{"id":"https://openalex.org/W2012148544","doi":"https://doi.org/10.1210/jc.79.2.461","title":"A comparison of octreotide, bromocriptine, or a combination of both drugs in acromegaly","display_name":"A comparison of octreotide, bromocriptine, or a combination of both drugs in acromegaly","publication_year":1994,"publication_date":"1994-08-01","ids":{"openalex":"https://openalex.org/W2012148544","doi":"https://doi.org/10.1210/jc.79.2.461","mag":"2012148544","pmid":"https://pubmed.ncbi.nlm.nih.gov/8045964"},"language":"en","primary_location":{"id":"doi:10.1210/jc.79.2.461","doi":"https://doi.org/10.1210/jc.79.2.461","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.79.2.461","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029997255","display_name":"A K Fl\u00f8gstad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A K Fl\u00f8gstad","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020174799","display_name":"Johan Halse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Halse","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110227587","display_name":"P. N. Grass","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Grass","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078323979","display_name":"Eva Abisch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Abisch","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111600631","display_name":"O. Dj\u00f8seland","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O Dj\u00f8seland","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089817546","display_name":"Klaus Kutz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kutz","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054385542","display_name":"Egil Bodd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Bodd","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071721348","display_name":"Jak Jervell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Jervell","raw_affiliation_strings":["Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department B, Rikshospitalet, National Hospital, Oslo, Norway","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":2.2514,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.86518771,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"79","issue":"2","first_page":"461","last_page":"465"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acromegaly","display_name":"acromegaly","score":0.9929999709129333},{"id":"https://openalex.org/keywords/octreotide","display_name":"octreotide","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bromocriptine","display_name":"bromocriptine","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.875},{"id":"https://openalex.org/keywords/growth-hormone-secretion","display_name":"growth hormone secretion","score":0.8019999861717224},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9819999933242798},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8849999904632568},{"id":"https://openalex.org/keywords/somatostatin-analogs","display_name":"somatostatin analogues","score":0.7379999756813049},{"id":"https://openalex.org/keywords/dopamine-agonists","display_name":"dopamine agonists","score":0.828000009059906},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.6359999775886536},{"id":"https://openalex.org/keywords/growth-hormone-suppression","display_name":"growth hormone suppression","score":0.38999998569488525},{"id":"https://openalex.org/keywords/somatostatin-receptor-agonists","display_name":"somatostatin receptor agonists","score":0.45399999618530273},{"id":"https://openalex.org/keywords/growth-hormone-receptor-antagonist","display_name":"growth hormone receptor antagonist","score":0.3310000002384186},{"id":"https://openalex.org/keywords/pituitary-adenoma","display_name":"pituitary adenoma","score":0.5759999752044678}],"concepts":[{"id":"https://openalex.org/C2776856834","wikidata":"https://www.wikidata.org/wiki/Q413581","display_name":"Bromocriptine","level":4,"score":0.9600231647491455},{"id":"https://openalex.org/C2777433750","wikidata":"https://www.wikidata.org/wiki/Q189580","display_name":"Acromegaly","level":4,"score":0.9262967109680176},{"id":"https://openalex.org/C2781025020","wikidata":"https://www.wikidata.org/wiki/Q419935","display_name":"Octreotide","level":3,"score":0.8675968647003174},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7428823113441467},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6931419968605042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6290494203567505},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5555009245872498},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5227206349372864},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4736534357070923},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3512321710586548},{"id":"https://openalex.org/C2776297358","wikidata":"https://www.wikidata.org/wiki/Q407166","display_name":"Somatostatin","level":2,"score":0.1423211693763733},{"id":"https://openalex.org/C2779064019","wikidata":"https://www.wikidata.org/wiki/Q66590068","display_name":"Prolactin","level":3,"score":0.13175839185714722},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.1051064133644104},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0944262444972992}],"mesh":[{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000172","descriptor_name":"Acromegaly","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D001971","descriptor_name":"Bromocriptine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013006","descriptor_name":"Growth Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015282","descriptor_name":"Octreotide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.79.2.461","doi":"https://doi.org/10.1210/jc.79.2.461","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.79.2.461","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jcem.79.2.8045964","doi":"https://doi.org/10.1210/jcem.79.2.8045964","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.79.2.8045964","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:8045964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8045964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323260","display_name":"Universitetet i Oslo","ror":"https://ror.org/01xtthb56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W203404296","https://openalex.org/W1553253964","https://openalex.org/W1970258174","https://openalex.org/W1972650975","https://openalex.org/W1982357798","https://openalex.org/W2005614064","https://openalex.org/W2012615488","https://openalex.org/W2017602672","https://openalex.org/W2025997743","https://openalex.org/W2030579930","https://openalex.org/W2038594553","https://openalex.org/W2047702417","https://openalex.org/W2052910600","https://openalex.org/W2066167958","https://openalex.org/W2067868348","https://openalex.org/W2071369211","https://openalex.org/W2083894069","https://openalex.org/W2090065340","https://openalex.org/W2092766569","https://openalex.org/W2156966502","https://openalex.org/W2267726834"],"related_works":["https://openalex.org/W2085276910","https://openalex.org/W2120602690","https://openalex.org/W1997194267","https://openalex.org/W2109654188","https://openalex.org/W2008407034","https://openalex.org/W1982357798","https://openalex.org/W2072909375","https://openalex.org/W2416349777","https://openalex.org/W2078254519","https://openalex.org/W40461728"],"abstract_inverted_index":{"We":[0],"investigated":[1],"the":[2,22,39,90,93,117,155,226,270,291],"pharmacokinetics":[3],"of":[4,21,29,111,166,171,221,228,232,260,265,272,293,300],"bromocriptine":[5,43,73,87,133,180,233,239,268,273],"and":[6,10,32,57,71,74,84,98,108,123,144,164,190,198,210,267,274,278],"octreotide,":[7,301],"both":[8,89,276],"individually":[9],"in":[11,13],"combination,":[12],"12":[14],"patients":[15],"with":[16,243,246,262,285],"active":[17],"acromegaly.":[18],"The":[19,218,230],"pharmacodynamics":[20],"drugs":[23],"were":[24,77,120,127,223,255],"assessed":[25],"by":[26,225,235],"12-h":[27,69],"profiles":[28,76],"GH":[30,94,143,158,189,209,277],"secretion":[31],"insulin-like":[33],"growth":[34],"factor-I":[35],"(IGF-I)":[36],"measurements.":[37],"During":[38,86,114],"42-day":[40],"study":[41],"period,":[42],"was":[44,159,176,240],"administered":[45,241],"for":[46,140,142,150,157,186,188,196,206,208,216],"28":[47],"days":[48,65,80],"(from":[49],"day":[50,95],"8;":[51],"5":[52],"mg,":[53],"orally,":[54],"twice":[55,62],"daily)":[56,63],"octreotide":[58,75,115,199,222,244,266],"(200":[59],"micrograms,":[60],"sc,":[61],"from":[64],"15-42.":[66],"IGF-I":[67,100,167,279],"levels,":[68],"GH,":[70],"plasma":[72],"obtained":[78],"on":[79],"0,":[81],"14,":[82],"28,":[83],"42.":[85],"treatment,":[88,116,154],"area":[91],"under":[92],"curves":[96],"(AUC)":[97],"mean":[99],"decreased":[101],"to":[102,161,168],"64%":[103],"(95%":[104,136,146,182,192,202,212],"confidence":[105,137,147,183,193,203,213],"limits,":[106,138,148,184,194,204,214],"43-72%":[107],"48-82%,":[109],"respectively)":[110],"initial":[112,172],"values.":[113,173],"respective":[118],"values":[119],"23%":[121],"(18-30%)":[122],"32%":[124],"(21-36%),":[125],"which":[126],"greater":[128],"decreases":[129],"than":[130,179,283],"those":[131],"during":[132],"treatment":[134,259,284,305],"[36%":[135],"32-54%)":[139],"AUC":[141,156,187,207],"50%":[145],"34-58%)":[149],"IGF-I].":[151,217],"With":[152],"combined":[153],"reduced":[160],"16%":[162],"(12-21%)":[163],"that":[165],"25%":[169],"(16-27%)":[170],"This":[174,289],"combination":[175,264],"more":[177,281],"effective":[178],"[25%":[181],"22-37%)":[185],"39%":[191],"25-43%)":[195],"IGF-I]":[197],"alone":[200,248],"[78%":[201],"53-89%)":[205],"78%":[211],"57-98%)":[215],"pharmacokinetic":[219],"parameters":[220,254],"unchanged":[224],"coadministration":[227],"bromocriptine.":[229],"bioavailability":[231,271],"increased":[234],"approximately":[236],"40%":[237],"when":[238],"together":[242],"compared":[245],"administration":[247],"(P":[249],"<":[250],"0.01).":[251],"Bromocriptine":[252],"disposition":[253],"unaltered.":[256],"In":[257],"conclusion,":[258],"acromegalics":[261],"a":[263],"increases":[269],"reduces":[275],"levels":[280],"effectively":[282],"either":[286],"drug":[287,296],"alone.":[288],"presents":[290],"possibility":[292],"less":[294],"frequent":[295],"administrations,":[297],"lower":[298,304],"doses":[299],"and,":[302],"consequently,":[303],"costs.":[306]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
