{"id":"https://openalex.org/W2012151374","doi":"https://doi.org/10.1172/jci58406","title":"Quantity, not quality, of antibody response decreased in the elderly","display_name":"Quantity, not quality, of antibody response decreased in the elderly","publication_year":2011,"publication_date":"2011-07-25","ids":{"openalex":"https://openalex.org/W2012151374","doi":"https://doi.org/10.1172/jci58406","mag":"2012151374","pmid":"https://pubmed.ncbi.nlm.nih.gov/21785210","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148749"},"language":"en","primary_location":{"id":"doi:10.1172/jci58406","doi":"https://doi.org/10.1172/jci58406","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci58406","pdf_url":"http://www.jci.org/articles/view/58406/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/58406/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113928053","display_name":"Bonnie B. Blomberg","orcid":"https://orcid.org/0000-0002-3753-6058","observed_orcids":["https://orcid.org/0000-0002-3753-6058"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie B. Blomberg","raw_affiliation_strings":["Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030792723","display_name":"Daniela Frasca","orcid":"https://orcid.org/0000-0002-9816-6679","observed_orcids":["https://orcid.org/0000-0002-9816-6679"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniela Frasca","raw_affiliation_strings":["Microbiology & Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology & Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":34,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":"8","first_page":"2981","last_page":"2983"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.012199999764561653,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/influenza-vaccination","display_name":"influenza vaccination","score":0.9589999914169312},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8019999861717224},{"id":"https://openalex.org/keywords/serum-antibody-response","display_name":"serum antibody response","score":0.8059999942779541},{"id":"https://openalex.org/keywords/antibody-quality","display_name":"antibody quality","score":0.8240000009536743},{"id":"https://openalex.org/keywords/vaccine-efficacy","display_name":"vaccine efficacy","score":0.5809999704360962},{"id":"https://openalex.org/keywords/immunosenescence","display_name":"immunosenescence","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.8315713405609131},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.7035484313964844},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.6579270362854004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6388757228851318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5796820521354675},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5142928957939148},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5036577582359314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1941707730293274},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.17362892627716064}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003140","descriptor_name":"Communicable Disease Control","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005853","descriptor_name":"Geriatrics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci58406","doi":"https://doi.org/10.1172/jci58406","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci58406","pdf_url":"http://www.jci.org/articles/view/58406/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2252365","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148749","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3148749","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3148749","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:21785210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21785210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1172/jci58406","doi":"https://doi.org/10.1172/jci58406","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci58406","pdf_url":"http://www.jci.org/articles/view/58406/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2426505218","display_name":"Regulation of B Lymphocyte Defects in Senescent Humans","funder_award_id":"R01AG032576","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3479276667","display_name":null,"funder_award_id":"NICHD\u2010R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3811745418","display_name":"Regulation of Immunoglobulin Class Switch in Aged Mice","funder_award_id":"R37AG023717","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4110906","display_name":null,"funder_award_id":"AG32576","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G523154166","display_name":null,"funder_award_id":"AG23717","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6557301757","display_name":"Regulation of primary and memory B cell vaccine responses in the elderly","funder_award_id":"R56AG032576","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320308306","display_name":"Muscular Dystrophy Association","ror":"https://ror.org/01frxsf98"},{"id":"https://openalex.org/F4320312337","display_name":"FightSMA","ror":"https://ror.org/00zbvt830"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012151374.pdf","grobid_xml":"https://content.openalex.org/works/W2012151374.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W181611809","https://openalex.org/W1480510972","https://openalex.org/W1539270061","https://openalex.org/W1576064052","https://openalex.org/W1625913856","https://openalex.org/W1967938917","https://openalex.org/W1998709016","https://openalex.org/W2005284010","https://openalex.org/W2058144955","https://openalex.org/W2089244708","https://openalex.org/W2095069717","https://openalex.org/W2105359173","https://openalex.org/W2109057963","https://openalex.org/W2110962836","https://openalex.org/W2123708888","https://openalex.org/W2126095167","https://openalex.org/W2129973151","https://openalex.org/W2148589887","https://openalex.org/W2149051721","https://openalex.org/W2370317860"],"related_works":["https://openalex.org/W2095069717","https://openalex.org/W2105359173","https://openalex.org/W2784496013","https://openalex.org/W2040143553","https://openalex.org/W2546075975","https://openalex.org/W2935808855","https://openalex.org/W1977170046","https://openalex.org/W2468369521","https://openalex.org/W2025892793","https://openalex.org/W3102850153"],"abstract_inverted_index":{"The":[0],"burden":[1],"of":[2,54,62,90,109],"disease":[3],"during":[4],"seasonal":[5],"influenza":[6,77,110],"epidemics":[7],"is":[8,87],"felt":[9],"most":[10],"keenly":[11],"among":[12],"the":[13,17,55,63,70,88,91,107],"very":[14],"young":[15,25],"and":[16,24,65,93],"elderly.":[18],"Although":[19],"vaccination":[20,78,111],"effectively":[21],"protects":[22],"children":[23],"adults":[26],"against":[27],"infection,":[28],"it":[29,86],"has":[30,37],"limited":[31],"efficacy":[32],"in":[33,79,112],"elderly":[34,80],"individuals.":[35,81],"This":[36],"been":[38],"linked":[39],"to":[40,44,99,105],"a":[41,46],"reduced":[42,71],"ability":[43],"induce":[45],"robust":[47],"serum":[48,72],"antibody":[49,73],"response.":[50],"In":[51],"this":[52,113],"issue":[53],"JCI,":[56],"Sasaki":[57],"et":[58],"al.":[59],"identify":[60],"some":[61],"cellular":[64],"molecular":[66],"deficits":[67],"that":[68,85,97],"underlie":[69],"response":[74],"induced":[75],"by":[76],"Importantly,":[82],"they":[83],"show":[84],"quantity":[89],"response,":[92],"not":[94],"its":[95],"quality,":[96],"needs":[98],"be":[100],"improved":[101],"if":[102],"we":[103],"are":[104],"enhance":[106],"success":[108],"vulnerable":[114],"population.":[115]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}