will":[200],"provide":[201],"opportunities":[202],"identify":[204],"affected":[205],"lineages":[206],"develop":[211],"new":[213],"strategy":[214],"treatment":[217],"WS.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
