{"id":"https://openalex.org/W2012115247","doi":"https://doi.org/10.1074/jbc.m109.020933","title":"Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response","display_name":"Scavenger Receptor BI Protects against Septic Death through Its Role in Modulating Inflammatory Response","publication_year":2009,"publication_date":"2009-06-03","ids":{"openalex":"https://openalex.org/W2012115247","doi":"https://doi.org/10.1074/jbc.m109.020933","mag":"2012115247","pmid":"https://pubmed.ncbi.nlm.nih.gov/19491399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2740408"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m109.020933","doi":"https://doi.org/10.1074/jbc.m109.020933","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020933","pdf_url":"http://www.jbc.org/article/S0021925817492660/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925817492660/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101711971","display_name":"Ling Guo","orcid":"https://orcid.org/0000-0003-1573-7382","observed_orcids":["https://orcid.org/0000-0003-1573-7382"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ling Guo","raw_affiliation_strings":["Department of Pediatrics, University of Kentucky Medical School, Lexington, Kentucky 40536, USA","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Kentucky Medical School, Lexington, Kentucky 40536, USA","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020184727","display_name":"Zhiqing Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhiqing Song","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643011","display_name":"Mengting Li","orcid":"https://orcid.org/0000-0001-6867-1052","observed_orcids":["https://orcid.org/0000-0001-6867-1052"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengting Li","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Qingan Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingan Wu","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411793","display_name":"Dan Wang","orcid":"https://orcid.org/0000-0002-0646-7141","observed_orcids":["https://orcid.org/0000-0002-0646-7141"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Wang","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Feng","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112105777","display_name":"Philip A. Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip Bernard","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079061954","display_name":"Alan Daugherty","orcid":"https://orcid.org/0000-0003-2093-3775","observed_orcids":["https://orcid.org/0000-0003-2093-3775"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Daugherty","raw_affiliation_strings":["Department of Internal Medicine, University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060777324","display_name":"Bin Huang","orcid":"https://orcid.org/0000-0002-9075-1531","observed_orcids":["https://orcid.org/0000-0002-9075-1531"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Huang","raw_affiliation_strings":["Kentucky Cancer Registry, University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kentucky Cancer Registry, University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102972256","display_name":"Xiang\u2010An Li","orcid":"https://orcid.org/0000-0002-6899-7332","observed_orcids":["https://orcid.org/0000-0002-6899-7332"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiang-An Li","raw_affiliation_strings":["Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","Department of Pediatrics","University of Kentucky Medical School, Lexington, Kentucky 40536"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics; University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Pediatrics","institution_ids":[]},{"raw_affiliation_string":"University of Kentucky Medical School, Lexington, Kentucky 40536","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5102972256"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":6.2467,"has_fulltext":true,"cited_by_count":107,"citation_normalized_percentile":{"value":0.96428571,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"284","issue":"30","first_page":"19826","last_page":"19834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8500999808311462,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.11079999804496765,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scavenger-receptor-bi","display_name":"scavenger receptor BI","score":0.9509999752044678},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.984000027179718},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.699999988079071},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7720000147819519},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.9129999876022339},{"id":"https://openalex.org/keywords/high-density-lipoprotein-receptor","display_name":"high-density lipoprotein receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sepsis-mortality","display_name":"sepsis mortality","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.7634997367858887},{"id":"https://openalex.org/C41443022","wikidata":"https://www.wikidata.org/wiki/Q27796666","display_name":"Scavenger receptor","level":4,"score":0.6986491680145264},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6661295294761658},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5379842519760132},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5061067938804626},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.467684805393219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.403954416513443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3923298120498657},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34595370292663574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32026195526123047},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.11819100379943848},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.04812392592430115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003345","descriptor_name":"Corticosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051122","descriptor_name":"Scavenger Receptors, Class B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.m109.020933","doi":"https://doi.org/10.1074/jbc.m109.020933","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020933","pdf_url":"http://www.jbc.org/article/S0021925817492660/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:19491399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19491399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2740408","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2740408/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m109.020933","doi":"https://doi.org/10.1074/jbc.m109.020933","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m109.020933","pdf_url":"http://www.jbc.org/article/S0021925817492660/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2142382651","display_name":"Center of Research in Obesity and Cardiovascular Disease (1P20 RR021954-01A1)","funder_award_id":"P20RR021954","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2210379418","display_name":null,"funder_award_id":"0530241N","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G4797731823","display_name":"Center of Biomedical Research Excellence- Women's Health","funder_award_id":"P20RR015592","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5161234890","display_name":null,"funder_award_id":"2P0RR015592","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G989448801","display_name":"Role of SR-BI in LPS detoxification","funder_award_id":"R01GM085231","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320318046","display_name":"Children's Miracle Network Hospitals","ror":"https://ror.org/02ksjb929"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012115247.pdf","grobid_xml":"https://content.openalex.org/works/W2012115247.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1514452974","https://openalex.org/W1588516858","https://openalex.org/W1821918060","https://openalex.org/W1965983458","https://openalex.org/W1976455881","https://openalex.org/W1977504620","https://openalex.org/W1983588728","https://openalex.org/W1985170971","https://openalex.org/W1987525850","https://openalex.org/W2005797047","https://openalex.org/W2015569104","https://openalex.org/W2018557879","https://openalex.org/W2018788678","https://openalex.org/W2020892886","https://openalex.org/W2037299442","https://openalex.org/W2037363239","https://openalex.org/W2040915824","https://openalex.org/W2044894291","https://openalex.org/W2046921036","https://openalex.org/W2047057336","https://openalex.org/W2049927822","https://openalex.org/W2052067930","https://openalex.org/W2055948530","https://openalex.org/W2062297873","https://openalex.org/W2065699321","https://openalex.org/W2066736055","https://openalex.org/W2072051243","https://openalex.org/W2073308465","https://openalex.org/W2081293223","https://openalex.org/W2085333465","https://openalex.org/W2087051893","https://openalex.org/W2088220499","https://openalex.org/W2096478292","https://openalex.org/W2098958062","https://openalex.org/W2110600904","https://openalex.org/W2129319296","https://openalex.org/W2130086266","https://openalex.org/W2145532583","https://openalex.org/W2145577370","https://openalex.org/W2156818917","https://openalex.org/W2161419248","https://openalex.org/W2164724187","https://openalex.org/W2169144885","https://openalex.org/W2169283243","https://openalex.org/W2169914332","https://openalex.org/W4234317413"],"related_works":["https://openalex.org/W72707951","https://openalex.org/W1989192104","https://openalex.org/W2307952032","https://openalex.org/W73366008","https://openalex.org/W4405418459","https://openalex.org/W7140207754","https://openalex.org/W2018767491","https://openalex.org/W7160293302","https://openalex.org/W2127324544","https://openalex.org/W3171180083"],"abstract_inverted_index":{"Sepsis":[0],"is":[1,8,29,215],"a":[2,24,30,165,216],"leading":[3],"cause":[4],"of":[5,34,80,104,119,124,153,173,196,220],"death":[6],"that":[7,19,151,213],"characterized":[9],"by":[10],"uncontrolled":[11],"inflammatory":[12,69,73,85,108,120,167,234],"response.":[13],"In":[14,208],"this":[15],"study,":[16],"we":[17,100,149,169],"report":[18],"scavenger":[20],"receptor":[21],"BI":[22],"(SR-BI),":[23],"high":[25],"density":[26],"lipoprotein":[27],"receptor,":[28],"critical":[31,217],"survival":[32],"factor":[33],"sepsis.":[35,179],"We":[36],"induced":[37,51],"sepsis":[38,81,197,221],"using":[39],"an":[40,145],"established":[41],"septic":[42,142],"animal":[43],"model,":[44],"cecal":[45],"ligation":[46],"and":[47,82,198,238,242],"puncture":[48],"(CLP).":[49],"CLP":[50,91,206],"100%":[52],"fatality":[53,60],"in":[54,61,128,192,222,232,236],"SR-BI-null":[55,65,113,162,185],"mice":[56,66,114,134,163,186],"but":[57],"only":[58],"21%":[59],"wild":[62,125,182],"type":[63,126,183],"littermates.":[64],"exhibited":[67],"aberrant":[68],"responses":[70],"with":[71,181],"delayed":[72,166],"cytokine":[74,86,109],"generation":[75],"at":[76],"the":[77,95,102,171,193],"early":[78,194],"stage":[79,195],"highly":[83],"elevated":[84,199],"production":[87],"20":[88,203],"h":[89,204],"after":[90],"treatment.":[92,207],"To":[93,159],"understand":[94,160],"mechanisms":[96],"underlying":[97],"SR-BI":[98,106,136,154,174,214,224],"protection,":[99],"elucidated":[101,170],"effect":[103,172],"macrophage":[105],"on":[107,175],"generation.":[110],"Macrophages":[111],"from":[112],"produced":[115],"significantly":[116],"higher":[117],"levels":[118,191,202],"cytokines":[121],"than":[122],"those":[123],"controls":[127],"response":[129,235],"to":[130,140],"LPS.":[131],"Importantly,":[132],"transgenic":[133],"overexpressing":[135],"were":[137],"more":[138],"resistant":[139],"CLP-induced":[141],"death.":[143],"Using":[144],"HEK-Blue(TM)":[146],"cell":[147],"system,":[148],"demonstrated":[150],"expression":[152],"suppressed":[155],"TLR4-mediated":[156],"NF-kappaB":[157],"activation.":[158],"why":[161],"had":[164,187],"response,":[168],"LPS":[176,190,201,240],"clearance":[177],"during":[178],"Compared":[180],"controls,":[184],"lower":[188],"plasma":[189,200],"following":[205],"conclusion,":[209],"our":[210],"findings":[211],"demonstrate":[212],"protective":[218,227],"modulator":[219],"mice.":[223],"exerts":[225],"its":[226,230],"function":[228],"through":[229],"role":[231],"modulating":[233],"macrophages":[237],"facilitating":[239],"recruitment":[241],"clearance.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}