{"id":"https://openalex.org/W2012129117","doi":"https://doi.org/10.1038/nrc3640","title":"Tetraspanin proteins promote multiple cancer stages","display_name":"Tetraspanin proteins promote multiple cancer stages","publication_year":2013,"publication_date":"2013-12-23","ids":{"openalex":"https://openalex.org/W2012129117","doi":"https://doi.org/10.1038/nrc3640","mag":"2012129117","pmid":"https://pubmed.ncbi.nlm.nih.gov/24505619"},"language":"en","primary_location":{"id":"doi:10.1038/nrc3640","doi":"https://doi.org/10.1038/nrc3640","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc3640","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2012129117"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044165924","display_name":"Martin E. Hemler","orcid":"https://orcid.org/0000-0002-7218-0173","observed_orcids":["https://orcid.org/0000-0002-7218-0173"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin E. Hemler","raw_affiliation_strings":["Dana\u2013Farber Cancer Institute, Boston, 02215, Massachusetts, USA","Dana-Farber Cancer Institute, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana\u2013Farber Cancer Institute, Boston, 02215, Massachusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Dana-Farber Cancer Institute, Boston, USA","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044165924"],"corresponding_institution_ids":["https://openalex.org/I4210117453"],"apc_list":null,"apc_paid":null,"fwci":4.8158,"has_fulltext":false,"cited_by_count":421,"citation_normalized_percentile":{"value":0.97727273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"14","issue":"1","first_page":"49","last_page":"60"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tetraspanins","display_name":"tetraspanins","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tumor-promotion","display_name":"tumor promotion","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7950000166893005},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.7409999966621399},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/mouse-tumor-model","display_name":"mouse tumor model","score":0.8450000286102295}],"concepts":[{"id":"https://openalex.org/C2777208748","wikidata":"https://www.wikidata.org/wiki/Q24773957","display_name":"Tetraspanin","level":3,"score":0.9978547692298889},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6241295337677002},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6236365437507629},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5872997045516968},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5416778326034546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49855470657348633},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4663267433643341},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4108753800392151},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36439114809036255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09177225828170776}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059470","descriptor_name":"Tetraspanins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D059470","descriptor_name":"Tetraspanins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nrc3640","doi":"https://doi.org/10.1038/nrc3640","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nrc3640","pdf_url":null,"source":{"id":"https://openalex.org/S160464432","display_name":"Nature reviews. Cancer","issn_l":"1474-175X","issn":["1474-175X","1474-1768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Cancer","raw_type":"journal-article"},{"id":"pmid:24505619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24505619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Cancer","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3579377750","display_name":"Support of carcinoma metastasis by integrin a6-CD151-PKC complexes","funder_award_id":"R01CA042368","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":185,"referenced_works":["https://openalex.org/W156564485","https://openalex.org/W224770303","https://openalex.org/W1491388699","https://openalex.org/W1515952044","https://openalex.org/W1529076521","https://openalex.org/W1537880401","https://openalex.org/W1547008859","https://openalex.org/W1555802352","https://openalex.org/W1599923672","https://openalex.org/W1606755376","https://openalex.org/W1611220303","https://openalex.org/W1676754695","https://openalex.org/W1900346306","https://openalex.org/W1908004582","https://openalex.org/W1930568966","https://openalex.org/W1964287760","https://openalex.org/W1966014033","https://openalex.org/W1966177933","https://openalex.org/W1967038940","https://openalex.org/W1967427925","https://openalex.org/W1969986893","https://openalex.org/W1970651122","https://openalex.org/W1971759686","https://openalex.org/W1971874657","https://openalex.org/W1973498127","https://openalex.org/W1974591885","https://openalex.org/W1974931878","https://openalex.org/W1977036616","https://openalex.org/W1978233348","https://openalex.org/W1978806870","https://openalex.org/W1980473926","https://openalex.org/W1981862901","https://openalex.org/W1982299105","https://openalex.org/W1983882927","https://openalex.org/W1984109999","https://openalex.org/W1984885025","https://openalex.org/W1985056244","https://openalex.org/W1985412310","https://openalex.org/W1989097613","https://openalex.org/W1993247439","https://openalex.org/W1997580724","https://openalex.org/W1998459062","https://openalex.org/W1999363076","https://openalex.org/W1999576341","https://openalex.org/W2000293051","https://openalex.org/W2000738994","https://openalex.org/W2002560040","https://openalex.org/W2002942039","https://openalex.org/W2003404530","https://openalex.org/W2003549561","https://openalex.org/W2004471993","https://openalex.org/W2005942119","https://openalex.org/W2007000115","https://openalex.org/W2008076617","https://openalex.org/W2008442497","https://openalex.org/W2013094398","https://openalex.org/W2015700573","https://openalex.org/W2017306734","https://openalex.org/W2018180485","https://openalex.org/W2020459118","https://openalex.org/W2020691341","https://openalex.org/W2021235009","https://openalex.org/W2022739314","https://openalex.org/W2023165881","https://openalex.org/W2023345577","https://openalex.org/W2023606269","https://openalex.org/W2025614160","https://openalex.org/W2025683762","https://openalex.org/W2026700392","https://openalex.org/W2027509786","https://openalex.org/W2027671821","https://openalex.org/W2032194098","https://openalex.org/W2033439473","https://openalex.org/W2034213209","https://openalex.org/W2038998884","https://openalex.org/W2041649971","https://openalex.org/W2042397395","https://openalex.org/W2044682313","https://openalex.org/W2046635810","https://openalex.org/W2047236596","https://openalex.org/W2047394367","https://openalex.org/W2048386264","https://openalex.org/W2049324168","https://openalex.org/W2050615234","https://openalex.org/W2051082229","https://openalex.org/W2052872544","https://openalex.org/W2055584330","https://openalex.org/W2057600239","https://openalex.org/W2058332629","https://openalex.org/W2059812456","https://openalex.org/W2063186096","https://openalex.org/W2065011123","https://openalex.org/W2067259360","https://openalex.org/W2067871959","https://openalex.org/W2070734444","https://openalex.org/W2071685106","https://openalex.org/W2072035809","https://openalex.org/W2072388293","https://openalex.org/W2072467425","https://openalex.org/W2074885850","https://openalex.org/W2078162414","https://openalex.org/W2079278662","https://openalex.org/W2079375104","https://openalex.org/W2079997015","https://openalex.org/W2082225358","https://openalex.org/W2086302029","https://openalex.org/W2086681390","https://openalex.org/W2088020343","https://openalex.org/W2088883508","https://openalex.org/W2088930528","https://openalex.org/W2091603746","https://openalex.org/W2093555572","https://openalex.org/W2096052997","https://openalex.org/W2099338410","https://openalex.org/W2102040455","https://openalex.org/W2102202748","https://openalex.org/W2107203636","https://openalex.org/W2107492957","https://openalex.org/W2107861221","https://openalex.org/W2107967984","https://openalex.org/W2108810465","https://openalex.org/W2108910766","https://openalex.org/W2109718230","https://openalex.org/W2110413857","https://openalex.org/W2111865362","https://openalex.org/W2113552329","https://openalex.org/W2113641572","https://openalex.org/W2114185268","https://openalex.org/W2114579860","https://openalex.org/W2114672913","https://openalex.org/W2115792261","https://openalex.org/W2115963681","https://openalex.org/W2117660132","https://openalex.org/W2118832127","https://openalex.org/W2118876004","https://openalex.org/W2118969537","https://openalex.org/W2120517969","https://openalex.org/W2121273108","https://openalex.org/W2122295858","https://openalex.org/W2124393085","https://openalex.org/W2124744205","https://openalex.org/W2124981584","https://openalex.org/W2125282776","https://openalex.org/W2126037485","https://openalex.org/W2132291337","https://openalex.org/W2132543766","https://openalex.org/W2133152055","https://openalex.org/W2134197339","https://openalex.org/W2134495659","https://openalex.org/W2138106088","https://openalex.org/W2138587586","https://openalex.org/W2139567707","https://openalex.org/W2139855087","https://openalex.org/W2143563593","https://openalex.org/W2144092904","https://openalex.org/W2144936650","https://openalex.org/W2145345239","https://openalex.org/W2146710073","https://openalex.org/W2147971089","https://openalex.org/W2149271515","https://openalex.org/W2149412729","https://openalex.org/W2151754338","https://openalex.org/W2152313975","https://openalex.org/W2152720326","https://openalex.org/W2153219837","https://openalex.org/W2153320683","https://openalex.org/W2153783648","https://openalex.org/W2153840858","https://openalex.org/W2155835218","https://openalex.org/W2158213958","https://openalex.org/W2159800908","https://openalex.org/W2160235573","https://openalex.org/W2163169267","https://openalex.org/W2165688379","https://openalex.org/W2166753067","https://openalex.org/W2167499172","https://openalex.org/W2168438265","https://openalex.org/W2169401333","https://openalex.org/W2187099333","https://openalex.org/W2274019805","https://openalex.org/W2321016452","https://openalex.org/W2328643048","https://openalex.org/W2337074633","https://openalex.org/W2412470478","https://openalex.org/W4230963859"],"related_works":["https://openalex.org/W197286840","https://openalex.org/W1969986893","https://openalex.org/W4407292303","https://openalex.org/W2064608769","https://openalex.org/W4327971510","https://openalex.org/W2803823272","https://openalex.org/W4400829928","https://openalex.org/W2118832127","https://openalex.org/W1978233348","https://openalex.org/W1984109999"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":31},{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":39},{"year":2020,"cited_by_count":40},{"year":2019,"cited_by_count":29},{"year":2018,"cited_by_count":41},{"year":2017,"cited_by_count":46},{"year":2016,"cited_by_count":38},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":23},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}