{"id":"https://openalex.org/W2012017615","doi":"https://doi.org/10.1038/cddis.2013.294","title":"Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone","display_name":"Withaferin A: a proteasomal inhibitor promotes healing after injury and exerts anabolic effect on osteoporotic bone","publication_year":2013,"publication_date":"2013-08-22","ids":{"openalex":"https://openalex.org/W2012017615","doi":"https://doi.org/10.1038/cddis.2013.294","mag":"2012017615","pmid":"https://pubmed.ncbi.nlm.nih.gov/23969857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3763455"},"language":"en","primary_location":{"id":"doi:10.1038/cddis.2013.294","doi":"https://doi.org/10.1038/cddis.2013.294","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.294","pdf_url":"https://www.nature.com/articles/cddis2013294.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/cddis2013294.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067644651","display_name":"Vikram Khedgikar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"V Khedgikar","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226001, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102980636","display_name":"Priyanka Kushwaha","orcid":"https://orcid.org/0000-0003-3202-7649","observed_orcids":["https://orcid.org/0000-0003-3202-7649"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P Kushwaha","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054221385","display_name":"Jyoti Gautam","orcid":"https://orcid.org/0000-0003-2961-9547","observed_orcids":["https://orcid.org/0000-0003-2961-9547"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"J Gautam","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028638112","display_name":"Ashwni Verma","orcid":"https://orcid.org/0000-0003-3717-0233","observed_orcids":["https://orcid.org/0000-0003-3717-0233"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Verma","raw_affiliation_strings":["Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246"]},{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010244816","display_name":"Bendangla Changkija","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"B Changkija","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"A Kumar","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":null,"display_name":"S Sharma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"S Sharma","raw_affiliation_strings":["Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246"]},{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113526900","display_name":"Gaurav Nagar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"G K Nagar","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014236716","display_name":"Divya Ramesh Singh","orcid":"https://orcid.org/0000-0002-2487-4082","observed_orcids":["https://orcid.org/0000-0002-2487-4082"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"D Singh","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004203270","display_name":"Prabodh Kumar Trivedi","orcid":"https://orcid.org/0000-0001-6463-1731","observed_orcids":["https://orcid.org/0000-0001-6463-1731"]},"institutions":[{"id":"https://openalex.org/I170396143","display_name":"National Botanical Research Institute","ror":"https://ror.org/036568k33","country_code":"IN","type":"facility","lineage":["https://openalex.org/I170396143","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P K Trivedi","raw_affiliation_strings":["Plant Gene Expression Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India","Plant Gene Expression Division, CSIR-National Botanical Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Gene Expression Division, CSIR-National Botanical Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I170396143"]},{"raw_affiliation_string":"Plant Gene Expression Division, CSIR-National Botanical Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I170396143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054448239","display_name":"Neelam S. Sangwan","orcid":"https://orcid.org/0000-0002-7766-5428","observed_orcids":["https://orcid.org/0000-0002-7766-5428"]},"institutions":[{"id":"https://openalex.org/I68145777","display_name":"Central Institute of Medicinal and Aromatic Plants","ror":"https://ror.org/0527mfk98","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I68145777"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"N S Sangwan","raw_affiliation_strings":["Plant Biology Division, Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226001, India","Plant Biology Division, Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plant Biology Division, Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, 226001, India","institution_ids":["https://openalex.org/I68145777"]},{"raw_affiliation_string":"Plant Biology Division, Metabolic and Structural Biology, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India","institution_ids":["https://openalex.org/I68145777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030014884","display_name":"Prabhat Ranjan Mishra","orcid":"https://orcid.org/0000-0002-7418-8283","observed_orcids":["https://orcid.org/0000-0002-7418-8283"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"P R Mishra","raw_affiliation_strings":["Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246"]},{"raw_affiliation_string":"Division of Pharmaceutics, CSIR-Central Drug Research Institute, Lucknow, India,","institution_ids":["https://openalex.org/I185249246"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032880706","display_name":"Ritu Trivedi","orcid":"https://orcid.org/0000-0002-9524-2541","observed_orcids":["https://orcid.org/0000-0002-9524-2541"]},"institutions":[{"id":"https://openalex.org/I185249246","display_name":"Central Drug Research Institute","ror":"https://ror.org/04t8qjg16","country_code":"IN","type":"facility","lineage":["https://openalex.org/I185249246","https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"R Trivedi","raw_affiliation_strings":["Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, 226001, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]},{"raw_affiliation_string":"Division of Endocrinology and Center for Research in Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Lucknow, India","institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5032880706"],"corresponding_institution_ids":["https://openalex.org/I185249246","https://openalex.org/I66760702"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":{"value":4990,"currency":"USD","value_usd":4990},"fwci":4.6189,"has_fulltext":true,"cited_by_count":142,"citation_normalized_percentile":{"value":0.96455001,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"4","issue":"8","first_page":"e778","last_page":"e778"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6786999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12298","display_name":"Phytochemicals and Medicinal Plants","score":0.3100999891757965,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14331","display_name":"Medicinal Plant Pharmacodynamics Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/withaferin-a","display_name":"withaferin A","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ashwagandha","display_name":"Withania somnifera","score":0.8799999952316284},{"id":"https://openalex.org/keywords/withanolides","display_name":"withanolides","score":0.8989999890327454},{"id":"https://openalex.org/keywords/proteasome-inhibition","display_name":"proteasome inhibition","score":0.9049999713897705},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/osteoblastogenesis","display_name":"osteoblastogenesis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.6179999709129333},{"id":"https://openalex.org/keywords/smurf2","display_name":"Smurf2","score":0.9860000014305115},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rankl-rank-signaling","display_name":"RANK/RANKL signaling","score":0.6110000014305115},{"id":"https://openalex.org/keywords/osteoprotegerin","display_name":"osteoprotegerin","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.953000009059906},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ovariectomy-induced-osteoporosis","display_name":"ovariectomy-induced osteoporosis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.593999981880188},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.47200000286102295},{"id":"https://openalex.org/keywords/trabecular-bone-microarchitecture","display_name":"trabecular bone microarchitecture","score":0.7160000205039978},{"id":"https://openalex.org/keywords/bone-strength","display_name":"bone strength","score":0.6439999938011169},{"id":"https://openalex.org/keywords/bone-turnover-markers","display_name":"bone turnover markers","score":0.6129999756813049},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ayurveda","display_name":"Ayurveda","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2776598214","wikidata":"https://www.wikidata.org/wiki/Q6606395","display_name":"Withaferin A","level":4,"score":0.7937266826629639},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.7764647006988525},{"id":"https://openalex.org/C2776363554","wikidata":"https://www.wikidata.org/wiki/Q14907085","display_name":"RUNX2","level":4,"score":0.6454311609268188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5109833478927612},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5035375952720642},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4705500900745392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44070690870285034},{"id":"https://openalex.org/C2780426850","wikidata":"https://www.wikidata.org/wiki/Q3357478","display_name":"Osteoprotegerin","level":4,"score":0.41150572896003723},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.41020888090133667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4027765393257141},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.298190712928772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27405911684036255},{"id":"https://openalex.org/C2780069950","wikidata":"https://www.wikidata.org/wiki/Q852660","display_name":"Withania somnifera","level":3,"score":0.2636157274246216},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1883964240550995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1238584816455841},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11222660541534424},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005269","descriptor_name":"Femur","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010010","descriptor_name":"Osteoclasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010052","descriptor_name":"Ovariectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044767","descriptor_name":"Ubiquitin-Protein Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045930","descriptor_name":"Anabolic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D045930","descriptor_name":"Anabolic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D045930","descriptor_name":"Anabolic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D045930","descriptor_name":"Anabolic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D054358","descriptor_name":"Withanolides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D061988","descriptor_name":"Proteasome Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1038/cddis.2013.294","doi":"https://doi.org/10.1038/cddis.2013.294","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.294","pdf_url":"https://www.nature.com/articles/cddis2013294.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2760954","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3763455","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23969857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23969857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell death & disease","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3763455","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3763455/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death Dis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/cddis.2013.294","doi":"https://doi.org/10.1038/cddis.2013.294","is_oa":true,"landing_page_url":"https://doi.org/10.1038/cddis.2013.294","pdf_url":"https://www.nature.com/articles/cddis2013294.pdf","source":{"id":"https://openalex.org/S185208586","display_name":"Cell Death and Disease","issn_l":"2041-4889","issn":["2041-4889"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Death & Disease","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1641210900","display_name":null,"funder_award_id":"BSC0201","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"},{"id":"https://openalex.org/G2682439238","display_name":null,"funder_award_id":"ESC-0103","funder_id":"https://openalex.org/F4320320721","funder_display_name":"Council of Scientific and Industrial Research, India"}],"funders":[{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012017615.pdf","grobid_xml":"https://content.openalex.org/works/W2012017615.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1520951628","https://openalex.org/W1782777016","https://openalex.org/W1922207530","https://openalex.org/W1964483457","https://openalex.org/W1967267975","https://openalex.org/W1967502057","https://openalex.org/W1968425609","https://openalex.org/W1969001131","https://openalex.org/W1971157583","https://openalex.org/W1972135859","https://openalex.org/W1973526333","https://openalex.org/W1973621507","https://openalex.org/W1976475315","https://openalex.org/W1979560551","https://openalex.org/W1986179699","https://openalex.org/W1986227530","https://openalex.org/W1987176983","https://openalex.org/W1992422220","https://openalex.org/W2004190331","https://openalex.org/W2015725833","https://openalex.org/W2020615661","https://openalex.org/W2020641663","https://openalex.org/W2028627202","https://openalex.org/W2029697567","https://openalex.org/W2036008223","https://openalex.org/W2039839937","https://openalex.org/W2042028347","https://openalex.org/W2045805069","https://openalex.org/W2065697878","https://openalex.org/W2076408697","https://openalex.org/W2076624423","https://openalex.org/W2082190072","https://openalex.org/W2082552678","https://openalex.org/W2085627522","https://openalex.org/W2089858094","https://openalex.org/W2094071522","https://openalex.org/W2096234941","https://openalex.org/W2108595411","https://openalex.org/W2110149781","https://openalex.org/W2113240961","https://openalex.org/W2117539495","https://openalex.org/W2120530429","https://openalex.org/W2121551386","https://openalex.org/W2121680389","https://openalex.org/W2127114287","https://openalex.org/W2128447822","https://openalex.org/W2130766059","https://openalex.org/W2131350538","https://openalex.org/W2132572939","https://openalex.org/W2137388847","https://openalex.org/W2146696914","https://openalex.org/W2153817682","https://openalex.org/W2157445945","https://openalex.org/W2158866825","https://openalex.org/W2159403469","https://openalex.org/W2161882340","https://openalex.org/W2256257390","https://openalex.org/W2412367416","https://openalex.org/W2418219748","https://openalex.org/W4244095134","https://openalex.org/W7097347689"],"related_works":["https://openalex.org/W1993932976","https://openalex.org/W4414348587","https://openalex.org/W4409826748","https://openalex.org/W1969790775","https://openalex.org/W3084412590","https://openalex.org/W7155892785","https://openalex.org/W4233557815","https://openalex.org/W4287878552","https://openalex.org/W2580565358","https://openalex.org/W1986848926"],"abstract_inverted_index":{"Withania":[0],"somnifera":[1],"or":[2],"Ashwagandha":[3],"is":[4],"a":[5,50,391],"medicinal":[6],"herb":[7],"of":[8,42,61,80,105,112,131,139,151,176,219,221,248,264,272,280,294,306,337,360],"Ayurveda.":[9],"Though":[10],"the":[11,43,62,258,273,281,310,335,345],"extract":[12],"and":[13,54,75,84,90,109,117,157,239,261,283,290,292,304,319,328,349,364,382],"purified":[14],"molecules,":[15],"withanolides,":[16],"from":[17],"this":[18],"plant":[19],"have":[20,24],"been":[21,35],"shown":[22],"to":[23,56,133,173,182,250],"different":[25],"pharmacological":[26],"activities,":[27],"their":[28],"effect":[29,68],"on":[30,69],"bone":[31,165,259,286,302,312,339,356,376,392],"formation":[32,303,377],"has":[33],"not":[34],"studied.":[36],"Here,":[37],"we":[38],"show":[39,126,225],"that":[40,127,226,373],"one":[41],"withanolide,":[44],"withaferin":[45],"A":[46],"(WFA)":[47],"acts":[48],"as":[49,210,313,390],"proteasomal":[51,380],"inhibitor":[52],"(PI)":[53],"binds":[55],"specific":[57],"catalytic":[58],"\u03b2":[59],"subunit":[60],"20S":[63],"proteasome.":[64],"It":[65,298],"exerts":[66],"positive":[67],"osteoblast":[70,73,88,135,184],"by":[71,102,119,164,188,194,212,231,236,243,378],"increasing":[72],"proliferation":[74],"differentiation.":[76],"WFA":[77,96,132,189,202,232,249,267,333,374],"increased":[78,254,262,276,300],"expression":[79,104,138,171,263,293,305],"osteoblast-specific":[81],"transcription":[82,153],"factor":[83,114,146,154,179,206,215],"mineralizing":[85],"genes,":[86],"promoted":[87,234,334],"survival":[89],"suppressed":[91,240],"inflammatory":[92],"cytokines.":[93],"In":[94],"osteoclast,":[95],"treatment":[97,130,175],"decreased":[98,137,187,285],"osteoclast":[99,241],"number":[100],"directly":[101],"decreasing":[103,120],"tartarate-resistant":[106],"acid":[107],"phosphatase":[108],"receptor":[110],"activator":[111],"nuclear":[113,205,217],"kappa-B":[115,207],"(RANK)":[116],"indirectly":[118],"osteoprotegrin/RANK":[121],"ligand":[122],"ratio.":[123],"Our":[124],"data":[125,224,371],"in":[128,227,257,309,344],"vitro":[129,228],"calvarial":[134],"cells":[136,185,256],"E3":[140],"ubiquitin":[141,144],"ligase,":[142],"Smad":[143,159],"regulatory":[145],"2":[147,155],"(Smurf2),":[148],"preventing":[149],"degradation":[150],"Runt-related":[152],"(RunX2)":[156],"relevant":[158],"proteins,":[160],"which":[161],"are":[162],"phosphorylated":[163],"morphogenetic":[166],"protein":[167],"2.":[168],"Increased":[169],"Smurf2":[170],"due":[172],"exogenous":[174],"tumor":[177,213],"necrosis":[178,214],"\u03b1":[180],"(TNF\u03b1)":[181],"primary":[183],"was":[186,192,352],"treatment.":[190],"This":[191],"corroborated":[193],"using":[195],"small":[196],"interfering":[197],"RNA":[198],"against":[199],"Smurf2.":[200],"Further,":[201],"also":[203,299],"blocked":[204],"(NF-kB)":[208],"signaling":[209],"assessed":[211],"stimulated":[216],"translocation":[218],"p65-subunit":[220],"NF-kB.":[222],"Overall":[223],"proteasome":[229],"inhibition":[230],"simultaneously":[233],"osteoblastogenesis":[235],"stabilizing":[237],"RunX2":[238],"differentiation,":[242],"inhibiting":[244],"osteoclastogenesis.":[245],"Oral":[246],"administration":[247],"osteopenic":[251],"ovariectomized":[252],"mice":[253],"osteoprogenitor":[255],"marrow":[260],"osteogenic":[265,307],"genes.":[266,297],"supplementation":[268],"improved":[269],"trabecular":[270],"micro-architecture":[271],"long":[274],"bones,":[275],"biomechanical":[277],"strength":[278],"parameters":[279],"vertebra":[282],"femur,":[284],"turnover":[287],"markers":[288],"(osteocalcin":[289],"TNF\u03b1)":[291],"skeletal":[295],"osteoclastogenic":[296],"new":[301],"genes":[308],"femur":[311,346],"compared":[314],"with":[315,354],"vehicle":[316],"groups":[317],"(Sham)":[318],"ovariectomy":[320],"(OVx),":[321],"Bortezomib":[322],"(known":[323],"PI),":[324],"injectible":[325],"parathyroid":[326],"hormone":[327],"alendronate":[329],"(FDA":[330],"approved":[331],"drugs).":[332],"process":[336],"cortical":[338,350],"regeneration":[340],"at":[341],"drill-holes":[342],"site":[343],"mid-diaphysis":[347],"region":[348],"gap":[351],"bridged":[353],"woven":[355],"within":[357],"11":[358],"days":[359],"both":[361],"estrogen":[362],"sufficient":[363],"deficient":[365],"(ovariectomized,":[366],"Ovx)":[367],"mice.":[368],"Together":[369],"our":[370],"suggest":[372],"stimulates":[375],"abrogating":[379],"machinery":[381],"provides":[383],"knowledge":[384],"base":[385],"for":[386],"its":[387],"clinical":[388],"evaluation":[389],"anabolic":[393],"agent.":[394]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}