{"id":"https://openalex.org/W2012084718","doi":"https://doi.org/10.1002/ange.19911031105","title":"Proteasekatalysierte kinetisch kontrollierte Peptidsynthese","display_name":"Proteasekatalysierte kinetisch kontrollierte Peptidsynthese","publication_year":1991,"publication_date":"1991-11-01","ids":{"openalex":"https://openalex.org/W2012084718","doi":"https://doi.org/10.1002/ange.19911031105","mag":"2012084718"},"language":"de","primary_location":{"id":"doi:10.1002/ange.19911031105","doi":"https://doi.org/10.1002/ange.19911031105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.19911031105","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018783910","display_name":"Volker Schellenberger","orcid":"https://orcid.org/0000-0002-3491-8229","observed_orcids":["https://orcid.org/0000-0002-3491-8229"]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Schellenberger","raw_affiliation_strings":["Fachbereich Biowissenschaften der Universita\u0308t Talstra\u00dfe 33, O-7010 Leipzig","Fachbereich Biowissenschaften der Universit\u00e4t Talstra\u00dfe 33, O\u20107010 Leipzig"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fachbereich Biowissenschaften der Universita\u0308t Talstra\u00dfe 33, O-7010 Leipzig","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Fachbereich Biowissenschaften der Universit\u00e4t Talstra\u00dfe 33, O\u20107010 Leipzig","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047363996","display_name":"Hans\u2010Dieter Jakubke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Hans\u2010Dieter Jakubke","raw_affiliation_strings":["Fachbereich Biowissenschaften der Universita\u0308t Talstra\u00dfe 33, O-7010 Leipzig","Fachbereich Biowissenschaften der Universit\u00e4t Talstra\u00dfe 33, O\u20107010 Leipzig"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fachbereich Biowissenschaften der Universita\u0308t Talstra\u00dfe 33, O-7010 Leipzig","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Fachbereich Biowissenschaften der Universit\u00e4t Talstra\u00dfe 33, O\u20107010 Leipzig","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047363996"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.6521,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.64877584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"103","issue":"11","first_page":"1440","last_page":"1452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.01640000008046627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cysteine-protease","display_name":"cysteine protease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/racemization","display_name":"racemization","score":0.6330000162124634},{"id":"https://openalex.org/keywords/enantiomeric-purity","display_name":"enantiomeric purity","score":0.5659999847412109},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.45500001311302185},{"id":"https://openalex.org/keywords/enzyme-specificity","display_name":"enzyme specificity","score":0.5379999876022339},{"id":"https://openalex.org/keywords/peptide-bond-formation","display_name":"peptide bond formation","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5506300330162048},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.419400155544281},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3542133569717407},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11732065677642822}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.19911031105","doi":"https://doi.org/10.1002/ange.19911031105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.19911031105","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W199748819","https://openalex.org/W203082127","https://openalex.org/W205682231","https://openalex.org/W617205846","https://openalex.org/W619425183","https://openalex.org/W1497457065","https://openalex.org/W1530639541","https://openalex.org/W1668227969","https://openalex.org/W1754330606","https://openalex.org/W1859811746","https://openalex.org/W1889077695","https://openalex.org/W1947477961","https://openalex.org/W1959911680","https://openalex.org/W1965269696","https://openalex.org/W1968855030","https://openalex.org/W1969719875","https://openalex.org/W1974926247","https://openalex.org/W1977737796","https://openalex.org/W1979818944","https://openalex.org/W1983279218","https://openalex.org/W1985469117","https://openalex.org/W1986457099","https://openalex.org/W1988320424","https://openalex.org/W1988578338","https://openalex.org/W1988888572","https://openalex.org/W1990566833","https://openalex.org/W1992250926","https://openalex.org/W1993973444","https://openalex.org/W1997509365","https://openalex.org/W1999563041","https://openalex.org/W1999736751","https://openalex.org/W2001262910","https://openalex.org/W2006838325","https://openalex.org/W2007609350","https://openalex.org/W2009570597","https://openalex.org/W2012176370","https://openalex.org/W2013930980","https://openalex.org/W2014316343","https://openalex.org/W2014913120","https://openalex.org/W2015391756","https://openalex.org/W2015496343","https://openalex.org/W2018124270","https://openalex.org/W2021240740","https://openalex.org/W2023268443","https://openalex.org/W2029521241","https://openalex.org/W2030312294","https://openalex.org/W2030508029","https://openalex.org/W2031665112","https://openalex.org/W2031817642","https://openalex.org/W2032920834","https://openalex.org/W2034006076","https://openalex.org/W2035860907","https://openalex.org/W2039601890","https://openalex.org/W2042375671","https://openalex.org/W2043820238","https://openalex.org/W2044509942","https://openalex.org/W2048109378","https://openalex.org/W2050353347","https://openalex.org/W2054971302","https://openalex.org/W2058819042","https://openalex.org/W2059131368","https://openalex.org/W2063543985","https://openalex.org/W2064952084","https://openalex.org/W2066131418","https://openalex.org/W2068943002","https://openalex.org/W2070846389","https://openalex.org/W2076706083","https://openalex.org/W2083219028","https://openalex.org/W2087018195","https://openalex.org/W2088977899","https://openalex.org/W2089314802","https://openalex.org/W2093386317","https://openalex.org/W2105800282","https://openalex.org/W2112636022","https://openalex.org/W2114828970","https://openalex.org/W2116286070","https://openalex.org/W2117470898","https://openalex.org/W2140422547","https://openalex.org/W2140872076","https://openalex.org/W2145031943","https://openalex.org/W2156065136","https://openalex.org/W2166604935","https://openalex.org/W2203848431","https://openalex.org/W2213852111","https://openalex.org/W2217601343","https://openalex.org/W2286616009","https://openalex.org/W2314988558","https://openalex.org/W2318157495","https://openalex.org/W2613467369","https://openalex.org/W2833117375","https://openalex.org/W3044617864","https://openalex.org/W3169460802","https://openalex.org/W4205170238","https://openalex.org/W4240203432","https://openalex.org/W4240264814","https://openalex.org/W4285719527","https://openalex.org/W4297959863"],"related_works":["https://openalex.org/W2073723813","https://openalex.org/W2000586519","https://openalex.org/W1984815039","https://openalex.org/W2147380656","https://openalex.org/W2187957892","https://openalex.org/W2109945128","https://openalex.org/W4237372872","https://openalex.org/W1999563041","https://openalex.org/W2073500178","https://openalex.org/W2953298539"],"abstract_inverted_index":{"Abstract":[0],"Trotz":[1],"des":[2,97],"enormen":[3],"Fortschritts":[4],"bei":[5,177,193],"der":[6,16,20,36,44,60,68,79,81,128,132,162,201],"Synthese":[7,59,112],"von":[8,26,52,63,124,130,206,217,223],"Peptiden":[9,64],"und":[10,15,65,156,164,181,188,219],"Proteinen":[11,66],"mit":[12,40,67,103],"kommerziellen":[13],"Peptidsynthesizern":[14],"gro\u00dfen":[17],"biotechnologischen":[18],"M\u00f6glichkeiten":[19,127],"DNA\u2010Rekombinationstechnik":[21],"ist":[22,90,173],"zur":[23,58,221],"racemisierungssicheren":[24],"Verkn\u00fcpfung":[25],"Peptidsegmenten":[27,53],"eine":[28,166,174,214],"C\u2010N\u2010Ligase":[29],"ein":[30,71],"wichtiges":[31],"Hilfsmittel.":[32],"Da":[33],"die":[34,91,110,138,141,160,204],"Aktivierung":[35],"\u03b1\u2010Carboxyfunktion":[37],"eines":[38],"Peptidsegmentes":[39],"dem":[41],"partiellen":[42],"Verlust":[43],"Enantiomerenreinheit":[45],"verbunden":[46],"sein":[47,151],"kann,":[48],"bergen":[49],"chemische":[50],"Verkn\u00fcpfungen":[51],"Racemisierungsgefahren.":[54],"Die":[55],"Natur":[56],"hat":[57],"riesigen":[61],"Sequenzvielfalt":[62],"Peptidyltransferase":[69,92],"nur":[70,93,136],"einziges":[72],"Enzym":[73],"entwickelt,":[74],"das":[75],"unabh\u00e4ngig":[76],"vom":[77],"Charakter":[78],"Seitenkettenfunktionen":[80],"proteinogenen":[82],"Aminos\u00e4urebausteine":[83],"seine":[84],"volle":[85],"katalytische":[86],"Funktion":[87],"entfaltet.":[88],"Jedoch":[89],"als":[94,146,192],"integraler":[95],"Bestandteil":[96],"Ribosoms":[98],"in":[99,168],"einer":[100,178],"koordinierten":[101],"Interaktion":[102],"anderen":[104],"ribosomalen":[105],"Faktoren":[106],"wirksam,":[107],"d.h.":[108],"f\u00fcr":[109,119,213],"enzymatische":[111,120],"nicht":[113],"zu":[114,190],"verwenden.":[115],"Alternativ":[116],"bieten":[117],"sich":[118],"Peptidsynthesen,":[121],"wenn":[122],"man":[123],"den":[125,199],"eingeschr\u00e4nkten":[126],"Nutzung":[129,216],"Multienzymkomplexen":[131],"bakteriellen":[133],"Peptidsynthese":[134],"absieht,":[135],"noch":[137],"Proteasen":[139],"an,":[140],"aber":[142],"aufgrund":[143],"ihrer":[144],"in\u2010vivo\u2010Funktion":[145],"Hydrolasen":[147],"keine":[148],"idealen":[149],"C\u2010N\u2010Ligasen":[150],"k\u00f6nnen.":[152],"Erst":[153],"gezielte":[154],"thermodynamische":[155],"reaktionskinetische":[157],"Manipulationen":[158],"erm\u00f6glichen":[159],"Umkehrung":[161],"Proteasewirkung":[163],"damit":[165],"Programmierung":[167],"Richtung":[169],"Ligation.":[170],"Ohne":[171],"Zweifel":[172],"synthesebeg\u00fcnstigende":[175],"Einflu\u00dfnahme":[176],"durch":[179],"Serin\u2010":[180,218],"Cysteinproteasen":[182,220],"katalysierten":[183],"kinetisch":[184,207],"kontrollierten":[185,208],"Reaktionsf\u00fchrung":[186],"variabler":[187],"effizienter":[189],"realisieren":[191],"gleichgewichtskontrollierten":[194],"Synthesen.":[195,209],"Dieser":[196],"Beitrag":[197],"beschreibt":[198],"Einflu\u00df":[200],"Enzymspezifit\u00e4t":[202],"auf":[203],"Effizienz":[205],"Es":[210],"werden":[211],"Schlu\u00dffolgerungen":[212],"breitere":[215],"Katalyse":[222],"C\u2010N\u2010Verkn\u00fcpfungen":[224],"abgeleitet.":[225]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}