{"id":"https://openalex.org/W2012138688","doi":"https://doi.org/10.3892/ijo.3.5.1011","title":"EVALUATION OF THE ANTINEOPLASTIC ACTIVITIES OF THE RIMINOPHENAZINE AGENTS CLOFAZIMINE AND B669 IN TUMOR-BEARING RATS AND MICE","display_name":"EVALUATION OF THE ANTINEOPLASTIC ACTIVITIES OF THE RIMINOPHENAZINE AGENTS CLOFAZIMINE AND B669 IN TUMOR-BEARING RATS AND MICE","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2012138688","doi":"https://doi.org/10.3892/ijo.3.5.1011","mag":"2012138688","pmid":"https://pubmed.ncbi.nlm.nih.gov/21573467"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.3.5.1011","doi":"https://doi.org/10.3892/ijo.3.5.1011","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.3.5.1011","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111649695","display_name":"CEJ VANRENSBURG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"CEJ VANRENSBURG","raw_affiliation_strings":["NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND","institution_ids":["https://openalex.org/I181231927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081239414","display_name":"Chrisna Durandt","orcid":"https://orcid.org/0000-0002-5679-4669","observed_orcids":["https://orcid.org/0000-0002-5679-4669"]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"C DURANDT","raw_affiliation_strings":["NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND","institution_ids":["https://openalex.org/I181231927"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019040313","display_name":"PJ GARLINSKI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"PJ GARLINSKI","raw_affiliation_strings":["NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND","institution_ids":["https://openalex.org/I181231927"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061910751","display_name":"O'Sullivan Jf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"JF OSULLIVAN","raw_affiliation_strings":["NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NATL UNIV IRELAND UNIV COLL DUBLIN,DEPT CHEM,DUBLIN 4,IRELAND","institution_ids":["https://openalex.org/I181231927"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181231927"],"apc_list":null,"apc_paid":null,"fwci":1.6546,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.81057359,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"5","first_page":"1011","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14275","display_name":"Historical Medical Research and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clofazimine","display_name":"clofazimine","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dmba-induced-mammary-tumors","display_name":"DMBA-induced mammary tumors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2776297342","wikidata":"https://www.wikidata.org/wiki/Q418611","display_name":"Clofazimine","level":3,"score":0.9300293922424316},{"id":"https://openalex.org/C2778938436","wikidata":"https://www.wikidata.org/wiki/Q5205596","display_name":"DMBA","level":4,"score":0.9078991413116455},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6426547765731812},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5512548089027405},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.48198097944259644},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.47567835450172424},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4642316699028015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4517780840396881},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4019516706466675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3864918351173401},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35762032866477966},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2949950695037842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25806790590286255},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18914738297462463},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.18442097306251526},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.11484503746032715},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.3.5.1011","doi":"https://doi.org/10.3892/ijo.3.5.1011","is_oa":false,"landing_page_url":"https://doi.org/10.3892/ijo.3.5.1011","pdf_url":null,"source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:21573467","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21573467","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1546256568","https://openalex.org/W2467509114","https://openalex.org/W4405820281","https://openalex.org/W2424223456","https://openalex.org/W2341689528","https://openalex.org/W2229848528","https://openalex.org/W7017894381","https://openalex.org/W63275489","https://openalex.org/W4281815704","https://openalex.org/W4389426563"],"abstract_inverted_index":{"The":[0],"riminophenazine":[1],"agents":[2],"clofazimine":[3,58],"and":[4,59],"its":[5],"analogue":[6],"B669":[7],"displayed":[8],"anti-tumor":[9],"activity":[10],"at":[11,35],"30":[12],"mg/kg/day":[13,40],"in":[14,53],"benzo[a]pyrene":[15],"(BP)":[16],"induced":[17],"sarcomas":[18],"of":[19,32,57],"mice":[20],"as":[21,23],"well":[22],"dimethylbenz-anthracene":[24],"(DMBA)-induced":[25],"rat":[26],"mammary":[27],"tumors.":[28],"No":[29],"hematological":[30],"toxicity":[31],"these":[33],"drugs":[34],"doses":[36],"up":[37],"to":[38,51],"60":[39],"for":[41],"one":[42],"month":[43],"was":[44],"observed.":[45],"This":[46],"is":[47],"the":[48],"first":[49],"study":[50],"document":[52],"vivo":[54],"anti-neoplastic":[55],"activities":[56],"B669.":[60]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}