{"id":"https://openalex.org/W2012121216","doi":"https://doi.org/10.1097/00001813-200503000-00008","title":"Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells","display_name":"Inhibitory effect of norcantharidin, a derivative compound from blister beetles, on tumor invasion and metastasis in CT26 colorectal adenocarcinoma cells","publication_year":2005,"publication_date":"2005-02-03","ids":{"openalex":"https://openalex.org/W2012121216","doi":"https://doi.org/10.1097/00001813-200503000-00008","mag":"2012121216","pmid":"https://pubmed.ncbi.nlm.nih.gov/15711181"},"language":"en","primary_location":{"id":"doi:10.1097/00001813-200503000-00008","doi":"https://doi.org/10.1097/00001813-200503000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001813-200503000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100731675","display_name":"Yu-Jen Chen","orcid":"https://orcid.org/0000-0001-9794-8938","observed_orcids":["https://orcid.org/0000-0001-9794-8938","https://orcid.org/0000-0002-1953-4614"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2802753785","display_name":"Mackay Memorial Hospital","ror":"https://ror.org/015b6az38","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802753785"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Jen Chen","raw_affiliation_strings":["Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Mackay Memorial Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2802753785"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108552887","display_name":"Chwen\u2010Jen Shieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130510345","display_name":"Dayeh University","ror":"https://ror.org/03c6e8r26","country_code":"TW","type":"education","lineage":["https://openalex.org/I130510345"]},{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chwen-Jen Shieh","raw_affiliation_strings":["Department of Bioindustry Technology, Dayeh University, Changhua, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioindustry Technology, Dayeh University, Changhua, Taiwan","institution_ids":["https://openalex.org/I130510345"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013341045","display_name":"Tung\u2010Hu Tsai","orcid":"https://orcid.org/0000-0002-9007-2547","observed_orcids":["https://orcid.org/0000-0002-9007-2547"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]},{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Hu Tsai","raw_affiliation_strings":["Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, National Research Institute of Chinese Medicine, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210094085"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067175625","display_name":"Cheng\u2010Deng Kuo","orcid":"https://orcid.org/0000-0002-3989-1950","observed_orcids":["https://orcid.org/0000-0002-3989-1950"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Deng Kuo","raw_affiliation_strings":["Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111637593","display_name":"Low-Tone Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Low-Tone Ho","raw_affiliation_strings":["Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102743324","display_name":"Tsung\u2010Yun Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tsung-Yun Liu","raw_affiliation_strings":["Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011493063","display_name":"Hui\u2010Fen Liao","orcid":"https://orcid.org/0000-0001-9060-2176","observed_orcids":["https://orcid.org/0000-0001-9060-2176"]},"institutions":[{"id":"https://openalex.org/I183570559","display_name":"National Chiayi University","ror":"https://ror.org/04gknbs13","country_code":"TW","type":"education","lineage":["https://openalex.org/I183570559"]},{"id":"https://openalex.org/I205612303","display_name":"Chinese Culture University","ror":"https://ror.org/04shepe48","country_code":"TW","type":"education","lineage":["https://openalex.org/I205612303"]},{"id":"https://openalex.org/I2803004286","display_name":"Taipei Veterans General Hospital","ror":"https://ror.org/03ymy8z76","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2803004286"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hui-Fen Liao","raw_affiliation_strings":["Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","Department of Molecular Biology and Biochemistry, National Chiayi University, Chaiyi, Taiwan","Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan","Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"Department of Molecular Biology and Biochemistry, National Chiayi University, Chaiyi, Taiwan","institution_ids":["https://openalex.org/I183570559"]},{"raw_affiliation_string":"Graduate Institute of Sport Coaching Science, Chinese Culture University, Taipei, Taiwan","institution_ids":["https://openalex.org/I205612303"]},{"raw_affiliation_string":"Sponsorship: This study was supported by grants 377-1 and 361-4 from Taipei Veterans General Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I2803004286"]},{"raw_affiliation_string":"We would like to dedicate this work to the memory of our advisor, Professor Sheng-Yuan Wang","institution_ids":[]},{"raw_affiliation_string":"to H.-F. Liao, Department of Molecular Biology and Biochemistry, National Chiayi University, 300 University Road, Chiayi 600, Taiwan","institution_ids":["https://openalex.org/I183570559"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5011493063"],"corresponding_institution_ids":["https://openalex.org/I183570559","https://openalex.org/I205612303","https://openalex.org/I2803004286"],"apc_list":null,"apc_paid":null,"fwci":0.7593,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.71682363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"16","issue":"3","first_page":"293","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norcantharidin","display_name":"norcantharidin","score":1.0},{"id":"https://openalex.org/keywords/blister-beetles","display_name":"Meloidae","score":0.9750000238418579},{"id":"https://openalex.org/keywords/colorectal-adenocarcinoma","display_name":"colorectal adenocarcinoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/ct26-cells","display_name":"CT26 cells","score":0.9359999895095825},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9890000224113464},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9670000076293945},{"id":"https://openalex.org/keywords/desmoglein","display_name":"desmoglein","score":0.9200000166893005},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.996999979019165},{"id":"https://openalex.org/keywords/alpha-catenin","display_name":"alpha-catenin","score":0.7429999709129333},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8610000014305115}],"concepts":[{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6704702377319336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5361957550048828},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4987185001373291},{"id":"https://openalex.org/C2780906345","wikidata":"https://www.wikidata.org/wiki/Q410884","display_name":"Cantharidin","level":2,"score":0.49267011880874634},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.48767340183258057},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.47805219888687134},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.47389450669288635},{"id":"https://openalex.org/C185946421","wikidata":"https://www.wikidata.org/wiki/Q3146527","display_name":"ICAM-1","level":3,"score":0.4617479145526886},{"id":"https://openalex.org/C149402561","wikidata":"https://www.wikidata.org/wiki/Q24776048","display_name":"Cadherin","level":3,"score":0.45552074909210205},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.43917906284332275},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43828973174095154},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.380468487739563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3773190379142761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3378438949584961},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2794552445411682},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.27762407064437866},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23176926374435425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2071702480316162},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20550104975700378},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020778","descriptor_name":"Matrix Metalloproteinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061965","descriptor_name":"Matrix Metalloproteinase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/00001813-200503000-00008","doi":"https://doi.org/10.1097/00001813-200503000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001813-200503000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S158028025","display_name":"Anti-Cancer Drugs","issn_l":"0959-4973","issn":["0959-4973","1473-5741"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-Cancer Drugs","raw_type":"journal-article"},{"id":"pmid:15711181","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15711181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anti-cancer drugs","raw_type":"Journal Article"},{"id":"pmh:oai:https://irlib.pccu.edu.tw/:987654321/2402","doi":null,"is_oa":false,"landing_page_url":"https://irlib.pccu.edu.tw//handle/987654321/2402","pdf_url":null,"source":{"id":"https://openalex.org/S7407064331","display_name":"Chinese Culture University Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1964835379","https://openalex.org/W1974917142","https://openalex.org/W1984642803","https://openalex.org/W1989862901","https://openalex.org/W1990015831","https://openalex.org/W1995022664","https://openalex.org/W2027880353","https://openalex.org/W2038591527","https://openalex.org/W2038741264","https://openalex.org/W2042145715","https://openalex.org/W2069969595","https://openalex.org/W2088536713","https://openalex.org/W2088929622","https://openalex.org/W2095315800","https://openalex.org/W2142904922","https://openalex.org/W2146278165","https://openalex.org/W2157233598","https://openalex.org/W2166127140","https://openalex.org/W2183148396","https://openalex.org/W2261754245","https://openalex.org/W2409983089","https://openalex.org/W2470192113"],"related_works":["https://openalex.org/W7137414172","https://openalex.org/W3083667025","https://openalex.org/W2377105342","https://openalex.org/W2024028023","https://openalex.org/W2376464158","https://openalex.org/W2021769394","https://openalex.org/W2946732098","https://openalex.org/W2045002831","https://openalex.org/W2183148396","https://openalex.org/W7030509108"],"abstract_inverted_index":{"Norcantharidin":[0],"(NCTD),":[1],"a":[2,40,81,85,92],"potential":[3],"anti-cancer":[4],"drug,":[5],"is":[6],"the":[7,20,65,74,127,136,140],"demethylated":[8],"analog":[9],"of":[10,22,32,60,67,77,87,94,118,131,139],"cantharidin":[11],"isolated":[12],"from":[13],"blister":[14],"beetles.":[15],"The":[16],"present":[17],"study":[18],"investigated":[19],"effect":[21],"NCTD":[23,33,48,72,90,119],"on":[24],"tumor":[25,152],"invasion":[26,59,153],"and":[27,42,70,102,104,114,134,154],"metastasis.":[28,155],"A":[29],"cytotoxicity":[30],"assay":[31],"in":[34,45,80,112,122,149],"CT26":[35,51,78,132],"colorectal":[36],"adenocarcinoma":[37],"cells":[38,52,79,133],"showed":[39,55,91],"dose-":[41],"time-dependent":[43],"decrease":[44],"cell":[46,58],"viability.":[47],"(50":[49],"microM)-treated":[50],"not":[53],"only":[54],"an":[56],"inhibited":[57],"65.6%,":[61],"but":[62],"also":[63],"decreased":[64,73],"activity":[66],"matrix":[68],"metalloproteinase-2":[69],"-9.":[71],"adhesive":[75],"ability":[76],"dose-dependent":[82],"manner.":[83],"At":[84],"concentration":[86],"100":[88],"microM,":[89],"down-expression":[93],"several":[95],"cadherin-catenin":[96],"adhesion":[97],"molecules,":[98],"including":[99],"Desmoglein,":[100],"N-cadherin,":[101],"alpha-":[103],"beta-catenin,":[105],"while":[106],"there":[107],"were":[108],"no":[109],"obvious":[110],"changes":[111],"E-cadherin":[113],"gamma-catenin.":[115],"Intraperitoneal":[116],"injection":[117],"(2":[120],"mg/kg/day)":[121],"BALB/c":[123],"mice":[124],"reduced":[125],"both":[126,151],"pulmonary":[128],"metastatic":[129],"capacity":[130],"prolonged":[135],"survival":[137],"day":[138],"mice.":[141],"These":[142],"results":[143],"demonstrated":[144],"that":[145],"it":[146],"was":[147],"effective":[148],"blocking":[150]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
