{"id":"https://openalex.org/W2012104309","doi":"https://doi.org/10.1124/mol.104.009019","title":"Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor","display_name":"Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor","publication_year":2005,"publication_date":"2005-03-11","ids":{"openalex":"https://openalex.org/W2012104309","doi":"https://doi.org/10.1124/mol.104.009019","mag":"2012104309","pmid":"https://pubmed.ncbi.nlm.nih.gov/15761118"},"language":"en","primary_location":{"id":"doi:10.1124/mol.104.009019","doi":"https://doi.org/10.1124/mol.104.009019","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.104.009019","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028915250","display_name":"Oliver Burk","orcid":"https://orcid.org/0000-0001-8990-9656","observed_orcids":["https://orcid.org/0000-0001-8990-9656"]},"institutions":[{"id":"https://openalex.org/I4210120009","display_name":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology","ror":"https://ror.org/02pnjnj33","country_code":"DE","type":"facility","lineage":["https://openalex.org/I2802101015","https://openalex.org/I4210120009","https://openalex.org/I4403386655"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Oliver Burk","raw_affiliation_strings":["Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany. oliver.burk@ikp-stuttgart.de","Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany. oliver.burk@ikp-stuttgart.de","institution_ids":["https://openalex.org/I4210120009"]},{"raw_affiliation_string":"Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany","institution_ids":["https://openalex.org/I4210120009"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068055000","display_name":"Katja A. Arnold","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katja A. Arnold","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026380931","display_name":"Andreas Klaus Nussler","orcid":"https://orcid.org/0000-0002-6666-6791","observed_orcids":["https://orcid.org/0000-0002-6666-6791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas K. Nussler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066057635","display_name":"Elke Schaeffeler","orcid":"https://orcid.org/0009-0005-2997-0355","observed_orcids":["https://orcid.org/0009-0005-2997-0355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Schaeffeler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033628541","display_name":"\u0415. \u0410. \u0415\u0444\u0438\u043c\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-5145-2168","observed_orcids":["https://orcid.org/0000-0002-5145-2168"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina Efimova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030268279","display_name":"Bonnie A. Avery","orcid":"https://orcid.org/0000-0002-0925-1338","observed_orcids":["https://orcid.org/0000-0002-0925-1338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bonnie A. Avery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080219849","display_name":"Mitchell A. Avery","orcid":"https://orcid.org/0000-0002-2177-7535","observed_orcids":["https://orcid.org/0000-0002-2177-7535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mitchell A. Avery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030993480","display_name":"Martin F. Fromm","orcid":"https://orcid.org/0000-0002-0334-7478","observed_orcids":["https://orcid.org/0000-0002-0334-7478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin F. Fromm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023657124","display_name":"Michel F Eichelbaum","orcid":"https://orcid.org/0000-0001-5029-8472","observed_orcids":["https://orcid.org/0000-0001-5029-8472"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michel Eichelbaum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":8.9574,"has_fulltext":false,"cited_by_count":228,"citation_normalized_percentile":{"value":0.99019102,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"67","issue":"6","first_page":"1954","last_page":"1965"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.13979999721050262,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.996999979019165},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.9129999876022339},{"id":"https://openalex.org/keywords/pregnane-x-receptor","display_name":"pregnane X receptor","score":0.9639999866485596},{"id":"https://openalex.org/keywords/constitutive-androstane-receptor","display_name":"constitutive androstane receptor","score":1.0},{"id":"https://openalex.org/keywords/cytochrome-p450-induction","display_name":"cytochrome P450 induction","score":0.890999972820282},{"id":"https://openalex.org/keywords/cyp2b6","display_name":"CYP2B6","score":0.8629999756813049},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":1.0},{"id":"https://openalex.org/keywords/mdr1","display_name":"MDR1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.7440000176429749},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.9240000247955322},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.6340000033378601},{"id":"https://openalex.org/keywords/intestinal-cells","display_name":"intestinal cells","score":0.6499999761581421},{"id":"https://openalex.org/keywords/nuclear-receptor-coregulators","display_name":"nuclear receptor coregulators","score":0.781000018119812},{"id":"https://openalex.org/keywords/autoinduction","display_name":"autoinduction","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C132040763","wikidata":"https://www.wikidata.org/wiki/Q409867","display_name":"Pregnane X receptor","level":5,"score":0.9779829382896423},{"id":"https://openalex.org/C193264327","wikidata":"https://www.wikidata.org/wiki/Q14905078","display_name":"Constitutive androstane receptor","level":5,"score":0.9467498660087585},{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.8501511812210083},{"id":"https://openalex.org/C109650736","wikidata":"https://www.wikidata.org/wiki/Q424440","display_name":"CYP3A4","level":4,"score":0.7623015642166138},{"id":"https://openalex.org/C50605568","wikidata":"https://www.wikidata.org/wiki/Q14912267","display_name":"CYP2B6","level":5,"score":0.7499940395355225},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6340900659561157},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6010940074920654},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5340892672538757},{"id":"https://openalex.org/C63932345","wikidata":"https://www.wikidata.org/wiki/Q422500","display_name":"Nuclear receptor","level":4,"score":0.48790809512138367},{"id":"https://openalex.org/C2780655410","wikidata":"https://www.wikidata.org/wiki/Q2700511","display_name":"Pregnane","level":2,"score":0.48331594467163086},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.46150946617126465},{"id":"https://openalex.org/C2781160685","wikidata":"https://www.wikidata.org/wiki/Q5276420","display_name":"Dihydroartemisinin","level":5,"score":0.4455246031284332},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.4255574345588684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41813066601753235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4028015434741974},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2588862180709839},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22667577862739563},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.14651864767074585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14443382620811462},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.13816967606544495},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.117369145154953},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.09007221460342407},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0886838436126709},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06626984477043152}],"mesh":[{"descriptor_ui":"D000077297","descriptor_name":"Pregnane X Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000090702","descriptor_name":"Constitutive Androstane Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011987","descriptor_name":"Receptors, Steroid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1124/mol.104.009019","doi":"https://doi.org/10.1124/mol.104.009019","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.104.009019","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:15761118","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15761118","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1545401674","https://openalex.org/W1650427240","https://openalex.org/W1692234463","https://openalex.org/W1754249143","https://openalex.org/W1825408640","https://openalex.org/W1922401242","https://openalex.org/W1968535758","https://openalex.org/W1974192933","https://openalex.org/W1990770244","https://openalex.org/W1997538585","https://openalex.org/W2001782586","https://openalex.org/W2010902409","https://openalex.org/W2011426437","https://openalex.org/W2014879174","https://openalex.org/W2040567225","https://openalex.org/W2050736612","https://openalex.org/W2051212479","https://openalex.org/W2061783580","https://openalex.org/W2064259517","https://openalex.org/W2064855181","https://openalex.org/W2078387155","https://openalex.org/W2079052325","https://openalex.org/W2092025577","https://openalex.org/W2097675898","https://openalex.org/W2098184601","https://openalex.org/W2103610164","https://openalex.org/W2106497801","https://openalex.org/W2110367490","https://openalex.org/W2114756989","https://openalex.org/W2128772465","https://openalex.org/W2129972061","https://openalex.org/W2154021375","https://openalex.org/W2161816485","https://openalex.org/W2163154965","https://openalex.org/W2168348871","https://openalex.org/W2171073007","https://openalex.org/W2327807854","https://openalex.org/W2411094575","https://openalex.org/W2418418519","https://openalex.org/W2499926109","https://openalex.org/W6638475381","https://openalex.org/W6717033484","https://openalex.org/W6876286289"],"related_works":["https://openalex.org/W2130341652","https://openalex.org/W1555567157","https://openalex.org/W2357086515","https://openalex.org/W1518770440","https://openalex.org/W3036086142","https://openalex.org/W2130449545","https://openalex.org/W7096277253","https://openalex.org/W1692234463","https://openalex.org/W2154021375","https://openalex.org/W2431341871"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
