{"id":"https://openalex.org/W2012173368","doi":"https://doi.org/10.1089/neu.2012.2782","title":"Donepezil Is Ineffective in Promoting Motor and Cognitive Benefits after Controlled Cortical Impact Injury in Male Rats","display_name":"Donepezil Is Ineffective in Promoting Motor and Cognitive Benefits after Controlled Cortical Impact Injury in Male Rats","publication_year":2012,"publication_date":"2012-12-10","ids":{"openalex":"https://openalex.org/W2012173368","doi":"https://doi.org/10.1089/neu.2012.2782","mag":"2012173368","pmid":"https://pubmed.ncbi.nlm.nih.gov/23227953","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636588"},"language":"en","primary_location":{"id":"doi:10.1089/neu.2012.2782","doi":"https://doi.org/10.1089/neu.2012.2782","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2012.2782","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3636588","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014001228","display_name":"Kaitlyn E. Shaw","orcid":"https://orcid.org/0009-0005-6692-4091","observed_orcids":["https://orcid.org/0009-0005-6692-4091"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn E. Shaw","raw_affiliation_strings":["Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091244574","display_name":"Corina O. Bondi","orcid":"https://orcid.org/0000-0002-5733-4912","observed_orcids":["https://orcid.org/0000-0002-5733-4912"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corina O. Bondi","raw_affiliation_strings":["Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennslyvania","Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039646991","display_name":"Samuel H. Light","orcid":"https://orcid.org/0000-0002-8074-1348","observed_orcids":["https://orcid.org/0000-0002-8074-1348"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel H. Light","raw_affiliation_strings":["Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086010304","display_name":"Lire A. Massimino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lire A. Massimino","raw_affiliation_strings":["Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013603390","display_name":"Rose L. McAloon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rose L. McAloon","raw_affiliation_strings":["Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074128127","display_name":"Christina M. Monaco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina M. Monaco","raw_affiliation_strings":["Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055486451","display_name":"Anthony E. Kline","orcid":"https://orcid.org/0000-0002-7218-3454","observed_orcids":["https://orcid.org/0000-0002-7218-3454"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210086114","display_name":"Center for the Neural Basis of Cognition","ror":"https://ror.org/00jfeg660","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210086114","https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anthony E. Kline","raw_affiliation_strings":["Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennslyvania","Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennslyvania","Department of Psychology, University of Pittsburgh, Pittsburgh, Pennslyvania","Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennslyvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210086114"]},{"raw_affiliation_string":"Department of Psychology, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennslyvania","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5055486451"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210086114"],"apc_list":null,"apc_paid":null,"fwci":1.1813,"has_fulltext":false,"cited_by_count":75,"citation_normalized_percentile":{"value":0.77250347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"30","issue":"7","first_page":"557","last_page":"564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.8187999725341797,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.17739999294281006,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":1.0},{"id":"https://openalex.org/keywords/acetylcholinesterase-inhibitors","display_name":"acetylcholinesterase inhibitors","score":0.9760000109672546},{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.9739999771118164},{"id":"https://openalex.org/keywords/controlled-cortical-impact","display_name":"controlled cortical impact","score":0.906000018119812},{"id":"https://openalex.org/keywords/motor-recovery","display_name":"motor recovery","score":0.6990000009536743},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.8090000152587891},{"id":"https://openalex.org/keywords/beam-balance","display_name":"beam balance","score":0.7200000286102295},{"id":"https://openalex.org/keywords/morris-water-maze","display_name":"Morris water maze","score":0.8859999775886536},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6690000295639038},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.9548312425613403},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.6909722089767456},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.6500006914138794},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6287896633148193},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.6167881488800049},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5543187260627747},{"id":"https://openalex.org/C131783052","wikidata":"https://www.wikidata.org/wiki/Q7333746","display_name":"Righting reflex","level":3,"score":0.5270942449569702},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.46192166209220886},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.45713552832603455},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4236324429512024},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.37172889709472656},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.32450419664382935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28392016887664795},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.26887619495391846},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.26568394899368286},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1712934970855713},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.10122552514076233},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001930","descriptor_name":"Brain Injuries","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D002800","descriptor_name":"Cholinesterase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/neu.2012.2782","doi":"https://doi.org/10.1089/neu.2012.2782","is_oa":false,"landing_page_url":"https://doi.org/10.1089/neu.2012.2782","pdf_url":null,"source":{"id":"https://openalex.org/S85864898","display_name":"Journal of Neurotrauma","issn_l":"0897-7151","issn":["0897-7151","1557-9042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurotrauma","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2949427","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3636588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3636588","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3636588","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurotrauma","raw_type":"Text"},{"id":"pmid:23227953","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23227953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurotrauma","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2949427","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3636588","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G532568550","display_name":"Environmental Enrichment and Cholinergic Mechanisms after TBI","funder_award_id":"R01NS060005","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5912778632","display_name":null,"funder_award_id":"HD069620","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7251040674","display_name":null,"funder_award_id":"NS060005","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7584811201","display_name":"Understanding the Impact of Antipsychotic Drugs on Recovery After TBI","funder_award_id":"R01HD069620","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W133656256","https://openalex.org/W180469417","https://openalex.org/W1511602449","https://openalex.org/W1583163021","https://openalex.org/W1964328737","https://openalex.org/W1967045853","https://openalex.org/W1968886560","https://openalex.org/W1972911528","https://openalex.org/W1973056192","https://openalex.org/W1976292748","https://openalex.org/W1979096671","https://openalex.org/W1981665280","https://openalex.org/W1984433537","https://openalex.org/W1985390891","https://openalex.org/W1991920192","https://openalex.org/W1993985283","https://openalex.org/W1999613916","https://openalex.org/W1999839898","https://openalex.org/W2003736780","https://openalex.org/W2004770795","https://openalex.org/W2008025002","https://openalex.org/W2008047192","https://openalex.org/W2010033950","https://openalex.org/W2016014863","https://openalex.org/W2017443170","https://openalex.org/W2017688638","https://openalex.org/W2018978473","https://openalex.org/W2023313786","https://openalex.org/W2030155410","https://openalex.org/W2031576658","https://openalex.org/W2034849152","https://openalex.org/W2036590087","https://openalex.org/W2044443383","https://openalex.org/W2044533734","https://openalex.org/W2046840006","https://openalex.org/W2050990096","https://openalex.org/W2056194749","https://openalex.org/W2060026001","https://openalex.org/W2061610504","https://openalex.org/W2064036287","https://openalex.org/W2065294305","https://openalex.org/W2070526131","https://openalex.org/W2077624784","https://openalex.org/W2079160346","https://openalex.org/W2081483183","https://openalex.org/W2089736801","https://openalex.org/W2089770491","https://openalex.org/W2089939044","https://openalex.org/W2090437944","https://openalex.org/W2092166572","https://openalex.org/W2092281175","https://openalex.org/W2100265206","https://openalex.org/W2104346865","https://openalex.org/W2106499273","https://openalex.org/W2107307178","https://openalex.org/W2119400520","https://openalex.org/W2119836736","https://openalex.org/W2120174717","https://openalex.org/W2125325229","https://openalex.org/W2131115138","https://openalex.org/W2136942291","https://openalex.org/W2145541602","https://openalex.org/W2146031912","https://openalex.org/W2154905383","https://openalex.org/W2158024903","https://openalex.org/W2164145341","https://openalex.org/W2169473035","https://openalex.org/W2299522025","https://openalex.org/W2353300853","https://openalex.org/W2404971042","https://openalex.org/W2736091234"],"related_works":["https://openalex.org/W2044533734","https://openalex.org/W2351020572","https://openalex.org/W2802080232","https://openalex.org/W2785467876","https://openalex.org/W324583972","https://openalex.org/W2021157766","https://openalex.org/W2106757561","https://openalex.org/W2146031912","https://openalex.org/W2008025002","https://openalex.org/W4400291853"],"abstract_inverted_index":{"The":[0],"acetylcholinesterase":[1],"(AChE)":[2],"inhibitor":[3],"donepezil":[4,39,71,217,257],"is":[5,44,258,275,284],"used":[6],"as":[7,17],"a":[8,18,45,87],"therapy":[9],"for":[10,20,40,139],"Alzheimer's":[11],"disease":[12],"and":[13,23,102,110,122,133,149,158,177,240,243],"has":[14],"been":[15],"recommended":[16],"treatment":[19],"enhancing":[21,41],"attention":[22],"memory":[24],"after":[25,79,131,266,295],"traumatic":[26],"brain":[27],"injury":[28,209],"(TBI).":[29],"Although":[30],"select":[31],"clinical":[32],"case":[33],"studies":[34,50],"support":[35],"the":[36,52,59,167,179,190,205,213,228,273,279],"use":[37],"of":[38,47,55,61,70,175,208,212,216,256],"cognition,":[42],"there":[43],"paucity":[46],"experimental":[48],"TBI":[49,109,191],"assessing":[51],"potential":[53],"efficacy":[54],"this":[56,62],"pharmacotherapy.":[57],"Hence,":[58],"aim":[60],"pre-clinical":[63],"study":[64],"was":[65,143],"to":[66,72,107,224,278,286],"evaluate":[67],"several":[68],"doses":[69,215,231],"determine":[73,287],"its":[74],"effect":[75],"on":[76,155,272],"functional":[77,264],"outcome":[78],"TBI.":[80,296],"Ninety":[81],"anesthetized":[82],"adult":[83],"male":[84],"rats":[85],"received":[86,204],"controlled":[88],"cortical":[89,94],"impact":[90],"(CCI;":[91],"2.8":[92],"mm":[93],"depth":[95],"at":[96],"4":[97],"m/sec)":[98],"or":[99,119,220],"sham":[100,112,168],"injury,":[101,269],"then":[103],"were":[104,134,164,181,187],"randomly":[105],"assigned":[106],"six":[108,111],"groups":[113,170,192,203],"(donepezil":[114],"0.25,":[115],"0.5,":[116],"1.0,":[117],"2.0,":[118],"3.0":[120,241],"mg/kg,":[121],"saline":[123],"vehicle":[124],"1.0":[125],"mL/kg).":[126],"Treatments":[127],"began":[128],"24":[129],"h":[130],"surgery":[132],"administered":[135],"i.p.":[136],"once":[137],"daily":[138],"19":[140],"days.":[141],"Function":[142],"assessed":[144],"by":[145],"motor":[146,219],"(beam":[147],"balance/walk)":[148],"cognitive":[150,221,244],"(Morris":[151],"water":[152],"maze)":[153],"tests":[154],"days":[156],"1-5":[157],"14-19,":[159],"respectively.":[160],"No":[161],"significant":[162,185],"differences":[163,186],"observed":[165],"among":[166,189],"control":[169],"in":[171,193,262],"any":[172],"evaluation,":[173],"regardless":[174],"dose,":[176],"therefore":[178],"data":[180,251],"pooled.":[182],"Furthermore,":[183],"no":[184],"revealed":[188],"acute":[194],"neurological":[195],"assessments":[196],"(e.g.,":[197],"righting":[198],"reflex),":[199],"suggesting":[200],"that":[201,253],"all":[202],"same":[206],"level":[207],"severity.":[210],"None":[211],"five":[214],"improved":[218],"function":[222],"relative":[223],"vehicle-treated":[225],"controls.":[226],"Moreover,":[227],"two":[229],"highest":[230],"significantly":[232],"impaired":[233],"beam-balance":[234],"(3.0":[235,246],"mg/kg),":[236,242],"beam-walk":[237],"(2.0":[238],"mg/kg":[239],"performance":[245],"mg/kg)":[247],"versus":[248],"vehicle.":[249],"These":[250],"indicate":[252],"chronic":[254],"administration":[255],"not":[259],"only":[260],"ineffective":[261],"promoting":[263],"improvement":[265],"moderate":[267],"CCI":[268],"but":[270],"depending":[271],"dose":[274],"actually":[276],"detrimental":[277],"recovery":[280],"process.":[281],"Further":[282],"work":[283],"necessary":[285],"if":[288],"other":[289],"AChE":[290],"inhibitors":[291],"exert":[292],"similar":[293],"effects":[294]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":40},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}