{"id":"https://openalex.org/W2012160343","doi":"https://doi.org/10.1016/0165-4608(92)90384-k","title":"Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells","display_name":"Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2012160343","doi":"https://doi.org/10.1016/0165-4608(92)90384-k","mag":"2012160343","pmid":"https://pubmed.ncbi.nlm.nih.gov/1423235"},"language":"en","primary_location":{"id":"doi:10.1016/0165-4608(92)90384-k","doi":"https://doi.org/10.1016/0165-4608(92)90384-k","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-4608(92)90384-k","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038717201","display_name":"Paul E. Nisson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul E. Nisson","raw_affiliation_strings":["Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD","Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD","institution_ids":[]},{"raw_affiliation_string":"Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108365070","display_name":"Paul C. Watkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul C. Watkins","raw_affiliation_strings":["Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Analysis Laboratory, Life Technologies Inc., Gaithersburg, MD, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073693721","display_name":"Nicoletta Sacchi","orcid":"https://orcid.org/0000-0002-7164-401X","observed_orcids":["https://orcid.org/0000-0002-7164-401X"]},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Nicoletta Sacchi","raw_affiliation_strings":["Department of Biology and Genetics, School of Medicine, University of Milan, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology and Genetics, School of Medicine, University of Milan, Milan, Italy","institution_ids":["https://openalex.org/I189158943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073693721"],"corresponding_institution_ids":["https://openalex.org/I189158943"],"apc_list":null,"apc_paid":null,"fwci":6.0084,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.96787021,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"63","issue":"2","first_page":"81","last_page":"88"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/pml-rara-fusion","display_name":"PML-RARA fusion","score":0.6019999980926514},{"id":"https://openalex.org/keywords/fusion-genes","display_name":"fusion genes","score":0.7549999952316284},{"id":"https://openalex.org/keywords/fusion-transcripts","display_name":"fusion transcripts","score":0.746999979019165},{"id":"https://openalex.org/keywords/chromosome-8","display_name":"chromosome 8","score":0.746999979019165},{"id":"https://openalex.org/keywords/cyclin-d2","display_name":"cyclin D2","score":0.7760000228881836},{"id":"https://openalex.org/keywords/translocation-detection","display_name":"translocation detection","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8375648260116577},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.7448305487632751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6837567090988159},{"id":"https://openalex.org/C26260077","wikidata":"https://www.wikidata.org/wiki/Q5099361","display_name":"Chimeric gene","level":4,"score":0.6760109066963196},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.6350401043891907},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.5403632521629333},{"id":"https://openalex.org/C94671646","wikidata":"https://www.wikidata.org/wiki/Q207551","display_name":"Intron","level":3,"score":0.529015302658081},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5270911455154419},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5253440737724304},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.5162568092346191},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.4641711711883545},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30043864250183105},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002891","descriptor_name":"Chromosomes, Human, Pair 21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0165-4608(92)90384-k","doi":"https://doi.org/10.1016/0165-4608(92)90384-k","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0165-4608(92)90384-k","pdf_url":null,"source":{"id":"https://openalex.org/S4210175027","display_name":"Cancer Genetics and Cytogenetics","issn_l":"0165-4608","issn":["0165-4608","1873-4456"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics and Cytogenetics","raw_type":"journal-article"},{"id":"pmid:1423235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1423235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics and cytogenetics","raw_type":"Journal Article"},{"id":"pmid:8467483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8467483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics and cytogenetics","raw_type":"Published Erratum"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1525850954","https://openalex.org/W1540357669","https://openalex.org/W1923636344","https://openalex.org/W1994082723","https://openalex.org/W2008079574","https://openalex.org/W2011679894","https://openalex.org/W2030701381","https://openalex.org/W2039263836","https://openalex.org/W2048835029","https://openalex.org/W2050753155","https://openalex.org/W2051296872","https://openalex.org/W2055043387","https://openalex.org/W2065252273","https://openalex.org/W2067726537","https://openalex.org/W2068728784","https://openalex.org/W2075785338","https://openalex.org/W2075793367","https://openalex.org/W2089921110","https://openalex.org/W2108388593","https://openalex.org/W2118916876","https://openalex.org/W2134812217","https://openalex.org/W2170051465","https://openalex.org/W6667513904","https://openalex.org/W6669540929"],"related_works":["https://openalex.org/W2279693825","https://openalex.org/W2068728784","https://openalex.org/W2280905264","https://openalex.org/W2338753933","https://openalex.org/W1524671781","https://openalex.org/W1538796191","https://openalex.org/W221180449","https://openalex.org/W58708874","https://openalex.org/W2402005622","https://openalex.org/W2036772303"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
