{"id":"https://openalex.org/W2012172816","doi":"https://doi.org/10.1002/eji.200838987","title":"Semi\u2010mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen\u2010induced arthritis mice","display_name":"Semi\u2010mature DC are immunogenic and not tolerogenic when inoculated at a high dose in collagen\u2010induced arthritis mice","publication_year":2009,"publication_date":"2009-04-06","ids":{"openalex":"https://openalex.org/W2012172816","doi":"https://doi.org/10.1002/eji.200838987","mag":"2012172816","pmid":"https://pubmed.ncbi.nlm.nih.gov/19350558"},"language":"en","primary_location":{"id":"doi:10.1002/eji.200838987","doi":"https://doi.org/10.1002/eji.200838987","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.200838987","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077285430","display_name":"Dae\u2010Seog Lim","orcid":"https://orcid.org/0000-0002-0637-4682","observed_orcids":["https://orcid.org/0000-0002-0637-4682"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dae\u2010Seog Lim","raw_affiliation_strings":["Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034654748","display_name":"Mi\u2010Sun Kang","orcid":"https://orcid.org/0000-0001-8078-4666","observed_orcids":["https://orcid.org/0000-0001-8078-4666"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mi\u2010Sun Kang","raw_affiliation_strings":["Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034981531","display_name":"Ju\u2010Ah Jeong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ju\u2010Ah Jeong","raw_affiliation_strings":["Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031820564","display_name":"Yong\u2010Soo Bae","orcid":"https://orcid.org/0000-0002-2233-9449","observed_orcids":["https://orcid.org/0000-0002-2233-9449"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yong\u2010Soo Bae","raw_affiliation_strings":["Department of Biological Science, Sungkyunkwan University, Cheoncheon-dong, Suwon, Gyeonggi-do, Korea","Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Science, Sungkyunkwan University, Cheoncheon-dong, Suwon, Gyeonggi-do, Korea","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Research Institute for DC Immunotherapy, CreaGene Inc., 2F Jungang Induspia V, Sangdaewon-dong, Jungwon-gu, Seongnam-si, Gyeonggi-do, Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031820564"],"corresponding_institution_ids":["https://openalex.org/I848706"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":2.0671,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.86425466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"39","issue":"5","first_page":"1334","last_page":"1343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.1324000060558319,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/collagen-induced-arthritis","display_name":"collagen-induced arthritis","score":0.7770000100135803},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tolerogenicity","display_name":"tolerogenicity","score":0.8579999804496765},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6790000200271606},{"id":"https://openalex.org/keywords/treg-induction","display_name":"Treg induction","score":0.6000000238418579},{"id":"https://openalex.org/keywords/th2-cytokines","display_name":"Th2 cytokines","score":0.7789999842643738},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7599999904632568},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.6499999761581421},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9860000014305115},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.4860000014305115}],"concepts":[{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.74156653881073},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.6541457772254944},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6515800356864929},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5434359312057495},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5026111602783203},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.48990434408187866},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4855487048625946},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4750497341156006},{"id":"https://openalex.org/C2778844214","wikidata":"https://www.wikidata.org/wiki/Q24963555","display_name":"Collagen-induced arthritis","level":3,"score":0.45483559370040894},{"id":"https://openalex.org/C180032290","wikidata":"https://www.wikidata.org/wiki/Q1664296","display_name":"Inoculation","level":2,"score":0.4493161737918854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40260013937950134},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39743128418922424},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.14548829197883606},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006651","descriptor_name":"Histocytochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013047","descriptor_name":"Specific Pathogen-Free Organisms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051858","descriptor_name":"Forkhead Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.200838987","doi":"https://doi.org/10.1002/eji.200838987","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.200838987","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:19350558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19350558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1530044612","https://openalex.org/W1581720110","https://openalex.org/W1619959770","https://openalex.org/W1765181150","https://openalex.org/W1773520471","https://openalex.org/W1856738731","https://openalex.org/W1987628377","https://openalex.org/W1990065831","https://openalex.org/W1991536229","https://openalex.org/W1994426347","https://openalex.org/W1997708871","https://openalex.org/W2001009931","https://openalex.org/W2006249161","https://openalex.org/W2021107622","https://openalex.org/W2029437196","https://openalex.org/W2034141629","https://openalex.org/W2039706531","https://openalex.org/W2039880390","https://openalex.org/W2041406972","https://openalex.org/W2042844150","https://openalex.org/W2048152449","https://openalex.org/W2064573340","https://openalex.org/W2068034922","https://openalex.org/W2074477433","https://openalex.org/W2087810525","https://openalex.org/W2092235636","https://openalex.org/W2093608608","https://openalex.org/W2097811455","https://openalex.org/W2118857294","https://openalex.org/W2120010406","https://openalex.org/W2122689765","https://openalex.org/W2128798413","https://openalex.org/W2154122248","https://openalex.org/W2156964052","https://openalex.org/W2158692368","https://openalex.org/W2161545566","https://openalex.org/W2162819001","https://openalex.org/W2171398137","https://openalex.org/W2564152524"],"related_works":["https://openalex.org/W1493519017","https://openalex.org/W2053259871","https://openalex.org/W1481613249","https://openalex.org/W1543774404","https://openalex.org/W2068256031","https://openalex.org/W2967559605","https://openalex.org/W7096275474","https://openalex.org/W1973839849","https://openalex.org/W2061602802","https://openalex.org/W2328235013"],"abstract_inverted_index":{"Semi-mature":[0],"DC":[1],"(smDC)":[2],"have":[3],"been":[4],"shown":[5],"to":[6,12,31,127,170],"be":[7,32,168],"tolerogenic":[8,37],"and":[9,61,109,140],"thus":[10],"applicable":[11],"the":[13,24,118,132,135,162,171,180],"treatment":[14,181],"of":[15,27,57,73,89,120,174,182],"autoimmune":[16],"disease.":[17],"However,":[18],"in":[19,79,111,131,176],"our":[20],"repeated":[21],"experiments,":[22],"even":[23],"same":[25,133],"batches":[26],"smDC":[28,51,74,90,121,151,175],"were":[29,52,142],"found":[30],"profoundly":[33],"immunogenic":[34],"rather":[35],"than":[36],"when":[38],"inoculated":[39],"at":[40,97],"high":[41,84],"doses":[42,69,85],"into":[43],"arthritic":[44,93],"mice.":[45],"In":[46],"a":[47],"cytokine":[48],"chip":[49],"assay,":[50,134],"characterized":[53],"by":[54],"remarkable":[55],"production":[56],"IL-2,":[58],"IL-3,":[59],"IL-5,":[60],"IL-13":[62],"together":[63],"with":[64],"well-known":[65],"Th2":[66,106,138],"cytokines.":[67],"Low":[68],"(2":[70,86],"x":[71,87,125,129],"10(5))":[72],"showed":[75],"excellent":[76],"anti-arthritic":[77],"activity":[78],"collagen-induced":[80],"arthritis":[81],"animals,":[82],"whereas":[83],"10(6))":[88],"uniformly":[91],"accelerated":[92],"symptoms.":[94],"SmDC,":[95],"vaccinated":[96],"lower":[98],"doses,":[99],"markedly":[100],"induced":[101],"forkhead":[102],"box":[103],"P3":[104],"Treg,":[105],"cytokines":[107],"(IL-4/IL-10),":[108],"TGF-\u00e2":[110],"their":[112],"immune":[113],"deviation.":[114],"Interestingly,":[115],"however,":[116],"as":[117],"number":[119],"increased":[122],"from":[123],"2":[124,128],"10(5)":[126],"10(6)":[130],"Treg":[136],"population,":[137],"cytokines,":[139],"TGF-beta":[141],"dramatically":[143],"reduced.":[144],"Our":[145],"present":[146],"study":[147],"clearly":[148],"indicates":[149],"that":[150],"could":[152],"induce":[153],"either":[154],"T-cell":[155,158],"tolerance":[156],"or":[157],"activation,":[159],"depending":[160],"on":[161],"inoculum":[163],"size.":[164],"Special":[165],"attention":[166],"should":[167],"paid":[169],"optimal":[172],"range":[173],"DC-mediated":[177],"immunotherapy":[178],"for":[179],"rheumatoid":[183],"arthritis.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}