{"id":"https://openalex.org/W2012159508","doi":"https://doi.org/10.1002/bms.1200110813","title":"Bis(trifluoromethyl)aryl derivatives for drug analysis by gas chromatography electron capture negative ion chemical ionization mass spectrometry. Application to the measurement of low levels of clondine in plasma","display_name":"Bis(trifluoromethyl)aryl derivatives for drug analysis by gas chromatography electron capture negative ion chemical ionization mass spectrometry. Application to the measurement of low levels of clondine in plasma","publication_year":1984,"publication_date":"1984-08-01","ids":{"openalex":"https://openalex.org/W2012159508","doi":"https://doi.org/10.1002/bms.1200110813","mag":"2012159508","pmid":"https://pubmed.ncbi.nlm.nih.gov/6478049"},"language":"en","primary_location":{"id":"doi:10.1002/bms.1200110813","doi":"https://doi.org/10.1002/bms.1200110813","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bms.1200110813","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"S. Murray","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Murray","raw_affiliation_strings":["Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108230384","display_name":"D. S. Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. S. Davies","raw_affiliation_strings":["Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, Ducane Road, London W12 OHS, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":5.1738,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.95067265,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"8","first_page":"435","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.08479999750852585,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.7099999785423279},{"id":"https://openalex.org/keywords/selected-ion-monitoring","display_name":"selected ion monitoring","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.7174623012542725},{"id":"https://openalex.org/C205759337","wikidata":"https://www.wikidata.org/wiki/Q1748259","display_name":"Electron ionization","level":4,"score":0.6901541948318481},{"id":"https://openalex.org/C2776442012","wikidata":"https://www.wikidata.org/wiki/Q2302144","display_name":"Trifluoromethyl","level":3,"score":0.6680635809898376},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6661437153816223},{"id":"https://openalex.org/C51884965","wikidata":"https://www.wikidata.org/wiki/Q471254","display_name":"Chemical ionization","level":4,"score":0.6391997933387756},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.5785158276557922},{"id":"https://openalex.org/C2781076698","wikidata":"https://www.wikidata.org/wiki/Q718074","display_name":"Aryl","level":3,"score":0.5626702904701233},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.5498412847518921},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.516523540019989},{"id":"https://openalex.org/C105066094","wikidata":"https://www.wikidata.org/wiki/Q109910","display_name":"Electron capture","level":3,"score":0.5047265291213989},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.46061182022094727},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.45304301381111145},{"id":"https://openalex.org/C198291218","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Ionization","level":3,"score":0.4170971214771271},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.23482468724250793},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003000","descriptor_name":"Clonidine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/bms.1200110813","doi":"https://doi.org/10.1002/bms.1200110813","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bms.1200110813","pdf_url":null,"source":{"id":"https://openalex.org/S37349105","display_name":"Journal of Mass Spectrometry","issn_l":"1076-5174","issn":["1076-5174","1096-9888"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:6478049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6478049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedical mass spectrometry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.44999998807907104,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W130740266","https://openalex.org/W144174057","https://openalex.org/W1535459198","https://openalex.org/W1838585930","https://openalex.org/W1981379527","https://openalex.org/W2020958813","https://openalex.org/W2025518366","https://openalex.org/W2026249471","https://openalex.org/W2029631833","https://openalex.org/W2040099354","https://openalex.org/W2047806034","https://openalex.org/W2050455619","https://openalex.org/W2051465719","https://openalex.org/W2898025128"],"related_works":["https://openalex.org/W2148068540","https://openalex.org/W2403841148","https://openalex.org/W2087697911","https://openalex.org/W2072386808","https://openalex.org/W1986906520","https://openalex.org/W1964581327","https://openalex.org/W2005224496","https://openalex.org/W1992133164","https://openalex.org/W2016491656","https://openalex.org/W2168439469"],"abstract_inverted_index":{"A":[0],"gas":[1],"chromatographic":[2],"mass":[3,40,72,76,133],"spectrometric":[4],"assay":[5,172],"for":[6,173,197],"clonidine":[7,29,64,116,162,174,207],"in":[8,62,74,175,208],"plasma":[9,176],"with":[10,48,87,127,177],"a":[11,15,113,118,140,178,194,212],"detection":[12],"limit":[13,196],"of":[14,28,42,69,108,115,135,155,161,170,180,200,206],"few":[16],"picograms":[17],"per":[18],"ml":[19],"was":[20,121],"required.":[21],"The":[22,130],"p-trifluoromethylbenzyl,":[23],"pentafluorobenzyl":[24],"and":[25,32,54,94,193],"pentafluorobenzoyl":[26],"derivatives":[27],"were":[30,92,97],"synthesized":[31,93,122],"the":[33,58,63,80,125,136,168],"electron":[34,110],"capture":[35],"negative":[36,103,131],"ion":[37,67,104,132,149],"chemical":[38],"ionization":[39],"spectra":[41,77],"these":[43,75,88,95],"compounds":[44,96],"show":[45],"extensive":[46],"fragmentation":[47],"prominent":[49],"ions":[50,73],"at":[51,143,183,189],"m/z":[52,144],"35":[53],"37":[55],"due":[56],"to":[57,99,158],"two":[59],"chlorine":[60],"atoms":[61],"molecule.":[65],"Selected":[66],"monitoring":[68],"specific":[70],"high":[71],"indicated":[78],"that":[79],"required":[81],"sensitivity":[82],"could":[83],"not":[84],"be":[85,164],"obtained":[86],"derivatives.":[89],"Several":[90],"bis(trifluoromethyl)pyrimidines":[91],"found":[98],"give":[100],"an":[101,153,171],"intense":[102],"current":[105],"under":[106],"conditions":[107],"resonance":[109],"capture.":[111],"Consequently,":[112],"derivative":[114,156],"containing":[117],"bis(trifluoromethyl)aryl":[119],"group":[120],"by":[123],"reacting":[124],"drug":[126],"3,5-bis(trifluoromethyl)benzoyl":[128],"chloride.":[129],"spectrum":[134],"reaction":[137],"product":[138],"has":[139],"base":[141],"peak":[142],"673":[145],"and,":[146],"when":[147],"this":[148],"is":[150],"specifically":[151],"monitored,":[152],"amount":[154],"equivalent":[157],"1":[159],"picogram":[160],"can":[163],"detected.":[165],"This":[166],"allowed":[167],"development":[169],"precision":[179],"8%":[181],"(SD)":[182,188],"50":[184,214],"pg":[185,191,202],"ml-1,":[186],"22%":[187],"20":[190],"ml-1":[192],"lower":[195],"quantitative":[198],"determination":[199],"10":[201,209],"ml-1.":[203],"Plasma":[204],"concentrations":[205],"subjects":[210],"given":[211],"single":[213],"micrograms":[215],"oral":[216],"dose":[217],"are":[218],"reported.":[219]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}