{"id":"https://openalex.org/W2012170416","doi":"https://doi.org/10.1117/12.2079212","title":"Multi-channel beam-scanning imaging at kHz frame rates by Lissajous trajectory microscopy","display_name":"Multi-channel beam-scanning imaging at kHz frame rates by Lissajous trajectory microscopy","publication_year":2015,"publication_date":"2015-03-09","ids":{"openalex":"https://openalex.org/W2012170416","doi":"https://doi.org/10.1117/12.2079212","mag":"2012170416","pmid":"https://pubmed.ncbi.nlm.nih.gov/27041787","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4815030"},"language":"en","primary_location":{"id":"doi:10.1117/12.2079212","doi":"https://doi.org/10.1117/12.2079212","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2079212","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4815030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043111707","display_name":"Justin A. Newman","orcid":"https://orcid.org/0000-0002-2498-1259","observed_orcids":["https://orcid.org/0000-0002-2498-1259"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin A. Newman","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013106947","display_name":"Shane Z. Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shane Z. Sullivan","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072171335","display_name":"Ryan D. Muir","orcid":"https://orcid.org/0000-0001-5628-1313","observed_orcids":["https://orcid.org/0000-0001-5628-1313"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan D. Muir","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102710520","display_name":"Suhas Sreehari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suhas Sreehari","raw_affiliation_strings":["Electrical and Computer Engineering, Purdue University, 465 Northwestern Avenue, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Purdue University, 465 Northwestern Avenue, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056657991","display_name":"Charles A. Bouman","orcid":"https://orcid.org/0000-0001-8504-0383","observed_orcids":["https://orcid.org/0000-0001-8504-0383"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles A. Bouman","raw_affiliation_strings":["Electrical and Computer Engineering, Purdue University, 465 Northwestern Avenue, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering, Purdue University, 465 Northwestern Avenue, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061854559","display_name":"Garth J. Simpson","orcid":"https://orcid.org/0000-0002-3932-848X","observed_orcids":["https://orcid.org/0000-0002-3932-848X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garth J. Simpson","raw_affiliation_strings":["Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Purdue University, United States#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.9093,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.70043732,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"9330","issue":null,"first_page":"933009","last_page":"933009"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":0.015399999916553497,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrafast-imaging","display_name":"ultrafast imaging","score":0.8029999732971191},{"id":"https://openalex.org/keywords/resonant-mirror","display_name":"resonant mirror","score":0.6000000238418579},{"id":"https://openalex.org/keywords/model-based-image-reconstruction","display_name":"model-based image reconstruction","score":0.8550000190734863},{"id":"https://openalex.org/keywords/maximum-a-posteriori-estimation","display_name":"maximum a posteriori estimation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/markov-random-field-prior","display_name":"Markov random field prior","score":0.9359999895095825},{"id":"https://openalex.org/keywords/image-interpolation","display_name":"image interpolation","score":0.609000027179718},{"id":"https://openalex.org/keywords/multi-channel-imaging","display_name":"multi-channel imaging","score":0.6990000009536743},{"id":"https://openalex.org/keywords/multimodal-imaging","display_name":"multimodal imaging","score":0.7170000076293945},{"id":"https://openalex.org/keywords/second-harmonic-generation","display_name":"second harmonic generation","score":0.6290000081062317},{"id":"https://openalex.org/keywords/two-photon-fluorescence","display_name":"two-photon fluorescence","score":0.9190000295639038},{"id":"https://openalex.org/keywords/photomultiplier-tube","display_name":"photomultiplier tubes","score":0.8220000267028809},{"id":"https://openalex.org/keywords/photodiode","display_name":"photodiode","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C207168407","wikidata":"https://www.wikidata.org/wiki/Q594135","display_name":"Lissajous curve","level":2,"score":0.8439674377441406},{"id":"https://openalex.org/C3261483","wikidata":"https://www.wikidata.org/wiki/Q119565","display_name":"Frame rate","level":2,"score":0.7268773317337036},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6011635065078735},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.5683622360229492},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5652996897697449},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5334425568580627},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.48055747151374817},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.4403602182865143},{"id":"https://openalex.org/C205372480","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"Image resolution","level":2,"score":0.41412442922592163},{"id":"https://openalex.org/C141379421","wikidata":"https://www.wikidata.org/wiki/Q6094427","display_name":"Iterative reconstruction","level":2,"score":0.41262930631637573},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.3915215730667114},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1117/12.2079212","doi":"https://doi.org/10.1117/12.2079212","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.2079212","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},{"id":"pmid:27041787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27041787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of SPIE--the International Society for Optical Engineering","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3785422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4815030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4815030","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4815030","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Proc SPIE Int Soc Opt Eng","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3785422","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4815030","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6616246480","display_name":"Ultrafast Nonlinear Optical Approaches toward High-Throughput Membrane Protein Na","funder_award_id":"R01GM103910","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7387141839","display_name":"Nonlinear Optical Imaging for Guiding Protein Structure Determination","funder_award_id":"R01GM103401","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1979968811","https://openalex.org/W1987315996","https://openalex.org/W1999432488","https://openalex.org/W2007031588","https://openalex.org/W2011219144","https://openalex.org/W2063017729","https://openalex.org/W2070737749","https://openalex.org/W2071689705","https://openalex.org/W2088333674","https://openalex.org/W2091699485","https://openalex.org/W2115969927","https://openalex.org/W2136537123","https://openalex.org/W4240127036"],"related_works":["https://openalex.org/W2298681576","https://openalex.org/W2063017729","https://openalex.org/W2011219144","https://openalex.org/W2590875401","https://openalex.org/W2975438751","https://openalex.org/W3004044226","https://openalex.org/W3092216104","https://openalex.org/W2966966111","https://openalex.org/W4389953907","https://openalex.org/W4297342098"],"abstract_inverted_index":{"A":[0,76],"beam-scanning":[1],"microscope":[2,24],"based":[3],"on":[4,35,175],"Lissajous":[5,48,67],"trajectory":[6,38,49,68],"imaging":[7,14,133,178,194],"is":[8,84,134],"described":[9],"for":[10,92,118,131,167,180,192],"achieving":[11],"streaming":[12],"2D":[13],"with":[15,71,109,142,195],"continuous":[16],"frame":[17,155,211],"rates":[18],"up":[19],"to":[20,30,87,96,152,202],"1.4":[21],"kHz.":[22],"The":[23,100,183],"utilizes":[25],"two":[26],"fast-scan":[27],"resonant":[28],"mirrors":[29],"direct":[31],"the":[32,40,46,62,66,89,93,143,150],"optical":[33],"beam":[34],"a":[36,104,106,110,176,186],"circuitous":[37],"through":[39],"field":[41,115],"of":[42,65,162,185],"view.":[43],"By":[44],"separating":[45],"full":[47,98],"time-domain":[50],"data":[51,91,174,188],"into":[52],"sub-trajectories":[53],"(partial,":[54],"undersampled":[55],"trajectories)":[56],"effective":[57],"frame-rates":[58],"much":[59],"higher":[60,210],"than":[61],"repeat":[63],"time":[64],"are":[69,123],"achieved":[70],"many":[72],"unsampled":[73,94],"pixels":[74,95],"present.":[75],"model-based":[77],"image":[78,119,197],"reconstruction":[79],"(MBIR)":[80],"3D":[81],"in-painting":[82,145],"algorithm":[83,102],"then":[85],"used":[86],"interpolate":[88],"missing":[90],"recover":[97],"images.":[99],"MBIR":[101,144],"uses":[103],"maximum":[105],"posteriori":[107],"estimation":[108],"generalized":[111],"Gaussian":[112],"Markov":[113],"random":[114],"prior":[116],"model":[117],"interpolation.":[120],"Because":[121],"images":[122,157],"acquired":[124],"using":[125,209],"photomultiplier":[126],"tubes":[127],"or":[128],"photodiodes,":[129],"parallelization":[130],"multi-channel":[132,187],"straightforward.":[135],"Preliminary":[136],"results":[137],"show":[138],"that":[139],"when":[140],"combined":[141],"algorithm,":[146],"this":[147],"technique":[148],"has":[149],"ability":[151],"generate":[153],"kHz":[154],"rate":[156],"across":[158],"6":[159],"total":[160],"dimensions":[161],"space,":[163],"time,":[164],"and":[165,170],"polarization":[166],"SHG,":[168],"TPEF,":[169],"confocal":[171],"reflective":[172],"birefringence":[173],"multimodal":[177,193],"platform":[179],"biomedical":[181],"imaging.":[182],"use":[184],"acquisition":[189],"card":[190],"allows":[191],"perfect":[196],"overlay.":[198],"Image":[199],"blur":[200],"due":[201],"sample":[203],"motion":[204],"was":[205],"also":[206],"reduced":[207],"by":[208],"rates.":[212]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}