{"id":"https://openalex.org/W2012010107","doi":"https://doi.org/10.1097/00005344-199904000-00001","title":"Welsh Onion (Allium fistulosum L.) Extracts Alter Vascular Responses in Rat Aortae","display_name":"Welsh Onion (Allium fistulosum L.) Extracts Alter Vascular Responses in Rat Aortae","publication_year":1999,"publication_date":"1999-04-01","ids":{"openalex":"https://openalex.org/W2012010107","doi":"https://doi.org/10.1097/00005344-199904000-00001","mag":"2012010107","pmid":"https://pubmed.ncbi.nlm.nih.gov/10218719"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199904000-00001","doi":"https://doi.org/10.1097/00005344-199904000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199904000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105533494","display_name":"Jia-Huey Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I56019348","display_name":"Chia Nan University of Pharmacy and Science","ror":"https://ror.org/02834m470","country_code":"TW","type":"education","lineage":["https://openalex.org/I56019348"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Jia-Huey Chen","raw_affiliation_strings":["Department of Food Health, Chia Nan College of Pharmacy and Science, Taichung, Taiwan, ROC","*Department of Food Science, National Chung Hsing University, Taichung","Department of Food Health, Chia Nan College of Pharmacy and Science","\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Health, Chia Nan College of Pharmacy and Science, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"*Department of Food Science, National Chung Hsing University, Taichung","institution_ids":["https://openalex.org/I162838928"]},{"raw_affiliation_string":"Department of Food Health, Chia Nan College of Pharmacy and Science","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111898417","display_name":"Shun-Jen Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I56019348","display_name":"Chia Nan University of Pharmacy and Science","ror":"https://ror.org/02834m470","country_code":"TW","type":"education","lineage":["https://openalex.org/I56019348"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shun-Jen Tsai","raw_affiliation_strings":["Department of Food Health, Chia Nan College of Pharmacy and Science","*Department of Food Science, National Chung Hsing University, Taichung","\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Health, Chia Nan College of Pharmacy and Science","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"*Department of Food Science, National Chung Hsing University, Taichung","institution_ids":["https://openalex.org/I162838928"]},{"raw_affiliation_string":"\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042823626","display_name":"Hsiun\u2010ing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162838928","display_name":"National Chung Hsing University","ror":"https://ror.org/05vn3ca78","country_code":"TW","type":"education","lineage":["https://openalex.org/I162838928"]},{"id":"https://openalex.org/I56019348","display_name":"Chia Nan University of Pharmacy and Science","ror":"https://ror.org/02834m470","country_code":"TW","type":"education","lineage":["https://openalex.org/I56019348"]},{"id":"https://openalex.org/I91807558","display_name":"National Cheng Kung University","ror":"https://ror.org/01b8kcc49","country_code":"TW","type":"education","lineage":["https://openalex.org/I91807558"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Hsiun-ing Chen","raw_affiliation_strings":["Department of Food Health, Chia Nan College of Pharmacy and Science","*Department of Food Science, National Chung Hsing University, Taichung","\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Health, Chia Nan College of Pharmacy and Science","institution_ids":["https://openalex.org/I56019348"]},{"raw_affiliation_string":"*Department of Food Science, National Chung Hsing University, Taichung","institution_ids":["https://openalex.org/I162838928"]},{"raw_affiliation_string":"\u2020Department of Physiology, National Cheng-Kung University Medical College, Tainan, Taiwan, R.O.C","institution_ids":["https://openalex.org/I91807558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5042823626","https://openalex.org/A5105533494"],"corresponding_institution_ids":["https://openalex.org/I162838928","https://openalex.org/I56019348","https://openalex.org/I91807558"],"apc_list":null,"apc_paid":null,"fwci":1.4629,"has_fulltext":false,"cited_by_count":36,"citation_normalized_percentile":{"value":0.82742489,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"4","first_page":"515","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11979","display_name":"Garlic and Onion Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allium-fistulosum","display_name":"Allium fistulosum","score":1.0},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.6549999713897705},{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.8140000104904175},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endothelium-independent-relaxation","display_name":"endothelium-independent relaxation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/thromboxane-a2","display_name":"thromboxane A2","score":0.9330000281333923},{"id":"https://openalex.org/keywords/endothelium-derived-contracting-factor","display_name":"endothelium-derived contracting factor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/aortic-rings","display_name":"aortic rings","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.4480000138282776},{"id":"https://openalex.org/keywords/dietary-plant-extract","display_name":"dietary plant extract","score":0.38600000739097595}],"concepts":[{"id":"https://openalex.org/C2910404987","wikidata":"https://www.wikidata.org/wiki/Q27938","display_name":"Allium fistulosum","level":3,"score":0.9472314715385437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5181745290756226},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4029552638530731},{"id":"https://openalex.org/C2776460402","wikidata":"https://www.wikidata.org/wiki/Q49391","display_name":"Allium","level":2,"score":0.397754967212677},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3671298027038574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3096272349357605}],"mesh":[{"descriptor_ui":"D000490","descriptor_name":"Allium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199904000-00001","doi":"https://doi.org/10.1097/00005344-199904000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199904000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:10218719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10218719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1972773259","https://openalex.org/W1979591663","https://openalex.org/W1984519108","https://openalex.org/W1985143568","https://openalex.org/W1992297713","https://openalex.org/W1992318304","https://openalex.org/W2002208004","https://openalex.org/W2008044033","https://openalex.org/W2010807769","https://openalex.org/W2011910449","https://openalex.org/W2013376946","https://openalex.org/W2014980041","https://openalex.org/W2030087792","https://openalex.org/W2045461798","https://openalex.org/W2059469379","https://openalex.org/W2060694645","https://openalex.org/W2077119701","https://openalex.org/W2082086650","https://openalex.org/W2084578803","https://openalex.org/W2086827040","https://openalex.org/W2092643965","https://openalex.org/W2127065175","https://openalex.org/W2159915456","https://openalex.org/W2296864267","https://openalex.org/W2316789677","https://openalex.org/W2462784791","https://openalex.org/W2915170088","https://openalex.org/W4246338940"],"related_works":["https://openalex.org/W2358215760","https://openalex.org/W1984519108","https://openalex.org/W2110283442","https://openalex.org/W7006515962","https://openalex.org/W2058381766","https://openalex.org/W1935833961","https://openalex.org/W2283519323","https://openalex.org/W2592728548","https://openalex.org/W2224924949","https://openalex.org/W4224311843"],"abstract_inverted_index":{"Welsh":[0,26,57,84,133,153],"onion,":[1],"a":[2],"member":[3],"of":[4,13,46,52,109,122,140],"the":[5,43,56,128,131,138],"genus":[6],"Allium,":[7],"has":[8],"been":[9],"consumed":[10],"for":[11],"prevention":[12],"cardiovascular":[14],"disorders.":[15],"However,":[16],"its":[17],"underlying":[18],"mechanisms":[19],"are":[20],"still":[21],"unclear.":[22],"We":[23,150],"investigated":[24],"whether":[25],"onion":[27,58,85,134,154],"extracts":[28,86],"(green":[29],"or":[30,34],"white":[31],"portion,":[32],"raw":[33,103],"boiled)":[35],"can":[36,156],"alter":[37],"vascular":[38,60,158],"responses":[39,61],"in":[40,42,55,98,160],"vitro":[41],"thoracic":[44],"aortae":[45],"Sprague-Dawley":[47],"rats.":[48],"The":[49],"possible":[50],"roles":[51],"endothelium-derived":[53,117,142],"factors":[54],"extract-induced":[59],"were":[62,95],"examined":[63],"by":[64,116],"applying":[65],"various":[66],"inhibitors,":[67],"such":[68],"as":[69],"Nomega-nitro-L-arginine":[70],"(10(-4)":[71],"M),":[72,75],"tetraethylammonium":[73],"(10(-3)":[74],"and":[76,163],"SQ29548":[77],"(10(-5)":[78],"M).":[79],"Our":[80],"results":[81],"showed":[82],"that":[83,152],"caused":[87],"vasodilation":[88],"on":[89],"precontracted":[90],"vessel":[91,99],"rings.":[92],"These":[93],"effects":[94],"most":[96],"pronounced":[97],"rings":[100],"treated":[101],"with":[102],"green-leaf":[104],"extract":[105,135,155],"(RG).":[106],"Low":[107],"doses":[108,121],"RG":[110,123],"induced":[111,124],"vasorelaxation,":[112],"which":[113,145],"was":[114],"mediated":[115],"nitric":[118],"oxide.":[119],"High":[120],"endothelium-independent":[125,164],"vasorelaxation.":[126],"On":[127],"other":[129],"hand,":[130],"boiled":[132],"also":[136],"stimulated":[137],"release":[139],"an":[141],"contracting":[143],"factor,":[144],"might":[146],"be":[147],"thromboxane":[148],"A2.":[149],"conclude":[151],"modulate":[157],"tone":[159],"both":[161],"endothelium-dependent":[162],"manners.":[165]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}