{"id":"https://openalex.org/W2012128216","doi":"https://doi.org/10.1159/000234095","title":"Susceptibility of Cartilage to Damage by Immunological Inflammation","display_name":"Susceptibility of Cartilage to Damage by Immunological Inflammation","publication_year":2009,"publication_date":"2009-08-05","ids":{"openalex":"https://openalex.org/W2012128216","doi":"https://doi.org/10.1159/000234095","mag":"2012128216","pmid":"https://pubmed.ncbi.nlm.nih.gov/2942490"},"language":"en","primary_location":{"id":"doi:10.1159/000234095","doi":"https://doi.org/10.1159/000234095","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000234095","pdf_url":null,"source":{"id":"https://openalex.org/S4210168027","display_name":"International Archives of Allergy and Applied Immunology","issn_l":"0020-5915","issn":["0020-5915","2571-6662"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Applied Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074797419","display_name":"A. Y. Al-Duaij","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.Y. Al-Duaij","raw_affiliation_strings":["Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012414937","display_name":"F.B. De Brito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F.B. De Brito","raw_affiliation_strings":["Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113379453","display_name":"A. D. Sedgwick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133836048","display_name":"Royal Veterinary College","ror":"https://ror.org/01wka8n18","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I133836048"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A.D. Sedgwick","raw_affiliation_strings":["Department of Pharmacology, The Royal Veterinary College, Hatfield, Herts., UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The Royal Veterinary College, Hatfield, Herts., UK","institution_ids":["https://openalex.org/I133836048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110017513","display_name":"D.L. Scott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.L. Scott","raw_affiliation_strings":["Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012696881","display_name":"D. A. Willoughby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D.A. Willoughby","raw_affiliation_strings":["Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology, St. Bartholomew's Hospital Medical College, London","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.15324452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"80","issue":"4","first_page":"435","last_page":"437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.8759999871253967,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.1160999983549118,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.8820000290870667},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.8309999704360962},{"id":"https://openalex.org/keywords/pertussis-vaccine","display_name":"pertussis vaccine","score":0.8730000257492065},{"id":"https://openalex.org/keywords/air-pouch-model","display_name":"air pouch model","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mononuclear-cell-infiltration","display_name":"mononuclear cell infiltration","score":0.9160000085830688},{"id":"https://openalex.org/keywords/proteoglycan-loss","display_name":"proteoglycan loss","score":0.972000002861023},{"id":"https://openalex.org/keywords/cartilage-damage","display_name":"cartilage damage","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cartilage-implantation","display_name":"cartilage implantation","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7699068784713745},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6822453141212463},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6072574853897095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4850879907608032},{"id":"https://openalex.org/C2909674901","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Cartilage damage","level":5,"score":0.413443386554718},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35869982838630676},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3423672914505005},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.2742162346839905},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.1952010691165924},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.07376641035079956},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001183","descriptor_name":"Arthus Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010567","descriptor_name":"Pertussis Vaccine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000234095","doi":"https://doi.org/10.1159/000234095","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000234095","pdf_url":null,"source":{"id":"https://openalex.org/S4210168027","display_name":"International Archives of Allergy and Applied Immunology","issn_l":"0020-5915","issn":["0020-5915","2571-6662"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Archives of Allergy and Applied Immunology","raw_type":"journal-article"},{"id":"pmid:2942490","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2942490","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International archives of allergy and applied immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W80566703","https://openalex.org/W60146387","https://openalex.org/W2472087089","https://openalex.org/W1666551977","https://openalex.org/W2094577332","https://openalex.org/W2013027311","https://openalex.org/W1976997505","https://openalex.org/W2036725076","https://openalex.org/W1969559716","https://openalex.org/W2026514331"],"abstract_inverted_index":{"Injection":[0],"of":[1,11,22,28,38,40,60],"ovalbumin":[2],"into":[3],"subcutaneous":[4],"air":[5,107],"pouches":[6,39,80,108],"prepared":[7],"on":[8,48,116],"the":[9,16,20,49,96],"backs":[10],"rats":[12,43],"previously":[13],"sensitised":[14,42],"to":[15,85,104,112],"antigen":[17],"resulted":[18,52],"in":[19,53,77,92,106],"induction":[21],"a":[23,32,54,65],"small":[24],"and":[25,56,62],"transient":[26],"accumulation":[27,59],"inflammatory":[29],"fluid":[30,61],"with":[31,44,64,98],"predominantly":[33,66],"polymorph":[34],"cell":[35],"infiltrate.":[36],"Challenge":[37],"appropriately":[41],"Bordetella":[45],"pertussis":[46],"vaccine,":[47],"other":[50],"hand,":[51],"larger":[55],"more":[57],"prolonged":[58],"cells":[63],"mononuclear":[67],"presence.":[68],"When":[69],"intact":[70],"homologous":[71],"femoral":[72],"head":[73],"cartilage":[74,97],"was":[75,83,109],"implanted":[76],"these":[78],"inflamed":[79],"proteoglycan":[81,118],"loss":[82],"found":[84,111],"be":[86,113],"not":[87],"different":[88],"from":[89],"similar":[90],"implants":[91],"non-inflamed":[93],"pouches.":[94],"Coating":[95],"human":[99],"heat-aggregated":[100],"immunoglobulin":[101],"G":[102],"prior":[103],"implantation":[105],"also":[110],"without":[114],"effect":[115],"subsequent":[117],"loss.":[119]},"counts_by_year":[{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
