{"id":"https://openalex.org/W2012161562","doi":"https://doi.org/10.1186/bcr3319","title":"Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer","display_name":"Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer","publication_year":2012,"publication_date":"2012-09-12","ids":{"openalex":"https://openalex.org/W2012161562","doi":"https://doi.org/10.1186/bcr3319","mag":"2012161562","pmid":"https://pubmed.ncbi.nlm.nih.gov/22971289","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4053102"},"language":"en","primary_location":{"id":"doi:10.1186/bcr3319","doi":"https://doi.org/10.1186/bcr3319","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3319","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3319","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3319","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090652957","display_name":"Christopher Switzer","orcid":"https://orcid.org/0000-0002-4321-0011","observed_orcids":["https://orcid.org/0000-0002-4321-0011"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher H Switzer","raw_affiliation_strings":["Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058844905","display_name":"Robert Y.S. Cheng","orcid":"https://orcid.org/0000-0003-0287-6439","observed_orcids":["https://orcid.org/0000-0003-0287-6439"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Y-S Cheng","raw_affiliation_strings":["Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002365439","display_name":"Lisa A. Ridnour","orcid":"https://orcid.org/0000-0001-9446-8349","observed_orcids":["https://orcid.org/0000-0001-9446-8349"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A Ridnour","raw_affiliation_strings":["Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017672961","display_name":"Sharon Anneve Glynn","orcid":"https://orcid.org/0000-0003-1459-2580","observed_orcids":["https://orcid.org/0000-0003-1459-2580"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["IE","US"],"is_corresponding":false,"raw_author_name":"Sharon A Glynn","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, Maryland, 20892, USA","Prostate Cancer Institute, National University of Ireland Galway, Galway, Ireland","Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"raw_affiliation_string":"Prostate Cancer Institute, National University of Ireland Galway, Galway, Ireland","institution_ids":["https://openalex.org/I188760350"]},{"raw_affiliation_string":"Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027170042","display_name":"Stefan Ambs","orcid":"https://orcid.org/0000-0001-7651-9309","observed_orcids":["https://orcid.org/0000-0001-7651-9309"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stefan Ambs","raw_affiliation_strings":["Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, 37 Convent Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044929543","display_name":"David A. Wink","orcid":"https://orcid.org/0000-0002-5652-7480","observed_orcids":["https://orcid.org/0000-0002-5652-7480"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A Wink","raw_affiliation_strings":["Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiation Biology Branch, National Cancer Institute, NIH, 10 Center Drive, Bethesda, Maryland, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090652957"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":3.105,"has_fulltext":true,"cited_by_count":93,"citation_normalized_percentile":{"value":0.91852283,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"14","issue":"5","first_page":"R125","last_page":"R125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3012999892234802,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.24230000376701355,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.23729999363422394,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ets1","display_name":"ETS1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.9269999861717224},{"id":"https://openalex.org/keywords/basal-like-breast-cancer","display_name":"basal-like breast cancer","score":0.8949999809265137},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/nos2","display_name":"NOS2","score":0.7829999923706055},{"id":"https://openalex.org/keywords/ras-mek-erk-pathway","display_name":"Ras/MEK/ERK pathway","score":0.9089999794960022},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.781000018119812},{"id":"https://openalex.org/keywords/ets-binding-site","display_name":"Ets binding site","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5870000123977661},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.8080000281333923},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9900000095367432},{"id":"https://openalex.org/keywords/p-cadherin","display_name":"P-cadherin","score":0.734000027179718},{"id":"https://openalex.org/keywords/s100a8","display_name":"S100A8","score":0.9459999799728394},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9559999704360962},{"id":"https://openalex.org/keywords/stem-like-phenotype","display_name":"stem cell-like phenotype","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.8281610608100891},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7721676230430603},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.7265015840530396},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6794601678848267},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6307957172393799},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5636674165725708},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5363876223564148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5330103039741516},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4675914943218231},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4357849955558777},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41965538263320923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40579891204833984},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40162593126296997},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24973464012145996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17665645480155945}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011960","descriptor_name":"Receptors, Estrogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050784","descriptor_name":"Proto-Oncogene Protein c-ets-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/bcr3319","doi":"https://doi.org/10.1186/bcr3319","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3319","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3319","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},{"id":"pmid:22971289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22971289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast cancer research : BCR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4053102","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4053102/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Res","raw_type":"Text"},{"id":"pmh:oai:https://researchrepository.universityofgalway.ie:10379/14092","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/14092","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:http://www.rian.ie/163942/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10379/14092","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:aran.library.nuigalway.ie/:10379/14092","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/14092","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchrepository.universityofgalway.ie:10379/14092","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/14092","pdf_url":null,"source":{"id":"https://openalex.org/S7407055151","display_name":"University of Galway Research Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.lenus.ie:10147/253667","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10147/253667","pdf_url":null,"source":{"id":"https://openalex.org/S4306401756","display_name":"Lenus, The Irish Health Repository (Dr Steevens Hospital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"doi:10.13025/27199","doi":"https://doi.org/10.13025/27199","is_oa":true,"landing_page_url":"https://doi.org/10.13025/27199","pdf_url":null,"source":{"id":"https://openalex.org/S4306402280","display_name":"Research Repository UCD (University College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I100930933","host_organization_name":"University College Dublin","host_organization_lineage":["https://openalex.org/I100930933"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.1186/bcr3319","doi":"https://doi.org/10.1186/bcr3319","is_oa":true,"landing_page_url":"https://doi.org/10.1186/bcr3319","pdf_url":"https://breast-cancer-research.biomedcentral.com/counter/pdf/10.1186/bcr3319","source":{"id":"https://openalex.org/S42140187","display_name":"Breast Cancer Research","issn_l":"1465-5411","issn":["1465-5411","1465-542X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Breast Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012161562.pdf","grobid_xml":"https://content.openalex.org/works/W2012161562.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1037557563","https://openalex.org/W1511331938","https://openalex.org/W1512538844","https://openalex.org/W1605046409","https://openalex.org/W1861588860","https://openalex.org/W1969785844","https://openalex.org/W1972398306","https://openalex.org/W1978116541","https://openalex.org/W1980458823","https://openalex.org/W1983405524","https://openalex.org/W1987630960","https://openalex.org/W1997656209","https://openalex.org/W2002575458","https://openalex.org/W2007916146","https://openalex.org/W2013575559","https://openalex.org/W2013899180","https://openalex.org/W2017982658","https://openalex.org/W2025152386","https://openalex.org/W2031137690","https://openalex.org/W2036730547","https://openalex.org/W2050878011","https://openalex.org/W2051746356","https://openalex.org/W2056108847","https://openalex.org/W2058836844","https://openalex.org/W2059425044","https://openalex.org/W2063317245","https://openalex.org/W2071367819","https://openalex.org/W2076186971","https://openalex.org/W2077004299","https://openalex.org/W2081453778","https://openalex.org/W2086091769","https://openalex.org/W2087739228","https://openalex.org/W2090046344","https://openalex.org/W2090458427","https://openalex.org/W2090576400","https://openalex.org/W2095795467","https://openalex.org/W2101236733","https://openalex.org/W2113125059","https://openalex.org/W2114558237","https://openalex.org/W2116025995","https://openalex.org/W2120512382","https://openalex.org/W2120789358","https://openalex.org/W2131994307","https://openalex.org/W2138292652","https://openalex.org/W2139795964","https://openalex.org/W2140807512","https://openalex.org/W2141865234","https://openalex.org/W2143580838","https://openalex.org/W2149477089","https://openalex.org/W2153454576","https://openalex.org/W2153490235","https://openalex.org/W2154157590","https://openalex.org/W2155547047","https://openalex.org/W2155921154","https://openalex.org/W2160740865","https://openalex.org/W2171480404","https://openalex.org/W2253277805","https://openalex.org/W2317059134","https://openalex.org/W2322518660","https://openalex.org/W2328310528","https://openalex.org/W2491654005"],"related_works":["https://openalex.org/W2138950473","https://openalex.org/W2135903110","https://openalex.org/W2024279924","https://openalex.org/W2141865234","https://openalex.org/W1993484190","https://openalex.org/W1511331938","https://openalex.org/W2077004299","https://openalex.org/W2089315287","https://openalex.org/W2510876230","https://openalex.org/W2094283635"],"abstract_inverted_index":{"INTRODUCTION:":[0],"The":[1],"Ets-1":[2,23,74,177,199,213,231,249,271,296],"transcription":[3],"factor":[4,182],"is":[5,48,163,178,272,311],"a":[6,33,41,134,217,222,273],"candidate":[7],"breast":[8,35,58,84,116,152,204,238,292,309],"cancer":[9,36,59,85,117,205,239,293],"oncogene":[10],"that":[11,47,146,159,176,210,224,270,281],"regulates":[12],"the":[13,30,71,131,160,164,179,283],"expression":[14,129,157,234,306],"of":[15,32,73,133,144,172,184,230,235,277,285,303],"genes":[16,94,145],"involved":[17,225],"in":[18,54,75,81,96,113,149,170,197,202,290,294,307],"tumor":[19],"progression":[20],"and":[21,60,65,78,192,246,257,297],"metastasis.":[22],"signaling":[24,77,121,219,280],"has":[25],"also":[26],"been":[27],"linked":[28,313],"to":[29,194,314],"development":[31,284],"basal-like":[34,66,115,237],"phenotype.":[37],"We":[38],"recently":[39],"described":[40],"nitric":[42,98],"oxide":[43,99],"(NO)-induced":[44],"gene":[45],"signature":[46],"associated":[49],"with":[50,154],"poor":[51,315],"disease":[52,288],"outcome":[53],"estrogen":[55],"receptor-negative":[56],"(ER-)":[57],"contains":[61],"both":[62,188],"stem":[63],"cell-like":[64],"components.":[67],"Thus,":[68],"we":[69],"examined":[70,112],"role":[72],"NO":[76,120,211,279],"NO-induced":[79,233],"phenotypes":[80],"ER-":[82,203,291],"human":[83,114,150,308],"cells.":[86,206],"METHODS:":[87],"Promoter":[88,141],"region":[89,142],"analyses":[90],"were":[91,111,123],"performed":[92],"on":[93],"upregulated":[95],"inducible":[97],"synthase":[100],"(NOS2)":[101],"high":[102,155],"expressing":[103],"tumors":[104,153,310],"for":[105],"Ets-binding":[106,161],"sites.":[107],"In":[108],"vitro":[109],"mechanisms":[110],"cells":[118],"lines.":[119],"effects":[122],"studied":[124],"using":[125],"either":[126],"forced":[127,189],"NOS2":[128,156,190,305],"or":[130],"use":[132],"chemical":[135],"NO-donor,":[136],"diethlylenetriamine":[137],"NONOate":[138],"(DETANO).":[139],"RESULTS:":[140],"analysis":[143],"are":[147],"up-regulated":[148],"ER-negative":[151],"revealed":[158],"sequence":[162],"only":[165],"common":[166],"promoter":[167],"element":[168],"present":[169],"all":[171],"these":[173],"genes,":[174],"indicating":[175],"key":[180,274],"transcriptional":[181,200,214,275],"down-stream":[183],"oncogenic":[185,278],"NOS2-signaling.":[186],"Accordingly,":[187],"over-expression":[191],"exposure":[193],"NO-donors":[195],"resulted":[196],"significant":[198],"activation":[201],"Functional":[207],"studies":[208],"showed":[209],"activated":[212],"activity":[215],"via":[216],"Ras/MEK/ERK":[218],"pathway":[220],"by":[221],"mechanism":[223],"Ras":[226],"S-nitrosylation.":[227],"RNA":[228],"knock-down":[229,250],"suppressed":[232],"selected":[236],"markers":[240],"such":[241],"as":[242,261,263],"P-cadherin,":[243],"S100A8,":[244],"IL-8":[245],"\u03b1\u03b2-crystallin.":[247],"Additionally,":[248],"reduced":[251],"NO-mediated":[252],"cellular":[253],"proliferation,":[254],"matrix":[255],"metalloproteinase":[256],"cathepsin":[258],"B":[259],"activities,":[260],"well":[262],"matrigel":[264],"invasion.":[265],"CONCLUSIONS:":[266],"These":[267],"data":[268],"show":[269],"mediator":[276],"promotes":[282],"an":[286,295],"aggressive":[287],"phenotype":[289],"Ras-dependent":[298],"manner,":[299],"providing":[300],"novel":[301],"clues":[302],"how":[304],"functionally":[312],"patient":[316],"survival.":[317]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
