{"id":"https://openalex.org/W2012092425","doi":"https://doi.org/10.1007/s11060-012-0923-3","title":"Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide","display_name":"Hyperoxia resensitizes chemoresistant human glioblastoma cells to temozolomide","publication_year":2012,"publication_date":"2012-07-05","ids":{"openalex":"https://openalex.org/W2012092425","doi":"https://doi.org/10.1007/s11060-012-0923-3","mag":"2012092425","pmid":"https://pubmed.ncbi.nlm.nih.gov/22763762","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3434886"},"language":"en","primary_location":{"id":"doi:10.1007/s11060-012-0923-3","doi":"https://doi.org/10.1007/s11060-012-0923-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11060-012-0923-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11060-012-0923-3.pdf","source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11060-012-0923-3.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Stella Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Stella Sun","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068409200","display_name":"Derek Lee","orcid":"https://orcid.org/0000-0002-1042-9543","observed_orcids":["https://orcid.org/0000-0002-1042-9543"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Derek Lee","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083972140","display_name":"Nikki Pui Yue Lee","orcid":"https://orcid.org/0000-0002-5750-8361","observed_orcids":["https://orcid.org/0000-0002-5750-8361"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Nikki P. Lee","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108668296","display_name":"Jenny Kan-Suen Pu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Jenny K. S. Pu","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086759252","display_name":"Thian\u2010Sze Wong","orcid":"https://orcid.org/0000-0002-8245-4019","observed_orcids":["https://orcid.org/0000-0002-8245-4019"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"Stanley T. S. Wong","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111895578","display_name":"Wai\u2010Man Lui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"W. M. Lui","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111518451","display_name":"C. F. Fung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":false,"raw_author_name":"C. F. Fung","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050516829","display_name":"Gkk Leung","orcid":"https://orcid.org/0000-0003-3147-3057","observed_orcids":["https://orcid.org/0000-0003-3147-3057"]},"institutions":[{"id":"https://openalex.org/I2800810863","display_name":"Queen Mary Hospital","ror":"https://ror.org/02xkx3e48","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I1294586568","https://openalex.org/I2800810863"]},{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["CN","HK"],"is_corresponding":true,"raw_author_name":"Gilberto K. K. Leung","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]},{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050516829"],"corresponding_institution_ids":["https://openalex.org/I2800810863","https://openalex.org/I889458895"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":1.6363,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83113353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"3","first_page":"467","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.8349999785423279},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.906000018119812},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5379999876022339},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6380000114440918},{"id":"https://openalex.org/keywords/caspase-dependent-cell-death","display_name":"caspase-dependent cell death","score":0.9190000295639038},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intratumoral-hypoxia","display_name":"intratumoral hypoxia","score":0.9160000085830688},{"id":"https://openalex.org/keywords/oxygen-therapy","display_name":"oxygen therapy","score":0.6470000147819519},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.8986954689025879},{"id":"https://openalex.org/C2780672939","wikidata":"https://www.wikidata.org/wiki/Q5958429","display_name":"Hyperoxia","level":3,"score":0.8530842065811157},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6408823728561401},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5756914615631104},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5292263031005859},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5275834798812866},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5213790535926819},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4678440988063812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3643123209476471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26602962613105774},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23832538723945618},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.15328100323677063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1329260766506195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1318294107913971},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.12277781963348389},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0878349244594574},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.0640583336353302},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077204","descriptor_name":"Temozolomide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003606","descriptor_name":"Dacarbazine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018496","descriptor_name":"Hyperoxia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018906","descriptor_name":"Antineoplastic Agents, Alkylating","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11060-012-0923-3","doi":"https://doi.org/10.1007/s11060-012-0923-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11060-012-0923-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11060-012-0923-3.pdf","source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2448435","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3434886","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22763762","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22763762","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuro-oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3434886","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3434886/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurooncol","raw_type":"Text"},{"id":"pmh:oai:hub.hku.hk:10722/159945","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10722/159945","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1007/s11060-012-0923-3","doi":"https://doi.org/10.1007/s11060-012-0923-3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11060-012-0923-3","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11060-012-0923-3.pdf","source":{"id":"https://openalex.org/S175922936","display_name":"Journal of Neuro-Oncology","issn_l":"0167-594X","issn":["0167-594X","1573-7373"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322170","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012092425.pdf","grobid_xml":"https://content.openalex.org/works/W2012092425.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W16180300","https://openalex.org/W110291667","https://openalex.org/W198973836","https://openalex.org/W225683512","https://openalex.org/W1523171941","https://openalex.org/W1575883964","https://openalex.org/W1780453311","https://openalex.org/W1967973606","https://openalex.org/W1976860925","https://openalex.org/W1977288387","https://openalex.org/W1988662519","https://openalex.org/W1988812283","https://openalex.org/W2000029548","https://openalex.org/W2000537119","https://openalex.org/W2000647702","https://openalex.org/W2011810742","https://openalex.org/W2021187634","https://openalex.org/W2021994448","https://openalex.org/W2030473301","https://openalex.org/W2030603545","https://openalex.org/W2040113269","https://openalex.org/W2041748316","https://openalex.org/W2054618461","https://openalex.org/W2061119124","https://openalex.org/W2061956427","https://openalex.org/W2069415914","https://openalex.org/W2078462514","https://openalex.org/W2083081144","https://openalex.org/W2092881471","https://openalex.org/W2105100844","https://openalex.org/W2106452645","https://openalex.org/W2106816824","https://openalex.org/W2111391193","https://openalex.org/W2111527534","https://openalex.org/W2112514371","https://openalex.org/W2117144947","https://openalex.org/W2119277399","https://openalex.org/W2119472742","https://openalex.org/W2121243468","https://openalex.org/W2121585125","https://openalex.org/W2123730023","https://openalex.org/W2133508691","https://openalex.org/W2149294451","https://openalex.org/W2151896963","https://openalex.org/W2158681922","https://openalex.org/W2160650707","https://openalex.org/W2162193371","https://openalex.org/W2184471213","https://openalex.org/W2213951317","https://openalex.org/W2279320372","https://openalex.org/W2428247593","https://openalex.org/W4292820908"],"related_works":["https://openalex.org/W2174249922","https://openalex.org/W3029437071","https://openalex.org/W4391163967","https://openalex.org/W2900696497","https://openalex.org/W2133259051","https://openalex.org/W6964927627","https://openalex.org/W7212292733","https://openalex.org/W1509754880","https://openalex.org/W2947320259","https://openalex.org/W2221578148"],"abstract_inverted_index":{"Temozolomide":[0],"(TMZ)":[1],"is":[2,11,236],"standard":[3],"chemotherapy":[4,36],"for":[5,241],"glioblastoma":[6],"multiforme":[7],"(GBM).":[8],"Intratumoral":[9],"hypoxia":[10],"common":[12],"in":[13,37,200,210,223],"GBM":[14,53,63,69,224],"and":[15,55,57,72,86,115,119,141,183,214],"may":[16,207],"be":[17,208],"associated":[18,186],"with":[19,76,104,187],"the":[20,33,48,150,165,171,178],"development":[21],"of":[22,35,51,82,112,138,190,212,228,243],"TMZ":[23,77,108,124,136,169,182,221],"resistance.":[24],"Oxygen":[25],"therapy":[26],"has":[27],"previously":[28],"been":[29],"reported":[30],"to":[31,65,78,94,168,196],"potentiate":[32],"effect":[34],"cancer.":[38],"In":[39],"this":[40],"study,":[41],"we":[42],"investigated":[43],"whether":[44,56],"hyperoxia":[45,126,184,213,219,235],"can":[46],"enhance":[47],"TMZ-induced":[49],"cytotoxicity":[50,114],"human":[52,68],"cells,":[54,202],"how":[58],"it":[59],"would":[60],"resensitize":[61],"TMZ-resistant":[62,83,244],"cells":[64,70,84,143,163,174,225],"TMZ.":[66],"TMZ-sensitive":[67],"(D54-S":[71],"U87-S)":[73],"were":[74,91,127,185],"treated":[75],"develop":[79],"isogenic":[80],"subclones":[81],"(D54-R":[85],"U87-R).":[87],"All":[88],"cell":[89,113,151,216],"lines":[90],"then":[92],"exposed":[93],"different":[95],"oxygen":[96,154],"levels":[97],"(1,":[98],"21,":[99],"40,":[100],"or":[101,105],"80":[102,157],"%),":[103,161],"without":[106],"concomitant":[107],"treatment,":[109],"before":[110],"assessment":[111],"morphology.":[116],"Cell":[117],"death":[118],"survival":[120],"pathways":[121],"elicited":[122],"by":[123,129,226],"and/or":[125],"elucidated":[128],"western":[130],"blotting.":[131],"Our":[132],"results":[133],"showed":[134],"that":[135,204],"sensitivity":[137],"both":[139],"chemo-sensitive":[140],"resistant":[142,162],"was":[144],"enhanced":[145,220],"significantly":[146],"under":[147,175],"hyperoxia.":[148],"At":[149],"line-specific":[152],"optimum":[153],"concentration":[155],"(D54-R,":[156],"%;":[158],"U87-R,":[159],"40":[160],"had":[164],"same":[166],"response":[167],"as":[170],"parent":[172],"chemosensitive":[173],"normoxia":[176],"via":[177,231],"caspase-dependent":[179],"pathway.":[180],"Both":[181],"increased":[188],"phosphorylation":[189],"ERK":[191],"p44/42":[192],"MAPK":[193],"(Erk1/2),":[194],"but":[195],"a":[197,237],"lesser":[198],"extent":[199],"D54-R":[201],"suggesting":[203],"Erk1/2":[205],"activity":[206],"involved":[209],"regulation":[211],"TMZ-mediated":[215],"death.":[217],"Overall,":[218],"toxicity":[222],"induction":[227],"apoptosis,":[229],"possibly":[230],"MAPK-related":[232],"pathways.":[233],"Induced":[234],"potentially":[238],"promising":[239],"approach":[240],"treatment":[242],"GBM.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
