{"id":"https://openalex.org/W2012149653","doi":"https://doi.org/10.1016/0167-7799(92)90214-g","title":"The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases","display_name":"The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2012149653","doi":"https://doi.org/10.1016/0167-7799(92)90214-g","mag":"2012149653","pmid":"https://pubmed.ncbi.nlm.nih.gov/1368394"},"language":"en","primary_location":{"id":"doi:10.1016/0167-7799(92)90214-g","doi":"https://doi.org/10.1016/0167-7799(92)90214-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-7799(92)90214-g","pdf_url":null,"source":{"id":"https://openalex.org/S147849156","display_name":"Trends in biotechnology","issn_l":"0167-7799","issn":["0167-7799","0167-9430","1879-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biotechnology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075507189","display_name":"Andrew Docherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J.P. Docherty","raw_affiliation_strings":["Celltech Ltd, Slough, UK","A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Celltech Ltd, Slough, UK","institution_ids":[]},{"raw_affiliation_string":"A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086365608","display_name":"James P. O\u2019Connell","orcid":"https://orcid.org/0000-0002-3138-8074","observed_orcids":["https://orcid.org/0000-0002-3138-8074"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James O'Connell","raw_affiliation_strings":["A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111649724","display_name":"Tom Crabbe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tom Crabbe","raw_affiliation_strings":["A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024018741","display_name":"Sarojani Angal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarojani Angal","raw_affiliation_strings":["A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. J. P. Docherty, J. O'Connell, T. Crabbe and S. Angal are at Celltech Ltd, 216 Bath Road, Slough, UK SL1 4EN","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016235541","display_name":"Gillian Murphy","orcid":"https://orcid.org/0000-0003-0287-1910","observed_orcids":["https://orcid.org/0000-0003-0287-1910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gillian Murphy","raw_affiliation_strings":["G. Murphy is at the Strangeways Research Laboratory, Cambridge, UK CB1 4RN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G. Murphy is at the Strangeways Research Laboratory, Cambridge, UK CB1 4RN","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":3.2949,"has_fulltext":false,"cited_by_count":186,"citation_normalized_percentile":{"value":0.93908629,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"10","issue":"6","first_page":"200","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-inhibitors","display_name":"matrix metalloproteinase inhibitors","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tissue-destruction","display_name":"tissue destruction","score":0.796999990940094},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7730000019073486},{"id":"https://openalex.org/keywords/structure-function-analysis","display_name":"structure-function analysis","score":0.9279999732971191},{"id":"https://openalex.org/keywords/rational-drug-design","display_name":"rational drug design","score":0.8510000109672546},{"id":"https://openalex.org/keywords/therapeutic-compounds","display_name":"therapeutic compounds","score":0.3449999988079071}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.9021406769752502},{"id":"https://openalex.org/C2775958869","wikidata":"https://www.wikidata.org/wiki/Q16966320","display_name":"Matrix metalloproteinase inhibitor","level":3,"score":0.5334669947624207},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5253916382789612},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.5019986629486084},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4554147720336914},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4506877660751343},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4469609558582306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42970627546310425},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4206297993659973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.41007760167121887},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3498242497444153},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3443170487880707},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3307010531425476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2907017469406128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2841698229312897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.25858116149902344},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.19839689135551453},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.13012132048606873},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12091228365898132},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001709","descriptor_name":"Biotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003240","descriptor_name":"Connective Tissue Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003240","descriptor_name":"Connective Tissue Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008666","descriptor_name":"Metalloendopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0167-7799(92)90214-g","doi":"https://doi.org/10.1016/0167-7799(92)90214-g","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0167-7799(92)90214-g","pdf_url":null,"source":{"id":"https://openalex.org/S147849156","display_name":"Trends in biotechnology","issn_l":"0167-7799","issn":["0167-7799","0167-9430","1879-3096"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Biotechnology","raw_type":"journal-article"},{"id":"pmid:1368394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1368394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W125666021","https://openalex.org/W205278663","https://openalex.org/W332108910","https://openalex.org/W1482195692","https://openalex.org/W1510586846","https://openalex.org/W1523927558","https://openalex.org/W1524239466","https://openalex.org/W1530138845","https://openalex.org/W1534999453","https://openalex.org/W1554043067","https://openalex.org/W1558047875","https://openalex.org/W1567385135","https://openalex.org/W1571553794","https://openalex.org/W1580647893","https://openalex.org/W1583304743","https://openalex.org/W1585596487","https://openalex.org/W1585695184","https://openalex.org/W1593920002","https://openalex.org/W1628604166","https://openalex.org/W1664158328","https://openalex.org/W1669342624","https://openalex.org/W1700189391","https://openalex.org/W1823810252","https://openalex.org/W1872370876","https://openalex.org/W1882182790","https://openalex.org/W1970293798","https://openalex.org/W1980480613","https://openalex.org/W1994897036","https://openalex.org/W1995716214","https://openalex.org/W1999225211","https://openalex.org/W2000212022","https://openalex.org/W2000532033","https://openalex.org/W2003035656","https://openalex.org/W2008943241","https://openalex.org/W2010295725","https://openalex.org/W2021116136","https://openalex.org/W2025448804","https://openalex.org/W2026151657","https://openalex.org/W2033252495","https://openalex.org/W2038652930","https://openalex.org/W2043254359","https://openalex.org/W2043765747","https://openalex.org/W2044425673","https://openalex.org/W2052605451","https://openalex.org/W2054703329","https://openalex.org/W2057708262","https://openalex.org/W2071072558","https://openalex.org/W2076474819","https://openalex.org/W2077483002","https://openalex.org/W2078150766","https://openalex.org/W2086447944","https://openalex.org/W2092449976","https://openalex.org/W2106827172","https://openalex.org/W2107908226","https://openalex.org/W2109658199","https://openalex.org/W2114341924","https://openalex.org/W2133692536","https://openalex.org/W2133915610","https://openalex.org/W2135649915","https://openalex.org/W2144712422","https://openalex.org/W2154610968","https://openalex.org/W2182736053","https://openalex.org/W2337245168","https://openalex.org/W2339025468","https://openalex.org/W2397048910","https://openalex.org/W2418747844","https://openalex.org/W4247241827"],"related_works":["https://openalex.org/W4235022528","https://openalex.org/W2042896784","https://openalex.org/W2419692483","https://openalex.org/W4239037900","https://openalex.org/W625384268","https://openalex.org/W2416507457","https://openalex.org/W3023224794","https://openalex.org/W7048699785","https://openalex.org/W2001921851","https://openalex.org/W2083001139"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}