{"id":"https://openalex.org/W2012134758","doi":"https://doi.org/10.1021/jm8011799","title":"Prodrugs of Perzinfotel with Improved Oral Bioavailability","display_name":"Prodrugs of Perzinfotel with Improved Oral Bioavailability","publication_year":2009,"publication_date":"2009-01-15","ids":{"openalex":"https://openalex.org/W2012134758","doi":"https://doi.org/10.1021/jm8011799","mag":"2012134758","pmid":"https://pubmed.ncbi.nlm.nih.gov/19146418"},"language":"en","primary_location":{"id":"doi:10.1021/jm8011799","doi":"https://doi.org/10.1021/jm8011799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm8011799","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052065164","display_name":"Reinhardt B Baudy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhardt B. Baudy","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038094973","display_name":"John A. Butera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Butera","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006147441","display_name":"Magid A. Abou-Gharbia","orcid":"https://orcid.org/0000-0001-7524-6011","observed_orcids":["https://orcid.org/0000-0001-7524-6011"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Magid A. Abou-Gharbia","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420468","display_name":"Hong Chen","orcid":"https://orcid.org/0000-0003-3478-6139","observed_orcids":["https://orcid.org/0000-0003-3478-6139","https://orcid.org/0009-0001-5315-1676"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Chen","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112442003","display_name":"Boyd L. Harrison","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boyd Harrison","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051412032","display_name":"Uday Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uday Jain","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017672217","display_name":"Ronald L. Magolda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald Magolda","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035899395","display_name":"Jean Y. Sze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean Y. Sze","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066104695","display_name":"Michael R. Brandt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael R. Brandt","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018168426","display_name":"Terri A. Cummons","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Terri A. Cummons","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065078239","display_name":"Di Kowal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Kowal","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010982846","display_name":"Menelas N. Pangalos","orcid":"https://orcid.org/0000-0001-9783-0956","observed_orcids":["https://orcid.org/0000-0001-9783-0956"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Menelas N. Pangalos","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056851685","display_name":"Bojana Zupan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bojana Zupan","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112762242","display_name":"Matthew Hoffmann","orcid":"https://orcid.org/0000-0002-3440-974X","observed_orcids":["https://orcid.org/0000-0002-3440-974X"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Hoffmann","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael May","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042969090","display_name":"Cheryl P. Mugford","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl Mugford","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044387434","display_name":"Jeffrey D. Kennedy","orcid":"https://orcid.org/0000-0002-8771-4967","observed_orcids":["https://orcid.org/0000-0002-8771-4967"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Kennedy","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032459319","display_name":"Wayne E. Childers","orcid":"https://orcid.org/0000-0003-0527-3684","observed_orcids":["https://orcid.org/0000-0003-0527-3684"]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":null,"type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wayne E. Childers","raw_affiliation_strings":["Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical & Screening Sciences, Wyeth Research, CN-8000, Princeton, New Jersey 08543, Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey, and Wyeth Drug Safety & Metabolism, Collegeville, Pennsylvania","institution_ids":["https://openalex.org/I4403928396"]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5032459319"],"corresponding_institution_ids":["https://openalex.org/I4403928396"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.9721,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.85064785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"52","issue":"3","first_page":"771","last_page":"778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.1388999968767166,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.10379999876022339,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.9269999861717224},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8309999704360962},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8389999866485596},{"id":"https://openalex.org/keywords/inflammatory-pain","display_name":"inflammatory pain","score":0.7369999885559082},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antinociceptive-activity","display_name":"antinociceptive activity","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9428160190582275},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.9366748332977295},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8739646673202515},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7581974267959595},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.7454363107681274},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7301384210586548},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5435987710952759},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.41920533776283264},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2336006462574005},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12853077054023743},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10526809096336365}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001646","descriptor_name":"Bile","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005750","descriptor_name":"Gastric Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005750","descriptor_name":"Gastric Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005750","descriptor_name":"Gastric Juice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D053961","descriptor_name":"Azabicyclo Compounds","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm8011799","doi":"https://doi.org/10.1021/jm8011799","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm8011799","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:19146418","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19146418","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1964030958","https://openalex.org/W1980378724","https://openalex.org/W2027176443","https://openalex.org/W2054341074","https://openalex.org/W2060344358","https://openalex.org/W2067354763","https://openalex.org/W2079404537","https://openalex.org/W2084631926","https://openalex.org/W2087253553","https://openalex.org/W2087454739","https://openalex.org/W2089750922","https://openalex.org/W2095412563","https://openalex.org/W2108999942","https://openalex.org/W2130569324","https://openalex.org/W2160631696","https://openalex.org/W2270130143","https://openalex.org/W2416160527","https://openalex.org/W4250721025","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2056003358","https://openalex.org/W2036303424","https://openalex.org/W2384132825","https://openalex.org/W2385321286","https://openalex.org/W2069835464","https://openalex.org/W2073311134","https://openalex.org/W2314489661","https://openalex.org/W1990788570","https://openalex.org/W2084665561","https://openalex.org/W2147616806"],"abstract_inverted_index":{"Previous":[0],"studies":[1,71],"with":[2,105],"perzinfotel":[3],"(1),":[4],"a":[5,83,97,115,126],"potent,":[6],"selective,":[7],"competitive":[8],"NMDA":[9],"receptor":[10],"antagonist,":[11],"showed":[12],"it":[13],"to":[14,66],"be":[15],"efficacious":[16],"in":[17,55,125],"inflammatory":[18,130],"and":[19,37,49,113],"neuropathic":[20],"pain":[21],"models.":[22],"To":[23],"increase":[24],"the":[25,74,143],"low":[26],"oral":[27,86,100,123],"bioavailability":[28,144],"of":[29,76,79,88,102,118,129,145],"1":[30,67,80,121],"(3-5%),":[31],"prodrug":[32,140],"derivatives":[33],"(3a-h)":[34],"were":[35],"synthesized":[36],"evaluated.":[38],"The":[39],"oxymethylene-spaced":[40,139],"diphenyl":[41],"analogue":[42],"3a":[43,62,89,108],"demonstrated":[44],"good":[45],"stability":[46],"at":[47],"acidic":[48],"neutral":[50],"pH,":[51],"as":[52,54],"well":[53],"simulated":[56],"gastric":[57],"fluid.":[58],"In":[59],"rat":[60],"plasma,":[61],"was":[63,90,109],"rapidly":[64],"converted":[65],"via":[68],"2a.":[69],"Pharmacokinetic":[70],"indicated":[72],"that":[73,94,137],"amount":[75],"systemic":[77],"exposure":[78],"produced":[81,95],"by":[82,96],"10":[84],"mg/kg":[85,99],"dose":[87,101],"2.5-fold":[91],"greater":[92],"than":[93,120],"30":[98],"1.":[103,146],"Consistent":[104],"these":[106,134],"results,":[107],"significantly":[110],"more":[111],"potent":[112],"had":[114],"longer":[116],"duration":[117],"activity":[119],"following":[122],"administration":[124],"rodent":[127],"model":[128],"pain.":[131],"Taken":[132],"together,":[133],"results":[135],"demonstrate":[136],"an":[138],"approach":[141],"increased":[142]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-09T09:14:12.587421","created_date":"2025-10-10T00:00:00"}