{"id":"https://openalex.org/W2012172422","doi":"https://doi.org/10.1074/jbc.m512921200","title":"Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases","display_name":"Identification of Mcm2 Phosphorylation Sites by S-phase-regulating Kinases","publication_year":2006,"publication_date":"2006-01-30","ids":{"openalex":"https://openalex.org/W2012172422","doi":"https://doi.org/10.1074/jbc.m512921200","mag":"2012172422","pmid":"https://pubmed.ncbi.nlm.nih.gov/16446360"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m512921200","doi":"https://doi.org/10.1074/jbc.m512921200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m512921200","pdf_url":"http://www.jbc.org/article/S0021925819563803/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819563803/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114134797","display_name":"Alessia Montagnoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Montagnoli","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062095629","display_name":"Barbara Valsasina","orcid":"https://orcid.org/0009-0003-4114-0907","observed_orcids":["https://orcid.org/0009-0003-4114-0907"]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Barbara Valsasina","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018690973","display_name":"Deborah H. Brotherton","orcid":"https://orcid.org/0000-0001-8750-8496","observed_orcids":["https://orcid.org/0000-0001-8750-8496"]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Deborah Brotherton","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040015786","display_name":"Sonia Troiani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sonia Troiani","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011360407","display_name":"Sonia Rainoldi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sonia Rainoldi","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063451090","display_name":"Pierluigi Tenca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierluigi Tenca","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Antonio Molinari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Molinari","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068292360","display_name":"Corrado Santocanale","orcid":"https://orcid.org/0000-0003-1337-5656","observed_orcids":["https://orcid.org/0000-0003-1337-5656"]},"institutions":[{"id":"https://openalex.org/I4210127540","display_name":"Nerviano Medical Sciences","ror":"https://ror.org/038mzt421","country_code":"IT","type":"company","lineage":["https://openalex.org/I4210127540"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Corrado Santocanale","raw_affiliation_strings":["Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Nerviano Medical Sciences-Oncology, Via Pasteur 10, 20014 Nerviano, Italy","institution_ids":["https://openalex.org/I4210127540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5068292360"],"corresponding_institution_ids":["https://openalex.org/I4210127540"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":5.6141,"has_fulltext":true,"cited_by_count":227,"citation_normalized_percentile":{"value":0.97485685,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"281","issue":"15","first_page":"10281","last_page":"10290"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.5580999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.2125999927520752,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.09570000320672989,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mcm2","display_name":"MCM2","score":0.9359999895095825},{"id":"https://openalex.org/keywords/mcm-helicase","display_name":"MCM helicase","score":0.7820000052452087},{"id":"https://openalex.org/keywords/phosphorylation-sites","display_name":"phosphorylation sites","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cdc7-kinase","display_name":"Cdc7 kinase","score":0.9459999799728394},{"id":"https://openalex.org/keywords/cdk2","display_name":"CDK2","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cdk1","display_name":"CDK1","score":0.996999979019165},{"id":"https://openalex.org/keywords/casein-kinase-2","display_name":"casein kinase 2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/dna-replication","display_name":"DNA replication","score":0.8080000281333923},{"id":"https://openalex.org/keywords/s-phase-entry","display_name":"S phase entry","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chromatin-association","display_name":"chromatin association","score":0.6880000233650208},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7253939509391785},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.713661789894104},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5533775091171265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47410279512405396},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.41726964712142944},{"id":"https://openalex.org/C2910050888","wikidata":"https://www.wikidata.org/wiki/Q4857068","display_name":"Protein-Serine-Threonine Kinases","level":4,"score":0.4159734845161438},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4120582938194275},{"id":"https://openalex.org/C87325107","wikidata":"https://www.wikidata.org/wiki/Q7251493","display_name":"Protein phosphorylation","level":4,"score":0.4106902778148651},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.377058744430542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.317380428314209},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.20215249061584473},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08060842752456665},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000095043","descriptor_name":"Cyclin-Dependent Kinase-Activating Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004265","descriptor_name":"DNA Helicases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007477","descriptor_name":"Ions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016203","descriptor_name":"CDC2 Protein Kinase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018844","descriptor_name":"Cyclin-Dependent Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044786","descriptor_name":"S-Phase Kinase-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047390","descriptor_name":"Casein Kinase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051357","descriptor_name":"Cyclin-Dependent Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064111","descriptor_name":"Minichromosome Maintenance Complex Component 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m512921200","doi":"https://doi.org/10.1074/jbc.m512921200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m512921200","pdf_url":"http://www.jbc.org/article/S0021925819563803/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16446360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16446360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m512921200","doi":"https://doi.org/10.1074/jbc.m512921200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m512921200","pdf_url":"http://www.jbc.org/article/S0021925819563803/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012172422.pdf","grobid_xml":"https://content.openalex.org/works/W2012172422.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1496762058","https://openalex.org/W1566625041","https://openalex.org/W1896375581","https://openalex.org/W1915683836","https://openalex.org/W1968074226","https://openalex.org/W1969584077","https://openalex.org/W1973466091","https://openalex.org/W1990512216","https://openalex.org/W1993143177","https://openalex.org/W1996739296","https://openalex.org/W2018370137","https://openalex.org/W2019331336","https://openalex.org/W2036086205","https://openalex.org/W2036534300","https://openalex.org/W2051729520","https://openalex.org/W2056590571","https://openalex.org/W2057896961","https://openalex.org/W2082507962","https://openalex.org/W2086549586","https://openalex.org/W2093703127","https://openalex.org/W2102502435","https://openalex.org/W2106130068","https://openalex.org/W2107073425","https://openalex.org/W2127493676","https://openalex.org/W2133631672","https://openalex.org/W2142837955","https://openalex.org/W2170609809","https://openalex.org/W2172189589","https://openalex.org/W2188497916"],"related_works":["https://openalex.org/W1974217591","https://openalex.org/W2087497699","https://openalex.org/W2059901121","https://openalex.org/W2884761957","https://openalex.org/W2027594270","https://openalex.org/W2005727369","https://openalex.org/W2008685538","https://openalex.org/W2078813646","https://openalex.org/W2036078296","https://openalex.org/W2084518357"],"abstract_inverted_index":{"Minichromosome":[0],"maintenance":[1],"2-7":[2],"proteins":[3],"play":[4],"a":[5,119,141],"pivotal":[6],"role":[7],"in":[8,13,74,90,108,160,165,193,247],"replication":[9,46],"of":[10,22,44,82,94,115,191,214],"the":[11,23,35,67,83,91,157,170,176,194,204,212,215,230,243],"genome":[12],"eukaryotic":[14],"organisms.":[15],"Upon":[16],"entry":[17,58],"into":[18],"S-phase":[19,57,60],"several":[20],"subunits":[21],"MCM":[24,37,235],"hexameric":[25],"complex":[26],"are":[27,63,162,221,237],"phosphorylated.":[28],"It":[29],"is":[30,201],"thought":[31],"that":[32,104,155,211],"phosphorylation":[33,88,190],"activates":[34],"intrinsic":[36],"DNA":[38],"helicase":[39],"activity,":[40],"thus":[41],"allowing":[42],"formation":[43],"active":[45],"forks.":[47],"Cdc7,":[48,97],"Cdk2,":[49,98],"and":[50,53,59,62,78,100,129,138,140,153,186,246],"ataxia":[51,127],"telangiectasia":[52,128],"Rad3-related":[54],"kinases":[55,241],"regulate":[56],"progression":[61],"known":[64],"to":[65,118,123,182,249],"phosphorylate":[66],"Mcm2":[68,95,107,172,192,216],"subunit.":[69],"In":[70],"this":[71],"work,":[72],"by":[73,96,126,146,219,239],"vitro":[75,161],"kinase":[76,184,197],"reactions":[77],"mass":[79],"spectrometry":[80],"analysis":[81,209],"products,":[84],"we":[85],"have":[86],"mapped":[87],"sites":[89,133,158,200],"N":[92],"terminus":[93],"Cdk1,":[99,139],"CK2.":[101,147],"We":[102,148],"found":[103,154],"Cdc7":[105,183,187,220],"phosphorylates":[106],"at":[109],"least":[110],"three":[111],"different":[112],"sites,":[113],"one":[114],"which":[116],"corresponds":[117],"site":[120,143],"also":[121,163],"reported":[122],"be":[124],"phosphorylated":[125,145,164,218],"Rad3-related.":[130],"Three":[131],"serine/proline":[132],"were":[134],"identified":[135,159],"for":[136,232],"Cdk2":[137],"unique":[142],"was":[144],"raised":[149],"specific":[150],"anti-phosphopeptide":[151],"antibodies":[152],"all":[156,169],"cells.":[166],"Importantly,":[167],"although":[168],"Cdc7-dependent":[171],"phosphosites":[173],"fluctuate":[174],"during":[175,203],"cell":[177,205,244],"cycle":[178,245],"with":[179,225],"kinetics":[180],"similar":[181],"activity":[185],"protein":[188],"levels,":[189],"putative":[195],"cyclin-dependent":[196],"(Cdk)":[198],"consensus":[199],"constant":[202],"cycle.":[206],"Furthermore,":[207],"our":[208],"indicates":[210],"majority":[213],"isoforms":[217],"not":[222],"stably":[223],"associated":[224],"chromatin.":[226],"This":[227],"study":[228],"forms":[229],"basis":[231],"understanding":[233],"how":[234],"functions":[236],"regulated":[238],"multiple":[240],"within":[242],"response":[248],"external":[250],"perturbations.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}