{"id":"https://openalex.org/W2012104985","doi":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","title":"Acquired von Willebrand's disease: demonstration of a circulating inhibitor to the factor VIII complex in four cases","display_name":"Acquired von Willebrand's disease: demonstration of a circulating inhibitor to the factor VIII complex in four cases","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W2012104985","doi":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","mag":"2012104985","pmid":"https://pubmed.ncbi.nlm.nih.gov/6405778"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2141.1983.tb02091.x","doi":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041112172","display_name":"B. Sampson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barbara M. Sampson","raw_affiliation_strings":["Department of Haematology, Royal Hallamshire Hospital, Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Hallamshire Hospital, Sheffield","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110154091","display_name":"Mike Greaves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M. Greaves","raw_affiliation_strings":["Department of Haematology, Royal Hallamshire Hospital, Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Hallamshire Hospital, Sheffield","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108398556","display_name":"R G Mal\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. G. Malia","raw_affiliation_strings":["Department of Haematology, Royal Hallamshire Hospital, Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Hallamshire Hospital, Sheffield","institution_ids":["https://openalex.org/I2801732343"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112772747","display_name":"F E Preston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801732343","display_name":"Royal Hallamshire Hospital","ror":"https://ror.org/00514rc81","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801732343","https://openalex.org/I4210102902"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F. E. Preston","raw_affiliation_strings":["Department of Haematology, Royal Hallamshire Hospital, Sheffield"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, Royal Hallamshire Hospital, Sheffield","institution_ids":["https://openalex.org/I2801732343"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110154091"],"corresponding_institution_ids":["https://openalex.org/I2801732343"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":2.827,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.90708146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"54","issue":"2","first_page":"233","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.2321999967098236,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acquired-von-willebrand-syndrome","display_name":"acquired von Willebrand syndrome","score":0.968999981880188},{"id":"https://openalex.org/keywords/factor-viii-inhibitors","display_name":"factor VIII inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/ristocetin-cofactor-activity","display_name":"ristocetin cofactor activity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/igg-fraction","display_name":"IgG fraction","score":0.7229999899864197},{"id":"https://openalex.org/keywords/monoclonal-gammopathy","display_name":"monoclonal gammopathy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hemorrhagic-diathesis","display_name":"bleeding tendency","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.7581372261047363},{"id":"https://openalex.org/C2778780528","wikidata":"https://www.wikidata.org/wiki/Q709360","display_name":"Von Willebrand disease","level":4,"score":0.598644495010376},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5194275379180908},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5080771446228027},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48561230301856995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3056131601333618},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.29137688875198364}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005169","descriptor_name":"Factor VIII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012310","descriptor_name":"Ristocetin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014842","descriptor_name":"von Willebrand Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2141.1983.tb02091.x","doi":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2141.1983.tb02091.x","pdf_url":null,"source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:6405778","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6405778","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W71404268","https://openalex.org/W114075343","https://openalex.org/W230817699","https://openalex.org/W1981239145","https://openalex.org/W1982525084","https://openalex.org/W1985653460","https://openalex.org/W1986039575","https://openalex.org/W2002155176","https://openalex.org/W2006102088","https://openalex.org/W2015510572","https://openalex.org/W2023701069","https://openalex.org/W2033708208","https://openalex.org/W2037368022","https://openalex.org/W2046313141","https://openalex.org/W2051881354","https://openalex.org/W2052439909","https://openalex.org/W2096426797","https://openalex.org/W2096643534","https://openalex.org/W2150770007","https://openalex.org/W2158841112","https://openalex.org/W2166203567","https://openalex.org/W2225112376","https://openalex.org/W2248000639","https://openalex.org/W2314077524","https://openalex.org/W2336940765","https://openalex.org/W2337853676","https://openalex.org/W2341014652","https://openalex.org/W2342848296","https://openalex.org/W2395940814"],"related_works":["https://openalex.org/W2018457377","https://openalex.org/W1981239145","https://openalex.org/W2945557904","https://openalex.org/W2329570522","https://openalex.org/W2085941504","https://openalex.org/W7096034482","https://openalex.org/W2884661165","https://openalex.org/W2946599727","https://openalex.org/W2037197317","https://openalex.org/W2470847582"],"abstract_inverted_index":{"We":[0,139],"have":[1],"studied":[2,145],"four":[3,92],"patients":[4,12,25,39,93,133,144],"suffering":[5],"from":[6,90],"acquired":[7,135],"von":[8,136],"Willebrand's":[9,137],"disease.":[10,138],"All":[11],"had":[13,26],"a":[14,27,41,101,155],"severe":[15],"bleeding":[16],"diathesis":[17],"with":[18,71,134,169],"recurrent":[19],"life-threatening":[20],"haemorrhages.":[21],"Three":[22],"of":[23,32,60,75,81,103,119,154,173],"the":[24,57,72,95,116,120,132,143,146,152,159,170],"monoclonal":[28],"gammopathy":[29],"and":[30,78,94,163],"one":[31],"these":[33],"developed":[34],"multiple":[35],"myeloma.":[36],"In":[37,50,62],"three":[38,121],"tested,":[40],"plasma":[42,77,89],"inhibitor":[43,157,166],"to":[44,56,68,127,151,158],"ristocetin":[45],"cofactor":[46],"activity":[47,65],"was":[48,54,66,83,125,149,167],"detected.":[49],"each":[51],"case":[52],"this":[53,165],"localized":[55],"IgG":[58,73,96,171],"fraction":[59,74,97,172],"plasma.":[61,174],"addition,":[63],"VIII:C":[64,82,105],"found":[67,126],"be":[69,128],"associated":[70,168],"patients'":[76],"altered":[79],"mobility":[80],"detected":[84],"on":[85,112],"Laurell":[86],"immunoelectrophoresis.":[87],"Furthermore,":[88],"all":[91],"therefrom":[98],"resulted":[99],"in":[100,131,142],"dissociation":[102],"normal":[104],"into":[106],"two":[107],"components":[108],"separable":[109],"by":[110],"gel-filtration":[111],"Sepharose":[113],"6B.":[114],"Finally":[115],"circulating":[117,156],"half-life":[118],"factor":[122,160],"VIII":[123,161],"activities":[124],"markedly":[129],"reduced":[130],"conclude":[140],"that":[141,164],"coagulation":[147],"defect":[148],"related":[150],"presence":[153],"complex":[162]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}