{"id":"https://openalex.org/W2012161992","doi":"https://doi.org/10.1002/ijc.2910350107","title":"A re\u2010examination of the epstein\u2010barr virus carrier state in healthy seropositive individuals","display_name":"A re\u2010examination of the epstein\u2010barr virus carrier state in healthy seropositive individuals","publication_year":1985,"publication_date":"1985-01-15","ids":{"openalex":"https://openalex.org/W2012161992","doi":"https://doi.org/10.1002/ijc.2910350107","mag":"2012161992","pmid":"https://pubmed.ncbi.nlm.nih.gov/2981780"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.2910350107","doi":"https://doi.org/10.1002/ijc.2910350107","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910350107","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2012161992"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087046707","display_name":"Q. Y. Yao","orcid":"https://orcid.org/0000-0003-2737-7070","observed_orcids":["https://orcid.org/0000-0003-2737-7070"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Q. Y. Yao","raw_affiliation_strings":["Department of Pathology, University of Bristol Medical School, Bristol, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Bristol Medical School, Bristol, U.K","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039856726","display_name":"Alan B. Rickinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"A. B. Rickinson","raw_affiliation_strings":["Department of Pathology, University of Bristol Medical School, Bristol, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Bristol Medical School, Bristol, U.K","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110071109","display_name":"M. Anthony Epstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M. A. Epstein","raw_affiliation_strings":["Department of Pathology, University of Bristol Medical School, Bristol, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Bristol Medical School, Bristol, U.K","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039856726"],"corresponding_institution_ids":["https://openalex.org/I36234482"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":8.3519,"has_fulltext":false,"cited_by_count":337,"citation_normalized_percentile":{"value":0.97835079,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"35","issue":"1","first_page":"35","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/asymptomatic-carriage","display_name":"asymptomatic carriage","score":0.7749999761581421},{"id":"https://openalex.org/keywords/viral-shedding","display_name":"viral shedding","score":0.7350000143051147},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.8923348188400269},{"id":"https://openalex.org/C2776752453","wikidata":"https://www.wikidata.org/wiki/Q174778","display_name":"Pharynx","level":2,"score":0.7459165453910828},{"id":"https://openalex.org/C12914427","wikidata":"https://www.wikidata.org/wiki/Q7933612","display_name":"Viral shedding","level":3,"score":0.6684530377388},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6587222218513489},{"id":"https://openalex.org/C2776989088","wikidata":"https://www.wikidata.org/wiki/Q16364","display_name":"Throat","level":2,"score":0.648769736289978},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6195821166038513},{"id":"https://openalex.org/C15224491","wikidata":"https://www.wikidata.org/wiki/Q7169338","display_name":"Permissive","level":2,"score":0.5249416828155518},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4684790372848511},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46255674958229065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4387551248073578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4323849678039551},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42592093348503113},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2023860514163971},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D000956","descriptor_name":"Antigens, Viral","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002353","descriptor_name":"Carrier State","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004854","descriptor_name":"Herpesvirus 4, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D010614","descriptor_name":"Pharynx","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012698","descriptor_name":"Serologic Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019309","descriptor_name":"Epstein-Barr Virus Nuclear Antigens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.2910350107","doi":"https://doi.org/10.1002/ijc.2910350107","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ijc.2910350107","pdf_url":null,"source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:2981780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2981780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W25411737","https://openalex.org/W87308075","https://openalex.org/W159877543","https://openalex.org/W173493661","https://openalex.org/W1557311411","https://openalex.org/W1840160864","https://openalex.org/W1917993909","https://openalex.org/W1968849119","https://openalex.org/W1970748912","https://openalex.org/W1973062635","https://openalex.org/W1976337084","https://openalex.org/W1980056316","https://openalex.org/W1986414072","https://openalex.org/W1997347525","https://openalex.org/W2025451399","https://openalex.org/W2035240982","https://openalex.org/W2037226571","https://openalex.org/W2039456736","https://openalex.org/W2040083468","https://openalex.org/W2040549887","https://openalex.org/W2045120099","https://openalex.org/W2048710399","https://openalex.org/W2055620164","https://openalex.org/W2062860095","https://openalex.org/W2065625045","https://openalex.org/W2080249344","https://openalex.org/W2124147502","https://openalex.org/W2235446800","https://openalex.org/W2276236900","https://openalex.org/W2341995850","https://openalex.org/W4211078387","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2152607746","https://openalex.org/W1985234536","https://openalex.org/W2084536063","https://openalex.org/W2065625045","https://openalex.org/W2380341765","https://openalex.org/W2077502954","https://openalex.org/W2413161695","https://openalex.org/W1986414072","https://openalex.org/W4206710629","https://openalex.org/W7118885289"],"abstract_inverted_index":{"A":[0],"panel":[1],"of":[2,14,23,32,42,79,93,102,111,128,137,154,160,169,185,203,219],"24":[3],"healthy":[4],"seropositive":[5],"donors":[6,88,107,133],"have":[7],"been":[8],"followed":[9],"prospectively":[10],"over":[11],"a":[12,33,50,118,124,145,200],"period":[13],"15":[15],"months":[16],"and":[17,73,166,210],"monitored":[18],"(1)":[19],"for":[20,39,68,75,215],"the":[21,28,40,47,76,85,149,158,164,167,175,186,193,204,216],"level":[22,41,78,159],"EB":[24,94,150,206],"virus":[25,95,112,138,151,161,187,207],"shedding":[26,139],"in":[27,46,52,84,114,163,174,192],"throat":[29,97,115],"by":[30],"means":[31],"sensitive":[34],"cord-blood":[35],"transformation":[36],"assay;":[37],"(2)":[38],"virus-infected":[43],"B":[44,171],"cells":[45,83,172],"blood":[48],"via":[49],"new":[51],"vitro":[53],"protocol":[54],"where":[55],"\"spontaneous":[56],"transformation\"":[57],"can":[58],"be":[59,213],"seen":[60],"to":[61],"titrate":[62],"against":[63],"input":[64],"cell":[65],"number;":[66],"(3)":[67],"anti-EB":[69],"viral":[70],"antibody":[71],"titres":[72],"(4)":[74],"prevailing":[77],"virus-specific":[80],"memory":[81],"T":[82],"circulation.":[86,176],"Six":[87],"shed":[89,108],"easily":[90],"detectable":[91,113],"levels":[92,110],"into":[96],"washings":[98,116],"on":[99,117,123],"every":[100],"occasion":[101],"testing,":[103],"whilst":[104],"16":[105],"other":[106],"lower":[109],"majority":[119],"(10":[120],"donors)":[121,127],"or":[122],"minority":[125],"(6":[126],"test":[129],"occasions;":[130],"only":[131],"2/24":[132],"gave":[134],"no":[135],"evidence":[136],"at":[140,188],"any":[141],"time.":[142],"There":[143],"was":[144],"direct":[146],"relationship":[147],"between":[148],"shedder":[152],"status":[153],"an":[155],"individual":[156],"(i.e.,":[157],"replication":[162,184],"pharynx)":[165],"number":[168],"infected":[170],"present":[173],"These":[177],"results":[178],"indicate":[179],"that":[180,220],"chronic,":[181],"usually":[182],"low-grade,":[183],"some":[189],"permissive":[190],"site":[191],"oro-":[194],"and/or":[195],"naso-pharynx":[196],"is":[197],"very":[198],"often":[199],"stable":[201],"accompaniment":[202],"asymptomatic":[205],"carrier":[208],"state,":[209],"may":[211],"indeed":[212],"essential":[214],"long-term":[217],"maintenance":[218],"state.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}