{"id":"https://openalex.org/W2012111032","doi":"https://doi.org/10.1097/00006231-199607000-00012","title":"Influence of size of regions of interest on the measurement of uptake of 123I-\u03b1-methyl tyrosine by brain tumours","display_name":"Influence of size of regions of interest on the measurement of uptake of 123I-\u03b1-methyl tyrosine by brain tumours","publication_year":1996,"publication_date":"1996-07-01","ids":{"openalex":"https://openalex.org/W2012111032","doi":"https://doi.org/10.1097/00006231-199607000-00012","mag":"2012111032","pmid":"https://pubmed.ncbi.nlm.nih.gov/8843121"},"language":"en","primary_location":{"id":"doi:10.1097/00006231-199607000-00012","doi":"https://doi.org/10.1097/00006231-199607000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006231-199607000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077009005","display_name":"Torsten Kuwert","orcid":"https://orcid.org/0000-0001-5682-8139","observed_orcids":["https://orcid.org/0000-0001-5682-8139"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"T. KUWERT","raw_affiliation_strings":["Department of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","Nuclear Medicine and","to T. Kuwert, Department of Nuclear Medicine, WWU M\u00fcnster, Albert-Schweitzer-Str. 33, 48129 M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Nuclear Medicine and","institution_ids":[]},{"raw_affiliation_string":"to T. Kuwert, Department of Nuclear Medicine, WWU M\u00fcnster, Albert-Schweitzer-Str. 33, 48129 M\u00fcnster, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047256387","display_name":"Carlo Morgenroth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C. MORGENROTH","raw_affiliation_strings":["Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053677286","display_name":"Burkhard Woesler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. WOESLER","raw_affiliation_strings":["Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040744664","display_name":"Peter Matheja","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. MATHEJA","raw_affiliation_strings":["Nuclear Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113589922","display_name":"Stefan Palkovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. PALKOVIC","raw_affiliation_strings":["Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056770720","display_name":"Bernhard Vollet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. VOLLET","raw_affiliation_strings":["Nuclear Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028012490","display_name":"Michael Andreas Sch\u00e4fers","orcid":"https://orcid.org/0000-0002-4008-2755","observed_orcids":["https://orcid.org/0000-0002-4008-2755"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. SCH\u00c4FERS","raw_affiliation_strings":["Nuclear Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007279505","display_name":"HANDSDETLEF WASSMANN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. WASSMANN","raw_affiliation_strings":["Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany","institution_ids":["https://openalex.org/I22465464"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110388420","display_name":"Otmar Schober","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"O. SCHOBER","raw_affiliation_strings":["Nuclear Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077009005"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":null,"apc_paid":null,"fwci":2.2509,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86573062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"7","first_page":"609","last_page":"615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9775000214576721,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/region-of-interest","display_name":"region of interest","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tumor-uptake","display_name":"tumor uptake","score":0.4830000102519989},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8629999756813049},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.996999979019165},{"id":"https://openalex.org/keywords/benign-brain-tumors","display_name":"benign brain tumors","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tumor-grade","display_name":"tumor grade","score":0.4099999964237213},{"id":"https://openalex.org/keywords/significance-testing","display_name":"significance testing","score":0.37599998712539673},{"id":"https://openalex.org/keywords/spect-imaging","display_name":"SPECT imaging","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6449298858642578},{"id":"https://openalex.org/C2779190346","wikidata":"https://www.wikidata.org/wiki/Q3801335","display_name":"Iodine-123","level":2,"score":0.6378039717674255},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5714340209960938},{"id":"https://openalex.org/C12868164","wikidata":"https://www.wikidata.org/wiki/Q1424533","display_name":"Mann\u2013Whitney U test","level":2,"score":0.5515900254249573},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.5427108407020569},{"id":"https://openalex.org/C19609008","wikidata":"https://www.wikidata.org/wiki/Q2138203","display_name":"Region of interest","level":2,"score":0.4840823709964752},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.4624175727367401},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4198523759841919},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3272705078125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2887696623802185},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.278315007686615},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0972551703453064}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007457","descriptor_name":"Iodine Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008579","descriptor_name":"Meningioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008781","descriptor_name":"Methyltyrosines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009837","descriptor_name":"Oligodendroglioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018315","descriptor_name":"Glioma, Subependymal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00006231-199607000-00012","doi":"https://doi.org/10.1097/00006231-199607000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00006231-199607000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S108023290","display_name":"Nuclear Medicine Communications","issn_l":"0143-3636","issn":["0143-3636","1473-5628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear Medicine Communications","raw_type":"journal-article"},{"id":"pmid:8843121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8843121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nuclear medicine communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1965662896","https://openalex.org/W2057057993","https://openalex.org/W1576024548","https://openalex.org/W2013418540","https://openalex.org/W2006278031","https://openalex.org/W2117044004","https://openalex.org/W1939797249","https://openalex.org/W2096119582","https://openalex.org/W1992814170","https://openalex.org/W2028984033"],"abstract_inverted_index":{"The":[0,183],"aim":[1],"of":[2,10,15,17,26,38,40,44,83,131,138,179,186,212],"this":[3,155,230],"study":[4],"was":[5,60,77,144],"to":[6,34,165,227],"assess":[7],"the":[8,13,36,84,118,139,180,190],"influence":[9,37],"variations":[11,228],"in":[12,23,48,62,202,216,229],"size":[14,39,143],"regions":[16],"interest":[18],"(ROIs)":[19],"on":[20,42,208],"uptake":[21,51,59,122,159,173,200,218],"values":[22,123,130,160,201],"brain":[24,66,99,203],"tumours":[25,67,168,176,204,223],"L-3-iodine-123-alpha-methyl":[27],"tyrosine":[28],"(IMT).":[29],"In":[30],"addition,":[31],"we":[32],"attempted":[33],"establish":[35],"ROIs":[41,110],"levels":[43,185,211],"significance":[45,187,213],"assessing":[46,214],"differences":[47,215],"mean":[49],"IMT":[50,58,158,172,199,217],"between":[52,194,219],"high-grade":[53,88,220],"and":[54,95,136,150,196,221],"low-grade":[55,105,175,222],"tumours.":[56],"Relative":[57],"determined":[61],"19":[63],"patients":[64,103],"with":[65,104],"using":[68,189],"a":[69],"MULTISPECT":[70],"3":[71],"triple-headed":[72],"camera.":[73],"Reconstructed":[74],"image":[75],"resolution":[76],"14":[78],"mm":[79],"at":[80,177],"FWHM.":[81],"Ten":[82],"subjects":[85],"suffered":[86],"from":[87,97,163],"gliomas":[89,106],"(WHO":[90,107],"grade":[91,108],"III":[92],"or":[93],"IV)":[94],"nine":[96],"benign":[98],"tumours,":[100],"including":[101],"eight":[102],"II).":[109],"were":[111,193],"defined":[112],"by":[113],"selecting":[114],"those":[115],"pixels":[116],"within":[117],"tumour":[119],"that":[120],"exhibited":[121,169],"above":[124],"predefined":[125],"threshold":[126,129,181],"values.":[127,182],"Using":[128],"100,":[132],"95,":[133],"90,":[134],"85":[135],"80%":[137],"mean,":[140,157],"transaxial":[141],"ROI":[142,209],"approximately":[145],"0.1,":[146],"2.8,":[147],"4.3,":[148],"6.2":[149],"8.8":[151],"cm2,":[152],"respectively.":[153],"Over":[154],"range,":[156],"decreased":[161],"significantly":[162,170,206],"2.4":[164],"1.9.":[166],"High-grade":[167],"higher":[171],"than":[174],"each":[178],"corresponding":[184],"calculated":[188],"Mann-Whitney":[191],"U-test":[192],"0.01":[195],"0.02.":[197],"Although":[198],"are":[205,224],"dependent":[207],"size,":[210],"relatively":[225],"insensitive":[226],"parameter.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}