{"id":"https://openalex.org/W2012120561","doi":"https://doi.org/10.1002/ar.a.20063","title":"Age\u2010related expression patterns of Bag\u20101 and Bcl\u20102 in growth plate and articular chondrocytes","display_name":"Age\u2010related expression patterns of Bag\u20101 and Bcl\u20102 in growth plate and articular chondrocytes","publication_year":2004,"publication_date":"2004-07-03","ids":{"openalex":"https://openalex.org/W2012120561","doi":"https://doi.org/10.1002/ar.a.20063","mag":"2012120561","pmid":"https://pubmed.ncbi.nlm.nih.gov/15278942"},"language":"en","primary_location":{"id":"doi:10.1002/ar.a.20063","doi":"https://doi.org/10.1002/ar.a.20063","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ar.a.20063","pdf_url":null,"source":{"id":"https://openalex.org/S4210227131","display_name":"The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology","issn_l":"1552-4884","issn":["1552-4884","1552-4892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068006975","display_name":"Mary D. Kinkel","orcid":"https://orcid.org/0000-0002-1726-8842","observed_orcids":["https://orcid.org/0000-0002-1726-8842"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary D. Kinkel","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA. wehj@neoucom.edu","Department of Anatomy Northeastern Ohio Universities College of Medicine Rootstown, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA. wehj@neoucom.edu","institution_ids":["https://openalex.org/I95240055"]},{"raw_affiliation_string":"Department of Anatomy Northeastern Ohio Universities College of Medicine Rootstown, Ohio","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113650041","display_name":"Rieko Yagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rieko Yagi","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111728384","display_name":"Denise L. McBurney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise McBurney","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057610123","display_name":"Ashleigh E. Nugent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashleigh Nugent","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010132216","display_name":"Walter E. Horton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Walter E. Horton","raw_affiliation_strings":["","Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010132216"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":null,"apc_paid":null,"fwci":1.5507,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.812674,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"279A","issue":"2","first_page":"720","last_page":"728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bag-1","display_name":"BAG-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":1.0},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8190000057220459},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"articular cartilage","score":0.8539999723434448},{"id":"https://openalex.org/keywords/growth-plate","display_name":"growth plate","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cartilage-aging","display_name":"cartilage aging","score":0.9649999737739563},{"id":"https://openalex.org/keywords/chondrocyte-apoptosis","display_name":"chondrocyte apoptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/chondrocyte-phenotype","display_name":"chondrocyte phenotype","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chondrocyte-proliferation","display_name":"chondrocyte proliferation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/age-related-gene-expression","display_name":"age-related gene expression","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.918692946434021},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7594990134239197},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6764040589332581},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6207578778266907},{"id":"https://openalex.org/C2778486617","wikidata":"https://www.wikidata.org/wiki/Q18031654","display_name":"SOX9","level":4,"score":0.549017071723938},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.5466452836990356},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5083350539207458},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4613277018070221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4449653625488281},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3248615264892578},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2761177718639374},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.26116639375686646},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24757879972457886},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18230819702148438},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.16908088326454163},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11779698729515076},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10357266664505005},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006132","descriptor_name":"Growth Plate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ar.a.20063","doi":"https://doi.org/10.1002/ar.a.20063","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ar.a.20063","pdf_url":null,"source":{"id":"https://openalex.org/S4210227131","display_name":"The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology","issn_l":"1552-4884","issn":["1552-4884","1552-4892"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology","raw_type":"journal-article"},{"id":"pmid:15278942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15278942","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2959086559","display_name":null,"funder_award_id":"R01 AR 46459-02","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8298432324","display_name":"THE ROLE OF BCL2 PROTEINS IN CHONDROCYTE BIOLOGY","funder_award_id":"5r01ar046459-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W4996342","https://openalex.org/W1572735583","https://openalex.org/W1907188384","https://openalex.org/W1961585483","https://openalex.org/W1966460840","https://openalex.org/W1973060929","https://openalex.org/W1973357104","https://openalex.org/W1978177900","https://openalex.org/W1987956070","https://openalex.org/W1991625786","https://openalex.org/W2000421661","https://openalex.org/W2003756602","https://openalex.org/W2014099971","https://openalex.org/W2021177398","https://openalex.org/W2025270890","https://openalex.org/W2025958196","https://openalex.org/W2026314272","https://openalex.org/W2029583335","https://openalex.org/W2033466746","https://openalex.org/W2033890820","https://openalex.org/W2037513263","https://openalex.org/W2040744953","https://openalex.org/W2043479687","https://openalex.org/W2043694234","https://openalex.org/W2047878418","https://openalex.org/W2059233081","https://openalex.org/W2065151410","https://openalex.org/W2069941770","https://openalex.org/W2070935430","https://openalex.org/W2076867477","https://openalex.org/W2080889643","https://openalex.org/W2089874268","https://openalex.org/W2106133208","https://openalex.org/W2108740080","https://openalex.org/W2123883459","https://openalex.org/W2135636594","https://openalex.org/W2142581396","https://openalex.org/W2146828040","https://openalex.org/W2170335058","https://openalex.org/W2317350790","https://openalex.org/W4229954146"],"related_works":["https://openalex.org/W2145283482","https://openalex.org/W2005394663","https://openalex.org/W2109914347","https://openalex.org/W2070935430","https://openalex.org/W2065151410","https://openalex.org/W2089874268","https://openalex.org/W2436627941","https://openalex.org/W2018713088","https://openalex.org/W2523881372","https://openalex.org/W2043479687"],"abstract_inverted_index":{"Aging":[0],"cartilage":[1,167],"displays":[2],"increased":[3],"chondrocyte":[4,60,164],"apoptosis":[5,67],"and":[6,42,53,62,66,88,110,130,166],"decreased":[7],"responsiveness":[8],"of":[9,39,68,77,127,163],"chondrocytes":[10,90],"to":[11,117],"growth":[12,86,100,151],"factors.":[13],"The":[14],"molecular":[15],"mechanisms":[16],"responsible":[17],"for":[18,58,122],"these":[19],"changes":[20],"have":[21],"not":[22],"been":[23,120],"identified.":[24],"Bag-1":[25,78,96,102,131,145,157],"is":[26,56,72,104,158],"a":[27,36,114,148],"Bcl-2-binding":[28],"protein":[29],"that":[30,84,142,156],"promotes":[31],"cell":[32,50],"survival,":[33,51],"interacts":[34],"with":[35,133],"diverse":[37],"group":[38],"cellular":[40],"proteins,":[41],"may":[43],"integrate":[44],"multiple":[45],"pathways":[46],"involved":[47,159],"in":[48,79,91,106,135,150,160],"controlling":[49],"growth,":[52],"phenotype.":[54],"Bcl-2":[55,129],"important":[57],"maintaining":[59],"phenotype":[61,165],"delaying":[63],"terminal":[64],"differentiation":[65],"chondrocytes.":[69],"Comparatively":[70],"little":[71],"known":[73],"about":[74],"the":[75,92,95,99,107,125,136,161],"role":[76],"cartilage.":[80,138],"Here":[81],"we":[82],"show":[83],"both":[85,128],"plate":[87],"articular":[89,137],"mouse":[93],"express":[94],"protein.":[97],"In":[98],"plate,":[101],"expression":[103,126,146],"prominent":[105],"late":[108],"proliferative":[109],"prehypertrophic":[111],"chondrocytes,":[112],"displaying":[113],"pattern":[115],"similar":[116],"what":[118],"has":[119],"reported":[121],"Bcl-2.":[123],"Further,":[124],"declines":[132],"age":[134],"Growth":[139],"assays":[140],"demonstrate":[141],"knocking":[143],"down":[144],"causes":[147],"decrease":[149],"rate.":[152],"These":[153],"results":[154],"suggest":[155],"regulation":[162],"aging.":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}