{"id":"https://openalex.org/W2012081777","doi":"https://doi.org/10.3892/ijo.31.5.985","title":"mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review)","display_name":"mda-7/IL-24, novel anticancer cytokine: Focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review)","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2012081777","doi":"https://doi.org/10.3892/ijo.31.5.985","mag":"2012081777","pmid":"https://pubmed.ncbi.nlm.nih.gov/17912425"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.31.5.985","doi":"https://doi.org/10.3892/ijo.31.5.985","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.31.5.985","pdf_url":"http://www.spandidos-publications.com/ijo/31/5/985/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2012081777"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/ijo/31/5/985/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031490587","display_name":"Paul B. Fisher","orcid":"https://orcid.org/0000-0002-0085-4546","observed_orcids":["https://orcid.org/0000-0002-0085-4546"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Fisher","raw_affiliation_strings":["Pathology , Herbert Irving Comprehensive Cancer Center , Columbia University Medical Center , College of Physicians and Surgeons , New York , NY 10032 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology , Herbert Irving Comprehensive Cancer Center , Columbia University Medical Center , College of Physicians and Surgeons , New York , NY 10032 ;","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055054082","display_name":"John J. Nemunaitis","orcid":"https://orcid.org/0000-0002-2234-2381","observed_orcids":["https://orcid.org/0000-0002-2234-2381"]},"institutions":[{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Nemunaitis","raw_affiliation_strings":["Mary Crowley Research Center , Dallas , TX 75246 , USA","Mary Crowley Medical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Crowley Research Center , Dallas , TX 75246 , USA","institution_ids":["https://openalex.org/I4210087725"]},{"raw_affiliation_string":"Mary Crowley Medical Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111839131","display_name":"Neil N. Senzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4210087725","display_name":"Mary Crowley Cancer Research Center","ror":"https://ror.org/002ksg449","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087725"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neil Senzer","raw_affiliation_strings":["Departments of Pathology, Urology and Neurosurgery , Columbia University Medical Center , College of Physicians and Surgeons , BB1501 , 630 West 168th Street , New York , NY 10032 , USA","Mary Crowley Research Center , Dallas , TX 75246 , USA","Mary Crowley Medical Research Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology, Urology and Neurosurgery , Columbia University Medical Center , College of Physicians and Surgeons , BB1501 , 630 West 168th Street , New York , NY 10032 , USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Mary Crowley Research Center , Dallas , TX 75246 , USA","institution_ids":["https://openalex.org/I4210087725"]},{"raw_affiliation_string":"Mary Crowley Medical Research Center","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069980003","display_name":"Paul Dent","orcid":"https://orcid.org/0000-0001-6948-1875","observed_orcids":["https://orcid.org/0000-0001-6948-1875"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Dent","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109601699","display_name":"Steven Grant","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Grant","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111571624","display_name":"Adly Yacoub","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adly Yacoub","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Virginia Commonwealth University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Curiel","raw_affiliation_strings":["Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","(University of Alabama)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"(University of Alabama)","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036159485","display_name":"Igor P. Dmitriev","orcid":"https://orcid.org/0000-0001-9206-1975","observed_orcids":["https://orcid.org/0000-0001-9206-1975"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Dmitriev","raw_affiliation_strings":["Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","(University of Alabama)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"(University of Alabama)","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108198379","display_name":"Parameshwar J. Mahasreshti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parameshwar Mahasreshti","raw_affiliation_strings":["Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","(University of Alabama)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Gene Therapy , Departments of Medicine, Pathology and Surgery , University of Alabama , Birmingham , AL 35294 ;","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]},{"raw_affiliation_string":"(University of Alabama)","institution_ids":["https://openalex.org/I17301866"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097558757","display_name":"Anthony De Pass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anthony De Pass","raw_affiliation_strings":["Department of Biology , Long Island University-Brooklyn , Brooklyn , NY 11201 ;","Long Island University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology , Long Island University-Brooklyn , Brooklyn , NY 11201 ;","institution_ids":["https://openalex.org/I138873065"]},{"raw_affiliation_string":"Long Island University","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024548116","display_name":"Satoshi Inoue","orcid":"https://orcid.org/0000-0003-1247-3844","observed_orcids":["https://orcid.org/0000-0003-1247-3844"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoshi Inoue","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery , M.D. Anderson Cancer Center , Houston , TX 77030 ;","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery , M.D. Anderson Cancer Center , Houston , TX 77030 ;","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112369989","display_name":"Sunil Chada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunil Chada","raw_affiliation_strings":["Introgen Therapeutics, Inc. , Houston , TX 77030 ;","Introgen Therapeutics, Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Introgen Therapeutics, Inc. , Houston , TX 77030 ;","institution_ids":[]},{"raw_affiliation_string":"Introgen Therapeutics, Inc","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100385054","display_name":"Rong Li","orcid":"https://orcid.org/0000-0002-6476-1015","observed_orcids":["https://orcid.org/0000-0002-6476-1015"]},"institutions":[{"id":"https://openalex.org/I138873065","display_name":"Long Island University","ror":"https://ror.org/0324fzh77","country_code":"US","type":"education","lineage":["https://openalex.org/I138873065"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["Department of Biology , Long Island University-Brooklyn , Brooklyn , NY 11201 ;","Long Island University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology , Long Island University-Brooklyn , Brooklyn , NY 11201 ;","institution_ids":["https://openalex.org/I138873065"]},{"raw_affiliation_string":"Long Island University","institution_ids":["https://openalex.org/I138873065"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068736204","display_name":"Rajagopal Ramesh","orcid":"https://orcid.org/0000-0002-7658-5338","observed_orcids":["https://orcid.org/0000-0002-7658-5338"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajagopal Ramesh","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery , M.D. Anderson Cancer Center , Houston , TX 77030 ;","University of Texas, M. D. Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery , M.D. Anderson Cancer Center , Houston , TX 77030 ;","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"University of Texas, M. D. Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029495254","display_name":"Habib Boukerche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Habib Boukerche","raw_affiliation_strings":["National de la Sante et de la Recherche Medicale (INSERM) 1 , Lyon Cedex , France","Neurosurgery and","INSERM"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National de la Sante et de la Recherche Medicale (INSERM) 1 , Lyon Cedex , France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"INSERM","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074535368","display_name":"Lejuan Chatman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lejuan Chatman","raw_affiliation_strings":["Departments of 1 Urology ,","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Urology ,","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100697866","display_name":"Eun\u2010Jung Park","orcid":"https://orcid.org/0000-0002-2778-1834","observed_orcids":["https://orcid.org/0000-0002-2778-1834","https://orcid.org/0000-0002-5761-0454"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eun Park","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dongning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dongning Wang","raw_affiliation_strings":["Pathology , Herbert Irving Comprehensive Cancer Center , Columbia University Medical Center , College of Physicians and Surgeons , New York , NY 10032 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology , Herbert Irving Comprehensive Cancer Center , Columbia University Medical Center , College of Physicians and Surgeons , New York , NY 10032 ;","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045878","display_name":"Nicollaq Vozhilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicollaq Vozhilla","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074305621","display_name":"Seok\u2010Geun Lee","orcid":"https://orcid.org/0000-0002-0060-5777","observed_orcids":["https://orcid.org/0000-0002-0060-5777"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seok-Geun Lee","raw_affiliation_strings":["Departments of 1 Urology ,","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Urology ,","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069002313","display_name":"Paola M. Barral","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paola Barral","raw_affiliation_strings":["Departments of 1 Urology ,","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Urology ,","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105901340","display_name":"Ruoyu Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruoyu Xiao","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004806592","display_name":"Mohiuddin M. Taher","orcid":"https://orcid.org/0000-0003-3044-3809","observed_orcids":["https://orcid.org/0000-0003-3044-3809"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohiuddin Taher","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101702325","display_name":"Shijian Liu","orcid":"https://orcid.org/0000-0003-3420-7838","observed_orcids":["https://orcid.org/0000-0003-3420-7838"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shi-Jian Liu","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059781163","display_name":"Moira Sauane","orcid":"https://orcid.org/0000-0003-2710-3491","observed_orcids":["https://orcid.org/0000-0003-2710-3491"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moira Sauane","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091194969","display_name":"Devanand Sarkar","orcid":"https://orcid.org/0000-0003-0973-2323","observed_orcids":["https://orcid.org/0000-0003-0973-2323"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Devanand Sarkar","raw_affiliation_strings":["Neurosurgery and","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105350091","display_name":"Michelle R. Staudt","orcid":"https://orcid.org/0000-0002-3364-0894","observed_orcids":["https://orcid.org/0000-0002-3364-0894"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michelle Staudt","raw_affiliation_strings":["Departments of 1 Urology ,","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Urology ,","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062975163","display_name":"Pankaj Gupta","orcid":"https://orcid.org/0000-0001-7689-4352","observed_orcids":["https://orcid.org/0000-0001-7689-4352"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pankaj Gupta","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111587178","display_name":"Zao-zhong Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zao-Zhong Su","raw_affiliation_strings":["Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 8 Biochemistry and 9 Medicine , Virginia Commonwealth University , Richmond , VA 23284 ;","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105502162","display_name":"Luni Emdad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luni Emdad","raw_affiliation_strings":["Neurosurgery and","Columbia University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery and","institution_ids":[]},{"raw_affiliation_string":"Columbia University","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017719790","display_name":"Irina V. Lebedeva","orcid":"https://orcid.org/0000-0002-1693-9392","observed_orcids":["https://orcid.org/0000-0002-1693-9392"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Lebedeva","raw_affiliation_strings":["Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, NY 10032, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4390039230"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0715,"has_fulltext":true,"cited_by_count":92,"citation_normalized_percentile":{"value":0.94827975,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"31","issue":"5","first_page":"985","last_page":"1007"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.18039999902248383,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.17759999632835388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mda-7-il-24","display_name":"MDA-7/IL-24","score":0.9800000190734863},{"id":"https://openalex.org/keywords/il-24","display_name":"IL-24","score":0.8679999709129333},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9860000014305115},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.8149999976158142},{"id":"https://openalex.org/keywords/apoptosis-induction","display_name":"apoptosis induction","score":0.7820000052452087},{"id":"https://openalex.org/keywords/differentiation-therapy","display_name":"differentiation therapy","score":0.6600000262260437},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9290000200271606},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-tropism","display_name":"tumor tropism","score":0.515999972820282},{"id":"https://openalex.org/keywords/chromosome-1q","display_name":"chromosome 1q","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6875996589660645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6510087251663208},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5179194808006287},{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.5141168236732483},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5114111304283142},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4840223491191864},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.473730206489563},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.43661877512931824},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.43204981088638306},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4262910485267639},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4164118766784668},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3960036039352417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10595777630805969},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099180","descriptor_name":"Interleukin-24","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007378","descriptor_name":"Interleukins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017321","descriptor_name":"Clinical Trials, Phase I as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3892/ijo.31.5.985","doi":"https://doi.org/10.3892/ijo.31.5.985","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.31.5.985","pdf_url":"http://www.spandidos-publications.com/ijo/31/5/985/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:17912425","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17912425","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"},{"id":"pmh:oai:academicworks.cuny.edu:le_pubs-1074","doi":null,"is_oa":false,"landing_page_url":"https://academicworks.cuny.edu/le_pubs/63","pdf_url":null,"source":{"id":"https://openalex.org/S4377196304","display_name":"CUNY Academic Works (City University of New York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I174216632","host_organization_name":"City University of New York","host_organization_lineage":["https://openalex.org/I174216632"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publications and Research","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3892/ijo.31.5.985","doi":"https://doi.org/10.3892/ijo.31.5.985","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.31.5.985","pdf_url":"http://www.spandidos-publications.com/ijo/31/5/985/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1404568026","display_name":"Novel Approaches for Pancreatic Cancer Therapy","funder_award_id":"R01CA098712","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2128089068","display_name":"Analysis of Progression of the Transformed Phenotype","funder_award_id":"R01CA035675","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2178416488","display_name":"Extension of Radiotherapy Research","funder_award_id":"P01CA006294","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3226081760","display_name":"Cancer in Older Minority Populations Caribbean American*","funder_award_id":"U54CA101598","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3763675084","display_name":"Carcinoma cell radiosensitization by MAPK inhibition","funder_award_id":"R01CA088906","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3890719760","display_name":"Signaling Pathways Regulating Epithelial Cell Survival","funder_award_id":"R01DK052825","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3971002961","display_name":"Translational Applications of mda-7/IL-24 in Cancer","funder_award_id":"P01CA104177","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4119534169","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G4746178983","display_name":"Evaluate the antiangiogenic properties of mda-7/IL-24","funder_award_id":"R01CA102716","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5101765587","display_name":"Genetic Modulation of Cellular Radiation Responses","funder_award_id":"P01CA072955","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5804443229","display_name":"Cancers in Older Minority Populations: Caribbean American","funder_award_id":"U54CA101388","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5850682332","display_name":null,"funder_award_id":"W81XWH","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6485189692","display_name":null,"funder_award_id":"DAMD 17-03-1","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G682928740","display_name":null,"funder_award_id":"CA 89778","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8482518349","display_name":"MDA-7/IL-24 and free radicals in renal cancer therapy","funder_award_id":"R01CA108520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8834657173","display_name":"MDA-7: Novel Cancer Therapeutic Gene","funder_award_id":"R01CA097318","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000878657","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016672","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306548","display_name":"Samuel Waxman Cancer Research Foundation","ror":"https://ror.org/02qva2y28"},{"id":"https://openalex.org/F4320308035","display_name":"New York State Department of Health","ror":"https://ror.org/04hf5kq57"},{"id":"https://openalex.org/F4320308851","display_name":"Lustgarten Foundation","ror":"https://ror.org/030635250"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012081777.pdf","grobid_xml":"https://content.openalex.org/works/W2012081777.grobid-xml"},"referenced_works_count":128,"referenced_works":["https://openalex.org/W7317053","https://openalex.org/W17422182","https://openalex.org/W1548640328","https://openalex.org/W1555670022","https://openalex.org/W1555816219","https://openalex.org/W1572047430","https://openalex.org/W1583927081","https://openalex.org/W1585683447","https://openalex.org/W1593130318","https://openalex.org/W1599277155","https://openalex.org/W1880400410","https://openalex.org/W1909048318","https://openalex.org/W1964572311","https://openalex.org/W1964619238","https://openalex.org/W1966523626","https://openalex.org/W1967666165","https://openalex.org/W1968987342","https://openalex.org/W1969637872","https://openalex.org/W1970847065","https://openalex.org/W1970856195","https://openalex.org/W1978328945","https://openalex.org/W1978457328","https://openalex.org/W1981486175","https://openalex.org/W1983366532","https://openalex.org/W1988470304","https://openalex.org/W1989510923","https://openalex.org/W1989513172","https://openalex.org/W1996981135","https://openalex.org/W1997998868","https://openalex.org/W1998238314","https://openalex.org/W1999569536","https://openalex.org/W2000000541","https://openalex.org/W2001401716","https://openalex.org/W2004708951","https://openalex.org/W2004832301","https://openalex.org/W2005581733","https://openalex.org/W2006569353","https://openalex.org/W2008786326","https://openalex.org/W2010579356","https://openalex.org/W2010581370","https://openalex.org/W2014944687","https://openalex.org/W2015540775","https://openalex.org/W2016241489","https://openalex.org/W2019072035","https://openalex.org/W2020228079","https://openalex.org/W2021875656","https://openalex.org/W2022315435","https://openalex.org/W2022494582","https://openalex.org/W2023777764","https://openalex.org/W2025970479","https://openalex.org/W2026711972","https://openalex.org/W2027776572","https://openalex.org/W2027998129","https://openalex.org/W2028697132","https://openalex.org/W2029245342","https://openalex.org/W2029931954","https://openalex.org/W2030099710","https://openalex.org/W2031819782","https://openalex.org/W2031900842","https://openalex.org/W2039252608","https://openalex.org/W2043654385","https://openalex.org/W2044943819","https://openalex.org/W2047959564","https://openalex.org/W2048408428","https://openalex.org/W2050818262","https://openalex.org/W2054817881","https://openalex.org/W2055976012","https://openalex.org/W2056859858","https://openalex.org/W2057074963","https://openalex.org/W2057838364","https://openalex.org/W2060368233","https://openalex.org/W2064219151","https://openalex.org/W2071742694","https://openalex.org/W2072553587","https://openalex.org/W2072881240","https://openalex.org/W2072928113","https://openalex.org/W2074810910","https://openalex.org/W2074830112","https://openalex.org/W2076058175","https://openalex.org/W2078580761","https://openalex.org/W2080632821","https://openalex.org/W2081823691","https://openalex.org/W2083479959","https://openalex.org/W2083551839","https://openalex.org/W2093490741","https://openalex.org/W2093915058","https://openalex.org/W2100408045","https://openalex.org/W2101697884","https://openalex.org/W2101980928","https://openalex.org/W2102563906","https://openalex.org/W2105985724","https://openalex.org/W2107296168","https://openalex.org/W2115420461","https://openalex.org/W2115583464","https://openalex.org/W2119631008","https://openalex.org/W2128229361","https://openalex.org/W2131798870","https://openalex.org/W2134003680","https://openalex.org/W2135615816","https://openalex.org/W2141077451","https://openalex.org/W2143076511","https://openalex.org/W2146400618","https://openalex.org/W2151790613","https://openalex.org/W2152393440","https://openalex.org/W2157507291","https://openalex.org/W2159548259","https://openalex.org/W2160293376","https://openalex.org/W2161715870","https://openalex.org/W2166105600","https://openalex.org/W2168390838","https://openalex.org/W2170285778","https://openalex.org/W2170815810","https://openalex.org/W2183407261","https://openalex.org/W2234798757","https://openalex.org/W2238881100","https://openalex.org/W2275080335","https://openalex.org/W2305460139","https://openalex.org/W2318592626","https://openalex.org/W2321501275","https://openalex.org/W2323327334","https://openalex.org/W2329048545","https://openalex.org/W2395033756","https://openalex.org/W2405171099","https://openalex.org/W2410256850","https://openalex.org/W3022598401","https://openalex.org/W3160166586","https://openalex.org/W4246171915","https://openalex.org/W6600728650"],"related_works":["https://openalex.org/W2022494582","https://openalex.org/W1976253176","https://openalex.org/W2006569353","https://openalex.org/W1967666165","https://openalex.org/W2031900842","https://openalex.org/W2082328144","https://openalex.org/W2004832301","https://openalex.org/W2048077855","https://openalex.org/W1984952924","https://openalex.org/W2606033338"],"abstract_inverted_index":{"Subtraction":[0],"hybridization":[1],"applied":[2],"to":[3,132,142,149,240,244],"a":[4,45,49,61,140,180,212],"'differentiation":[5],"therapy'":[6],"model":[7],"of":[8,18,40,44,64,94,120,146,203,220,231,253,271],"cancer":[9,161],"employing":[10],"human":[11,65,167,221],"melanoma":[12,19,34],"cells":[13,91,148,243],"resulted":[14],"in":[15,60,78,165,170,179,185],"the":[16,144,254,269],"cloning":[17],"differentiation":[20],"associated":[21],"gene-7/interleukin-24":[22],"(mda-7/IL-24).":[23],"Initial":[24],"studies":[25,169,193,262],"confirm":[26],"an":[27,85,102,130,251],"inverse":[28],"correlation":[29],"between":[30],"mda-7":[31,41,69,107],"expression":[32,39],"and":[33,36,57,96,139,152,189,200,246],"development":[35],"progression.":[37],"Forced":[38],"by":[42,90,114,164],"means":[43],"plasmid":[46],"or":[47,75],"via":[48],"replication":[50],"incompetent":[51],"adenovirus":[52],"(Ad.mda-7)":[53],"promotes":[54],"growth":[55,73],"suppression":[56],"induces":[58],"apoptosis":[59],"broad":[62],"array":[63],"cancers.":[66,191,222,273],"In":[67,207],"contrast,":[68],"does":[70],"not":[71],"induce":[72],"suppressive":[74],"toxic":[76],"effects":[77],"normal":[79],"cells.":[80],"Based":[81],"on":[82,98,158,227],"structure":[83],"(containing":[84],"IL-10":[86],"signature":[87],"motif),":[88],"secretion":[89],"(including":[92],"subsets":[93],"T-cells)":[95],"location":[97],"chromosome":[99],"1q":[100],"(in":[101],"area":[103],"containing":[104],"IL-10-family":[105],"genes),":[106],"has":[108,266],"now":[109],"been":[110],"renamed":[111],"mda-7/IL-24.":[112],"Studies":[113],"several":[115],"laboratories":[116],"have":[117],"uncovered":[118],"many":[119],"mda-7/IL-24's":[121],"unique":[122,213,229],"properties,":[123],"including":[124],"cancer-specific":[125],"apoptosis-induction,":[126],"cell":[127],"cycle":[128],"regulation,":[129],"ability":[131,239],"inhibit":[133],"angiogenesis,":[134],"potent":[135,235],"'bystander":[136,236],"antitumor":[137,237],"activity'":[138],"capacity":[141],"enhance":[143],"sensitivity":[145],"tumor":[147,242],"radiation,":[150,245],"chemotherapy":[151],"monoclonal":[153],"antibody":[154],"therapy.":[155],"Moreover,":[156],"based":[157],"its":[159,234,247],"profound":[160],"tropism,":[162],"substantiated":[163],"vivo":[166],"xenograft":[168],"nude":[171],"mice,":[172],"mda-7/IL-24":[173,196,210,265],"(administered":[174],"as":[175],"Ad.mda-7)":[176],"was":[177],"evaluated":[178],"phase":[181,255],"I":[182,256],"clinical":[183,205,257],"trial":[184,258],"patients":[186],"with":[187,216],"melanomas":[188],"solid":[190],"These":[192,261],"document":[194],"that":[195,264],"is":[197,259],"well":[198],"tolerated":[199],"demonstrates":[201],"evidence":[202],"significant":[204],"activity.":[206],"these":[208],"contexts,":[209],"represents":[211],"cytokine":[214],"gene":[215],"potential":[217],"for":[218,268],"therapy":[219],"The":[223],"present":[224],"review":[225],"focuses":[226],"three":[228],"properties":[230],"mda-7/IL-24,":[232],"namely":[233],"activity',":[238],"sensitize":[241],"antiangiogenesis":[248],"properties.":[249],"Additionally,":[250],"overview":[252],"provided.":[260],"affirm":[263],"promise":[267],"management":[270],"diverse":[272]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}